JPH04166221A - Antimicroorganism membrane - Google Patents
Antimicroorganism membraneInfo
- Publication number
- JPH04166221A JPH04166221A JP2293976A JP29397690A JPH04166221A JP H04166221 A JPH04166221 A JP H04166221A JP 2293976 A JP2293976 A JP 2293976A JP 29397690 A JP29397690 A JP 29397690A JP H04166221 A JPH04166221 A JP H04166221A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- avidin
- group
- filter membrane
- antimicroorganism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 49
- 108090001008 Avidin Proteins 0.000 claims abstract description 18
- 230000003100 immobilizing effect Effects 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims description 17
- 230000000845 anti-microbial effect Effects 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 4
- 244000005700 microbiome Species 0.000 abstract description 10
- 239000011148 porous material Substances 0.000 abstract description 5
- 239000011347 resin Substances 0.000 abstract description 5
- 229920005989 resin Polymers 0.000 abstract description 5
- 229920001661 Chitosan Polymers 0.000 abstract description 4
- 229920002301 cellulose acetate Polymers 0.000 abstract description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract description 3
- 238000001035 drying Methods 0.000 abstract description 3
- 230000001678 irradiating effect Effects 0.000 abstract description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract description 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 abstract description 2
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 229920002492 poly(sulfone) Polymers 0.000 abstract description 2
- 229920000515 polycarbonate Polymers 0.000 abstract description 2
- 239000004417 polycarbonate Substances 0.000 abstract description 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 2
- 229920002635 polyurethane Polymers 0.000 abstract description 2
- 239000004814 polyurethane Substances 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000001471 micro-filtration Methods 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- YVXDRFYHWWPSOA-BQYQJAHWSA-N 1-methyl-4-[(e)-2-phenylethenyl]pyridin-1-ium Chemical group C1=C[N+](C)=CC=C1\C=C\C1=CC=CC=C1 YVXDRFYHWWPSOA-BQYQJAHWSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3823—Affinity chromatography of other types, e.g. avidin, streptavidin, biotin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
- B01D69/125—In situ manufacturing by polymerisation, polycondensation, cross-linking or chemical reaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/48—Antimicrobial properties
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、抗微生物膜に関する７更に詳しくは。[Detailed description of the invention] [Industrial application field] More particularly, the present invention relates to antimicrobial membranes.
ろ過膜に抗微生物特性を付与した抗微生物膜に関する。This invention relates to an antimicrobial membrane that imparts antimicrobial properties to a filtration membrane.
〔従来の技術〕および〔発明が解決しようとする課題〕
酢酸セルロース多孔質膜によって代表される、孔径約０
．２μｍ以下の精密ろ過膜を用い、大気中および溶液中
の微生物をろ過し、浄化する方法が従来から採用されて
いる。しかしながら、この方法では、１００％微生物を
阻止することは技術的にも国璽であった。それは、阻止
された微生物が膜表面で増殖し、遂には膜の片側に抜け
てしまうことが一因とされている。そこで、ろ過膜表面
での微生物の増殖を抑制することが強く要望されている
。[Prior art] and [Problem to be solved by the invention]
Pore size approximately 0, represented by cellulose acetate porous membranes
．． BACKGROUND ART Conventionally, a method of filtering and purifying microorganisms in the atmosphere and in solutions using a microfiltration membrane of 2 μm or less has been employed. However, with this method, 100% inhibition of microorganisms was technically the national seal. One reason for this is said to be that the microorganisms that are blocked proliferate on the membrane surface and eventually escape to one side of the membrane. Therefore, there is a strong demand for suppressing the growth of microorganisms on the surface of filtration membranes.
その対策としては、ろ過膜表面に抗生物質を固定化する
方法もあるが、抗生物質は分子量が小さいため、膜から
抜は落ちてしまう欠点がみられる。As a countermeasure, there is a method of immobilizing antibiotics on the surface of the filtration membrane, but since antibiotics have a small molecular weight, they have the disadvantage of being easily removed from the membrane.
