JP2531179B2 - Poultice - Google Patents

Description

TECHNICAL FIELD The present invention relates to poultices, and more particularly to poultices containing water before use.

(Prior Art) A poultice is intended for cooling an inflamed area, local action of a drug, protection of an affected area, etc. However, a large amount of poultice is contained in the poultice for percutaneous absorption of a drug and cooling of an inflamed area. It is necessary to keep water.

Conventionally, as a poultice, an adhesive water retention layer extended on a support cloth is used, but these poultices resist long-term storage such as separation of water during storage or loss of water and hardening. Not only that, but it was heavy and bulky because it contained a large amount of water, which was inconvenient for transportation and storage.

Therefore, the water-insoluble water-absorbent resin powder is inserted in a sandwich form between the water-permeable base cloth and the water-impermeable base cloth, a support to be a water-retaining layer, and a drug-containing pressure-sensitive adhesive layer on the surface of the water-impermeable base cloth. A poultice that is bonded and wet with water when used has been devised (Japanese Patent Publication No. 61-24367).

(Problems to be solved by the invention) However, since the water-absorbent resin used in the poultice is a powder, in order to fix it to the fibrous matrix, it is uniformly dispersed on a polyethylene nonwoven fabric,
On top of that, another base cloth is layered to form a sandwich, and steam is applied to this to make a water-containing gel, and then dried again,
Place it on an embossing roll, or sprinkle water-absorbent resin powder on a piece of paper or something similar to paper in advance to form a sheet, set it between the above two base cloths, and heat seal the periphery. A product cannot be manufactured without going through many complicated manufacturing steps such as

Further, when these poultices are cut and used in small portions, the water-absorbent resin powder swells and overflows between the two base fabrics. Furthermore, even though these poultices are effective as normal poultices, it is hard to say that they are necessarily suitable as poultices when strong cooling is required.

(Means for Solving Problems) As a result of various studies to solve the problems of the conventional products, the present inventors have found that a water-swellable fiber cloth in which a hydrophilic crosslinked polymer is bonded to synthetic fibers as a water retention layer. It has been found that these problems can be solved by using a water-like material and a water-cooling agent together, and completed the present invention.

The poultice of the present invention comprises a fiber in which a hydrophilic cross-linked polymer is bonded to a synthetic fiber, and a water-absorption amount of 30 ml / g or more is provided with a pressure-sensitive adhesive layer on one side of a water-swellable fiber cloth in a dry state. Along with, a water-cooling substance is kneaded into the pressure-sensitive adhesive layer, or is present between the pressure-sensitive adhesive layer and the water-swellable fiber cloth body, or on the non-sticky surface of the water-swellable fiber cloth body. The poultice that was present.

In the present invention, the fiber in which the hydrophilic crosslinked polymer is bonded to the synthetic fiber may be such that the hydrophilic crosslinked polymer and the synthetic fiber are bonded to each other to such an extent that they are not separated by normal force to form a fiber. With synthetic fibers such as acrylic fiber as the core,
There are a core provided with an outer layer made of a hydrophilic cross-linked polymer such as sodium polyacrylate, a copolymer of sodium acrylate and acrylamide, and the like.

These fibers have a water absorption of 30 ml / g or more, preferably 150 m
l / g or more.

These fibers are spun alone or mixed with other fibers to form a stretchable or non-stretchable cloth-like body such as a non-woven fabric or a woven fabric.

As such a cloth-like material, water-swellable fibers such as Lanseal F [trade name, manufactured by Nippon Exlan Co., Ltd.] and Sumikagel F type [trade name, manufactured by Sumitomo Chemical Co., Ltd.] can be used.

Adhesives are lipophilic adhesives (natural rubber, isoprene rubber, styrene-isoprene-styrene copolymer, styrene-butadiene-styrene copolymer, styrene-butadiene rubber, polyacrylic acid ester, etc.) or hydrophilic adhesives. Corticosteroids, anesthetics, antihistamines, antibacterial agents, antifungal agents, analgesic / antiinflammatory agents, antibiotics, poultices (camphor, menthol, sardine), etc. (carboxyvinyl polymer, polyvinylpyrrolidone, sodium polyacrylate, etc.) , Pine, peppermint oil, thymol,
(Acrinol, funnel extract, capsicum extract, etc.)
And kneading ingredients such as medicinal components and / or excipients, tackifying components, antioxidants, fragrances, and coloring agents.

The water-cooling substance is a substance that causes a cooling action by adding water, and is a substance that can be applied to the skin without any trouble.

For example, hydrated endothermic substances (anhydrous calcium chloride, anhydrous sodium sulfate, etc.) and substances that react with other substances in the presence of water to cause an endothermic action (such as a mixture of ammonium chloride and sodium nitrate) is there.

When the water-cooling substance is kneaded with the adhesive substance, a hydrophilic adhesive substance is used.

The poultice of the present invention can be manufactured as follows.

(1) Adhesive mixed with water-cooling agent The required components and water-cooling agent are weighed and kneaded with a hydrophilic adhesive substance by a conventional method to prepare an adhesive, which is then swelled in the water-swellable fiber cloth. Apply evenly on one side of the body and attach the separator to the adhesive side.

The non-adhesive surface of the water-swellable fibrous cloth is covered with a water-impermeable film having water volatilization holes, or the cloth is exposed without being covered.

 This is cut into an appropriate size and packaged to obtain a product.

(2) One in which the water-cooling agent is not kneaded with the pressure-sensitive adhesive The water-cooling agent is uniformly present on one side of the water-swellable fiber cloth.

a) When a water-cooling agent is present between the pressure-sensitive adhesive layer and the water-swellable fibrous cloth, the water-swellable fiber cloth is coated or covered with a water-impermeable film on the surface of the water-swellable fiber cloth. Without applying the adhesive, the adhesive is applied uniformly, and a separator is attached to the adhesive surface.

