JPH0761938B2 - Lumbago patch - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial field of application> The present invention relates to a lumbago patch, and more particularly to a lumbago patch having excellent support effect and heat retention effect.

<Prior Art> Conventionally, various patches have been developed. To summarize the technology similar to the present invention, the patch is applied in order to avoid skin damage due to sticking and to seek the duration of efficacy of the active drug. An agent prepared by applying a plaster on a breathable support at regular intervals such as spots, meshes or lines (Japanese Patent Laid-Open No. 56-2909). In order to determine the sustained release of the efficacy of the active ingredient, One formed intermittently with two or more kinds of plasters (containing a drug) having different degrees of polymerization or cross-linking (containing drug) on a support (JP-A-57-7411), containing two or more kinds of medicinal components, In order to obtain stability, each paste containing a medicinal component is divided into two or more blocks (JP-A-61-145112).

<Problems to be Solved by the Invention> However, conventional patches are those that support and fix the affected area of low back pain, have a heat-retaining effect, avoid skin disorders, have excellent adhesive strength, and can be expected to have a medicinal effect. Does not exist in.

The present inventors have completed the present invention as a result of intensive studies for the purpose of developing a patch having the above characteristics.

<Structure of the Invention> The patch for lumbago of the present invention comprises a combination of a foamable support A, a support B made of a woven or non-woven fabric, and a paste C containing a medicinal component. Attach the support B,
Further, it is completed by intermittently applying the paste C to the support B in a stripe shape.

When actually used as a patch, the support A used in the present invention is to exert an effect of fixing or supporting the affected area and a heat retaining effect, and various resins such as, for example, Polyethylene, a polyethylene-ethylene vinyl acetate copolymer, a mixture thereof, or a foam obtained by foaming a resin such as polypropylene or polyvinyl chloride is selectively used.

The foam is a cross-linking agent after the above resin is mixed with a foaming agent, a cross-linking agent (however, it is unnecessary when cross-linking by radiation), and if necessary, a polyfunctional monomer, etc., and molded into an appropriate shape such as a sheet. Those without addition of radiation irradiate and crosslink,
In addition, those to which a cross-linking agent is added are cross-linked by heating them at a temperature not lower than the decomposition temperature of the foaming agent and lower than the decomposition temperature of the foaming agent, and then further heated above the decomposition temperature of the foaming agent to foam or It is manufactured by a method of simultaneously performing foaming and foaming. The expansion ratio can be up to 5 to 50 times, but is preferably 10 to 25 times for the purpose of use in the present invention. In addition, the foaming form of the foam can be either a closed-cell form or an open-cell form. In the present invention, any form can be used, but it is possible to dissipate water. If the effect is expected more, it is more desirable that the open cells are mixed to the extent that the heat retention is not impaired.

Examples of commercially available foams include urethane, styrofoam, and cross-linked polyethylene foam (trade name Softlon).

In order to use the above-mentioned foam as the support A for the patch of the present invention, the thickness is approximately 0.5 to 10 mm, preferably 0.5 to 4 mm.
Form into a thin plate of mm.

The thus-produced support A has a heat retaining effect and an effect of fixing a part of the body, and is soft and comfortable to the skin, has an appropriate cushioning property, and has an appropriate elasticity.
It is characterized by being lightweight.

Next, as the woven or non-woven fabric used as the support B, any commonly used fabric such as flannel, cotton, silk, polyester, nylon, etc. can be used as long as it has a gap. For example, from thin and rough materials such as gauze to thickness
Even thick ones of about 2 mm can be used as long as they have a proper gap.

In the patch of the present invention, the support B is an anchor effect, that is, when a plaster described later is applied to the surface of the plaster, the plaster enters between the cloths, the cloth and the plaster are entangled, and the adhesion becomes strong,
Therefore, there is an effect that the plaster does not peel off from the cloth and the plaster does not remain on the skin after use as a patch.

Further, the support B has a water absorbing effect. That is, when a patch without support B is used, the plaster or support A does not have a water-absorbing effect, and therefore it is thought that perspiration may reduce the adhesive force or cause rash. In the patch of the present invention, since the support B is present, the cloth absorbs perspiration, and the adhesive strength and the rash can be prevented.

In addition, if one or a mixture of two or more kinds of fine powder such as starch derivative, polyvinyl alcohol derivative, acrylate polymer, etc. is attached to the surface of the woven fabric or the woven fabric which is usually used, The water absorption capacity can be further increased.

As the plaster of the present invention, a mixture prepared by a commonly used method with a medicinal component, an adhesive and, if necessary, an excipient is used.

Typical examples of medicinal components include salicylates such as methyl salicylate and glycol salicylate, arnica,
Various herbal medicines such as yellow oak, aloe, sanshin, chamomile, analgesic and anti-inflammatory agents such as indomethacin, ketoprofen, flurbiprofen, antihistamines such as diphenhydramine hydrochloride, chlorpheniramine maleate, etc., agents commonly used as external agents, such as camphor , Menthol, peppermint oil, thymol, capsicum extract, vanillylamide nonylate, vitamin E and the like.

Examples of excipients include kaolin, bentonite, titanium oxide, zinc white, and the like which are commonly used in external preparations. Further, an antioxidant can be added if necessary.

As an example of the adhesive forming the plaster, either novel or hydrophilic adhesive can be used, but lipophilic ones are often used.

An example of a lipophilic adhesive is styrene-isoprene-
Examples thereof include styrene tereblock copolymer rubber (ABA block copolymer), natural or synthetic rubber, terpene resin, alicyclic synthetic resin, rosin resin, liquid paraffin, and polybutene.

