JPH04305522A - Application agent for medical use - Google Patents

Abstract

PURPOSE:To obtain an application agent for medical use, having corset effects for fixing affected parts conversely to the aim of conventional application agents for the medical use, simultaneously excellent in fitness, improved in heat insulating effects, application force and pharmacodynamic effects and further having holding effects on its own shape. CONSTITUTION:An application agent for medical use is characterized in that a plaster layer containing a pharmacodynamically effective ingredient contained in a tacky agent is provided on one surface of a support having >=50mm stiffness measured by JIS L1005 and 0.2-7mm thickness and curved with the side of the support inside.

Description

[Detailed description of the invention]

0001

[Field of Industrial Application] The present invention relates to a medical patch comprising a paste layer made of an adhesive containing a medicinal ingredient on one side of a support.
When used for anti-inflammatory and analgesic treatment of tendon sheaths, muscle pain, etc., it has a corset effect that fixes the affected area, provides a good fit, has excellent heat retention effects, adhesive strength, and medicinal effects, and also has the effect of retaining its own form. This relates to medical patches.

0002

[Prior Art] Conventionally, this type of medical patch uses a woven or non-woven fabric such as sfumuslin, cotton cloth, flannel, or raised non-woven fabric, or a thin film as a support, and has an adhesive containing a medicinal ingredient. It is constructed by providing a plaster layer consisting of a material on one side of the support.

[0003] These supports made of woven fabrics, non-woven fabrics, or films have good heat retention, breathability, and water absorption properties so that the patch can follow the movements of the body and do not cause discomfort at the application site. The aim is to create a patch that is thin, flexible, and stretchable. Therefore, the support of commercially available patches is made of woven or nonwoven fabric having a bending resistance of about 17 to 28 mm according to JIS L 1005, for example.

0004

[Problems to be Solved by the Invention] However, conventional medical patches using supports made of the materials described above do not have the function of fixing or supporting the affected area.

[0005] Furthermore, a patch having such a structure has so-called stiffness and cannot maintain its own shape. Therefore, there is a problem in that during application, the patch after the release paper is removed is bent so that the plaster surfaces align, causing the plaster surfaces to stick together. Particularly in the case of lower back pain, since the affected area is the back of the lower back, it is difficult to align the application position and it is difficult for the user to apply it alone.

The purpose of the present invention is rather the opposite of the above-mentioned aims of conventional medical patches, and is to have a corset effect to fix the affected area, a good fit, a heat retention effect, and a patch. It is an object of the present invention to provide a medical patch that has excellent adhesion and medicinal efficacy, and also has the effect of retaining its own form.

[0007]

[Means for Solving the Problems] The present invention has been devised to achieve the above object, and by using a material having specific physical properties as a support, it is possible to achieve the above-mentioned corset effect and other remarkable effects. This was completed after gaining knowledge that it could be used to its full potential.

[0008] That is, the medical patch according to the present invention has the following features:
The plaster layer made of adhesive containing medicinal ingredients is JIS L
1005 with bending resistance of 50 mm or more and thickness of 0.2 to 7
It is characterized in that it is provided on one side of a support body of mm in diameter and is curved with the support side facing inward.

[0009] The components constituting the medical patch according to the present invention and the method for producing the patch will be explained below.

1) Support The support consists of a foam layer and a woven or nonwoven fabric laminated on one side of the same layer, or only of the woven or nonwoven fabric. In either case, the support is JISL 1
Bending resistance (45° cantilever method) according to 005 is 50m
m or more and has a thickness of 0.2 to 7 mm.

[0011] The bending resistance according to JIS L 1005 is 25 mm width x 15 at a temperature of 23°C and a relative humidity of 65%.
A 0 mm long test piece is pushed out in the direction of the slope from a smooth horizontal table with a 45° slope at the tip, and when the tip of the sample comes into contact with the slope, it is expressed as the distance pushed out. If this value is less than 50 mm, the feeling of pliability and fixing or supporting the affected area will be reduced. Therefore, the bending resistance of the foam layer is limited to 50 mm or more. A particularly preferable bending resistance is 100 mm or more.

[0012] The thickness of the support is in the range of 0.2 to 7 mm. The reason for this is that if it is thinner than 0.2 mm, the heat retention and corset effect will be low, and if it exceeds 7 mm, the corset effect will be good but it will feel uncomfortable and the attached part will be noticeable. A particularly preferred thickness of the support is in the range of 1 to 3 mm.

[0013] Also, the 20% modulus of the support is 0.7
kg/25mm width or more, preferably 1.0 kg/
The width is 25 mm or more.

