JPH04282160A - Transfusion liquid container - Google Patents

Abstract

PURPOSE:To mix the drug in a vial and a soln. in a short period of time without hindering the movement of liquid by an operation error, etc., by communicating a hollow communicating means as a communicating means with the plug body of a drug container through the closing bode of a flexible container, by which the movement of the soln., etc., in the flexible container is smoothly executed. CONSTITUTION:This container consists of the drug container 1, the flexible container 2, the communicating means 3, and a connecting body 4. The drug container (vial) 1 consists of a glass or plastic container contg. the drug, such as powder drug or freeze-dried drug. The mouth end part 6 of the via 1 is hermetically sealed by the plug body 7 and is housed into the connecting body 4 by positioning its mouth end part 6 downward. The communicating means 3 is constituted of a hollow piercing needle 12 and a piercing needle holding member 13. The piercing needle 12 pierces the plug body 7 and the closing body 10 when the vial 1 is pressed down by the cap 5 at the time of communicating. The inside of the vial 1 and the inside of the flexible container 2 are then communicated by the communicating means 3.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an infusion container used for drip injection, and is used in the medical field.

0002

[Prior Art] Traditionally, in hospitals and other medical institutions, in order to administer powdered or freeze-dried drugs such as antibiotics and anticancer drugs to patients, these drugs are dissolved in containers such as vials and then infused. It was done by injection. in this case,
Connect the container containing the drug mentioned above and the container containing the solution of the drug using a connecting tool such as a double-ended needle or connecting tube, transfer the solution to the container containing the drug, and dissolve the drug. There is. However, this operation is complicated and time-consuming, and since the connection hole is made in the container containing the drug in the open air, there is a possibility that the drug inside may become contaminated.

[0003] In order to solve the above problem, an infusion container as shown in Japanese Patent Publication No. 1983-501129 has been proposed. This infusion container includes a capsule containing a vial serving as a drug container, and a flexible container containing a solution having a drug solution outlet, which are connected via a tube. Inside the tube, a hollow puncture needle is attached to the vial side, and a breaking member is attached to the flexible container side. The breaking member closes the passage within the tube and prevents the flow of liquid.

In use, the vial inside the capsule is pushed down, the puncture needle pierces the rubber stopper of the vial, the flexible container and the vial are first connected, and then the breakable member inside the tube is bent manually, thereby The passage within the tube is opened to mix the drug and the solution.

[0005] Furthermore, as a further improvement, an infusion container as shown in Japanese Unexamined Patent Publication No. 2-1277 has been proposed. This infusion container includes a flexible container containing a dissolving solution or a diluting solution and having a liquid passage section with a closure at the uppermost end, a capsule connected to the flexible container, and a mouth portion with a pierced opening. It consists of a drug container sealed with a passable stopper and held within the capsule, and a communication means for communicating the interior of the flexible container with the interior of the drug container, the communication means having a hub in the middle. a hollow puncture needle having cutting edges at both ends; and after the stopper of the drug container is pierced by one blade of the puncture needle, the closure of the flexible container is pierced by the other blade of the puncture needle. and a braking means for controlling the communication order so that the communication order is controlled.

[0006]

[Problems to be Solved by the Invention] However, in the infusion container disclosed in Japanese Patent Publication No. 61-501129, improvements have been made in the point of communication between the drug container and the flexible container containing the solution. However, it still requires a considerable amount of time and effort, as the puncture needle must pierce the rubber stopper of the vial and then the breakable member must be manually broken to open the passage. Furthermore, if the breakable member is imperfectly bent, there is a problem in that it is difficult for the liquid to pass through and it takes a long time to dissolve. In addition, in the infusion container disclosed in JP-A-2-1277, improvements have been made in terms of the communication between the drug container and the flexible container containing the solution and the operational effort involved. However, the communication means includes a hollow puncture needle having a hub in the middle and cutting edges at both ends, and after the stopper of the drug container is pierced by one blade of the puncture needle, the other blade of the puncture needle pierces the stopper of the drug container. This requires a braking means with a complicated shape to control the communication order so that the closure of the flexible container is pierced, resulting in a problem of high manufacturing cost.

[0007] The present invention was made in view of these problems, and it ensures and facilitates communication between a drug container and a container for a solution or diluent (hereinafter referred to as a solution), and after communication, the drug and It is an object of the present invention to provide an infusion container that allows mixing of a solution in a short time and prevents the solution in a flexible container from leaking into a connecting body.

