JP3365806B2 - Automatic dispensing device - Google Patents
Automatic dispensing deviceInfo
- Publication number
- JP3365806B2 JP3365806B2 JP3676693A JP3676693A JP3365806B2 JP 3365806 B2 JP3365806 B2 JP 3365806B2 JP 3676693 A JP3676693 A JP 3676693A JP 3676693 A JP3676693 A JP 3676693A JP 3365806 B2 JP3365806 B2 JP 3365806B2
- Authority
- JP
- Japan
- Prior art keywords
- droplet
- liquid sample
- abnormality
- dispensing
- droplets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、例えば、自動分析装置
に備えられ液体試料等の吸引や吐出を行う自動分注装置
に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to, for example, an automatic dispensing device provided in an automatic analyzer for sucking and discharging a liquid sample or the like.
【０００２】[0002]
【従来の技術】自動分析装置において、例えば血液のよ
うな液体試料を分注する場合、液体試料中に含有される
固形物質がノズルの吸引口に吸着され、ノズルが閉塞し
てしまうことがある。そして、ノズルが閉塞すると円滑
な分注処理を行うことが困難になる。このため、例えば
特開平２−１８４７６２号公報に示されているように、
ノズルの閉塞状態の発生を検知する技術が提案されてい
る。2. Description of the Related Art In an automatic analyzer, when a liquid sample such as blood is dispensed, a solid substance contained in the liquid sample may be adsorbed by a suction port of the nozzle and the nozzle may be clogged. . When the nozzle is closed, it becomes difficult to perform a smooth dispensing process. Therefore, for example, as disclosed in Japanese Patent Laid-Open No. 2-184762,
Techniques have been proposed for detecting the occurrence of a blocked state of a nozzle.
【０００３】この特開平２−１８４７６２号公報の閉塞
検出方法においては、試料の吸引時にエアホ−スの内圧
が順次測定され、内圧の変化率が所定レベル以上である
場合に閉塞状態が生じたことが検出される。In the blockage detecting method disclosed in Japanese Unexamined Patent Publication No. 2-184762, the internal pressure of the air hose is sequentially measured when the sample is sucked, and the blockage occurs when the rate of change of the internal pressure is equal to or higher than a predetermined level. Is detected.
【０００４】[0004]
【発明が解決しようとする課題】ところで、自動分析の
ための分注作業において重要なのは、所定量の液体試料
を吸入することよりも、所定量の液体試料を吐出するこ
とである。そして、特開平２−１８４７６２号公報のよ
うに吸引時のエアホ−スの内圧を監視すれば、吸引時の
閉塞状態を検出できると考えられる。しかし、例えば吸
引時には異常がなかったにもかかわらず吐出時に閉塞状
態が生じた場合には、異常を検出することはできない。
そして、所定量の液体試料を吸引してもその一部がノズ
ル内に残れば、液体試料の吐出量は不足してしまう。本
発明の目的とするところは、液体試料の吐出時に異常を
検出することが可能な自動分析装置を提供することにあ
る。By the way, what is important in the dispensing work for automatic analysis is to discharge a predetermined amount of liquid sample rather than to suck a predetermined amount of liquid sample. It is considered that the closed state during suction can be detected by monitoring the internal pressure of the air hose during suction as in JP-A-2-184762. However, for example, if there is no abnormality at the time of suction but a blocked state occurs at the time of discharge, the abnormality cannot be detected.
Then, even if a predetermined amount of the liquid sample is sucked, if a part thereof remains in the nozzle, the discharge amount of the liquid sample will be insufficient. An object of the present invention is to provide an automatic analyzer capable of detecting an abnormality when a liquid sample is ejected.
