JPH04297401A - Industrial antimicrobial composition - Google Patents

Abstract

PURPOSE:To obtain an antimicrobial composition exhibiting stable and excellent antimicrobial activity against noxious microorganisms in industrial field over a wide pH range by using glutaraldehyde and 2,2'-methylenebis(4-chlorophenol) as active components. CONSTITUTION:The objective industrial antimicrobial composition contains glutaraldehyde and 2,2'-methylenebis (4-chlorophenol) at a weight ratio of 1:20 to 20:1, preferably 1:10 to 10:1. The composition is suitable for the slime-control of cooling water system and paper and pulp mill, preservation of starch, casein, etc., and antiseptic treatment of products such as latex, pigment, adhesive, coating material and metal cutting oil.

Description

[Detailed description of the invention]

0001

[Field of Industrial Application] The present invention relates to a novel industrial antibacterial composition, and more particularly to an industrial antibacterial composition that stably exhibits excellent antibacterial activity over a wide pH range against harmful microorganisms in the industrial field. It is something.

0002

[Prior Art] Conventionally, industrial antibacterial agents have been used in various fields to prevent so-called microbial disasters such as spoilage and mold growth caused by harmful microorganisms such as bacteria, mold, yeast, and algae in industrial products. It is widely used in For example, slime control in paper and pulp factories, antibacterial and antifungal applications such as paints, adhesives, thickeners such as starch and casein, pigments, latex, and oils such as metal processing oil, as well as wood, building materials, leather, etc. It is used for antibacterial and antifungal purposes in textiles, films, coated wires, telecommunications equipment, etc. However, in the microbial treatment in the industrial field, the reality is that there are very few antibacterial agents that act effectively in a wide pH range from acidity to alkalinity. For example, 2-(hydroxymethylamino)ethanol and quaternary ammonium salts are known as agents that exhibit particularly high antibacterial activity in alkaline conditions, but the former 2-(hydroxymethylamino)ethanol exhibits particularly high antibacterial activity in acidic conditions. The latter quaternary ammonium salts have the disadvantage of decreasing antibacterial activity, and on the other hand, the latter quaternary ammonium salts tend to cause foaming problems and adsorb to fine substances and pulp, resulting in loss of antibacterial activity, making it difficult to achieve stable microbial treatment. It has the disadvantage of being difficult to use. In addition, typical industrial antibacterial agents include halogenated isothiazolones, benzisothiazolones, and bromonitroalcohol-based agents, but although these antibacterial agents have high antibacterial activity in acidic conditions, they have no antibacterial activity in alkaline conditions. There is a problem in that it is difficult to perform stable microbial treatment because the activity is significantly reduced. For these reasons, conventionally, the company using the antibacterial agent or the company providing the agent uses different types of antibacterial agents depending on the pH of the industrial product being treated.
The problem arises that complexity cannot be avoided. By the way, among the microorganisms that cause problems in industrial products, it is known that Bacillus species, which are bacteria, are typical bacteria that have strong resistance to drugs and are difficult to treat with antibacterial agents. When this type of fungus becomes in an unsuitable environment for growth, it can change its form to a spore state that is less susceptible to external influences, and as a result, it becomes more resistant to drugs. Conventionally, industrial products containing such bacteria have been dealt with by increasing the amount of chemicals such as halogenated isothiazolones, benzisothiazolones, and bromonitroalcohols. On the other hand, against Bacillus bacteria, glutaraldehyde and 2,2'-methylenebis(4-chlorophenol)
(hereinafter abbreviated as dichlorofen) is known to exhibit excellent antibacterial activity, but both drugs have the drawback that their activity is significantly affected by pH.

0003

[Problems to be Solved by the Invention] Under these circumstances, the present invention provides an industrial antibacterial composition that stably exhibits excellent antibacterial activity over a wide pH range against harmful microorganisms in the industrial field. It was done for the purpose of

0004

[Means for Solving the Problems] As a result of intensive research to develop an industrial antibacterial composition having the above-mentioned preferable properties, the present inventor has found that by combining two specific antibacterial agents, the synergistic effect can be achieved. It was discovered that the antimicrobial agent stably exhibits excellent antibacterial activity in a wide pH range against harmful microorganisms in the industrial field, and based on this knowledge, the present invention was completed. That is, the present invention provides an industrial antibacterial composition containing glutaraldehyde and dichlorophene as active ingredients in a weight ratio of 1:20 to 20:1. The present invention will be explained in detail below.