[0008]

[Means for Solving the Problems] The infusion container of the present invention comprises a flexible container having a connecting port and containing a solution or diluent inside, and a connector connected to the flexible container. a medicine container having a stopper at the mouth portion held in the connecting body; and a communication device for communicating the inside of the flexible container and the inside of the drug container, the communication device for the stopper. It is characterized in that a connection means that can be easily and liquid-tightly connected to the communication tool is formed substantially integrally with the plug body on the side thereof.

[0009]

[Operation] In the present invention, by providing a connecting means that can be easily and liquid-tightly connected to the communicating device, the communicating device is first connected to the connecting means provided on the stopper of the drug container, and then , through the stopper of a drug container or the closure of a flexible container. Therefore, the inconvenience that the closing body is penetrated first and the solution or diluent in the flexible container leaks into the connecting body does not occur.

[0010] Furthermore, a hollow communicating tool is used as the communicating means, and the communicating tool penetrates the stopper of the drug container and the closure of the flexible container, thereby immediately establishing communication. Since the communication is through a hollow communication device, the movement of the liquid is smooth, and the movement of the liquid is not hindered by operational errors or the like. Therefore, the drug and solution can be mixed in a short time after communication.

[0011]

[Example] Next, an example of the present invention will be described. FIG. 1 is a cross-sectional view of a main part of an infusion container according to an embodiment of the present invention, FIG. 2 is a cross-sectional view of a main part of the infusion container of the same embodiment showing a connection between a communication tool and a connecting means, and FIG. A cross-sectional view of the essential parts showing the infusion container of the embodiment completely communicated with the communication device, FIG. 4 is a cross-sectional view of the main part showing another embodiment of the connecting means, and FIG. 5 shows the infusion container of the same embodiment in communication. FIG. 6 is a cross-sectional view of a main part showing still another embodiment of the connection means, and FIG. 7 is a cross-sectional view of a main part showing a state in which the infusion container of the same embodiment is completely communicated with a communication tool. FIG. 8 is a cross-sectional view of the main part showing still another embodiment of the connecting means, and FIG. 9 is a main part showing the infusion container of the same embodiment completely communicated with the communication device. 10 is a detailed sectional view of the plug shown in FIG. 1, FIG. 11 is a detailed sectional view of the plug shown in FIG. 4, and FIG. 12 is a detailed sectional view of the plug shown in FIGS. 6 and 8. It is.

The infusion container shown in FIG. 1 is composed of a drug container 1, a flexible container 2, a communicating device 3, a connector 4, and a cap 5. The drug container 1 is a container (hereinafter referred to as a vial) that holds a drug such as a powdered drug or a freeze-dried drug. The vial 1 is a well-known glass or plastic vial, the mouth part 6 of which is sealed with a stopper 7, and is housed in the connector 4 with the mouth part 6 facing down.

[0013] The flexible container 2 is a container for containing a solution.
Made of highly flexible materials such as low-density polyethylene resin, linear low-density polyethylene resin, polypropylene resin, soft polyester resin, chlorinated polyethylene resin, vinyl chloride resin, and ethylene-vinyl acetate copolymer. . Among these, polyolefin resins such as low-density polyethylene resin, linear low-density polyethylene resin, and polypropylene resin have excellent chemical resistance, have little elution into the solution, are inexpensive, and have excellent economic efficiency. Therefore, it is preferable. A connecting mouth portion 8 is formed at the upper end of the flexible container 2.
Further, a chemical liquid discharge port 9 is formed at the lower end. The connecting port 8 is sealed by a closing body 10. In this embodiment, the closure body 10 uses a plug made of a rubber-like elastic material, but other types of plugs may be used.

The connecting body 4 housing the vial 1 has an open upper end and a lower end connected to the connecting opening 8. This connecting body 4 connects the vial 1 and the flexible container 2 housed in the connecting body 4. The connecting body 4 is made of polyolefin resin, styrene resin, acrylic resin, polycarbonate resin, polyamide resin, or the like. Among these, by using polypropylene resin, methylpentene resin, etc., which are relatively easy to transmit ultraviolet rays, the inside of the connecting body 4 can be sterilized by irradiating ultraviolet rays from the outside of the connecting body 4, so sterilization can be easily performed. It's very desirable. Further, the upper end of the connecting body 4 is covered with a cap 5. This cap 5 is attached to vial 1
It functions to protect the vial 1 in a sterile manner and to push down the vial 1, and various structures can be used. Further, by providing a suspension means 11 on the upper surface of the cap 5, the infusion container according to the present invention can be used by being hung on a girdle stand or the like.