【０００５】[0005]
【課題を解決するための手段および作用】上記目的を達
成するために本発明は、所定量の液体試料を液滴に分割
して吐出する液滴吐出手段と、吐出された上記液滴を計
数する液滴計数手段と、上記液滴吐出手段の駆動タイミ
ングと上記液滴の滴下タイミングとを比較して、異常の
有無を判断する異常判断手段とを備えたことにある。ま
た、上記異常判断手段は、上記駆動タイミングと滴下タ
イミングとの時間差が予め設定された正常範囲内にある
か否かを判別することにある。 In order to achieve the above object, the present invention provides a droplet discharge means for dividing a predetermined amount of a liquid sample into droplets and discharging the droplets, and counting the discharged droplets. Droplet counting means and driving timing of the droplet discharging means
And an abnormality determination means for determining whether or not there is an abnormality by comparing the timing of the droplet and the timing of dropping the droplet . Well
In addition, the abnormality determining means is configured to detect the drive timing and the dropping target.
The time difference from the imming is within the preset normal range
It is to determine whether or not.
【０００６】こうすることによって本発明は、液体試料
の吐出時に異常を検出できるようにしたことにある。な
お、液体試料には、血液や尿などの検液、細胞溶解液、
各種試薬溶液等が挙げられる。In this way, the present invention is to make it possible to detect an abnormality when the liquid sample is ejected. Liquid samples include test liquids such as blood and urine, cell lysates,
Examples include various reagent solutions.
【０００７】[0007]
【実施例】以下、本発明の一実施例を図１及び図２に基
づいて説明する。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to FIGS.
【０００８】図１は本発明の一実施例を示しており、図
中の符号１は自動分析装置に備えられる自動分注装置で
ある。この自動分注装置１には、液滴吐出手段としての
シリンジ２と、分注ノズル３とが備えられている。シリ
ンジ２はシリンジ駆動源４に接続されており、シリンジ
駆動源４はシリンジ駆動源制御部５に接続されている。
そして、シリンジ駆動源４は制御部５の指示に従ってシ
リンジ２に吸引・吐出動作を行わせる。FIG. 1 shows an embodiment of the present invention. Reference numeral 1 in the figure is an automatic pipetting device provided in an automatic analyzer. This automatic dispensing device 1 is provided with a syringe 2 as a droplet discharge means and a dispensing nozzle 3. The syringe 2 is connected to the syringe drive source 4, and the syringe drive source 4 is connected to the syringe drive source controller 5.
Then, the syringe drive source 4 causes the syringe 2 to perform suction / discharge operations according to an instruction from the control unit 5.
【０００９】分注ノズル３はエアホ−ス６を介してシリ
ンジ２に接続されるとともに、図示しない移動機構に連
結されている。さらに、分注ノズル３は、矢印Ａで示す
よう試料管７と反応管８との間を水平移動するととも
に、矢印Ｂで示すように試料管７に対して上下移動す
る。そして、分注ノズル３は試料管７の中に進入する。
ノズル３の内径や先端形状は、形成しようとする液滴の
大きさや吐出量もしくは液体試料の性状等により、適宜
設定することができる。The dispensing nozzle 3 is connected to the syringe 2 via an air hose 6 and is also connected to a moving mechanism (not shown). Further, the dispensing nozzle 3 horizontally moves between the sample tube 7 and the reaction tube 8 as shown by an arrow A, and moves vertically with respect to the sample tube 7 as shown by an arrow B. Then, the dispensing nozzle 3 enters the sample tube 7.
The inner diameter and the tip shape of the nozzle 3 can be appropriately set depending on the size of the droplet to be formed, the discharge amount, the property of the liquid sample, and the like.
【００１０】また、自動分注装置１には液滴検出部９が
備えられている。この液滴検出部９は発光素子１０と受
光素子１１とを有しており、反応管８の上方に配置され
ている。両素子１０、１１は水平に対向しており、発光
素子１０の発した検出光１２が受光素子１１によって受
けられる。受光素子１１の出力はカウンタ１３に出力さ
れ、カウンタ１３の計数結果が異常判断手段としてのＣ
ＰＵ１４に送られる。ＣＰＵ１４はカウンタ１３の計数
結果に基づき所定の演算を行って演算結果を出力する。
ここで、液滴検出部９とカウンタ１３とによって液滴計
数手段１５が構成されている。つぎに、上述の自動分注
装置１の作用を説明する。Further, the automatic dispensing device 1 is provided with a droplet detecting section 9. The droplet detection unit 9 has a light emitting element 10 and a light receiving element 11, and is arranged above the reaction tube 8. Both elements 10 and 11 are horizontally opposed to each other, and the detection light 12 emitted from the light emitting element 10 is received by the light receiving element 11. The output of the light receiving element 11 is output to the counter 13, and the count result of the counter 13 is C as an abnormality determining means.
