KR101851397B1 - Adhesive patch and adhesive preparation - Google Patents

Abstract

The present invention provides an adhesive patch comprising a support, an adhesive layer on at least one surface of the support, and a release liner on the surface of the adhesive layer opposite the support,
(a) the side end of the adhesive layer is exposed,
(b) at one or more side end portions, a side end portion of the adhesive layer is located toward the center portion of the adhesive patch from the side end portion of the support,
(c) When the release liner is disposed horizontally so as to face downward, the distance A between the upper end of the support and the lower end of the release liner at the side end portion of the adhesive patch provides an adhesive patch exceeding the thickness B of the center portion of the adhesive patch do.

Description

[0001] ADHESIVE PATCH AND ADHESIVE PREPARATION [0002]

The present invention relates to an adhesive patch comprising a support and an adhesive layer formed on at least one surface of the support, and an adhesive formulation.

Recently, various adhesive patches and adhesive formulations have been developed. Adhesive patches and adhesive formulations are significantly superior in terms of trauma protection, continuous transdermal administration of drugs, drug metabolism by first pass through the liver, and prevention of various side effects.

Generally, the adhesive patches and adhesive formulations are provided with a release liner having a support made of a fabric, a nonwoven, a plastic film, etc., and an adhesive layer laminated on the support, generally laminated on the adhesive layer. This is provided in a package made of a packaging material, such as a resin film.

In such adhesive patches and adhesive formulations, the adhesive layer is required to have a constant thickness, taking into account the traumatic protection effect and effective drug content. However, when the adhesive layer becomes thick, the end portion of the adhesive patch or the like easily rubs against the clothes or the like, and the components of the adhesive layer flow out or protrude from the end of the adhesive patch or the like, The problem is raised during.

Cold flow occurs depending on the nature of the adhesive layer. This often occurs, especially when an adhesive patch or adhesive formulation is present under load for an extended period of time, i. E., When an adhesive patch or the like is contained in the package and stored for an extended period of time.

The adverse effect of cold air flow is due to, for example, the difficulty of removing adhesive patches or the like from the package, which is caused by adhesion of the outflowed or projected adhesive layer components into the package, the shearing or coloring of adhesive patches, And lower pharmacological effects of the adhesive formulation due to effluents such as drugs. Thus, it is preferred that the adhesive patches and adhesive formulations have an end that is not easily rubbed into the garment, does not allow easy cold air flow, and has an adhesive layer that retains its original shape.

As a technique for dealing with such a problem, JP-A-11-1432 (Patent Document 1) discloses an adhesive patch having a drying edge and a release liner and an adhesive layer extending from the support end. In such an adhesive patch, it is possible to suppress to some extent that the adhesive layer component flows out and protrudes from the end of the adhesive layer in contact with the release liner. However, in such an adhesive patch, the adhesive layer component may flow out and protrude from the end of the adhesive layer in contact with the support, and the preparation is not completely satisfactory.

JP-A-6-63071 (Patent Document 2) discloses a wound covering material (dressing material) having an outline and an adhesive layer suitable for the skin. As an example of such a wound covering material, the ends may be cut off in a straight line so that the adhesive layer components flow out and protrude from the ends, resulting in binding of components to the inner surface of the package.

As another example described in Patent Document 2, the end portion of the cover material is covered with a support. However, in this adhesive patch, the end of the support covers the end of the adhesive layer, and at the end of the adhesive patch, the end of the support aligns with the end of the release liner. Thus, the release liner can not easily detach its ends by the fingers during use. Further, since the end portion of the support needs to be able to bend or cover the end portion of the adhesive layer, there is a low degree of freedom in selection of its material and shape, particularly thickness, and the like. In particular, when the adhesive layer is thick, it is not easy to coat the end of the adhesive layer with the end of the extended support due to this in the industrial production stage. In fact, in this example, it is assumed that the end thickness of the adhesive layer of the adhesive patch is formed thinner than the thickness of the center portion, and the end thickness of the adhesive layer is difficult to maintain.

[Patent Literature]

Patent Document 1: JP-A-11-1432

Patent Document 2: JP-A-6-63071

It is therefore necessary to develop adhesive patches and adhesive formulations that satisfy (i) ease of peeling from the package, (ii) peel strength of the release liner from the adhesive layer during use, and (iii) Do.

The present invention has been made in view of this situation,

(i) the adhesive layer component is prevented from flowing out or protruding from the end of the adhesive patch or the like, and the adhesive patch or the like is prevented from being bonded to the inner surface of the package during storage in the package, ;

(ii) the frequency of friction at the ends is reduced, the ends are not easily twisted, the sufficient skin adhesion is ensured, and the preparation is fairly resistant to desorption at the skin surface, while being adhered to the skin;

(iii) during use, the release liner can be easily detached from the adhesive layer

Wherein the adhesive patch or adhesive preparation is characterized in that

The present inventors have conducted intensive studies as an attempt to solve the above-mentioned problems, and have found that at one or more lateral ends of an adhesive patch or the like, the side end portions of the adhesive layer are positioned toward the center portion of the adhesive patch or the like from the side end portions of the support It has been found that the above problem can be solved when the distance between the upper end of the support such as an adhesive patch and the lower end of the release liner at the end exceeds the thickness of the adhesive patch or the like at the central portion to induce the completion of the present invention.

Therefore, the present invention relates to the following [1] to [9].

[1] An adhesive patch comprising a support, an adhesive layer on at least one surface of the support, and a release liner on the surface of the adhesive layer opposite the support,

(a) the side end of the adhesive layer is exposed,

(b) at one or more side end portions, a side end portion of the adhesive layer is located toward the center portion of the adhesive patch from the side end portion of the support,

(c) when the release liner is disposed horizontally so as to face downward, the distance A between the upper end of the support and the lower end of the release liner at the lateral end of the adhesive patch exceeds the thickness B of the central portion of the adhesive patch.

[2] The adhesive patch according to the above-mentioned [1], wherein, at one or more side end portions, the side end portions of the adhesive layer are located from the side end portions of the support toward the center portion of the adhesive patch at 1 mu m to 1000 mu m.

[3] In the one or more side end portions, the distance A between the upper end of the support and the lower end of the release liner at the side end portion of the adhesive patch exceeds the thickness C of the adhesive patch at the side end portion of the adhesive layer ].

[4] The adhesive patch according to the above-mentioned [1], wherein at one or more side edges, the thickness C of the adhesive patch at the lateral end portion of the adhesive layer is equal to the thickness B of the center portion of the adhesive patch.

[5] The adhesive patch according to the above-mentioned [1], wherein at one or more side edges, the end of the adhesive layer has a concave shape.

[6] The adhesive patch according to any one of the above-mentioned [1] to [5], wherein the adhesive layer comprises a rubber adhesive.

[7] The adhesive patch according to any one of the above-mentioned [1] to [6], wherein the adhesive layer is not crosslinked.

[8] The adhesive patch according to any one of the above-mentioned [1] to [7], wherein the adhesive layer comprises an organic liquid component.