本発明の目的は、ろ過膜面上における微生物の増殖を阻
止せしめる抗微生物膜を程供することにある。An object of the present invention is to provide an antimicrobial membrane that inhibits the growth of microorganisms on the surface of a filtration membrane.
〔課題を解決するための手段〕および〔作用〕かかる本
発明の目的は、ろ過膜面−Ｌにアビジンを固定化せしめ
た抗微生物膜によって達成される。[Means for Solving the Problems] and [Operation] The objects of the present invention are achieved by an antimicrobial membrane in which avidin is immobilized on the filtration membrane surface -L.
アビジンは、鶏卵の卵白中に含まれ、ビオチンと特異的
に結合する分子景約６６００の糖たん白質である。そし
て、微生物の増殖に必要なビオチン（ビタミンＨ１補酵
素）の２モルと選択的に結合し−これを不活性化するこ
とにより、微生物の増殖を阻害する作用を有している。Avidin is a glycoprotein with a molecular weight of about 6,600 that is contained in the albumen of chicken eggs and specifically binds to biotin. It selectively binds to 2 moles of biotin (vitamin H1 coenzyme) necessary for the growth of microorganisms and inactivates it, thereby inhibiting the growth of microorganisms.
即ち、アビジン−ビオチン複合体はきわめて安定（解離
定数は１０−”Ｍ）で、ビオチンはビタミンとしての活
性ならびにビオチン酵素の補酵素としての活性を失うよ
うになる。That is, the avidin-biotin complex is extremely stable (dissociation constant: 10-''M), and biotin loses its activity as a vitamin as well as its activity as a coenzyme of the biotin enzyme.
本発明においては、かかる作用を有するアビジンをろ過
膜の表面および内部に固定化せしめることにより、膜面
上における微生物の増殖を阻止せんとするものである。The present invention aims to inhibit the growth of microorganisms on the membrane surface by immobilizing avidin, which has such an effect, on the surface and inside of the filtration membrane.
ろ過膜としては、酢酸セルロース、ポリスルホン、ポリ
ウレタン、ポリテトラフルオロエチレン、ポリカーボネ
ート、キトサンなどから成形された精密ろ過膜、限外ろ
過膜、更には孔径が人オーダーの気体分離膜などが用い
られる。As the filtration membrane, a microfiltration membrane or an ultrafiltration membrane formed from cellulose acetate, polysulfone, polyurethane, polytetrafluoroethylene, polycarbonate, chitosan, etc., or a gas separation membrane with a pore size on the order of a human being is used.
ろ過膜面上へのアビジンの固定化は、一般には水溶性光
架橋性樹脂の水溶液中にアビジンを混合し、それをろ過
膜面上に塗布し、乾燥させた後。Generally, avidin is immobilized on the filtration membrane surface by mixing avidin in an aqueous solution of a water-soluble photocrosslinkable resin, applying it onto the filtration membrane surface, and drying it.
紫外線照射して光架橋膜を形成させることにより行われ
る。This is done by irradiating ultraviolet rays to form a photocrosslinked film.
水溶性光架橋性樹脂としては、例えば分子中に光架橋性
基としてスチルバゾリウム基、ジアゾ基などの感光性基
、好ましくはスチルバゾリウム基を有するポリビニルア
ルコール、ポリエチレングリコールなどが用いられる。As the water-soluble photocrosslinkable resin, for example, polyvinyl alcohol, polyethylene glycol, and the like having a photosensitive group such as a stilbazolium group or a diazo group as a photocrosslinkable group in the molecule, preferably a stilbazolium group, are used.
アビジンは、このような水溶性光架橋性樹脂の約０．１
〜５重量％水溶液中に約０．０５〜１５重量％の濃度で
混入し、この溶液がろ過膜に塗布される。塗布方法には
特に制限がないが、一般的には浸漬法が用いられる。そ
の後、室温下で約１〜３時間程乾燥し、次いで波長３０
００〜４５００人の紫外線を約５〜６０秒間照射し、形
成された光架橋膜中にアビジンを固定化させる。Avidin is about 0.1% of such water-soluble photocrosslinkable resin.