It is sent to the PU 14. The CPU 14 performs a predetermined calculation based on the counting result of the counter 13 and outputs the calculation result.
Here, the droplet detecting unit 9 and the counter 13 constitute a droplet counting means 15. Next, the operation of the above-mentioned automatic dispensing device 1 will be described.
【００１１】まず、分注ノズル３の先端部が試料管７中
の液体試料１６に浸されると、シリンジ２が吸引駆動さ
れて液体試料１６の一部が分注ノズル３に吸引される。
このときの液体試料１６の吸引量は、シリンジ２の吸引
圧力と駆動時間とによって決まる。この後、分注ノズル
３は反応管８へ向って移動し、反応管８及び液滴検出部
９の上方で停止する。そして、シリンジ２が吐出駆動さ
れ、分注ノズル３から液体試料１６が反応管８に向けて
吐出される。First, when the tip of the dispensing nozzle 3 is immersed in the liquid sample 16 in the sample tube 7, the syringe 2 is driven to be sucked and a part of the liquid sample 16 is sucked into the dispensing nozzle 3.
The suction amount of the liquid sample 16 at this time is determined by the suction pressure of the syringe 2 and the driving time. After that, the dispensing nozzle 3 moves toward the reaction tube 8 and stops above the reaction tube 8 and the droplet detection unit 9. Then, the syringe 2 is driven to discharge, and the liquid sample 16 is discharged from the dispensing nozzle 3 toward the reaction tube 8.
【００１２】シリンジ２の駆動は小刻みに行われ、液体
試料１６は間欠的に吐出される。つまり、液体試料１６
の吐出はＮ回に分割して行われ、液体試料１６は図２中
に示すように滴となって次々に落下する。液体試料の一
回の滴下量は、（所定の分注量）／Ｎで表される。そし
て、この吐出分割回数Ｎや滴下量はシリンジ駆動源制御
部５に設定されており、このシリンジ駆動源制御部５に
よってシリンジ２のストロ−ク量や駆動速度が設定され
る。The syringe 2 is driven in small steps, and the liquid sample 16 is intermittently discharged. That is, the liquid sample 16
The liquid sample 16 is divided into N times, and the liquid sample 16 becomes a drop as shown in FIG. The amount of one drop of the liquid sample is expressed by (predetermined amount of dispensing) / N. The number N of ejection divisions and the drop amount are set in the syringe drive source control unit 5, and the stroke amount and drive speed of the syringe 2 are set by the syringe drive source control unit 5.
【００１３】Ｎの値は、分注ノズル３の構成等で規定さ
れる液滴の体積を一定にした場合、分注量から割り出せ
る。また、シリンジ２の駆動を適宜制御したり分注ノズ
ル３の構成を交換するなどして、液滴の体積を選択的に
切り換えるようにすれば、ある程度の範囲内（例えば10
〜500 μｌ）でＮ値を一定にしながら、種々の分注量を
扱える点で構成が簡単になる。The value of N can be calculated from the dispensed amount when the volume of the liquid droplets defined by the configuration of the dispenser nozzle 3 is constant. In addition, if the volume of the droplet is selectively switched by appropriately controlling the drive of the syringe 2 or exchanging the configuration of the dispensing nozzle 3, a certain range (for example, 10
The composition is simple in that various aliquots can be handled while keeping the N value constant at ~ 500 μl).