The industrial antibacterial composition of the present invention contains glutaraldehyde and dichlorophene as active ingredients, with a weight ratio of 1:20 to 20:1;
It is necessary to select the ratio preferably in the range of 1:10 to 10:1. If this blending ratio falls outside of the above range, the effects of the present invention will not be fully exhibited and the objectives of the present invention will not be achieved. Furthermore, other conventionally known industrial disinfectants may be blended into the antibacterial composition of the present invention as long as the purpose of the present invention is not impaired.

There are no particular restrictions on the formulation form of the composition of the present invention, and it can be used, for example, as a liquid solution dissolved in a solvent, a flowable agent dispersed in water as particles, or a solid agent kneaded into a synthetic resin. . When dissolved in a solvent to form a liquid agent, examples of the solvent include glycol ethers such as diethylene glycol monomethyl ether and ethylene glycol monomethyl ether, glycols such as ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, and polyethylene glycol; Examples include dimethylformamide, dimethyl sulfoxide, and water. These solvents may be used alone or in combination of two or more.

[0007] The antibacterial composition of the present invention thus combines glutaraldehyde and dichlorophene, and due to their synergistic effect, the antibacterial composition of the present invention has
It can stably exhibit excellent antibacterial activity. The field of application of the composition of the present invention is not particularly limited as long as it can be used as an industrial antibacterial agent, but it is generally used for slime control in cooling water systems and pulp and paper factories,
Preservatives such as starch and casein, latex, pigments,
It is suitably used for preservative purposes in products such as adhesives and paints, and in systems that use metal processing oils.

[0008] The amount of the antibacterial composition of the present invention to be added is appropriately selected depending on the type of object to which the composition is applied. is, the total amount of both components is 1
It is preferable to select a concentration of 100 to 100 μg/ml, or 10 to 3,000 μg/ml when used in other fields. Further, as for the addition method, both components may be added in predetermined proportions, or a mixture of both components in predetermined proportions may be added.

[0009]

EXAMPLES Next, the present invention will be explained in more detail with reference to examples, but the present invention is not limited to these examples in any way.

Examples 1 to 9 and Comparative Examples 1 and 2 Antibacterial compositions having the compositions shown below were prepared.

[0011]

Comparative Example 3 Caisson 886 (manufactured by Rohm & Haas, trade name, active ingredient: 14 wt%) was prepared as an antibacterial composition.

Comparative Example 4 An antibacterial composition consisting of 2-bromo-2-nitro-1,3-propanediol alone was prepared.

Test Example 1 The bactericidal effect on a spore suspension of Bacillus subtilis, a Gram-positive bacterium isolated and identified from a styrene-butadiene emulsion latex spoilage liquid, was investigated. That is, the uncorrupted latex was adjusted in advance to the pH shown below, and after adding 100 μg/ml of a predetermined antibacterial composition as an antibacterial agent thereto, the number of viable bacteria was measured by the agar plate method. For comparison, a similar test was also conducted in the case where no drug was added. The results are shown below.

[0015]
Number of viable bacteria (number/ml) Type of antibacterial composition pH 5.5 pH 7.0
pH 10.0 Example 2 9
．． 0×102 3.2×102 2.0×10
Example 5 5.5×10 5.
0×10 1.3×102 Example 8
10 or less 3.1×10 3
．． 5×103 Comparative example 1 3.8
×105 4.6×104 8.5×102
Comparative example 2 7.0×10 1.0
×103 3.9×105 Comparative example 3
3.3×104 7.3×104 4.1
×105 Comparative example 4 6.6×1
04 9.5×104 3.5×105
No additives 7.1×105 7.3×
105 4.5×105

From the above results, it can be seen that glutaraldehyde has a significant bactericidal effect on Bacillus subtilis spores at an alkaline pH of 10, and dichlorophene has a significant bactericidal effect at an acidic pH of 5.5. Furthermore, it can be seen that the antibacterial composition of the present invention using both components in combination exhibits a synergistic bactericidal effect and exhibits stable effects over a wide pH range. Inferred from the fact that Bacillus subtilis was the dominant bacterial species in the latex spoilage fluid, it is suggested that the antibacterial composition of the present invention exhibits an excellent effect in preserving industrial products.