[9] An adhesive agent comprising an adhesive patch according to any one of the above-mentioned [1] to [8], wherein the adhesive layer contains a drug.

In the adhesive patch or adhesive agent of the present invention, at one or more side end portions, the side end portion of the adhesive layer is located toward the center portion of the adhesive patch or the like from the side end portion of the support. Therefore, it is not easy for the adhesive layer component to flow out or protrude from the end of the adhesive patch or adhesive preparation, and the cold flow phenomenon is suppressed during the preservation of the adhesive patch or adhesive preparation. As a result, the bonding of the adhesive patch or the like to the inner surface of the package is suppressed, and the adhesive patch or the like can be easily detached from the package. Also, tackiness and tackiness to the hand causing unpleasant tactile sensation at the applied site occur less during use.

In addition, in the adhesive patches and adhesive formulations of the present invention, the side edges of the adhesive layer are exposed and are not coated with a support or release liner. This has the improved ease as described above in removing adhesive patches and the like from the package, which is due to the suppression of the adhesive layer component from flowing down or protruding, and the adhesive patch or the like of the present invention, when used, Allowing easy detachment from the finger by the finger.

Even more unpredictably, adhesive patches or the like having a distance A between the upper end of the support and the lower end of the release liner exceeding the distance B of the center portion of the adhesive patch or the like at one or more side edges do not easily fall off during application for a long period of time.

1 is a schematic cross-sectional view of one embodiment of an adhesive patch or adhesive formulation of the present invention.
2 is a schematic cross-sectional view of one embodiment of the adhesive patch or adhesive formulation of the present invention.
3 is a schematic cross-sectional view of one embodiment of the adhesive patch or adhesive formulation of the present invention.
4 is a schematic cross-sectional view of one embodiment of the adhesive patch or adhesive formulation of the present invention.
5 is a schematic cross-sectional view of one embodiment of the adhesive patch or adhesive formulation of the present invention.
6 is a sectional scanning electron micrograph of the end portion of the adhesive patch of Example 1. Fig.
7 is a cross-sectional scanning electron micrograph of the end portion of the adhesive patch of Example 2. Fig.
8 is a sectional scanning electron microscope photograph of the end portion of the adhesive patch of Comparative Example 1. Fig.
9 is a cross-sectional scanning electron micrograph of the end portion of the adhesive patch of Comparative Example 2. Fig.
10 is a cross-sectional scanning electron micrograph of the end portion of the adhesive patch of Comparative Example 3. Fig.
Figure 11 shows that the adhesive patch package is opened by cutting two faces with scissors or along the V-shaped mark to release the adhesive patch.

As used herein, the term "adhesive patch" is a concept including not only an agent for transdermal absorption of a drug but also a material for health care or skin hygiene that does not contain an active ingredient such as a drug, for example, a skin protection sheet. Containing the drug is specifically referred to as "adhesive formulation ".

As a material for health care or skin hygiene of the adhesive patch of the present invention, a bandage, a skin tape, a dressing material for covering a wound, etc. may be mentioned. They are provided in the form of films, sheets, pads, and the like. The adhesive formulation may also be provided as a transdermal absorption type formulation for the purpose of local or systemic action, which is of the matrix or storage type. The formulations may vary and may be patches, adhesive tapes, sheets, and the like. When briefly referred to below as "adhesive patch ", the term also includes adhesive formulations. Further, the laminate of the adhesive layer and the support is referred to as "main part of the adhesive patch ".

Hereinafter, the present invention will be described below with reference to the accompanying drawings. 1 to 5, each element is shown schematically, and the ratio of the size of elements, etc. is different from that of an actual adhesive patch or the like.

The adhesive patch of the present invention has a substantially flat planar shape. The flat shape of the patch of the present invention may be of any suitable shape such as, but not limited to, a substantially rectangular shape, a polygonal shape such as a triangle, a pentagon, etc., or a shape defined by a substantially straight line, a shape defined by a curved line such as an ellipse, . The size of the adhesive patch is not limited, and may be appropriately selected depending on the use of the adhesive patch, the application site, and the like. For example, when the adhesive patch has a generally rectangular shape, the length of one side thereof is generally 15 mm to 90 mm, and the length of the other side is generally 15 mm to 90 mm. In the present specification, when a plurality of distinguishable regions are present in the flat plane of the adhesive patch of the present invention, the region containing the gravity center of the flat plane of the adhesive patch is referred to as the center portion, The area containing the flat planar contour of the adhesive patch is referred to as the periphery. The thickness of the adhesive patch center is also the thickness of the core portion of the adhesive patch at the center of gravity of the flat plane of the adhesive patch.

The adhesive patch of the present invention has an adhesive layer on one or more surfaces of the support and a release liner on the opposite surface of the adhesive layer. The side end portions of the adhesive layer are exposed and at one or more lateral ends of the adhesive patch, the side end portions of the adhesive layer are positioned toward the center portion of the adhesive patch from the side end portions of the support. That is, in FIG. 1 schematically showing a cross section of the adhesive patch of the present invention, the upper end portion c of the support body 1 and the lower end portion d of the release liner 3 are joined at the side edge portion of the adhesive layer 2 The line segment cd is positioned toward the center of the adhesive patch from the line ab connecting the upper end a of the supporter 1 and the lower end b of the release liner 3. [ This shape can be formed by contouring the adhesive layer as mentioned above during the formation of the adhesive layer or release liner on the support. For example, the adhesive layer is formed such that the contour portion of the adhesive layer is positioned toward the center of the adhesive patch from a portion corresponding to the contour portion of the support of the adhesive patch. Alternatively, in the adhesive patch in which the side end portions of the support and the adhesive layer are on the same flat plane, the above-described shape is formed by leaving a portion of the side end portion of the adhesive layer. In the present specification, the cross section shown in each drawing is a cross section of the adhesive patch cut in the vertical direction from the surface of the support 1.

In addition, in the adhesive patch of the present invention, when the adhesive patch is disposed in a horizontal plane with the release liner facing downward, the distance A between the upper end of the support and the lower end of the release liner at the aforementioned lateral end of the adhesive patch, The length of the vertical line ab 'shown from the upper end a of the supporting body 1 to the lower end of the release liner 3 is equal to the length of the thickness B at the center of the adhesive patch, Exceeds the vertical line ef shown from the upper end (e) of the release liner (1) to the lower end of the release liner (3). In the present invention, A is preferably from 101 to 200% of B, more preferably from 101 to 150%. Unpredictably, when an adhesive patch having the above-described structure is applied to the skin, it is not easily detached for a long time. If a portion that does not include an adhesive layer is formed at the end of the adhesive patch, the skin adhesion force at the end of the adhesive patch is generally reduced and the adhesive patch is expected to be easily removed from the skin. However, according to the present invention having the above-described shape, when the adhesive patch is applied to the skin, the side edges of the support slightly push up the garment and drop the garment from the side edges. Thus, the major part of the adhesive patch does not come off the skin for a long time. As a method for realizing such a shape, there is a method including a step of laminating a support formed in advance on the adhesive layer in the above-described shape, and a step of laminating the plate-like support on the adhesive layer and an adhesive patch A method including a forming step may be used.

