JPH04308527A - Plaster for medical use - Google Patents

Abstract

PURPOSE:To provide a medical plaster exhibiting corset effect to fix the damaged body part and having excellent heat-insulation effect, adhesive force and pharmaceutical action. CONSTITUTION:The objective medical plaster is composed of a substrate (1) and a plaster layer (2) obtained by including pharmacodynamic component in a tacky adhesive agent and placed on one face of the substrate (1), wherein the substrate (1) is composed of a foamed layer (11) having essentially open-cell structure and a woven or nonwoven fabric (12) laminated on one face of the layer (11), the rigidity of the substrate (1) is >=40mm by JIS L-1005, the thickness of the substrate is 0.3-7mm and the plaster layer (2) is applied to essentially the whole surface of the woven or nonwoven fabric of the substrate (1).

Description

[Detailed description of the invention]

0001

[Field of Industrial Application] The present invention relates to a medical patch comprising a paste layer made of an adhesive containing a medicinal ingredient provided on one side of a support, and more particularly relates to a medical patch for treating low back pain, sprains, etc.
The present invention relates to a medical patch that exhibits a corset effect to fix the affected area when used for anti-inflammatory and analgesic treatment of tendon sheath, muscle pain, etc., and has excellent heat retention effect, adhesion strength, and medicinal efficacy.

0002

[Prior Art] Conventionally, this type of medical patch uses a woven or non-woven fabric such as sfumuslin, cotton cloth, flannel, or raised non-woven fabric, or a thin film as a support, and has an adhesive containing a medicinal ingredient. It is constructed by providing a plaster layer consisting of a material on one side of the support.

[0003] These supports made of woven fabrics, non-woven fabrics, or films have good heat retention, breathability, and water absorption properties so that the patch can follow the movements of the body and do not cause discomfort at the application site. The aim is to create a patch that is thin, flexible, and stretchable. Therefore, the support of commercially available patches is made of woven or nonwoven fabric having a bending resistance of about 17 to 28 mm according to JIS L 1005, for example.

0004

[Problems to be Solved by the Invention] However, conventional medical patches using supports made of the materials described above do not have the function of fixing or supporting the affected area.

The purpose of the present invention is rather the opposite of the above-mentioned aims of conventional medical patches, and is to exert a corset effect to immobilize the affected area, as well as to have a heat-retaining effect, adhesive strength, and medicinal efficacy. Our goal is to provide superior medical patches.

[0006]

[Means for Solving the Problems] The present invention has been devised to achieve the above object, and by using a material having specific physical properties as a support, it is possible to achieve the above-mentioned corset effect and other remarkable effects. This was completed after gaining knowledge that it could be used to its full potential.

That is, in a medical patch in which a plaster layer made of an adhesive containing a medicinal ingredient is provided on one side of a support, the support has a substantially closed-cell foam layer and the same layer. The support has a bending resistance according to JIS L 1005 of 40 mm or more and a thickness of 0.3 to 7 mm, and the plaster layer is made of a woven fabric or a non-woven fabric laminated on one side of the support. It is characterized in that it is provided over substantially the entire surface of the nonwoven fabric.

[0008] The components constituting the medical patch according to the present invention and the method for producing the patch will be explained below.

1) Support (a) The support consists of a foam layer and a woven fabric or non-woven fabric laminated on one side of the same layer, and conforms to JIS L 1005.
The material has a bending resistance (45° cantilever method) of 40 mm or more and a thickness of 0.2 to 7 mm.

[0010] The bending resistance according to JIS L 1005 is 25 mm width x 15 at a temperature of 23°C and a relative humidity of 65%.
A 0 mm long test piece is pushed out in the direction of the slope from a smooth horizontal table with a 45° slope at the tip, and when the tip of the test piece comes into contact with the slope, it is expressed as the distance pushed out. If this value is less than 40 mm, the feeling of pliability and fixing or supporting the affected area decreases. Moreover, if the above-mentioned value exceeds 660 mm, the support will be too hard and difficult to use, and the texture will be poor. Therefore, the bending resistance of the support is in the range of 40 to 600 mm, and a particularly preferable bending resistance is in the range of 100 to 350 mm.