【００１４】落下した液滴１６ａは、発光素子１０と受
光素子１１との間を通過し、検出光１２を遮る。受光素
子１１の出力信号には液滴１６ａが通過したことが表
れ、カウンタ１２はこの信号に基づいて液滴１６ａの通
過回数をカウントする。そして、カウンタ１３の計数結
果がＣＰＵ１４に送られる。The dropped liquid droplet 16a passes between the light emitting element 10 and the light receiving element 11 and blocks the detection light 12. The output signal of the light receiving element 11 indicates that the droplet 16a has passed, and the counter 12 counts the number of times the droplet 16a has passed based on this signal. Then, the counting result of the counter 13 is sent to the CPU 14.
【００１５】液体試料１６の分注終了後、ＣＰＵ１４が
カウンタ１３の計数結果と吐出分割数Ｎとを比較し、正
常な分注が行われたか否かを判断する。つまり、液滴検
出部８を通過した液滴数と吐出分割数Ｎとが等しけれ
ば、正常な分注が行われたことが判断される。もし、液
滴数が吐出分割数Ｎよりも少なければ、分注ノズル３に
閉塞状態が生じたことが検知され、吐出異常検出信号１
７が出力される。そして、この吐出異常検出信号１７に
基づいて、プリンタやディスプレイ等の出力装置が異常
の発生を知らせる。After the liquid sample 16 has been dispensed, the CPU 14 compares the count result of the counter 13 with the number N of ejection divisions to determine whether or not normal dispensing has been performed. That is, if the number of droplets that have passed through the droplet detection unit 8 and the number N of ejection divisions are equal, it is determined that normal dispensing has been performed. If the number of droplets is less than the number N of ejection divisions, it is detected that the dispensing nozzle 3 is blocked, and the ejection abnormality detection signal 1
7 is output. Then, based on the discharge abnormality detection signal 17, an output device such as a printer or a display notifies that an abnormality has occurred.
【００１６】上述の自動分注装置１によれば、液体試料
１６が分注ノズル３からＮ回に分割されて吐出され、分
注ノズル３から実際に吐出された液滴の数が液滴計数手
段により検出される。そして、液滴の数と吐出分割回数
とが比較されて、分注作業の異常の有無を判断される。
したがって、所定量の液体試料１６が実際に吐出された
か否かを判断でき、吐出時の異常を検出することが可能
になる。According to the above-mentioned automatic dispensing apparatus 1, the liquid sample 16 is discharged from the dispensing nozzle 3 divided into N times and the number of droplets actually discharged from the dispensing nozzle 3 is counted by the droplet count. Detected by means. Then, the number of droplets is compared with the number of divided discharges to determine whether or not there is an abnormality in the dispensing work.
Therefore, it is possible to judge whether the predetermined amount of the liquid sample 16 is actually ejected, and it is possible to detect an abnormality at the time of ejection.
【００１７】また、カウント方式であるために、１つの
液体試料の分注の間に、他の液体試料を同一または異な
る反応管に分注する、といった割り込み操作ないし連続
操作のタイミングがとり易いという効果もある。なお、
本発明は、上述の実施例に限定されるものではなく、要
旨を逸脱しない範囲で種々に変形することが可能であ
る。Further, because of the counting method, it is easy to set the timing of interrupt operation or continuous operation such as dispensing another liquid sample into the same or different reaction tube during dispensing of one liquid sample. There is also an effect. In addition,
The present invention is not limited to the above-described embodiments, but can be variously modified without departing from the scope of the invention.
