JP2990786B2 - Antimicrobial membrane - Google Patents
Antimicrobial membraneInfo
- Publication number
- JP2990786B2 JP2990786B2 JP2293976A JP29397690A JP2990786B2 JP 2990786 B2 JP2990786 B2 JP 2990786B2 JP 2293976 A JP2293976 A JP 2293976A JP 29397690 A JP29397690 A JP 29397690A JP 2990786 B2 JP2990786 B2 JP 2990786B2
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- avidin
- microorganisms
- immobilized
- filtration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012528 membrane Substances 0.000 title claims description 39
- 230000000845 anti-microbial effect Effects 0.000 title claims description 7
- 238000001914 filtration Methods 0.000 claims description 17
- 108090001008 Avidin Proteins 0.000 claims description 14
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 244000005700 microbiome Species 0.000 description 11
- 238000001471 micro-filtration Methods 0.000 description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- YVXDRFYHWWPSOA-BQYQJAHWSA-N 1-methyl-4-[(e)-2-phenylethenyl]pyridin-1-ium Chemical group C1=C[N+](C)=CC=C1\C=C\C1=CC=CC=C1 YVXDRFYHWWPSOA-BQYQJAHWSA-N 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3823—Affinity chromatography of other types, e.g. avidin, streptavidin, biotin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/48—Antimicrobial properties
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、抗微生物膜に関する。更に詳しくは、ろ過
膜に抗微生物特性を付与した抗微生物膜に関する。The present invention relates to an antimicrobial membrane. More specifically, the present invention relates to an antimicrobial membrane having antimicrobial properties imparted to a filtration membrane.
〔従来の技術〕および〔発明が解決しようとする課題〕 酢酸セルロース多孔質膜によって代表される、孔径約
0.2μm以下の精密ろ過膜を用い、大気中および溶液中
の微生物をろ過し、浄化する方法が従来から採用されて
いる。しかしながら、この方法では、100%微生物を阻
止することは技術的にも困難であった。それは、阻止さ
れた微生物が膜表面で増殖し、遂には膜の片側に抜けて
しまうことが一因とされている。そこで、ろ過膜表面で
の微生物の増殖を抑制することが強く要望されている。[Prior Art] and [Problems to be Solved by the Invention] Pore size represented by a cellulose acetate porous membrane
A method of filtering and purifying microorganisms in the atmosphere and in a solution using a microfiltration membrane of 0.2 μm or less has been conventionally employed. However, in this method, it was technically difficult to control 100% of microorganisms. It is attributed in part to the arrested microorganisms growing on the membrane surface and eventually escaping to one side of the membrane. Therefore, there is a strong demand for suppressing the growth of microorganisms on the surface of the filtration membrane.
その対策としては、ろ過膜表面に抗生物質を固定化す
る方法もあるが、抗生物質は分子量が小さいため、膜か
ら抜け落ちてしまう欠点がみられる。As a countermeasure, there is a method of immobilizing an antibiotic on the surface of a filtration membrane. However, since the antibiotic has a small molecular weight, there is a drawback that the antibiotic falls off the membrane.
本発明の目的は、ろ過膜面上における微生物の増殖を
阻止せしめる抗微生物膜を提供することにある。An object of the present invention is to provide an antimicrobial membrane that inhibits the growth of microorganisms on the surface of a filtration membrane.
〔課題を解決するための手段〕および〔作用〕 かかる本発明の目的は、ろ過膜面上にアビジンを固定
化せしめた抗微生物膜によって達成される。[Means for Solving the Problems] and [Action] The object of the present invention is achieved by an antimicrobial membrane having avidin immobilized on a filtration membrane surface.
アビジンは、鶏卵の卵白中に含まれ、ビオチンと特異
的に結合する分子量約6600の糖たん白質である。そし
て、微生物の増殖に必要なビオチン(ビタミンH、補酵
素)の2モルと選択的に結合し、これを不活性化するこ
とにより、微生物の増殖を阻害する作用を有している。
即ち、アビジン−ビオチン複合体はきわめて安定(解離
定数は10-15M)で、ビオチンはビタミンとしての活性な
らびにビオチン酵素の補酵素としての活性を失うように
なる。Avidin is a glycoprotein with a molecular weight of about 6600 that is specifically contained in egg white of chicken eggs and specifically binds to biotin. Then, it selectively binds to 2 moles of biotin (vitamin H, coenzyme) necessary for the growth of microorganisms and inactivates them, thereby inhibiting the growth of microorganisms.
That is, the avidin-biotin complex is extremely stable (dissociation constant is 10 −15 M), and biotin loses its activity as a vitamin and as a coenzyme of a biotin enzyme.
本発明においては、かかる作用を有するアビジンをろ
過膜の表面および内部に固定化せしめることにより、膜
面上における微生物の増殖を阻止せんとするものであ
る。In the present invention, the growth of microorganisms on the membrane surface is prevented by immobilizing avidin having such an action on the surface and inside of the filtration membrane.
ろ過膜としては、酢酸セルロース、ポリスルホン、ポ
リウレタン、ポリテトラフルオロエチレン、ポリカーボ
ネート、キトサンなどから成形された精密ろ過膜、限外
ろ過膜、更には孔径がÅオーダーの気体分離膜などが用
いられる。As the filtration membrane, a microfiltration membrane formed from cellulose acetate, polysulfone, polyurethane, polytetrafluoroethylene, polycarbonate, chitosan, or the like, an ultrafiltration membrane, and a gas separation membrane having a pore size on the order of Å are used.