The communication device 3 shown in FIG. 1 is composed of a hollow puncture needle 12 as a hollow tube and a puncture needle holding member 13.
As an example, the puncture needle 12 is fixed to the puncture needle holding member 13. The communication tool 3 is movably installed between the mouth part 6 and the connection mouth part 8 at the lower end of the connecting body 4.

In the present invention, examples of drugs to be placed in the vial 1 include cephalic antibiotics such as cefazolin sodium and ceftizoxime sodium, penicillin antibiotics such as ampicillin sodium and carpenicillin sodium, mitomycin C and fluorouracil. anti-ulcer agents such as famotidine and ranitidine hydrochloride, and thrombolytic agents such as urokinase.

Examples of the solution to be placed in the flexible container 2 include physiological saline, 5% glucose solution, distilled water for injection, and solutions containing various electrolytes.

The stopper 7 of the medicine container shown in FIG.
It has a connecting means 14 having a concave cavity formed on the side facing. An annular rib 15 is provided near the entrance of the connecting means 14 . The inner diameter of the annular rib 15 is made slightly smaller than the outer diameter of the puncture needle 12.

Next, a state in which the infusion container of the present invention is communicated with the communication device will be explained. First, when the vial 1 is pushed down with the cap 5, the puncture needle on the vial side of the communication device 3 and the connecting means 14 provided on the stopper of the vial are connected. The state at that time is shown in FIG. When the vial 1 is pushed down with the cap 5, the stopper 7 of the vial and the puncture needle 12 come into contact at the connecting means 14. Further, when the vial 1 is pushed down with the cap 5, the communicating device 3 is pushed down by the stopper 7, and the communicating device 3 moves toward the closure body 10 of the flexible container, and the puncture needle 12 on the connecting opening 8 side is opened. It hits the closure 10 of the flexible container. Next, the puncture needle 12 is connected to the connecting means 14
Comparing the resistance when the puncture needle 12 is inserted into the closure body 10 and the resistance when the puncture needle 12 is inserted into the connecting means 14, the resistance when the puncture needle 12 is inserted into the connecting means 14 is much smaller, so the puncture needle 12 and the connecting means 14 are inserted first. It will be connected. At this time, by making the inner diameter of the cavity of the connecting means 14 larger than the outer diameter of the puncture needle 12 and the inner diameter of the annular rib 15 smaller than the outer diameter of the puncture needle, the puncture needle 12 can be inserted into the connecting means 14. The resistance can be reduced, and the puncture needle 12 and the connecting means 14 can be easily connected in a liquid-tight manner.

Further, when the vial 1 is pushed down with the cap 5, the puncture needle 12 pierces the stopper 7 and the closure 10. Thereby, the inside of the vial 1 and the inside of the flexible container 2 are communicated with each other through the communication tool 3. Figure 3 shows the state at this time.
Shown below. At this time, it does not matter which of the plug body 7 or the closure body 10 the puncture needle 12 penetrates first. because,
Since the puncture needle 12 and the plug connecting means 14 are already connected, the solution in the flexible container 2 will not leak into the connecting body 4 even if the closure body 10 is penetrated first. be.

[0021] When the vial 1 and the flexible container 2 are brought into communication in this manner, the flexible container 2 is squeezed or kneaded to send a portion of the solution inside into the vial 1.
Dissolve the drug in vial 1. Then, when the flexible container 2 is pressed or squeezed again, the drug solution in the vial 1 returns to the flexible container 2. The returned medicinal solution is used as an infusion by connecting an infusion set or the like to the medicinal solution outlet 9 of the flexible container 2.