-5% by weight aqueous solution at a concentration of about 0.05-15% by weight, and this solution is applied to the filtration membrane. Although there are no particular restrictions on the coating method, a dipping method is generally used. After that, it is dried at room temperature for about 1 to 3 hours, and then
Avidin is immobilized in the formed photocrosslinked film by irradiating it with ultraviolet rays of 0.00 to 4500 for about 5 to 60 seconds.
こうした包括法による固定化法以外にも、例えばアミノ
基を有するキトサンろ過膜などの場合には、グルタルア
ルデヒドなどを用いる共有結合法によってもアビジンを
固定化することができる。In addition to the immobilization method using such an entrapment method, avidin can also be immobilized by a covalent bonding method using glutaraldehyde or the like, for example, in the case of a chitosan filtration membrane having an amino group.
このようにしてろ過膜面上に固定化されたアビジンは、
微生物に対して膜の表面および内部でのそれの増殖を有
効に阻止する働きを有している。Avidin immobilized on the filtration membrane surface in this way,
It has the function of effectively inhibiting the proliferation of microorganisms on the surface and inside the membrane.
次に、実施例について本発明を説明する。 Next, the present invention will be explained with reference to examples.
実施例１
酢酸セルロース製精密ろ過膜（孔径０，２μＬ厚さ０．
２ｏｏｏ）を、水溶性光架橋性ポリビニルアルコール（
光架橋性スチルバゾリウム基含有量１．４モル％、けん
化度８部、重合度１４００）の１重量２水溶液中にアビ
ジン（シグマ社製品）を０．５重量％混入した溶液中に
１分間浸漬し、室温下で２時間乾燥させた後、波長４０
００人の紫外線を各面３０秒間ずつ表裏両面に照射した
。Example 1 Cellulose acetate microfiltration membrane (pore size 0.2 μL thickness 0.2 μL)
2ooo), water-soluble photocrosslinkable polyvinyl alcohol (
It was immersed for 1 minute in a solution containing 0.5% by weight of avidin (product of Sigma) in a 1% by weight 2 aqueous solution containing 1.4 mol% of photocrosslinkable stilbazolium groups, a degree of saponification of 8 parts, and a degree of polymerization of 1400. , after drying at room temperature for 2 hours, wavelength 40
Both the front and back sides were irradiated with ultraviolet light from 00 people for 30 seconds on each side.
このようにして得られたアビジン固定化精密ろ過膜（直
径４ｃｍ）を、クリーンベンチ内に８隠したビニル管の
途中にセルを介して固定し、ビニル管の一端側を大気中
に開放とし、他端側をクリーンベンチ外に設置したポン
プに連結して吸引した。The avidin-immobilized microfiltration membrane (diameter 4 cm) thus obtained was fixed via a cell in the middle of a vinyl tube hidden in a clean bench, and one end of the vinyl tube was opened to the atmosphere. The other end was connected to a pump installed outside the clean bench for suction.
吸引を１時間続けた後、アビジン固定化精密ろ過膜をは
ずし、それをシャーレに入れ、その上側からブイヨン培
地（リービーヒ肉エキス７．５ｇ、ペプトン１０ｇ、
ＮａＣｎ ５ｇおよび寒天１５ｇを溶解； ＰＨ７，０
）を重層し、３７℃で４８時間培養したが、微生物のコ
ロニーは見られなかった。なお、使用した試薬、器具な
どは、ポンプ以外す入で滅菌処理済みのものを使用した
。After continuing the suction for 1 hour, remove the avidin-immobilized microfiltration membrane, place it in a petri dish, and add bouillon medium (7.5 g of Liebich meat extract, 10 g of peptone,
Dissolve 5g of NaCn and 15g of agar; PH7.0
) and cultured at 37°C for 48 hours, but no microbial colonies were observed. The reagents and instruments used, except for the pump, were sterilized.
比較例
上記実施例１において、アビジンを用いずに、単なる光
架橋膜を精密ろ過膜表面に形成させたものについて培養
を行ったところ、無数のコロニーが観察された。Comparative Example In Example 1, a simple photocrosslinked membrane was formed on the surface of a microfiltration membrane without using avidin, and when cultured, numerous colonies were observed.