In a preferred embodiment of the present invention, at one or more lateral end portions of the adhesive patch, the side end portions of the adhesive layer are located at a distance of 1 占 퐉 to 1000 占 퐉, more preferably 100 占 퐉 to 800 占 퐉 toward the center portion of the adhesive patch from the side end portions of the support do. 1, the length of a line ac connecting the upper end a of the supporting body 1 and the upper end c of the supporting body 1 at the side edge of the adhesive layer 2 is in the range of 1 탆 to 1000 탆, More preferably 100 占 퐉 to 800 占 퐉. When the side end portion of the adhesive layer 2 is located at 1 to 1000 占 from the side end portion of the support 1, the adhesive layer component flows or protrudes from the side end portion of the adhesive patch sufficiently And the adhesive force at the side end portion of the adhesive patch is not further reduced.

Further, in another preferred embodiment of the present invention, when the adhesive patch is disposed in a horizontal plane so that the release liner faces downward, at least one side edge portion of the adhesive patch, the distance between the support upper edge portion and the release liner lower edge portion at the side edge portion A exceeds the thickness C of the adhesive patch at the side edge of the adhesive layer. That is, in Fig. 2 showing a schematic cross-sectional view of the adhesive patch of the specific example, the vertical line ab 'shown from the upper end a of the support 1 to the lower end of the release liner 3 at the side edge of the adhesive patch The length exceeds the vertical line cd 'shown from the upper end c of the support 1 to the lower end of the release liner 3 at the side edge of the adhesive layer 2. In the present invention, A is preferably from 101 to 200% of C, and more preferably from 101 to 150%. In an adhesive patch of this embodiment, C exceeds B;

In addition, depending on the method of making and molding the adhesive patch, the adhesive patch may contain a thicker core than the peripheral and peripheral portions. In such a case, even when the thickness C of the adhesive patch at the side edge of the adhesive layer is thinner than the thickness B of the adhesive patch center portion, the distance A between the upper edge of the support and the lower edge of the release liner at the side edge portion, When the thickness exceeds B, the adhesive patch is included in the adhesive patch of the present invention by disposing the adhesive patch on the horizontal surface such that the release liner faces downward.

A schematic sectional view is shown in Fig. In an adhesive patch of this embodiment, at one or more lateral edges of the adhesive patch, the thickness C of the adhesive patch at the lateral end of the adhesive layer is equal to the thickness B of the central portion of the adhesive patch. As a result, (i) the adhesive patch does not easily attach to the inner wall surface of the package, the adhesive patch can easily be removed from the package, (ii) the release liner can be easily detached from the main part of the adhesive patch, ) The effect of the present invention, in which the main part of the adhesive patch is not easily removed from the skin, becomes clearer. Even when the adhesive patch has a peripheral portion and a central portion, the distance A between the upper end portion of the supporter and the lower end of the release liner at the side edge portion of the adhesive patch is larger than the thickness B of the adhesive patch center portion and the thickness C of the adhesive patch at the side edge portion of the adhesive layer, If equal to the thickness B of the patch center, the adhesive patch is included in this embodiment of the adhesive patch.

In another preferred embodiment of the present invention, the end of the adhesive layer at one or more lateral ends of the adhesive patch has a concave shape. Specifically, in Fig. 4 showing a schematic cross-sectional view of the adhesive patch of the specific example, the cross-section of the side end portion of the adhesive layer 2 has a single-layer annular arch on the central portion side. According to this structure, the release liner can be easily detached from the adhesive patch. While the above-described structure can be formed by various methods or the like, the side of the adhesive layer can be treated by laser irradiation or the like.

Although the support used in the adhesive patch of the present invention is not particularly limited, the active ingredient, the additive, etc. in the substantially impermeable support, that is, the adhesive layer, pass through the support and are lost from the back side of the adhesive patch to cause a reduced content A support made of a material that does not allow the release of the resin.

In the present invention, a single film of a resin or a metal foil, or a laminate thereof, is used as a support. In order to improve the adhesion (fixing property) between the support and the adhesive layer, it is preferable to use a laminate of a porous material and a resin film. In this case, the adhesive layer is laminated on the porous material of the laminate. The porous material has a concave portion and a convex portion, and has a void (bubble) in itself. Since the adhesive layer can enter the above-mentioned voids, it can effectively suppress the flow or protrusion of the adhesive layer component.

Examples of the above-mentioned porous material include a porous film and a sheet. When the sheet has a thickness of 200 mu m or more, it is preferable to use a porous film. The above-mentioned porous film may be a single-layer film or a laminate film, and preferably has a fixing property to suppress the migration of the adhesive layer into the porous material. Specific examples include paper, woven fabrics, nonwoven fabrics, knitted fabrics, mechanically perforated films and metal foils, laminates thereof, and the like. Of course, paper, fabric, nonwoven fabric, and laminate thereof are particularly preferred in terms of handling performance and the like, and nonwoven fabric is particularly preferred.

The porous material and the resin film may be made of the same material or different materials. It can be laminated according to known methods. It may suitably contain various additives such as an antioxidant, a pigment, an antistatic agent, etc., so long as it does not impair the characteristics of the present invention. In addition, the surface thereof may be subjected to a corona discharge treatment, an ultraviolet ray irradiation treatment, or the like.

Examples of the above-mentioned porous material constituting the support and the material of the resin film include

Polyester resins such as poly (ethylene terephthalate), and the like; Polyamide based resins such as nylon and the like; Olefin resins such as polyethylene, polypropylene and the like; Vinyl resins, ionomer resins including polyvinylidene chloride, polyvinyl chloride, Surlyn (registered trademark of DuPont), and the like, including Saran (registered trademark of Asahi Kasei Corporation or the US Dow Chemical Company); Acrylic resins such as ethylene-ethyl acrylate copolymer and the like; Fluorocarbon resins such as polytetrafluoroethylene and the like; Etc.

.

As will be described later, when a manufacturing method characterized by pressurizing and heating a region corresponding to the peripheral portion of the adhesive patch is used, the porous material and the resin film constituting the support are deformed by heating and softening, It is preferable that the adhesive layer component is made of a material that retains the shape of the adhesive layer, and therefore the adhesive layer component can move properly and mold the desired shape. As such a material, a thermoplastic resin such as a polyester-based resin; Olefin resins such as polypropylene and polyethylene are preferable, and polyester resins such as poly (ethylene terephthalate) are particularly preferable.

The thickness of the porous material is preferably in the range of 10 to 100 mu m to provide improved fixing properties, flexibility of the whole adhesive patch, bonding operability, and the like. When a fabric or a nonwoven fabric is used as a porous material, its basis weight is preferably 5 to 50 g / m ² , more preferably 10 to 30 g / m ² , in order to secure sufficient voids and realize fixing properties.