Next, another embodiment of the present invention will be explained based on FIGS. 4 and 5. The plug body 27 has a protruding connecting means 24 on the communicating device 3 side. The inside of the protruding connecting means 24 is hollow like the connecting means of the stopper 7 shown in FIG. 1, and has an annular rib 25. In this embodiment, the puncture needle 12 and the connecting means 24 are connected in advance. The state at this time is shown in FIG. Next, the method for communicating the infusion container of the present invention using the communication device is substantially the same as in the above embodiment. That is, when you push down the vial 1 with the cap 5,
The puncture needle 12 pierces the plug body 7 and the closure body 10. As a result, the inside of the vial 1 and the inside of the flexible container 2 are connected to the communication tool 3.
communicated by. The state at this time is shown in FIG. At this time, it does not matter which of the plug body 7 or the closure body 10 the puncture needle 12 penetrates first. This is because the puncture needle 12 and the plug connecting means 14 are already connected, so even if the closure body 10 is penetrated first, the solution in the flexible container 2 will not leak into the connecting body 4. It is from. In this embodiment, the puncture needle 12 and the connecting means 24 are connected in advance, but as in the embodiment shown in FIG. 12
Since the resistance to inserting the puncture needle 12 into the connecting means 24 is much smaller than the resistance to piercing the closure body 10, the resistance shown in FIG.
The same effects as in the embodiment shown in can be obtained.

Further, another embodiment of the present invention will be explained based on FIGS. 6 and 7. A through passage 32 is formed in the plug body 37 in advance, and the through passage 32 is sealed by a substantially spherical shielding body 33. This through path becomes the connection means referred to in the present invention. That is, the inner diameter of the through passage 32 is made larger than the outer diameter of the hollow tube 42 of the communicating tool 3, and the annular rib 35 having an inner diameter smaller than the outer diameter of the hollow tube 42 is placed near the entrance of the through passage on the communicating implement 3 side. to be installed. In this embodiment, the hollow pipe 42 and the through passage 32, which is a connecting means, are connected in advance. The state at this time is shown in FIG. The method of communicating the infusion container of the present invention with the communication device is substantially the same as in the embodiment described above. That is, when the vial 1 is pushed down with the cap 5, the hollow tube 42 pushes out the shield 33 from the through passage 32 into the vial 1, and the puncture needle 43 pierces the closure body 10. Thereby, the inside of the vial 1 and the inside of the flexible container 2 are communicated with each other through the communication tool 3. Figure 7 shows the state at this time.
Shown below. At this time, the hollow tube 42 passes through the shield 33 through the passage 3.
2 into the vial 1 and penetrate the puncture needle 43.
It does not matter which is done first, that is, the penetrating body 10 is penetrated through the closure body 10. This is because the hollow tube 42 is already connected to the through passage 32 which is the connection means of the stopper, so even if the closure body 10 is penetrated first, the solution in the flexible container 2 will not flow into the connecting body 4. This is because there will be no leakage. In this embodiment, the hollow pipe 42 and the through-hole 32, which is a connecting means, are connected in advance, but similarly to the embodiment shown in FIG. Even if the channel 32 is not connected in advance, the resistance to the hollow tube 42 being inserted into the through channel 32 is much smaller than the resistance to the puncture needle 43 penetrating the closure body 10, so the implementation shown in FIG. The same effect as the example is obtained.

Further, another embodiment of the present invention will be explained based on FIGS. 8 and 9. The closure body 37 used in the above embodiment is used as the closure body for the vial 1, and the closure body of the flexible container 2 also has a through passage 52 and a shield 53 similar to the closure body 37.
A closed body 50 composed of is used. In this embodiment, the hollow tube 42 of the communication device and the through passage 32 serving as the connecting means are connected in advance. The state at this time is shown in FIG. The method of communicating the infusion container of the present invention with the communication device is substantially the same as in the embodiment described above. That is, cap 5
Then, when the vial 1 is pushed down, the hollow tube 42 closes to the shield 3.
3 into the vial 1 through the passageway 32, and the other hollow tube 42 pushes out the shield 53 of the closure body 50 through the passageway 52 into the flexible container 2. Thereby, the inside of the vial 1 and the inside of the flexible container 2 are communicated with each other through the communication tool 3. The state at this time is shown in FIG. At this time, the hollow tube 42
which is the case where the shield 33 is pushed out from the through passage 32 into the vial 1 and the other hollow tube 42 pushes the shield 53 of the closure body 50 from the through passage 52 into the flexible container 2. It doesn't matter if it is done first. This is because the hollow tube 42 and the through-hole 32, which is the connecting means for the stopper, are already connected, so even if the closing body 50 is penetrated first, the solution in the flexible container 2 will not flow into the connecting body 4. This is because there will be no leakage.

