JPH0429033A - Blood plasma dripping controller - Google Patents

Abstract

PURPOSE:To adjust the dripped amount of blood plasma to a constant value by storing a memory with a backlash quantity including an actuator and a transmission means previously and adding the backlash quantity which is stored in the memory at the time of the reversing of an actuator. CONSTITUTION:The backlash quantity is calculated prior to a blood analysis. Namely, the actuator 1 is driven by a controller 8 to dip a dripping chip 7 in water. Then the actuator 1 is reversed by one step from the controller 8 and the rotation is stopped while water beings to be discharged by the chip 7. The controller 8 counts steps and the counted number of steps is stored in the memory 9. Further, when blood plasma is sucked and dripped in the blood analysis, the controller 8 reads the number of steps out of the memory 9 and send pulses as many as the steps to the actuator 1 to make the dripped amount from a nozzle 11 constant.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to a plasma dripping device for blood testing, and more particularly to a plasma dripping control device that controls the amount of plasma dripped at a constant level.

(b) Prior Art Generally, a blood test apparatus separates each component using a centrifuge and collects plasma, etc., and then performs each analytical test.

In this case, the large inspection device is automated and does not require manual operation for all operations, but requires a very manual device, which is extremely expensive.

Here, as an apparatus for collecting a plasma sample from blood, Japanese Patent Application Laid-Open No. 181057/1982 is provided with a plasma water chamber and a plasma chamber, and the plasma chamber is equipped with a plasma chamber in which blood constantly flows. It is configured to filter plasma from the bloodstream.

(c) Problems to be Solved by the Invention Although the above-mentioned prior art does specifically describe a technique for filtering plasma, it does not describe plasma dripping. The inspection equipment is
The health level of the person whose blood is sampled is determined by detecting how many components are contained in a predetermined amount of serum.

However, this predetermined amount is minute (about 10μ!), so in order to constantly detect and analyze a constant amount, special and large-scale equipment such as an encoder to control the amount using a microsyringe is required. was. Therefore, the blood test device itself has disadvantages in maintenance resulting from extra space, device cost, and mechanical complexity.

(d) Means for Solving the Problems The present invention provides a plasma dripping control device comprising an actuator for driving suction and ejection means, a transmission means for transmitting the driving force of the actuator, and a controller for controlling the actuator. The amount of backlash including the actuator and the transmission means is stored in a memory in advance, and when the actuator is reversed, the amount of backlash stored in the memory is added to keep the amount of plasma dripped constant.

(Thursday) Effect In the present invention, the amount of backlash of the actuator and the transmission means is stored in the memory in advance with the above-mentioned configuration, and when the actuator is reversed, the amount of backlash is added to adjust the amount of plasma dripped to a constant value. It is.

(F) Example The drawings show the configuration of the plasma dripping control device of the present invention. In the drawings, (1) shows an actuator as a driving source such as a stepping motor, and (2) converts the rotational force of the actuator into reciprocating motion. <3> is a block with a nut that drives the microsyringe <4), (5)
is an air pipe, (6) is a tip holder, (7) is a dripping tip, (8) is a controller, (9) is a memory for storing the amount of backlash in advance, and (10> is plasma).

Next, the operation of the apparatus of the present invention will be explained. First, before blood analysis is performed, the amount of backlash is calculated. The actuator (1) is driven by the controller (8) to perform suction operation, and the dripping tip (7) is placed under the water surface.

Therefore, the controller (8) moves the actuator (1) one step at a time in the direction of reverse rotation. As soon as water starts to be discharged from the dripping tip (7), its rotation is stopped. The input from the controller graph 8> is stopped, the number of steps is calculated, and the number of steps is stored in the memory (9).

On the other hand, during blood analysis, when inhaling and dropping plasma sample 10〉, the controller (8) reads the number of steps in the memory (9) and applies an extra (added state) pulse to the actuator 1 by that amount. ) to keep the amount of drops from the nozzle (11) constant.

In the above configuration, the microsyringe (4) rotates the actuator (1) (by a stepping motor, etc.), and the rotational driving force is converted into reciprocating motion by the feed screw (3), causing the piston bar <12) to move in the A direction. During suction, plasma (10) is sucked into the dripping tip (7) and its liquid level rises, and conversely, when the piston lever (12) is pushed completely in direction B, plasma (10) is dripped. The liquid is discharged from the tip of the tip (7), and the liquid level falls.

At the time of discharge, the plasma (10) is dropped in small amounts (approximately 10 μe) and is available for inspection and analysis.

In addition, in the above-mentioned suction and discharge, especially the dripping tip (7)
With no plasma inside, the piston lever (12) is pulled in direction A to suck plasma (10) into the dripping tip (7), and then it is first discharged, that is, dripped from the tip of the dripping tip (7). Sometimes, due to the negative pressure effect of the air inside the device, there is a drawback that the amount of dripping is small, but this correction can be done in the memory (9).
Store it in advance as a correction value in the controller (8).
), it is possible to drip a constant amount from beginning to end during the dripping operation.

(G) Effects of the Invention The plasma dropping device of the present invention has the advantage that when dropping plasma in a conventional blood test device, the amount of movement of the microsyringe is
Whereas the amount of dripping was not constant due to variations due to backlash, the amount of backlash can be corrected in advance,
Since it is possible to adjust the amount of dripping to a constant value, the device of the present invention is extremely effective when used in a blood test device. Furthermore, due to the simple mechanism, the cost is low and maintenance when replacing parts is easy.

[Brief explanation of drawings]

The drawing is a configuration diagram showing a plasma dripping control device of the present invention. (1) Actuator, (2> Feed screw, (3) Block with nut, <4> Micro syringe, <6) Tip holder, (7
)...Dripping tip, (8)...Controller, (9
)...Memory, (10)...Plasma.

Claims (1)

[Claims] (1) In a plasma dripping control device comprising an actuator that drives suction and ejection means, a transmission means that transmits the driving force of the actuator, and a controller that controls the actuator, the amount of backlash including the actuator and the transmission means is determined in advance. A plasma dripping control device, wherein the amount of plasma dripped is adjusted to a constant value by adding the amount of backlash stored in the memory when the actuator is reversed.