The thickness of the above-mentioned porous material was measured by coloring the adhesive patch with an aqueous ruthenic acid solution, imaging the slice prepared by the frozen section with an ultra-high resolution field emission scanning electron microscope (FE-SEM) at a magnification of 50 to 1000, Is measured by reading the scale. In this case, the concave and convex portions are present on the surface of the porous material. In the interglacial image, 10 convex portions are randomly selected, and the average thickness of the porous material in the convex portion is calculated and taken as the thickness of the porous material.

Furthermore, in the present invention, the basis weight of the porous material is measured by multiplying the thickness of the above-mentioned porous material and the specific gravity (apparent specific gravity) of the porous material and calculating the weight of the porous material per unit area.

The resin film to be laminated on the porous material may be a single layer film or a laminate film. Non-porous films made of resins that are impermeable to the active ingredients are preferred. Such a resin film inhibits the adhesive layer component from permeating through the rear surface of the support to reduce its content. Further, when the adhesive layer contains a drug, it is preferably used to realize the effect of a technique referred to as sealing bandage technique (ODT).

Although the thickness of the resin film is not particularly limited, it is preferably 1 to 45 탆. When it is 1 mu m or more, the moldability is excellent, the operability is excellent, and the ease of handling becomes easy. On the other hand, when it is 45 탆 or less, the uncomfortable feeling during application to the skin occurs less due to the stiffness of the resin film. As mentioned later, when the manufacturing method is used, in which pressurization and heating are applied to a region corresponding to the peripheral portion of the adhesive patch, excellent formability is observed. In the present invention, the thickness of the resin film is measured in the same manner as in the above-mentioned porous material.

Accordingly, a laminate film of a polyester film having a thickness of 1 to 45 탆 (more preferably, a poly (ethylene terephthalate) film) and a laminate film having a basis weight of 10 to 30 g / m < ² > (more preferably, poly (ethylene terephthalate)) can be mentioned.

Considering the skin-following power and comfort during application of the adhesive patch, the total thickness of the support is preferably 5 to 200 탆.

The constituent components of the adhesive layer and the production method thereof are described below. The amount of each component described below for the production of the adhesive layer is the proportion by weight of the respective components based on the amount of the total components excluding the solvent.

The adhesive layer may be formed by adding an adhesive to a solvent, if necessary, together with a component such as a drug, a tackifier, an organic liquid component and the like and mixing them to form a composition for forming an adhesive layer, , And drying the layer. The adhesive layer is preferably a hydrophobic adhesive layer from the viewpoint of adhesion to the skin, and accordingly, the anhydrous adhesive layer is preferable. From this aspect, the above-mentioned solvent is preferably an organic solvent.

The adhesive constituting the adhesive layer is not particularly limited, but examples thereof include an acrylic adhesive containing an acrylic polymer; Styrene-diene-styrene block copolymer (e.g., styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, etc.); Rubber adhesives such as polyisoprene, polyisobutylene, polybutadiene and the like; Silicone-based adhesives such as silicone rubber, dimethylsiloxane-based, diphenylsiloxane-based, and the like; Vinyl ether-based adhesives such as poly (vinyl methyl ether), poly (vinyl ethyl ether), poly (vinyl isobutyl ether) and the like; Vinyl ester-based adhesives such as vinyl acetate-ethylene copolymer and the like; Carboxylate components such as polyester adhesives including dimethyl terephthalate, dimethyl isophthalate, dimethyl phthalate and the like, and polyhydric alcohol components such as ethylene glycol and the like.

The adhesive layer may be a crosslinked adhesive layer obtained by subjecting the aforementioned adhesive layer to a crosslinking treatment or a non-crosslinked adhesive layer obtained without crosslinking treatment in the present invention. Here, the crosslinking treatment refers to a known treatment capable of forming intermolecular or intramolecular bonding in the adhesive layer constituting the adhesive layer. The cross-linking treatment simultaneously allows maintenance of sufficient skin adhesion of the adhesive patch and reduction of skin irritation, such as skin pulling feel and physical scratching of the skin stratum corneum, while peeling the adhesive patch from the skin surface. Examples of the cross-linking treatment include a chemical cross-linking treatment using a cross-linking agent, an ion cross-linking treatment, and a physical cross-linking treatment using an electron beam, ultraviolet light or the like. Examples of the crosslinking agent include metal salts such as zinc acetate, epoxy compounds, amide compounds, amine compounds, acid anhydrides, peroxides, isocyanate compounds and the like.

When the adhesive layer is a non-crosslinked adhesive layer, the adhesive layer component tends to flow out or protrude from the end of the adhesive patch. Even when the adhesive layer is a non-crosslinked adhesive layer, the adhesive patch of the present invention can effectively prevent the adhesive layer component from flowing out or protruding, and is particularly advantageous in such a case.

Similarly, when the adhesive layer comprises a rubber-based adhesive, the adhesive layer component tends to flow out or protrude from the end of the adhesive patch, and the adhesive patch of the present invention is particularly advantageous in such cases.

In order to realize adequate adhesion and dissolution properties of the drug, a mixture of the same or different components having different average molecular weights can be used as the rubber-based adhesive. Examples of polyisobutylene include high molecular weight polyisobutylene having a viscosity average molecular weight of 1,800,000 to 5,500,000, medium molecular weight polyisobutylene having a viscosity average molecular weight of 40,000 to 85,000, and, if necessary, low molecular weight polyisobutyl Mixtures of rhenylene are preferred. In the present invention, the viscosity average molecular weight is determined by measuring the flow time at 20 캜 using a Ubbelohde viscometer with capillary 1 and calculating the Staudinger index (J ₀ ) according to the following Schulz-Blaschke equation (equation (1)), The calculated J ₀ value is then calculated by substituting into the following Mark Houwink-Sakurada equation (equation (2)).

_{J 0 = η sp / c (} 1 + Aη sp) (1)

In the above equation, 侶_sp = t / t ₀ -1

 t; Solution flow time (Hagenbach-couette correction equation)

t ₀ ; Solvent flow time (Hagenbach-couette correction equation)

c; Solution concentration (g / cm ³ )

 A; Specific constants of the polymer solution

J ₀ = kMv ^? (2)

 Mv; Viscosity average molecular weight

 k, a; Specific constants of the polymer

In the case of polyisobutylene, the Mv value can be calculated from the J ₀ value by inserting A = 0.31, k = 3.06 × 10 ^-2 , and α = 0.65 into the above-mentioned equations (1) and (2).

When polyisobutylene is used as the adhesive, the high molecular weight polyisobutylene is generally added in an amount of 10 to 80 wt%, preferably 10 to 50 wt%, and the medium molecular weight polyisobutylene is generally used 0% by weight to 80% by weight, preferably 0% by weight to 60% by weight, of low molecular weight polyisobutylene is added in an amount of 0 to 90% by weight, preferably 10 to 80% Lt; / RTI > A commonly used adhesive layer is cured when the proportion of the high molecular weight component is increased and softened when the proportion of the low molecular weight component is increased.