【００１８】例えば、分注ノズル３の先端に交換可能な
チップを取付ける場合、取付け方が不十分だと、エア−
のリ−クが生じる。また、分注ノズル３やエアホ−ス６
に材料の劣化等を原因とする亀裂が生じている場合に
も、エア−の流通経路の途中でリ−クが生じる。そし
て、エア−がリ−クしていると、吸引圧や吐出圧が不安
定になり、チップや分注ノズル３の先端に形成される液
滴の大きさがばらついたり、液だれが発生したりして、
滴下のタイミングがずれる場合があり得る。この様な場
合には、シリンジ駆動源４の駆動タイミングと液滴の滴
下タイミングとの時間差を検出し、この時間差が予め設
定された正常範囲内にあるか否かを判別すれば、リ−ク
の発生を検知できる。For example, when a replaceable tip is attached to the tip of the dispensing nozzle 3, if the attachment is insufficient, the air-
Leak occurs. In addition, the dispensing nozzle 3 and the air hose 6
Even when a crack is generated in the air due to deterioration of the material, a leak occurs in the middle of the air flow path. When the air leaks, the suction pressure and the discharge pressure become unstable, and the size of the droplets formed on the tip of the tip or the dispensing nozzle 3 varies, or dripping occurs. Or
The timing of dropping may be shifted. In such a case, if the time difference between the drive timing of the syringe drive source 4 and the drop timing of the liquid droplet is detected and it is determined whether or not this time difference is within a preset normal range, the leak is detected. Can be detected.
【００１９】また、前述の実施例では、シリンジ２が小
刻みに駆動されて液滴が作成されるが、例えば分注ノズ
ル３の形状及びシリンジ２の駆動条件を、液体試料１６
が間欠的に次々に自然落下するよう設定し、液滴の自然
落下に合せて吐出分割回数Ｎを設定すれば、自然落下を
利用して、液体試料１６を滴下させることができる。そ
して、迅速且つ円滑な分注作業を行うことが可能にな
る。このとき、場合によっては、分注ノズル３の先端を
断続的または連続的に振動させたり、一定ピッチで上下
動を繰り返すことにより、滴下タイミングを促進させる
などの調節機構を設けてもよい。また、異常信号１７に
基づき、自動的に分注作業をやり直したり、分注ノズル
３の閉塞物を取り除く洗浄作業を行うといった応用も可
能である。Further, in the above-mentioned embodiment, the syringe 2 is driven in small steps to form liquid droplets. For example, the shape of the dispensing nozzle 3 and the driving condition of the syringe 2 may be changed.
However, if the number of discharge divisions N is set in accordance with the natural drop of the liquid droplets, the liquid sample 16 can be dropped by using the natural drop. Then, it becomes possible to perform a quick and smooth dispensing work. At this time, depending on the case, an adjusting mechanism may be provided such that the tip of the dispensing nozzle 3 is vibrated intermittently or continuously, or the vertical movement is repeated at a constant pitch to accelerate the dropping timing. Further, based on the abnormal signal 17, the dispensing work can be automatically redone or the cleaning work for removing the blockage of the dispensing nozzle 3 can be performed.
【００２０】[0020]
【発明の効果】以上説明したように本発明は、所定量の
液体試料を液滴に分割して吐出する液滴吐出手段と、吐
出された上記液滴を計数する液滴計数手段と、上記液滴
吐出手段の駆動タイミングと上記液滴の滴下タイミング
とを比較して、異常の有無を判断する異常判断手段とを
備えたものである。また、上記異常判断手段は、上記駆
動タイミングと滴下タイミングとの時間差が予め設定さ
れた正常範囲内にあるか否かを判別するものである。 The present invention described above, according to the present invention includes a droplet discharge means for discharging by dividing the predetermined amount of the liquid sample into droplets, and the droplet counting means for counting the droplets ejected, the Droplet
Driving timing of the ejection means and dropping timing of the droplets
And an abnormality determining means for determining whether or not there is an abnormality. Further, the abnormality determining means is
The time difference between the motion timing and the drip timing is set in advance.
It is to determine whether or not it is within the normal range.
【図１】本発明の一実施例を示す構成図。FIG. 1 is a configuration diagram showing an embodiment of the present invention.
【図２】液滴検出部の作用を説明する図。FIG. 2 is a diagram illustrating an operation of a droplet detection unit.