(a) Regarding the woven fabric or non-woven fabric that is an essential component of the support, woven fabrics of fibers such as cotton, cotton, nylon, and rayon are used, and the weaving method,
Density, fiber denier, etc. are not particularly limited.

[0015] Nonwoven fabrics include rayon, cellulose,
Fibers such as nylon, polypropylene, and polyethylene glycol terephthalate may be used alone or in combination with these fibers. The fibers of the nonwoven fabric may be short fibers or long fibers. Nonwoven fabrics also include felt. The weight of the woven fabric and nonwoven fabric is preferably in the range of 15 to 150 g/m2, and usually 40 to 70 g/m2.

[0016] The thickness of the woven fabric or nonwoven fabric bonded to the foam layer is preferably 0.1 to 0.3 mm.

(b) Examples of the resin for producing the foam layer, which is an optional additional component of the support, include polyethylene, ethylene-vinyl acetate copolymer, polyurethane, polypropylene, polyvinyl chloride, etc. . Although both crosslinked and non-crosslinked resins can be used, crosslinked resins are preferred. To obtain foam from these resins, a blowing agent, a crosslinking agent (not needed in the case of radiation crosslinking), a polyfunctional monomer as necessary, etc. are added to the resin, the mixture is molded into the desired shape, and the Methods such as crosslinking is performed by irradiation or heating at a temperature below the decomposition temperature of the blowing agent, and then foaming is performed by heating at a temperature above the decomposition temperature of the blowing agent, or crosslinking and foaming are performed simultaneously.

Regarding the cell form of the foam, it is possible to use closed cell foam, open cell foam, or a mixture of both, but if moisture volatility is expected, open cell foam may be used to the extent that it does not impede heat retention. A mixed closed cell foam is preferred. The foaming ratio is appropriately selected in the range of 5 to 55 times,
Considering the purpose of use of the foam in the present invention, 20 to 3
A 0x foamed product is preferred.

(c) When a laminate of a foam layer and a woven or nonwoven fabric is used as a support, the woven or nonwoven fabric can be attached to one side of the foam layer by a thermal lamination method, an adhesive method, or the like. Although it can be used as appropriate, a heating lamination method is preferable.

2) Plasma The plaster is composed of an adhesive containing medicinal ingredients.

(a) The adhesive is the base component of the paste and is appropriately selected from lipophilic (oil-based) adhesives and hydrophilic (water-based) adhesives.

[0022] Lipophilic adhesives are generally used in warm-sensitive adhesive patches. As a lipophilic adhesive, styrene-
Lipophilic polymers such as isoprene-styrene block copolymer rubber, polyacrylic acid ester polymer, natural rubber, and various synthetic rubbers, as well as terpene resins, alicyclic synthetic resins, and rosin resins, as necessary. Examples include those containing tackifiers such as, softeners such as liquid paraffin and polybutene, fillers such as titanium oxide and zinc oxide, and anti-aging agents such as BHT.

[0023] Hydrophilic adhesives are generally used in cold-feeling type patches. Hydrophilic adhesives include natural water-soluble polymers such as sodium alginate, gelatin, cornstarch, gum tragacanth, and casein; methylcellulose, carboxymethylcellulose, polyvinyl alcohol, sodium polyacrylate, methoxyethylene-maleic anhydride copolymer, polyvinyl Synthetic or semi-synthetic hydrophilic polymers such as ether are blended with moisturizing agents such as glycerin and propylene glycol, swelling agents such as water, acetone, methyl ethyl ketone, kaolin, bentonite, aluminum sulfate, zinc oxide, etc., if necessary. Things are exemplified.

(b) Typical examples of medicinal ingredients contained in the adhesive include the following: - Salicylic acid esters such as glycol salicylate and methyl salicylate, - Capsicum extract, nonylic acid vanillylamide, camphor, and peppermint. Drugs commonly used as external preparations such as oil, menthol, thymol, and vitamin E; -Various herbal medicines such as sagebrush, japonica, chamomile, aloe, and arnica; -Analgesic and anti-inflammatory agents such as indomethacin, ketoprofen, and chlorbiflofen.

[0025] The content of medicinal ingredients in the paste is preferably 0.
．． It is 1 to 1.5% by weight.

(c) A plaster is generally prepared by blending a medicinal ingredient and an adhesive in the required proportions by a conventional method, such as a hot melt method.

3) Formation of a plaster layer on the support The plaster layer containing the medicinal ingredient in the adhesive is formed on the side of the woven or non-woven fabric of the support by a hot melt method, a solvent method, a calendar method, etc. , is established using the following method.