For example, a tackifier such as a rosin resin, a polyterpene resin, a chroman-indene resin, a petroleum resin, a terpene-phenol resin, a xylene resin and the like may be contained in order to give sufficient adhesiveness to the adhesive layer . It can be used alone or as a mixture of two or more types. Examples of the above-mentioned petroleum resin include a petroleum resin obtained by partially or wholly hydrogenating an aliphatic (C5) petroleum resin, an aromatic (C9) petroleum resin, a copolymer (C5-C9) petroleum resin and an aromatic And an alicyclic saturated hydrocarbon resin. As the alicyclic saturated hydrocarbon resin, it is preferable to have a softening point by a ring method and a ball method at 90 to 150 캜. The content of the tackifier is not particularly limited, but is, for example, from 10% by weight to 40% by weight in view of imparting appropriate adhesiveness and cost effectiveness.

If desired, the adhesive layer may contain an organic liquid component. The organic liquid component is not particularly limited as long as it is a liquid at room temperature (25 占 폚) or a mixture of two or more types which finally becomes liquid at room temperature (25 占 폚). Examples of organic liquid components include glycols such as ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, dipropylene glycol, triethylene glycol, tripropylene glycol, poly (ethylene glycol), poly (propylene glycol) and the like; Vegetable fats and oils such as olive oil, castor oil, and the like; Animal fats and oils such as liquid lanolin; Hydrocarbons such as squalane and liquid paraffin; Various surfactants; Ethoxylated stearyl alcohol; Glycerol monoesters of fatty acids such as oleic acid monosylceride, caprylic acid monosylceride and lauric acid monosleiceride; Dialkyl esters of polyalkylene glycols such as polyethylene glycol dilaurate, polyethylene glycol diisostearate, polypropylene glycol diisostearate, polypropylene glycol diolate, and the like; Glycerol diesters such as glycerol diacetate and the like; Glycerol triesters such as glycerol triacetate, and the like, or mixtures thereof; Alkyl esters of fatty acids such as triethyl citrate and the like; Long chain alcohols such as isostearyl alcohol, oleyl alcohol and the like; Higher fatty acids such as caprylic acid, oleic acid, linoleic acid; Alkyl esters of higher fatty acids such as isopropyl myristate; Pyrrolidones such as N-methylpyrrolidone, N-dodecylpyrrolidone; Sulfoxides such as decyl methyl sulfoxide, and the like. It can be used alone or as a mixture of two or more types.

The content of the above-mentioned organic liquid component is preferably 10 wt% to 60 wt%, more preferably 15 wt% to 60 wt%, and most preferably 20 wt% to 60 wt%. When the content of the component is 10% by weight or more, the adhesive layer is easily plasticized, and the adhesive layer component easily flows out or protrudes from the end of the adhesive layer. Therefore, the present invention capable of effectively suppressing the above phenomenon is advantageous in such a case. When the organic liquid component is contained in a proportion of more than 60% by weight, the adhesive layer can not maintain the prescribed shape.

The organic solvent used in the production of the adhesive layer in the present invention is not particularly limited, but is preferably compatible with the above-mentioned components that constitute the adhesive layer and are easily volatilized in the drying step. Examples of organic liquid solvents are aromatic hydrocarbons such as benzene, toluene, xylene and the like; Aliphatic hydrocarbons such as n-hexane and the like; Esters such as ethyl acetate and the like; Alcohols such as methanol, ethanol, isopropanol and the like; Ethers such as diethyl ether, tetrahydrofuran and the like; Ketones such as acetone, and the like. It can be used alone or as a mixture of two or more types.

Although the method of mixing the above-described components is not limited, examples thereof include kneading machines such as a kneader, an oil-based mixer, a Henschel mixer, a roll mill; Dispersing machines such as colloid mills, homogenizers and the like; An agitating device such as a propeller-type blade stirrer, and the like. It can be used alone or as a mixture of two or more types.

The composition for forming the adhesive layer may be applied, for example, to a commonly used coater such as a rotogravure roll coater, a reverse roll coater, a kiss-roll coater, a dip roll coater, a bar coater, a knife coater, . For promoting the cross-linking reaction, improving the production efficiency, etc., it is preferable that the above-mentioned composition is dried under heating. Depending on the type of support to be coated with the composition, the drying temperature is, for example, about 40 ° C to 150 ° C.

The above-mentioned drying can be carried out according to a known method using air drying, or using a dryer, an oven, a far-infrared ray radiation or the like.

In the adhesive patch of the present invention, the adhesive layer has a thickness of 50 占 퐉 to 500 占 퐉, more preferably 100 占 퐉 to 300 占 퐉 in the core portion of the adhesive patch. In addition, it is preferable that the thickness of the adhesive layer in the entire central portion of the adhesive patch is within the above-mentioned range. When the adhesive layer has a thickness within the above-mentioned range, it is excellent in skin protection effect, can sufficiently contain an active ingredient such as a drug, and has excellent skin adhesion performance.

The release liner for protecting the adhesive surface can be laminated onto the adhesive surface of the adhesive layer of the major part of the adhesive patch before applying the major part of the adhesive patch to the skin. The release liner is not particularly limited, and examples of such materials include those well known in the art to those skilled in the art. Specific examples thereof include plastic films of polyester-based resin films such as poly (ethylene terephthalate); Vinyl resin films such as poly (vinyl chloride), poly (vinylidene chloride), polystyrene and the like; Acrylic resin films such as various acrylic acid type and methacrylic type polymers; Polycarbonate resin films; A polyimide resin film; Cellulose-based resin films such as acetylcellulose, regenerated cellulose (cellophane), celluloid and the like; High-quality paper, laminated films such as glazinc paper, and polyolefin-based films. For safety, economic efficiency and drug delivery characteristics, it is preferable to use a polyester-based resin film. The thickness of the above-mentioned release liner is generally from 10 mu m to 200 mu m, and preferably from 25 mu m to 100 mu m.

The release liner is preferably treated with an adhesive layer for easy peeling at the interface surface side to facilitate peeling from the adhesive layer. The easy peeling treatment is not particularly limited, but known methods can be applied. For example, a treatment method of forming a peeled-off layer using a stripping agent containing a curable silicone resin as a main component by coating methods such as bar coating, gravure coating and the like can be mentioned.

The thickness of the above-mentioned peeled-off layer is preferably 0.01 탆 to 5 탆 in order to ensure the peeling force and uniformity of the coating. The thickness of the release liner having the exfoliated layer is generally from 10 탆 to 200 탆, preferably from 50 탆 to 100 탆 in view of handling characteristics.