In this embodiment, the hollow tube 42 and the plug are connected in advance to the through passage 32, which is a connecting means, but similarly to the embodiment shown in FIG. Even if the through passage 32 is not connected, the insertion resistance between the annular rib provided in the through passage 52 and the hollow tube 42 is lower than the insertion resistance between the annular rib provided in the through passage 32 and the hollow tube 42 The insertion resistance of the hollow tube 42 into the through passage 52 can be reduced by making the through passage 52 larger, or by not providing an annular rib in the through passage 52 and making the inner diameter of the through passage 52 smaller than the outer diameter of the hollow tube 42. The same effect can be obtained by making the insertion resistance greater than that between the annular rib and the hollow tube 42.

Furthermore, in the same embodiment, the hollow tube 42 is
It is clear that an embodiment is also possible in which the through passage 32, which is the connecting means of the plug body, is connected to the hollow tube 42 and the through passage 52 of the closure body 50 is connected.

Although various embodiments have been described above, various modifications can be made to the present invention without departing from the gist thereof.

[0027]

Effects of the Invention As explained above, the infusion container of the present invention can prevent dissolution in the flexible container without controlling the order of penetration of the stopper of the drug container (vial) and the closure of the flexible container. No leakage of liquid, etc. occurs. Furthermore, by using the hollow communication device, the solution, etc. in the flexible container can be smoothly moved, and the drug and solution in the vial can be mixed in a short time.

[Brief explanation of the drawing]

FIG. 1 is a sectional view of a main part showing an embodiment of an infusion container according to the present invention.

FIG. 2 is a cross-sectional view of a main part showing a place where a communicating device and a connecting means of the infusion container of the same embodiment are communicated with each other.

FIG. 3 is a cross-sectional view of the essential parts of the infusion container of the same embodiment, showing the infusion container completely communicated with the communication device.

FIG. 4 is a sectional view of a main part showing another embodiment of a connecting means for a stopper used in an infusion container according to the present invention.

FIG. 5 is a cross-sectional view of the essential parts of the infusion container of the same embodiment, showing the infusion container completely communicated with the communication device.

FIG. 6 is a cross-sectional view of a main part showing still another embodiment of the connection means of the stopper used in the infusion container according to the present invention.

FIG. 7 is a sectional view of a main part of the infusion container of the same embodiment, showing the infusion container completely communicated with the communication device.

FIG. 8 is a cross-sectional view of a main part showing still another embodiment of a connecting means for a stopper used in an infusion container according to the present invention.

FIG. 9 is a cross-sectional view of the essential parts of the infusion container of the same embodiment, showing the infusion container completely communicated with the communication device.

FIG. 10 is a detailed sectional view of the plug used in the embodiment shown in FIG. 1;

FIG. 11 is a detailed sectional view of the plug used in the embodiment shown in FIG. 4;

12 is a detailed sectional view of the plug used in the embodiment shown in FIGS. 6 and 8. FIG.

[Explanation of symbols]

1. Drug container (vial) 2. Flexible container 3. Communication tool 4 Connected body 5 Cap 6 Mouth area 7 Plug body 8 Connection opening 9 Chemical solution outlet part 10 Closed body 11 Suspension means 12 Puncture needle 13 Puncture needle holding member 14 Connection means 15 Annular rib 24 Connection means 25 Annular rib 27 Plug body 32 Penetration path 33 Shield 35 Annular rib 37 Plug body 42 Hollow tube 43 Puncture needle 50 Closed body 52 Penetration path 53 Shield

Claims (7)

[Claims] 1. A flexible container having a connecting opening and storing a solution or diluent therein, a connecting body connected to the flexible container, and a mouth held in the connecting body. A drug container having a stopper at a portion thereof, and a communication tool that communicates the inside of the flexible container with the inside of the drug container, and easily liquid-tightly connected to the communication tool on the communication tool side of the stopper. 1. An infusion container characterized in that a connection means capable of connecting is formed substantially integrally with a stopper. 2. The infusion container according to claim 1, wherein the connecting means is a concave cavity formed of an elastic body, and the cavity has an annular rib whose inner diameter is smaller than the outer diameter of the communication device. . 3. The infusion container according to claim 1, wherein the communication device is connected to the connection means in advance. 4. The infusion container according to claim 1, wherein the drug container is a drug vial. 5. The infusion container according to claim 4, wherein the flexible container has a drug solution outlet in addition to the connecting port. 6. The infusion container according to claim 1, wherein the connector is airtightly covered with a cap for lowering the drug container. 7. The infusion container according to claim 1, wherein the communication device is a hollow tube having a holding member in the middle.