１…自動分注装置、２…シリンジ（液滴吐出手段）、９
…液滴検出部、１４…ＣＰＵ（異常判断手段）、１５…
液滴計数部、１６…液体試料、１６ａ…液滴。1 ... Automatic dispensing device, 2 ... Syringe (droplet discharging means), 9
... Droplet detector, 14 ... CPU (abnormality determination means), 15 ...
Droplet counter, 16 ... Liquid sample, 16a ... Droplet.
フロントページの続き (56)参考文献 特開 昭60−142261（ＪＰ，Ａ) 特開 平４−285840（ＪＰ，Ａ) 特開 平２−243961（ＪＰ，Ａ) 特開 平５−288757（ＪＰ，Ａ) 特公 平２−41710（ＪＰ，Ｂ２) 特公 昭64−9585（ＪＰ，Ｂ２) 特公 平４−26415（ＪＰ，Ｂ２) (58)調査した分野(Int.Cl.7，ＤＢ名) G01N 35/00 - 35/10 G01N 1/00 - 1/44 ＪＩＣＳＴファイル（ＪＯＩＳ)Continuation of front page (56) Reference JP-A-60-142261 (JP, A) JP-A-4-285840 (JP, A) JP-A-2-243961 (JP, A) JP-A-5-288757 (JP , A) Japanese Patent Publication No. 2-41710 (JP, B2) Japanese Patent Publication No. 64-9585 (JP, B2) Japanese Patent Publication No. 4-26415 (JP, B2) (58) Fields investigated (Int.Cl. 7 , DB) Name) G01N 35/00-35/10 G01N 1/00-1/44 JISST file (JOIS)
Claims (2)
する液滴吐出手段と、 吐出された上記液滴を計数する液滴計数手段と、上記液滴吐出手段の駆動タイミングと上記液滴の滴下タ
イミングとを比較して、 異常の有無を判断する異常判断
手段とを備えたことを特徴とする自動分注装置。1. A droplet discharge means for dividing and discharging a predetermined amount of a liquid sample into droplets, a droplet count means for counting the discharged droplets, a drive timing of the droplet discharge means, and the above. Droplet drop
An automatic dispensing device, comprising: abnormality determining means for determining presence or absence of abnormality by comparing with iming .
グと滴下タイミングとの時間差が予め設定された正常範
囲内にあるか否かを判別することを特徴とする請求項１
に記載の自動分注装置。 2. The abnormality determining means is the drive timing.
The time difference between the
The method according to claim 1, wherein it is determined whether or not it is inside the enclosure.
Automatic dispensing device described in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3676693A JP3365806B2 (en) | 1993-02-25 | 1993-02-25 | Automatic dispensing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3676693A JP3365806B2 (en) | 1993-02-25 | 1993-02-25 | Automatic dispensing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06249861A JPH06249861A (en) | 1994-09-09 |
| JP3365806B2 true JP3365806B2 (en) | 2003-01-14 |
Family
ID=12478887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3676693A Expired - Fee Related JP3365806B2 (en) | 1993-02-25 | 1993-02-25 | Automatic dispensing device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3365806B2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083762A (en) * | 1996-05-31 | 2000-07-04 | Packard Instruments Company | Microvolume liquid handling system |
| ATE377763T1 (en) * | 2002-01-25 | 2007-11-15 | Innovadyne Technologies Inc | CONTACTLESS METHOD FOR DISTRIBUTING SMALL LIQUID VOLUME |
| JP2010223638A (en) * | 2009-03-19 | 2010-10-07 | Beckman Coulter Inc | Dispensing device, automatic analyzer, and dispensation monitoring method of dispensing device |
| JP5686744B2 (en) * | 2010-01-13 | 2015-03-18 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| KR101810942B1 (en) * | 2015-09-04 | 2018-01-25 | (주)나노엔텍 | sample pretreatment system and controlling method of the same |
| CN116359128B (en) * | 2023-03-07 | 2024-04-30 | 广州市艾贝泰生物科技有限公司 | Distribution detection device |
-
1993
- 1993-02-25 JP JP3676693A patent/JP3365806B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06249861A (en) | 1994-09-09 |
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