[0028] First, the adhesive is used as it is or a solvent is added thereto as necessary, and this is made into a slimy state by heating or at room temperature, and a medicinal ingredient is added to this and the whole is mixed uniformly to prepare a paste. . Next, this paste is applied to the side surface of the woven or nonwoven fabric of the support using a coating machine. In this way, the paste may be applied directly to the support, or it may be applied to a release paper and then transferred.

As for the form of applying the paste to the support, the paste may be applied to the entire surface of the woven or non-woven fabric side of the support, or the paste may be applied in stripes or by dividing the coated area. mesh,
The plaster may be partially provided in a pattern in which non-coated areas are present between coated areas, such as in spots. When the plaster is provided over the entire surface of the support, it is generally preferable to perforate the final product to impart air permeability. When coating in the form of streaks, it is preferable to apply the coating so that the direction of the formed streaks coincides with the direction of the body's muscles at the time of application.

Finally, a release paper is attached to the entire surface of the plaster layer to protect the plaster layer, and the obtained product is cut into a predetermined sheet shape and packaged. Further, the product can be rolled and stacked without cutting it into a predetermined sheet shape. The product can also be obtained by applying a paste onto a release paper and laminating a support thereon.

[0031] The thickness of the plaster layer is generally 100 to 350 μm.
It is.

4) Giving a curved shape To give the adhesive patch a curved shape with the support side facing inside, the following method may be used, for example.

(a) When using a laminate of a foam layer and a woven or non-woven fabric as a support, the foam layer is stretched with the required strength and the woven or non-woven fabric is not subjected to any tension. Attach woven or non-woven fabric to one side of the layer. The woven or nonwoven fabric is attached to the foam layer by a method in which the foam layer is lightly exposed to flame and when the surface melts, the woven or nonwoven fabric is attached to it, or by an adhesive method. Alternatively, the support may be given a curved shape by thermoforming using a hot roll. In this way, the support is curved with the foam layer inside.

(b) When using a woven fabric and a nonwoven fabric as a support, a nonwoven fabric soaked in a binder that binds the fibers of the nonwoven fabric, or a nonwoven fabric mixed with low melting point fibers such as polyethylene, while applying tension. ,
A curved shape can be imparted by overlapping a woven fabric that does not apply tension and passing this overlapping body through a heated roll. In addition, while applying tension to a nonwoven fabric in which the surface layer is made of high melting point fibers such as cellulose, nylon, or polyethylene terephthalate, and the back layer is made of the above-mentioned low melting point fibers, the back layer is overlapped with a woven fabric that does not apply tension. A curved shape can also be imparted by combining and passing this stacked body through a hot roll. In these cases, the plaster is applied or transferred to the fabric surface.

[0035] The curvature of the patch is determined by assuming that the width of the patch is (w) and the internal height at the center of the width is (h) (Figure 2
), it is preferable to set it within a range that satisfies the relationship 0.35≧h/w≧0.02. If the value of h/w exceeds 0.35, the adhesion to the skin or fit of the patch will be poor;
If it is smaller than 0.02, a corset effect sufficient to fix the affected area will not be exhibited.

[0036]

[Operation] As described above, the patch according to the present invention meets the JIS standards.
Bending resistance according to L 1005 is 50 mm or more and thickness is 0.
Since it is equipped with a support body of 2 to 7 mm, it has sufficient rigidity to exhibit a corset effect capable of fixing or supporting the affected area. By supporting or fixing the affected area in this way, the affected area is kept at rest and healing is accelerated, and the user also tries to rest without unconsciously making unreasonable movements due to moderate discomfort with the patch, further speeding up the healing. Furthermore, this patch has a moderate heat retention effect, so
Blood circulation is improved and more effective therapeutic effects can be obtained. Moreover, it is satisfactory in terms of adhesive strength and medicinal efficacy.

[0037] Furthermore, since this patch is curved with the support side inward, the patch has good familiarity or fit to the skin.

Furthermore, this curved shape exhibits the effect of retaining its own shape, resulting in a patch that has so-called firmness and does not sag. Therefore, there is no problem that the patch after removing the release paper will bend to match the plaster surfaces and the plaster surfaces will stick to each other during application, and it is easy to align the application position even in cases of lower back pain, and the application can be done by the user alone. obtain.

[0039] It is also possible to provide patches of large size.

[0040]

[Example] Next, in order to specifically explain the present invention,
Examples of the present invention will be given, and performance evaluation of the obtained patches will also be shown.