[0011] The thickness of the support is in the range of 0.3 to 7 mm. The reason for this is that if the thickness is less than 0.3 mm, the heat retention is poor and the rigidity is not sufficient to provide a corset effect that can fix or support the affected area, and if the thickness exceeds 7 mm, the corset effect is good, but This is because there is a great sense of discomfort during application, and the applied area is conspicuous. A particularly preferred thickness of the support is in the range of 1 to 3 mm.

The 20% modulus of the support is preferably 0.7 kg/25 mm width or more, particularly preferably 1.0 kg/25 mm width or more.

(b) The foam that is a component of the support is made of resin such as polyethylene, ethylene-vinyl acetate copolymer, polyurethane, polypropylene, polyvinyl chloride, or the like. Although both crosslinked and non-crosslinked resins can be used, crosslinked resins are preferred. To obtain foam from these resins, a blowing agent, a crosslinking agent (not needed in the case of radiation crosslinking), a polyfunctional monomer as necessary, etc. are added to the resin, the mixture is molded into the desired shape, and the Methods such as crosslinking is performed by irradiation or heating at a temperature below the decomposition temperature of the blowing agent, and then foaming is performed by heating at a temperature above the decomposition temperature of the blowing agent, or crosslinking and foaming are performed simultaneously.

[0014] The foam is limited to a substantially closed cell cell morphology. The reason for this is that closed-cell foams have high rigidity and are convenient for exerting a corset effect to fix the affected area, and also have excellent heat retention effects. However, open cells may be mixed to the extent that the rigidity is not impaired. The foaming ratio is appropriately selected within the range of 5 to 55 times, but considering the purpose of use of the foam in the present invention, a foamed product with a foam ratio of 20 to 30 times is preferable.

(c) Regarding the woven fabric or non-woven fabric that is another component of the support, the woven fabric may be cotton, cotton, cotton,
A woven fabric of fibers such as nylon or rayon is used, and the weaving method, density, fiber denier, etc. are not particularly limited.

[0016] Nonwoven fabrics include rayon, cellulose,
Fibers such as nylon, polypropylene, and polyethylene glycol terephthalate may be used alone or in combination with these fibers. The fibers of the nonwoven fabric may be short fibers or long fibers. Nonwoven fabrics also include felt. The basis weight of the nonwoven fabric is preferably in the range of 15 g to 150 g/m2, and usually 40 g/m2.
A non-woven fabric of ~70 g/m2 is suitable.

[0017] The thickness of the woven or nonwoven fabric is preferably 0.
It is 1 to 0.3 mm.

(d) For bonding the woven or nonwoven fabric to one side of the foam layer, a heating lamination method, an adhesive method, or the like can be appropriately employed, but the heating lamination method is preferable.

2) Plasma The plaster is composed of an adhesive containing medicinal ingredients.

(a) The adhesive is the base component of the paste and is appropriately selected from lipophilic (oil-based) adhesives and hydrophilic (water-based) adhesives.

[0021] Lipophilic adhesives are generally used in warming type patches. As a lipophilic adhesive, styrene-
Lipophilic polymers such as isoprene-styrene block copolymer rubber, polyacrylic acid ester polymer, natural rubber, and various synthetic rubbers, as well as terpene resins, alicyclic synthetic resins, and rosin resins, as necessary. Examples include those containing tackifiers such as, softeners such as liquid paraffin and polybutene, fillers such as titanium oxide and zinc oxide, and anti-aging agents such as BHT.

[0022] Hydrophilic adhesives are generally used in cold-feeling type patches. Hydrophilic adhesives include natural water-soluble polymers such as sodium alginate, gelatin, cornstarch, gum tragacanth, and casein; methylcellulose, carboxymethylcellulose, polyvinyl alcohol, sodium polyacrylate, methoxyethylene-maleic anhydride copolymer, polyvinyl Synthetic or semi-synthetic hydrophilic polymers such as ether are blended with moisturizing agents such as glycerin and propylene glycol, swelling agents such as water, acetone, methyl ethyl ketone, kaolin, bentonite, aluminum sulfate, zinc oxide, etc., if necessary. Things are exemplified.

(b) Typical examples of medicinal ingredients contained in adhesives include the following: Salicylic acid esters such as glycol salicylate and methyl salicylate;
・Medicines commonly used as external preparations such as capsicum extract, nonylic acid vanillylamide, camphor, peppermint oil, menthol, thymol, and vitamin E. ・Various herbal medicines such as sardines, cypress, chamomile, aloe, and arnica. ・Indomethacin, ketoprofen, and chlorine. Analgesic anti-inflammatory drugs such as rubiflofen.