In the adhesive patch of the present invention, the release liner may have an extension extending surface-wise over the major portion of the adhesive patch. When the adhesive patch is contained in the package, even if the adhesive layer component flows out or protrudes from the end of the main part of the adhesive patch, since the extension part reduces the contact frequency of the end of the main part of the adhesive patch with respect to the inside of the package, The adhesive force to the inside of the package which causes difficulty in peeling the adhesive patch from the package can be suppressed. To provide this effect, at least one of the peripheral portions of the main portion of the adhesive patch preferably has a release liner having an extension, more preferably the release liner has an extension around the entire periphery of the main portion of the adhesive patch. It is further preferred that the length of the aforementioned extension of the release liner is from about 0.5 mm to 10 mm, more preferably from about 1 mm to 3 mm, to realize the effect described above and to ensure smooth insertion into the package.

The release liner may also have a split back. The dividing rear portion described above is produced by forming a dashed line on the surface image on the opposite surface of the contact surface of the release liner having the adhesive layer. The shape of the dashed line described above may be linear or curved (e.g., wave shape), or a combination thereof. The dashed line may be a solid line or a dashed line, or a combination thereof. Because the release liner has a split back, the release liner can be easily removed if an adhesive patch is used.

In the present invention, the adhesive layer may contain a drug if desired to form an adhesive formulation. Here, the drug is not particularly limited, and a drug for systemic action and a drug for local action can be used. Drugs that can be administered to mammals such as humans through the skin, i.e., transdermal absorption drugs, are preferred. Specifically, these medicaments may be used in combination with other medicines such as general anesthetics, antipsychotics, antidepressants, mood stabilizers, psychostimulants, hypnotics, anxiolytics, antiepileptics, migraine medicines, antiepileptics, dizziness drugs, local anesthetics, An antihypertensive agent, an anti-rheumatic drug, an antihistamine agent, an antiallergic agent, a cardiotonics, an antiarrhythmic agent, a diuretic agent, a hypotensive agent, a vasoconstrictor agent, a vasodilator, an angina pectoris, an antiinflammatory agent, a parkinsonism therapeutic drug, a corticosteroid, a nonsteroidal antiinflammatory agent, A therapeutic agent for diabetic nephropathy, a therapeutic agent for diabetes, a therapeutic agent for diabetic nephropathy, anaphnics, a bronchodilator, a therapeutic drug for bronchial asthma, a cough medicine, a gadam drug, a hormone agent, a hemostatic agent, Antimicrobial agents, anti-viral agents, anti-parasitic agents, anesthetics, smoking cessation agents, antimicrobial agents, antimicrobial agents, Include and the like. Such a drug may be used in the form of a glass or a salt.

The content of the above-mentioned drug in the adhesive preparation is not particularly limited as long as the effect of the drug for percutaneous absorption can be sufficiently exerted and the adhesive property of the adhesive layer and the like are not lowered. It is preferably 0.1 wt% to 60 wt%, more preferably 0.5 wt% to 40 wt% of the adhesive layer. If it is lower than 0.1% by weight, a sufficient therapeutic effect can not be obtained, and when it is higher than 60% by weight, skin irritation may occur and the therapeutic effect as well as the therapeutic effect can not be improved.

As a method for producing an adhesive patch, various methods are available as mentioned in the above description, such as the shape of an adhesive patch. However, in the case of industrial production, for example, the following method is preferable for high production efficiency.

First, the composition for forming the adhesive layer is applied to one surface of the release liner and dried to form an adhesive layer. The support is laminated thereon to form an original sheet for punching from an adhesive patch. Alternatively, the composition for forming the adhesive layer is applied to one surface of the support and dried to form an adhesive layer. The support is laminated thereon to form an original sheet for punching from an adhesive patch. The above-mentioned lamination method is not particularly limited, and for example, known methods such as application of a primer, adhesion, fusion bonding, melt bonding, pressure bonding and the like can be mentioned.

Thereafter, the original sheet for punching from the adhesive patch is stamped from the support side by pressing with a heated stamp having a predetermined shape. After the stamping process, the above-mentioned original sheet is punched at a predetermined punching position to form the adhesive patch of the present invention. The predetermined shape of the above-mentioned stamp is a shape which presses at least a portion corresponding to the peripheral portion of the adhesive patch during pressurization. By pressing the area corresponding to the periphery, the adhesive layer at the periphery of the adhesive patch can be reduced or eliminated. Further, in the adhesive patch in which the distance A between the upper end portion of the supporter and the lower end of the release liner at the side end portion of the adhesive patch exceeds the thickness B of the central portion of the adhesive patch at the side end portion of the adhesive patch, since the supporter has the resilience, the above-mentioned original sheet is pressed with the stamp, .

As mentioned above, the adhesive patch in which the distance A between the support upper end and the release liner lower end at the side end exceeds the thickness B of the center portion of the adhesive patch can be obtained preferably by using a heated stamp. A schematic cross-sectional view of the adhesive patch obtained by the method described above is shown in Fig. By stamping with a heated stamp, the support containing the portion adjacent to the center of the adhesive patch of the pressed region is softened by heat. As a result, the adhesive layer is peeled off in the pressed area, and formation of the thin peripheral part 5 having a thickness smaller than that of the central part 4 is promoted. The shape of the adhesive patch once formed is then allowed to cool or otherwise cooled and retains its shape. Thus, a preferred embodiment of the present invention comprises a peripheral portion 5 having a thickness smaller than that of the central portion 4, as shown in Fig. The temperature of the heated stamp varies depending on the material and thickness of the support, the composition of the adhesive layer, and the like, but is preferably 90 deg. C to 200 deg. C, and more preferably 120 deg. C to 180 deg.

In order to form the side end portions of the concave adhesive layer and to remove the adhesive layer at the peripheral portion, the pressure and the pressing time during pressing are preferably controlled. The pressure during pressurization depends on the material and thickness of the support, the composition of the adhesive layer, and the like. Preferably 10 N / 10 cm ² to 1,000,000 N / 10 cm ² (1.0 × 10 ⁴ N / m ² to 1.0 × 10 ⁹ N / m ² ), more preferably 500 N / 10 cm ² to 10,000 N / 10 cm ² (5.0 × 10 ⁵ N / m ² to 1.0 × 10 ⁷ N / m ² ). The pressing time also depends on the material and thickness of the support, the composition of the adhesive layer, and the like. Preferably 0.05 seconds to 5 seconds, more preferably 0.1 seconds to 2 seconds.

During the stamping process, the distance between the stamp and the stamping table is preferably +/- 10 mu m of the total thickness of the support, the periphery of the adhesive layer and the release liner.

The preferable shape of the stamp is any one containing a flat plate as a pressing surface which is in contact with and pressurized with an adhesive patch and is not particularly limited as long as it can press only the peripheral portion of the adhesive patch specifically. The plate-like piece as the pressing surface has a shape corresponding to the peripheral portion of the adhesive patch. For example, the shape of the stamp may consist of a first rectangle (square, oblong shape) on the periphery of the convex portion and a similar smaller second rectangle, the corresponding sides of the first and second rectangles being parallel to each other . Although the stamp material is not particularly limited, iron is preferable. Stainless steel can cause thermal distortion and its processing can be difficult. Aluminum and brass can be easily processed, but can be adversely bad in the stamping period.