Test Example 2 The antiseptic effect of the antibacterial composition of the present invention was confirmed by an antiseptic test using emulsion latex. That is, styrene-butadiene emulsion latex (pH 9.
0) and a predetermined antibacterial composition (antibacterial agent 100
Microbes obtained by rotting the latex were added once every two weeks to 106 microbes/ml in the test solution, and stored at 30°C. The number of viable bacteria was measured on the seventh day. The preservative effect is based on the fact that the number of bacteria in the test solution is 103 cells/ml or less 7 days after adding the bacteria.
We investigated the number of days to prevent corruption. Note that the same test was conducted in the case where no drug was added. The results are shown below.

[0018]

From the above results, it can be seen that the antibacterial composition of the present invention maintains its effect for a long period of time due to the synergistic effect, compared to when glutaraldehyde and dichlorophene are used alone. Test Example 3 2wt% used as an interlayer adhesive in a pulp and paper factory
Phosphate esterified starch slurry (pH 6.0),
Add the specified antibacterial composition so that the antibacterial agent concentration is 200 μg/ml, and after storing it for 7 days at 30°C, the pH of the test solution
The minimum concentration of antibacterial agent effective for preservation was determined by measuring the degree of decay based on deterioration and odor. The results are shown below.

[0020]

From the above results, it can be seen that the antibacterial composition of the present invention exhibits a preservative effect at a lower concentration than when glutaraldehyde and dichlorophene are used alone.

Test Example 4 White water (pH 8.0) from a paper mill manufacturing coated base paper
), a predetermined antibacterial composition was added so that the antibacterial agent concentration was 30 μg/ml, and after shaking at 30°C for 60 minutes, the number of viable bacteria in the test solution was measured by the agar plate method, and the sterilization rate was determined. I asked for it. Note that the same test was conducted in the case where no drug was added. The results are shown below.

[0023]

From the above results, it can be seen that the antibacterial composition of the present invention can perform sterilization treatment with an extremely high sterilization rate.

Test Example 5 The antibacterial composition of Example 5 was applied to a paper mill manufacturing coated base paper. That is, the antibacterial composition of Example 5 was applied to a machine chest in an amount of 30 μg three times a day.
/ml was injected for 30 minutes each, and the slime treatment was performed. The treatment effect was evaluated from the number of times the product was cut during operation and the state of slime generation in the system when the system was stopped.

[0026] At this factory, slime treatment was carried out in the same manner using the same additive amount of the chemical shown in Comparative Example 3, but within two weeks of operation, there were many paper breaks due to slime, and after the system was stopped, Slime formation was observed. On the other hand, in the treatment using the antibacterial composition of Example 5, there was no paper breakage, continuous operation was possible for one month, no slime was observed in the system when the operation was stopped, and a good treatment effect was achieved. Obtained.

[0027]

Effects of the Invention The industrial antibacterial composition of the present invention is a combination of glutaraldehyde and dichlorophene, and due to their synergistic effect, it is stable and excellent against harmful microorganisms in the industrial field over a wide pH range. It exhibits antibacterial activity. The industrial antibacterial composition is used, for example, for slime control in cooling water systems and paper and pulp factories, for preservatives such as starch and casein, latex, pigments, adhesives,
It is suitably used for preservative purposes in products such as paints, and in systems that use metal processing oils.

Claims (1)

[Claims] 1. An industrial antibacterial composition comprising glutaraldehyde and 2,2'-methylenebis(4-chlorophenol) as active ingredients in a weight ratio of 1:20 to 20:1.