The non-adhesive surface of the water-swellable fibrous cloth is covered with a water-impermeable film having a large number of fine holes, or is left uncovered.

b) When a water-cooling agent is present on the non-adhesive surface of the water-swellable fiber cloth, the water-swelling fiber cloth-free surface may or may not be covered with a water-impermeable film. The adhesive is applied uniformly and a separator is attached to the adhesive surface.

The non-adhesive surface of the water-swellable fiber cloth is covered with a water-impermeable film having a large number of fine pores or the same quality as the water-swellable fiber cloth.

Finally, this is cut into an appropriate size and packaged to obtain a product.

(Effect of the invention) Since the poultice of the present invention does not contain water, its volume is smaller than that of the conventional hydrous poultice, and it is convenient for storage, transportation, and carrying. Does not cause quality deterioration due to loss.

In addition, it can be used in emergency care as it can be carried in a dry state and soaked in water when used and applied to the affected area.
It is economical because it can be cut into an appropriate size for use.

Moreover, the amount of water retention in the product can be significantly increased as compared with the conventional hydrous poultice, and the addition of a water-cooling agent makes it possible to maintain a large cooling effect.

(Example) Hereinafter, the present invention will be specifically described with reference to Examples and Test Examples.

Example 1 Glycol salicylate 1.5 parts by weight peppermint oil 1.5 〃 dl-camphor 0.5 〃 diphenhydramine hydrochloride 0.02 〃 carboxyvinyl polymer 5.0 〃 polyvinylpyrrolidone 5.0 〃 propylene glycol 5.0 〃 glycerin 25.0 〃 anhydrous sodium sulfate 30.0 〃 sodium polyacetic acid 3.0 〃 4.0 〃 Ethyl alcohol 9.43 〃 Dry aluminum hydroxide 0.05 〃 Kaolin 10.0 〃 Total 100.00 〃 Weigh the above ingredients and knead them using an MS type pressure kneader (trade name, manufactured by Moriyama Seisakusho Co., Ltd.) by a conventional method. An adhesive was obtained.

Lanseal F TF-2 [trade name, manufactured by Nippon Exlan Co., Ltd.] is laminated with a polyethylene film having a large number of holes with a diameter of 1 mm, and the non-laminated surface is coated with the adhesive.
It was applied by a calendar roll at a rate of 100 g / 1000 cm ² . A silicone-treated polyester film was attached to this adhesive surface, cut into a size of 14 cm × 10 cm, and 6 sheets each were packaged to obtain a product.

Example 2 Glygolic salicylate 1.5 parts by weight peppermint oil 1.5 〃 dl-camphor 0.5 〃 diphenhydramine hydrochloride 0.02 〃 carboxyvinyl polymer 5.0 〃 polyvinylpyrrolidone 5.0 〃 propylene glycol 5.0 〃 glycerin 25.0 〃 titanium oxide 3.0 〃 9.43 sodium polyacrylate 4.0 alcohol 〃 Dry aluminum hydroxide 0.05 〃 Kaolin 10.0 〃 Calcium bicarbonate 30.0 〃 Total 100.00 〃 The above ingredients were weighed and an adhesive was obtained according to Example 1.

A polyethylene film having a large number of holes with a diameter of 1 mm was attached to Lanseal F TF-2, and calcium chloride was uniformly present on this non-attached surface at a rate of 30 g / 1000 cm ² , and then the adhesive was applied to this surface. Was applied by a calendar roll at a rate of 100 g / 1000 cm ² .

A silicone-treated polyester film was attached to this adhesive surface, cut into a size of 14 cm × 10 cm, and 6 sheets each were packaged to obtain a product.

Example 3 Sumikagel F-51 [trade name, manufactured by Sumitomo Chemical Co., Ltd.]
The pressure-sensitive adhesive prepared in Example 2 was applied at a rate of 100 g / 1000 cm ^{2 by} a calender roll, and a silicone-treated polyester film was attached to the attaching surface.

A 1: 1 mixture of ammonium chloride and sodium nitrate was uniformly present on the non-adhesive surface of this preparation at a rate of 30 g / 1000 cm ² , and then SUMIKAGEL F-51 of the same size and size was applied to this surface by a conventional means. Laminated, cut into a size of 14 cm x 10 cm, and packaged into 6 pieces each to obtain a product.

Test Example (1) The poultice prepared in Example 1 (14 cm × 10 cm, 17.2 g)
The sample was made to sufficiently contain water.

 The weight of the sample is 131.4 g and its water content is about 87%.

A conventional commercial hydrous poultice containing the same amount and the same amount of drug as the sample and a water content of about 50% was cut into the same size as the sample to serve as a control.

(2) A group of 6 healthy young men, a sample of which is attached to one shoulder of a virtuoso, and a control of which is attached to the other shoulder, and the strength and duration of its effect are determined by a questionnaire method using the following criteria. The results are shown in Table 1 as an average value.

Claims (1)

(57) [Claims] 1. A pressure-sensitive adhesive layer is provided on one side of a water-swellable fibrous cloth, which is made of fibers obtained by binding a hydrophilic cross-linked polymer to synthetic fibers and has a water absorption of 30 ml / g or more and is in a dry state. A water-cooling substance is kneaded into the pressure-sensitive adhesive layer, is present between the pressure-sensitive adhesive layer and the water-swellable fiber cloth, or is present on the non-adhesive surface of the water-swellable fiber cloth. Poultice.