Examples of hydrophilic adhesives include light liquid paraffin, isoprene rubber, and carboxy-modified liquid polyisoprene rubber.

Examples of the adhesive for adhering the support B to the foamable support A include synthetic rubber latex, chloroprene rubber, acrylic modified emulsion and the like.

The patch of the present invention can be produced by either the hot melt method or the solvent method. That is, one kind or a mixture of two or more kinds of pressure sensitive adhesives is added as it is or a solvent is added if necessary, and the pressure sensitive adhesives are liquefied at room temperature or at room temperature, and drug components are added thereto.
Mix evenly to make a plaster.

On the other hand, the foamable support A and the support B are laminated using an adhesive or by thermal lamination. The above-prepared plaster is applied onto the laminated support B by a plaster coating and winding machine.
At this time, instead of continuously laminating the plaster layer on the entire surface of the support B, the plaster is intermittently applied in a stripe shape and laminated by dividing the coating portion.

When the solvent is dissolved during the production of the plaster, the solvent is volatilized with a dryer or the like after the coating.

Finally, in order to obtain a product, after a release paper is attached over the entire surface of the plaster to protect the plaster surface, it is cut into a predetermined shape and packaged.

Further, in the production of the patch of the present invention, a method of applying a plaster to a release paper and bonding the support A and the support B bonded thereto can be used.

<Effects of the Invention> The patch of the present invention has the following excellent effects.

Due to the heat retention of the effervescent support, the support effect and the mild warmth of the drug, it is suitable for treatment of the affected area because it fixes because it warms the affected area when used on the affected area.

By applying the plaster discontinuously, such as stripping muscles, it is breathable, and since it does not suppress the skin respiration entirely, it prevents rashes.

 The discontinuous application allows the cloth to absorb sweat even if it sweats.

A general patch will lose its adhesive force when sweating and may cause a rash, but the patch of the present invention can prevent these by wicking sweat.

Example (1) 100 parts by weight of the ABA block copolymer rubber, 80 parts by weight of alicyclic resin, and 100 parts by weight of liquid paraffin were put in a dissolution tank so that the whole became uniform at 150 to 180 ° C. And heat and stir the adhesive.

On the other hand, 6 parts by weight of glycol salicylate, 1 part by weight of egg yolk oil, 1 part by weight of sanshin, 1 part by weight of chamomile and 0.03 part by weight of 6% capsicum extract were uniformly mixed to prepare a medicinal component, which was added to the above adhesive, Stir until everything is uniform.

(2) A release paper is attached to the raw material installation part of the coating machine, and the plaster is applied in the grooves of a coating roll having a large number of grooves with a width of 10 mm at intervals of 10 mm in the circumferential direction. The work roll was rolled on the release paper, and the paste was applied on the release paper in stripes at a thickness of 150 to 250 µ, a width of 10 mm, and 10 mm intervals.

(3) The non-woven fabric was laminated on the striped adhesive plaster coated on the release paper, the non-woven fabric surface was laminated toward the plaster surface, pressed through pinch rolls, and then rolled into a thick roll. .

The support is a 2 mm thick polyethylene foam (expansion ratio 1
5 times) was coated with a chloroprene rubber adhesive, and a long-fiber non-woven fabric of cotton was adhered.

(4) The patch prepared as described above was cut into a 200 mm × 100 mm sheet to prepare a standard product.

Test Example The effect of the patch of the present invention was examined by applying the preparation to 22 volunteers (10 boys and 12 girls) aged 18 to 56 years old who suffer from back pain. The results are as follows.

(1) Feeling of use When this product is applied to the waist, it is strongly irritated and sore and hurts 1 person 4.5% It feels warm and pleasant 11 50 Warm and pleasant 8 36.4 Weak warmth and dissatisfaction 2 9.1 Total warmth I do not feel 0 (2) About the support effect (3) Effect (4) Effect on sweat Five men put this product on their waists, and went into running and sauna. With sweating, if the plaster is applied to the entire surface, skin irritation will be strong and the adhesiveness will be poor, and it will slip off, but the adhesiveness will be reduced due to the presence of a moist and hygroscopic cloth. ， When firmly pressed, the effect of re-adhesion appeared.

That is, when the plaster is wet on the entire surface, the sticking property deteriorates as the amount of sweat increases, and there is a slippery but hygroscopic cloth, so the time to fall is extended. This is because the time and amount of sweating vary from person to person, so the data for 5 people were apt. Also, when sweating rapidly in a short time like in a sauna, the effect of this product is not so remarkable, but when sweating gradually from exercise, sweating from the cloth and dehumidifying effect are clear. Was recognized.

Front Page Continuation (72) Inventor Yoshiaki Nakai 3-14-10 Nihonbashi, Chuo-ku, Tokyo Daiichi Pharmaceutical Co., Ltd. (72) Inventor Hiroya Shimizu 3-14-10 Nihonbashi, Chuo-ku, Tokyo Daiichi Pharmaceutical Co., Ltd. In-house (56) References JP 61-267512 (JP, A) JP 47-33082 (JP, A) “Polymer Dictionary” edited by the Editorial Committee for Polymer Dictionary (46-6-30) Asakura Bookstore, "Insulation" section

Claims (1)

[Claims] 1. A support B made of a woven or non-woven fabric is applied on a foamable support A, and a paste containing a medicinal component is intermittently applied on the support B in a stripe shape. A patch for low back pain.