[0024] The content of medicinal ingredients in the paste is preferably 0.
．． It is 1 to 1.5% by weight.

(c) A plaster is generally prepared by blending a medicinal ingredient and an adhesive in the required proportions by a conventional method, such as a hot melt method.

3) Formation of a plaster layer on the support The plaster layer containing the medicinal ingredient in the adhesive is formed on the side of the woven or non-woven fabric of the support by a hot melt method, a solvent method, a calendar method, etc. , is established using the following method.

[0027] First, the adhesive is used as it is or a solvent is added thereto as necessary, and this is made into a slimy state by heating or at room temperature, and a medicinal ingredient is added to this and the whole is mixed uniformly to prepare a paste. . Next, this paste is applied to the side surface of the woven or nonwoven fabric of the support using a coating machine.

As for the form of applying the paste to the support, the paste is provided on substantially the entire surface of the woven or nonwoven fabric side of the support. Here, "coating substantially over the entire surface of the support" means excluding coating that forms a pattern with non-coated areas between coated areas, such as so-called streaks, networks, spots, etc. It is. Therefore, patches that have non-coated areas at the edges and a plaster covering the entire other parts, or patches that have a plaster covering the entire surface of one side of the support and are perforated for ventilation, It is included in the concept of a patch in which a plaster layer is coated on substantially the entire surface of a support.

Finally, a release paper is attached to the entire surface of the plaster to protect the plaster layer, and the obtained product is cut into a predetermined sheet shape and packaged. Further, the product can be rolled and stacked without cutting it into a predetermined sheet shape. The product can also be obtained by applying a paste onto a release paper and laminating a support thereon.

[0030] The thickness of the plaster layer is generally 100 to 350 μm.
It is.

[0031]

[Operation] As described above, the patch according to the present invention meets the JIS standards.
Bending resistance according to L 1005 40mm or more and thickness 0.3~
Since it is equipped with a support body of 7 mm, it has sufficient rigidity to exhibit a corset effect capable of fixing or supporting the affected area. By supporting or fixing the affected area in this way, the affected area is kept at rest, healing is accelerated, and
The user also tries to remain calm without unconsciously making forced movements due to the moderate discomfort caused by the patch, which further speeds up the healing process.

[0032] Furthermore, since this adhesive patch exhibits an appropriate heat-retaining effect due to the use of foam as a constituent member of the support, blood circulation is improved and a more sufficient therapeutic effect can be obtained.

[0033] Furthermore, it is satisfactory in terms of adhesive strength and medicinal efficacy.

Furthermore, since a woven fabric or non-woven fabric is used as a component of the support, if a plaster layer is provided thereon, a part of the plaster will penetrate into the gaps between the fibers of the woven fabric or non-woven fabric, thereby forming an anchor. As a result, the paste is firmly held on the support, and the bending resistance and modulus of the support are adjusted by the woven or nonwoven fabric.

[0035]

[Example] Next, in order to specifically explain the present invention,
Examples of the present invention and comparative examples for comparison therewith will be given, and performance evaluation of each patch will also be shown.

Example 1 1) Preparation of support FIG. 1 is a perspective view showing an example of a medical patch according to the present invention, and FIG. 2 is an enlarged sectional view taken along line II-II in FIG.

A commercially available electron beam crosslinked polyethylene foam with a foaming ratio of 30 times and substantially closed cells (
Manufactured by Sekisui Chemical Co., Ltd., product name "Sekisui Softron IF300"
A nonwoven fabric (12) made of a mixed paper of rayon and polyethylene glycol terephthalate (mixed paper weight ratio 80:20, thickness 0.25 mm, weight 70 g/m2) was applied on one side of a foam layer (11) with a thickness of 2.5 mm A long fiber nonwoven fabric) is laminated together using a thermal lamination method to form a support (
1). That is, the foam layer (11) was lightly exposed to flame, and when the surface melted, the nonwoven fabric (12) was laminated thereon to produce a support (1).

[0038] In this way, the foam layer (11) and the nonwoven fabric (12)
), JIS L1
The bending resistance according to 005 is 92 mm, the thickness is 2.3 mm,
20% modulus 1.5kg/25mm width.