The punching means for the adhesive patch or the like is not particularly limited, and a punching method using a laser, a press-cutting blade or the like can be mentioned. The original sheet is preferably punched into a press-cutting blade die set (male and female type), since the adjustment and positioning of the cut size is easy and a reliable end surface can be obtained.

In a preferred embodiment of the adhesive patch of the present invention, the release liner has an extension in at least one of the peripheral portions of the main portion of the adhesive patch, and in a more preferred embodiment, the release liner has an extension in all peripheral portions of the main portion of the adhesive patch . The extensions of one or more portions of the periphery can be readily formed by punching only the major portion of the adhesive patch using a press-cutting blade die set (male and female type) having the required shape and then punching the release liner.

The length of the extended release liner can be adjusted by varying the size difference in the male and female versions of the press-cutting blade die set. The length of the extended release liner can be extended by increasing the size difference. When the split back portion is set on the release liner, the center portion of the release liner is cut in half by a die roll, and the broken line is formed only in the release liner.

The adhesive patches and adhesive formulations of the present invention are preferably stored in a package. Such a package may be manufactured using a packaging material commonly used for packaging adhesive patches. Examples of the packaging material include polyolefin-based resin films such as a polyethylene film, a polypropylene film, a polymethylpentene film and the like; Vinyl resin films such as polyvinyl chloride films, polyvinylidene chloride films, polyvinyl alcohol films, polystyrene films, polyacrylonitrile films, ionomer films and the like; Polyester-based resin films such as poly (ethylene terephthalate) films, and the like; Polyamide-based resin films such as nylon films and the like; Cellulosic resin films such as cellophane; Polycarbonate resin films; And laminated films thereof; A laminated film thereof, aluminum and the like. The adhesive patch is housed in a package made using the packaging material described above and can be tightly sealed by known methods such as heat sealing or the like.

[Example]

The present invention will now be described more fully hereinafter with reference to Examples and Comparative Examples, which are not to be construed as limiting.

[Examples 1 and 2 and Comparative Examples 1 to 3]

(1) Production of adhesive sheet

≪ Preparation of composition for forming adhesive layer >

(Softening point by ring and ball method; 120 占 폚 to 160 占 폚, 1.127 kg), toluene (4.456 kg) and n-hexane (weight average molecular weight: 4,000,000, 0.620 kg), alicyclic saturated hydrocarbons (4.726 kg) were weighed and stirred in a mixing tank for at least 24 hours. The medium molecular weight polyisobutylene (viscosity average molecular weight: 55,000, 1.071 kg) was weighed, placed in a mixing tank, and the mixture was stirred for at least 24 hours. Isopropyl myristate (1.232 kg) and toluene (0.270 kg) were then weighed, placed in a mixing tank and the mixture stirred for 4 hours or longer to form a composition for forming an adhesive layer.

<Production of Original Sheet for Punching>

The above-mentioned composition was subjected to an easy-peel treatment (release treatment) of a release liner made of poly (ethylene terephthalate) (hereinafter referred to as "PET &quot;) by a coater consisting of a back roll and a coma roll so that the thickness of the adhesive layer after drying was 160 [ (Thickness 75 mu m), and dried. The resulting adhesive surface of the adhesive layer was adhered to the PET nonwoven surface of the support with a 3.5 mu m thick PET film and a laminate of PET nonwoven (basis weight: 10 g / m ² to 20 g / m ² ) To form an original sheet for punching from the adhesive patch.

(2) Formation of adhesive patches by punching and packaging machines

The above-mentioned original sheets for adhesive patch punching are punched by a punching and packaging machine equipped with stamping parts (hot pressing + stamped metal forming) and die set metal forming (male and female types) to form an adhesive patch. The stamping width of the stamped parts, the heating temperature and pressure during the stamping process were adjusted as shown in Table 1 below to form the adhesive patches of Examples 1 and 2 and Comparative Examples 1 to 3.

[Experimental Example 1] Evaluation of adhesive patch shape

Each adhesive patch of Examples and Comparative Examples was colored with aqueous ruthenic acid solution and cut with a freeze cutter (LR-85, manufactured by YAMATO KOHKI INDUSTRIAL CO., LTD.). Sections were taken by FE-SEM (S-4800, manufactured by Hitachi, Ltd.) at 50 magnification to 1000 magnification. In the electron micrographs of each adhesive patch, the gauge scale at the periphery and at the center was read to determine the thickness of the PET film and PET nonwoven fabric, and the thickness of the major part of the adhesive patch (total thickness of the adhesive layer and support). In this case, the concave and convex portions are present on the surface of the PET nonwoven fabric. In the section image, 10 convex portions were randomly selected and the average thickness of the PET nonwoven fabric at the convex portion was calculated and taken as the thickness of the PET nonwoven fabric. Thereafter, the thickness of the PET film and the thickness of the PET nonwoven fabric described above were subtracted from the thickness of the main portion of the adhesive patch, and the thickness of the adhesive layer was measured at the peripheral portion and the center portion. The distance A between the upper end of the support and the lower end of the release liner at the side edge of the adhesive patch and the distance between the side edge of the support and the side edge of the adhesive layer at the center side were measured. A section image of each of the adhesive patch ends in Examples and Comparative Examples is shown in FIG. 6 to FIG.

From the slice images of each adhesive patch end of Examples and Comparative Examples, each adhesive patch of the Examples and Comparative Examples

Whether or not the side end portion of the adhesive layer is located toward the center portion of the adhesive patch from the side end portion of the support,

(2) whether the distance between the upper end of the support and the lower end of the release liner at the side end exceeds the thickness of the center portion of the adhesive patch, and

(3) Whether the end of the adhesive layer has a concave shape

Lt; / RTI &gt;

In Table 2, when the observation result is YES, Y is displayed and when the result is NO, N is displayed. In each adhesive patch, the thickness of the center portion of the adhesive layer was the same as the thickness of the adhesive layer after drying the punched original sheet, which was 160 탆. Further, in the adhesive patches of Examples 1 and 2, the distance A between the upper end of the support at the side end portion and the lower end of the release liner was within the range of 101% to 150% of the thickness of the center portion of the adhesive patch. In the adhesive patch of Example 1, the side end portion of the adhesive layer was positioned at 500 mu m toward the center portion of the adhesive patch from the side end portion of the support. On the other hand, in the adhesive patch of Example 2, the side end portion of the adhesive layer was located at 50 mu m toward the center of the adhesive patch from the side end portion of the support.

[Experimental Example 2] Evaluation of performance of peeling adhesive patch from package

As shown in Fig. 11, the two sides of the adhesive patch package were opened with scissors or along the V-shaped mark. The adhesive patches were removed while holding the corners, and the performance of removing the adhesive patches from the package was evaluated according to the following three-step criteria.