1) Preparation of support A 2.5 mm thick foam made of commercially available electron beam cross-linked polyethylene foam (manufactured by Sekisui Chemical Co., Ltd., trade name: "Sekisui Softlon IF30025") with a foaming ratio of 30 times. The layer is a nonwoven fabric made of a mixed paper of rayon and polyethylene glycol terephthalate (mixed paper weight ratio 80:20,
A long fiber nonwoven fabric having a thickness of 0.25 mm and a weight of 70 g/m2 was bonded together by a thermal lamination method. That is,
The nonwoven fabric is pasted onto one side of the foam layer by pulling the foam layer with the required strength and applying no tension to the nonwoven fabric. The nonwoven fabric was attached to the foam layer by a method in which the foam layer was lightly exposed to flame and when the surface melted, the nonwoven fabric was attached to the foam layer.

In this way, a curved support (3) was prepared with the foam layer (1) on the inside and the nonwoven fabric (2) on the outside, as shown in the attached FIGS. 1 and 2. The previously defined h/w value is 0.15, the bending resistance according to JIS L 1005 is 92 mm, the thickness is 2.3 mm, and the 20% modulus is 1.5 kg/25 mm width.

2) Preparation of plaster Styrene-isoprene-styrene block copolymer 10
0 parts by weight, 120 parts by weight of liquid paraffin, 130 parts by weight of alicyclic resin, 5 parts by weight of titanium oxide, and 3 parts by weight of BHT, and 1.0 parts by weight of dried extract of Sanshishi and 6% as medicinal ingredients. Capsicum extract 0.
0.05 parts by weight was blended, and the hot melt method was used to obtain 130 to 14
A lipophilic paste was prepared by heating and stirring at a temperature of 0° C. to make the whole mixture uniform.

3) Coating the paste onto the support First, a 25 μm thick release paper made of polyethylene glycol terephthalate film having a silicone layer on one side was prepared, and on the silicone layer side of this release paper, the previously prepared adhesive was applied. Apply the plaster using a hot melt coating machine to a thickness of 250 μm and a coating width of 10
The coating was applied in a number of stripes parallel to the width direction of the support with an uncoated width of 10 mm. Immediately after that, the plaster layer was still 80-9.
While maintaining the temperature at 0°C, a plaster layer (4) is applied to the nonwoven fabric (2) side of the support (3) previously prepared by the transfer method.
pasted together.

4) Formation into a sheet This bonded product was cut into sheets measuring 220 mm in length and 100 mm in width to produce a patch (5) as a final product.

5) The patch obtained in the performance test example was applied to multiple volunteer subjects (22 males and 7 females, ages 37 to 57) with lower back pain, and a convex arc-shaped plaster layer was applied to the back of the lower back. The participants were asked to apply it along the curved surface of the screen and evaluate the feel of the application.

As a result, it was found that the patch of Example was extremely easy to apply, fit well to the curved surface of the back of the lower back, and provided a comfortable feeling of use. Furthermore, this patch was found to be excellent in terms of corset effect for fixing the affected area, heat retention effect, adhesion strength, and medicinal efficacy.

[0048]

Effects of the Invention According to the adhesive patch of the present invention, since a material having specific physical properties is used as a support, a corset effect capable of fixing or supporting the affected area can be exerted. By supporting or fixing the affected area in this way, the affected area can be kept at rest and healing can be accelerated, and the user can also try to rest without unconsciously making forced movements due to the moderate discomfort of the patch, allowing the area to heal. can be further accelerated. Furthermore, since this patch exhibits a moderate heat-retaining effect, it can improve blood circulation and exhibit a more sufficient therapeutic effect. Moreover, it is satisfactory in terms of adhesive strength and medicinal efficacy.

[0049] Furthermore, since this adhesive patch is curved with the support side inward, it is possible to improve the familiarity or fit of the adhesive patch to the skin.

Furthermore, this curved shape exhibits the effect of retaining its own shape, making it possible to obtain a patch that has so-called firmness and does not sag. Therefore, even in the case of lower back pain, it is easy to align the application position, and the application can be done by the user alone. It is also possible to provide patches of large size.

[Brief explanation of drawings]

FIG. 1 is a perspective view of the patch of the present invention.

FIG. 2 is a sectional view taken along line II-II in FIG. 1.

[Explanation of symbols]

(1)...Foam layer (2)...Nonwoven fabric (3)...Support (4)...Paste layer (5)...patch (w)...width of patch (h)...Internal height

Claims (1)

[Claims] Claim 1: A plaster layer made of an adhesive containing a medicinal ingredient is provided on one side of a support having a bending resistance of 50 mm or more according to JIS L 1005 and a thickness of 0.2 to 7 mm, with the support side facing inside. A medical patch characterized by being curved.