実施例２
実施例１のアビジン固定化精密ろ過膜を、クリーンベン
チ内で、水道水をＩＱろ過した後、実施例１と同様の方
法で培養したが、微生物のコロニーはみられなかった。Example 2 The avidin-immobilized microfiltration membrane of Example 1 was used to IQ-filtrate tap water in a clean bench and then cultured in the same manner as in Example 1, but no microbial colonies were observed.
実施例３
実施例１のアビジン固定化精密ろ過膜を、クリーンベン
チ内で、１日１回水道水を１ρろ過する操作を５日間く
り返した後、実施例１と同様の方法で培養したが、微生
物のコロニーはみられなかった。Example 3 The avidin-immobilized microfiltration membrane of Example 1 was cultured in the same manner as Example 1 after repeating the operation of filtering tap water by 1ρ once a day in a clean bench for 5 days. No microbial colonies were observed.
実施例４
キトサン製精密ろ過膜（孔径０．１μＬ厚さ０．２ｍｍ
）を、０．５％アビジン水溶液中に、４℃で１時間浸漬
した後、引き上げて２５℃で１時間風乾した。次に、こ
れを２％グルタルアルデヒド水溶液中に１０分間浸漬し
、水洗した。Example 4 Chitosan precision filtration membrane (pore size 0.1μL thickness 0.2mm
) was immersed in a 0.5% avidin aqueous solution at 4°C for 1 hour, then taken out and air-dried at 25°C for 1 hour. Next, this was immersed in a 2% glutaraldehyde aqueous solution for 10 minutes and washed with water.
このようにしてアビジンを固定化させた精密ろ過膜につ
いて、実施例］と同様の大気透過および実施例２と同様
の水道水ろ過をそれぞれ実施し、培養評価したが、いず
れも微生物のコロニーはみられなかった。The microfiltration membrane on which avidin was immobilized in this way was subjected to atmospheric permeation as in Example] and tap water filtration as in Example 2, and culture evaluation was performed, but no microbial colonies were found in either case. I couldn't.
Claims (1)
。1.An antimicrobial membrane formed by immobilizing avidin on the filtration membrane surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2293976A JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2293976A JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04166221A true JPH04166221A (en) | 1992-06-12 |
| JP2990786B2 JP2990786B2 (en) | 1999-12-13 |
Family
ID=17801633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2293976A Expired - Fee Related JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2990786B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028882A1 (en) * | 1996-02-07 | 1997-08-14 | Kimberly-Clark Worldwide, Inc. | Charge-modified nonwoven filter |
| JP2013534464A (en) * | 2010-06-01 | 2013-09-05 | スリーエム イノベイティブ プロパティズ カンパニー | Coated porous material |
| CN108310983A (en) * | 2018-02-02 | 2018-07-24 | 山西大学 | A kind of preparation of antibacterial pollution-resistant PVDF ultrafiltration membrane and regeneration method |
| CN114377554A (en) * | 2022-01-11 | 2022-04-22 | 浙江工业大学 | Preparation method of antibacterial polytetrafluoroethylene air filtering membrane |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101869350B1 (en) * | 2015-06-26 | 2018-07-23 | 고려대학교 산학협력단 | 3D-mesh structure and impeller having 3D-mesh structure |
-
1990
- 1990-10-31 JP JP2293976A patent/JP2990786B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028882A1 (en) * | 1996-02-07 | 1997-08-14 | Kimberly-Clark Worldwide, Inc. | Charge-modified nonwoven filter |
| JP2013534464A (en) * | 2010-06-01 | 2013-09-05 | スリーエム イノベイティブ プロパティズ カンパニー | Coated porous material |
| CN108310983A (en) * | 2018-02-02 | 2018-07-24 | 山西大学 | A kind of preparation of antibacterial pollution-resistant PVDF ultrafiltration membrane and regeneration method |
| CN114377554A (en) * | 2022-01-11 | 2022-04-22 | 浙江工业大学 | Preparation method of antibacterial polytetrafluoroethylene air filtering membrane |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2990786B2 (en) | 1999-12-13 |
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