<Evaluation Criteria>

○; No flow or protrusion of adhesive layer ingredients; Easy removal was possible

?; Flow or protrusion of the adhesive layer component in a portion of the adhesive patch; It was possible to remove it.

×; Significant flow down or protrusion of the adhesive layer component; It was hard to remove

[Experimental Example 3] Evaluation of skin adhesion performance

Expert assessors removed the adhesive patch from the package, glued the patch to the chest for 24 hours from the morning, and assessed the adhesion according to the following three-step criteria. During adhesion of the adhesive patch, the evaluator behaved as usual. If the evaluator took a bath in the morning, the patch was attached shortly after bathing (within 30 minutes). The same evaluator evaluated the adhesive patches of Examples and Comparative Examples at one time.

<Evaluation Criteria>

○; Adhesive patches were not dropped for 24 hours; The ends of the adhesive patches are not torn.

?; Adhesive patches were not dropped for 24 hours; The end of the adhesive patch is torn.

×; Adhesive patches lost within 24 hours

[Experimental Example 4] Evaluation of peel strength of release liner

Five male panels (over 50 years old) detached the release liner from the adhesive patch and evaluated their peel strength by sensory evaluation. The evaluation results were summarized by the following criteria.

<Evaluation summary standard>

○; Every panel feels easy detachment

?; Some panels feel difficulty in detachment

×; All panels feel difficulty in detachment

The evaluation results of the above-mentioned Experimental Examples 2 to 4 are also shown in Table 2 below.

From Table 2, in the adhesive patches of Examples 1 and 2 of the present invention, the side end portion of the adhesive layer was located at the side end portion from the side end portion of the support toward the center portion of the adhesive patch; The distance between the upper end of the support at the side end and the lower end of the release liner exceeds the thickness of the center of the adhesive patch; It is clear that the end portion of the adhesive layer is concave at the side end portion. These adhesive patches obtained excellent evaluation results on the peeling performance and the skin adhesion performance from the package. The adhesive patch of Example 1 in which the side end portion of the adhesive layer was located at 500 mu m on the side of the center of the adhesive patch from the side end portion of the support was located at a position where the side end portion of the adhesive layer was located at 50 mu m from the side end portion of the adhesive patch toward the center portion of the adhesive patch A further higher evaluation was obtained with respect to the peel strength of the release liner as compared to the adhesive patch of Example 2, In contrast, the adhesive patch of Comparative Example 1, in which the distance between the upper end of the support at the side end and the lower end of the release liner did not exceed the center thickness of the adhesive patch, was poorly evaluated in terms of skin adhesion performance. In addition, the adhesive patch of Comparative Example 2, in which the end of the adhesive layer was not concave at the side end portions, also obtained a low evaluation with respect to the peeling strength of the release liner. The side end portion of the adhesive layer is not located at the side end portion from the side end portion of the support toward the center portion of the adhesive patch; The distance between the upper end of the support at the side end and the lower end of the release liner does not exceed the thickness of the center of the adhesive patch; The adhesive patch of Comparative Example 3 in which the end portion of the adhesive layer was not concave at the side end portion was not evaluated with respect to the peeling performance from the package, the skin adhesion performance and the peeling strength of the release liner.

[Examples 3 and 4] Patch preparation

To the above-mentioned composition for forming an adhesive layer, 1 part by weight of indomethacin (an anti-inflammatory agent) was added per 100 parts by weight of the total formulation components except for toluene to prepare a composition for forming an adhesive layer for a percutaneous absorption preparation. Adhesive formulations were obtained in the same manner as in the above-mentioned Examples 1 and 2 using the above-described composition. The adhesive formulations of Examples 3 and 4 provide similar effects to those of the adhesive patches of Examples 1 and 2 mentioned above in terms of peel performance from the package, skin adhesion performance and peel strength of the release liner.

As described in detail above, the present invention can prevent the occurrence of a so-called cold air flow phenomenon during storage without causing the adhesive layer component to flow out and protrude from the end, easily attach to the inner surface of the package, And can provide an adhesive patch or adhesive formulation that causes unpleasant touch on the hand due to stickiness and less tactile feel on the application site during use. The present invention also provides an adhesive patch or adhesive formulation that ensures adequate skin adhesion, is fairly resistant to desorption from the skin surface, and allows for easy detachment of the release liner, and the frequency of friction of the ends with respect to clothing, etc., And the ends can provide an adhesive patch or adhesive formulation that is not easily twisted.

1 support
2 adhesive layer
3 peel liner
4 Central
5 Peripheral
a At the side edge of the adhesive patch,
b The lower end of the release liner at the side edge of the adhesive patch
a vertical line shown from the upper end portion (a) of the support to the lower end portion of the release liner at the side end portion of the adhesive patch b 'and a line connecting the lower end portion of the release liner
c At the side end of the adhesive layer,
d &lt; / RTI &gt; adhesive layer at the lower end of the release liner
the vertical line shown from the upper end portion (c) of the support to the lower end portion of the release liner at the side end portion of the d 'adhesive layer and the intersection of the lower end portion of the release liner
e In the core part of the adhesive patch,
f adhesive patch in the core portion of the release liner from the upper end (e) of the support to the lower end of the release liner, and the intersection of the lower end of the release liner
A distance between the upper end of the support at the side end of the adhesive patch and the lower end of the release liner
B Adhesive patch center thickness
The thickness of the adhesive patch at the side edge of the C adhesive layer

Claims (9)

An adhesive patch comprising a support, an adhesive layer on at least one surface of the support, and a release liner on the surface of the adhesive layer opposite the support,
(a) the side end of the adhesive layer is exposed,
(b) at one or more side end portions, a side end portion of the adhesive layer is located toward the center portion of the adhesive patch from the side end portion of the support,
(c) When the release liner is disposed horizontally so as to face downward, the distance A between the upper end of the support and the lower end of the release liner at the side edge of the adhesive patch is larger than the thickness (B) patch. The adhesive patch of claim 1, wherein at one or more side edges, the side edge portion of the adhesive layer is located from the side edge of the support toward the center of the adhesive patch at 1 mu m to 1000 mu m. The adhesive tape according to claim 1, wherein the distance (A) between the upper end of the support and the lower end of the release liner at the side edge portion of the adhesive patch at the one or more side edges exceeds the thickness (C) of the adhesive patch at the side edge portion of the adhesive layer In adhesive patch. The adhesive patch of claim 1, wherein at one or more lateral edges, the thickness (C) of the adhesive patch at the lateral end of the adhesive layer is equal to the thickness (B) of the central portion of the adhesive patch. The adhesive patch of claim 1, wherein at one or more side edges, the end of the adhesive layer has a concave shape. The adhesive patch of claim 1, wherein the adhesive layer comprises a rubber-based adhesive. The adhesive patch of claim 1, wherein the adhesive layer is not cross-linked. The adhesive patch of claim 1, wherein the adhesive layer comprises an organic liquid component. An adhesive formulation comprising an adhesive patch according to any one of claims 1 to 8, wherein the adhesive layer comprises a drug.

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