2) Preparation of plaster Styrene-isoprene-styrene block copolymer 10
0 parts by weight of liquid paraffin, 180 parts by weight of liquid paraffin, 140 parts by weight of alicyclic resin, 5 parts by weight of titanium oxide, and 3 parts by weight of BHT, and 1.0 parts by weight of dried Sanshishi extract as a medicinal ingredient. , 0.02 parts by weight of 6% capsicum extract and 3 parts by weight of camphor were mixed together and heated and stirred at a temperature of 130 to 140°C using the hot melt method to make the whole mixture uniform, thereby making a lipophilic paste. Ta.

3) Coating the paste onto the support: First, release paper (3) with a thickness of 25 μm made of polyethylene glycol terephthalate film having a silicone layer on one side.
, and coat the entire surface of the silicone layer side of the release paper (3) with the previously prepared paste to a thickness of 25 mm using a hot melt coating machine.
Immediately after applying the plaster layer (2) at a thickness of 0 μm, the thickness is still 80 μm.
While maintaining the temperature at ~90°C, the plaster layer (2) was laminated to the entire surface of the nonwoven fabric side of the support (1) previously prepared, and the resulting laminate was wound up into a roll.

4) Formation into a sheet A sheet measuring 215 mm in length x 100 mm in width with rounded corners was punched and cut to produce a patch as a final product.

Example 2 A patch was produced in the same manner as in Example 1 except that a hydrophilic adhesive made of sodium alginate was used in place of the lipophilic adhesive in Example 1. .

Comparative Example A commercially available patch (manufactured by Lion Corporation, trade name "Halix 55") was used as a target patch. This target patch has a nonwoven fabric as a support.

Each patch of the Performance Test Examples and Comparative Examples was administered to a plurality of volunteer subjects with back pain (12 males, 5 females, aged 23 to
At the age of 51, the device was pasted vertically on the lower back along the spine, and the performance was evaluated using a questionnaire.

[0045] As a result, compared to the target patch, the patch of Example 1 always supported the lower back and gave a sense of stability to the lower back,
It was recognized that it gave a sense of psychological relief, had excellent physical and psychological effects in addition to medicinal efficacy, and was also excellent in heat retention.

[0046]Although the patch of Example 2 is slightly inferior to the patch of Example 1 in terms of adhesiveness, it is clearly superior to the target patch in terms of corset effect, heat retention effect, adhesive strength, and medicinal efficacy. It was confirmed that it is excellent.

[0047]

Effects of the Invention According to the adhesive patch of the present invention, since a material having specific physical properties is used as a support, a corset effect capable of fixing or supporting the affected area can be exerted. By supporting or fixing the affected area in this way, the affected area can be kept at rest and healing can be accelerated, and the user can also try to rest without unconsciously making forced movements due to the moderate discomfort of the patch, allowing the area to heal. can be further accelerated.

[0048] Furthermore, by using a foam as a constituent member of the support, this adhesive patch exhibits an appropriate heat-retaining effect, thereby improving blood circulation and exhibiting a more sufficient therapeutic effect.

[0049] Furthermore, it is satisfactory in terms of adhesive strength and medicinal efficacy.

Furthermore, since a woven fabric or non-woven fabric is used as a component of the support, if a plaster layer is provided thereon, a part of the plaster will penetrate into the gaps between the fibers of the woven fabric or non-woven fabric, thereby forming an anchor. This effect allows the plaster to be firmly held on the support, and the bending resistance and modulus of the support can be adjusted by the woven or nonwoven fabric.

[Brief explanation of drawings]

FIG. 1 is a perspective view showing a medical patch according to an example.

FIG. 2 is an enlarged sectional view taken along line II-II in FIG. 1.

[Explanation of symbols]

(1) Support body (2) Plaster layer (3) Release paper (11) Foam layer (12) Non-woven fabric

Claims (1)

[Claims] Claim 1: A medical patch in which a plaster layer made of an adhesive containing a medicinal ingredient is provided on one side of a support, wherein the support has a substantially closed-cell foam layer and the same layer. The support has a bending resistance according to JIS L 1005 of 40 mm or more and a thickness of 0.3 to 7 mm, and the plaster layer is made of a woven fabric or a non-woven fabric laminated on one side of the support. A medical patch characterized in that it is provided over substantially the entire surface of a nonwoven fabric.