ろ過膜面上へのアビジンの固定化は、一般には水溶性
光架橋性樹脂の水溶液中にアビジンを混合し、それをろ
過膜面上に塗布し、乾燥させた後、紫外線照射して光架
橋膜を形成させることにより行われる。Avidin is generally immobilized on the filtration membrane surface by mixing avidin in an aqueous solution of a water-soluble photocrosslinkable resin, applying the mixture on the filtration membrane surface, drying, and then irradiating with ultraviolet light to perform photocrosslinking. This is performed by forming a film.
水溶性光架橋性樹脂としては、例えば分子中に光架橋
性基としてスチルバゾリウム基、ジアゾ基などの感光性
基、好ましくはスチルバゾリウム基を有するポリビニル
アルコール、ポリエチレングリコールなどが用いられ
る。As the water-soluble photocrosslinkable resin, for example, polyvinyl alcohol, polyethylene glycol, or the like having a photosensitive group such as a stilbazolium group or a diazo group as a photocrosslinkable group in the molecule, preferably a stilbazolium group is used.
アビジンは、このような水溶性光架橋性樹脂の約0.1
〜5重量%水溶液中に約0.05〜15重量%の濃度で混入
し、この溶液がろ過膜に塗布される。塗布方法には特に
制限がないが、一般的には浸漬法が用いられる。その
後、室温下で約1〜3時間程乾燥し、次いで波長3000〜
4500Åの紫外線を約5〜60秒間照射し、形成された光架
橋膜中にアビジンを固定化させる。Avidin is about 0.1% of such a water-soluble photocrosslinkable resin.
It is mixed in a 55% by weight aqueous solution at a concentration of about 0.05-15% by weight, and this solution is applied to a filtration membrane. Although there is no particular limitation on the application method, an immersion method is generally used. After that, it is dried at room temperature for about 1 to 3 hours,
Irradiation with ultraviolet rays at 4500 ° for about 5 to 60 seconds immobilizes avidin in the formed photocrosslinked film.
こうした包括法による固定化法以外にも、例えばアミ
ノ基を有するキトサンろ過膜などの場合には、グルタル
アルデヒドなどを用いる共有結合法によってもアビジン
を固定化することができる。In addition to the immobilization method by such an entrapment method, for example, in the case of a chitosan filtration membrane having an amino group, avidin can be immobilized by a covalent bonding method using glutaraldehyde or the like.
このようにしてろ過膜面上に固定化されたアビジン
は、微生物に対して膜の表面および内部でのそれの増殖
を有効に阻止する働きを有している。Avidin immobilized on the filtration membrane surface in this manner has a function of effectively preventing microorganisms from growing on and around the membrane.
次に、実施例について本発明を説明する。 Next, the present invention will be described with reference to examples.
実施例1 酢酸セルロース製精密ろ過膜(孔径0.2μm、厚さ0.2
mm)を、水溶性光架橋性ポリビニルアルコール(光架橋
性スチルバゾリウム基含有量1.4モル%、けん化度88
%、重合度1400)の1重量%水溶液中にアビジン(シグ
マ社製品)を0.5重量%混入した溶液中に1分間浸漬
し、室温下で2時間乾燥させた後、波長4000Åの紫外線
を各面30秒間ずつ表裏両面に照射した。Example 1 Cellulose acetate microfiltration membrane (pore size 0.2 μm, thickness 0.2
mm) with a water-soluble photocrosslinkable polyvinyl alcohol (photocrosslinkable stilbazolium group content 1.4 mol%, saponification degree 88
%, Polymerization degree 1400) in a 1% by weight aqueous solution containing 0.5% by weight of avidin (Sigma) and dried for 2 hours at room temperature. Irradiation was performed on both front and back sides for 30 seconds.
このようにして得られたアビジン固定化精密ろ過膜
(直径4cm)を、クリーンベンチ内に設置したビニル管
の途中にセルを介して固定し、ビニル管の一端側を大気
中に開放とし、他端側をクリーンベンチ外に設置したポ
ンプに連結して吸引した。The avidin-immobilized microfiltration membrane (4 cm in diameter) obtained in this way was fixed via a cell in the middle of a vinyl tube installed in a clean bench, and one end of the vinyl tube was opened to the atmosphere. The end was connected to a pump installed outside the clean bench and suctioned.
吸引を1時間続けた後、アビジン固定化精密ろ過膜を
はずし、それをシャーレに入れ、その上側からブイヨン
培地(リービーヒ肉エキス7.5g、ペプトン10g、NaCl5g
および寒天15gを溶解;pH7.0)を重層し、37℃で48時間
培養したが、微生物のコロニーは見られなかった。な
お、使用した試薬、器具などは、ポンプ以外すべて滅菌
処理済みのものを使用した。After the suction was continued for 1 hour, the avidin-immobilized microfiltration membrane was removed, and the membrane was placed in a petri dish, and a bouillon medium (7.5 g of Liebi meat extract, 10 g of peptone, 5 g of NaCl) was placed from above.
And 15 g of agar were dissolved; pH 7.0) was overlaid and cultured at 37 ° C. for 48 hours, but no colonies of microorganisms were found. The reagents and instruments used were all sterilized except for the pump.
比較例 上記実施例1において、アビジンを用いずに、単なる
光架橋膜を精密ろ過膜表面に形成させたものについて培
養を行ったところ、無数のコロニーが観察された。Comparative Example In Example 1, when a simple photocrosslinking membrane was formed on the surface of the microfiltration membrane without using avidin, the culture was performed. As a result, countless colonies were observed.
実施例2 実施例1のアビジン固定化精密ろ過膜を、クリーンベ
ンチ内で、水道水を1ろ過した後、実施例1と同様の
方法で培養したが、微生物のコロニーはみられなかっ
た。Example 2 The avidin-immobilized microfiltration membrane of Example 1 was subjected to one filtration of tap water in a clean bench, and then cultured in the same manner as in Example 1, but no colonies of microorganisms were observed.
実施例3 実施例1のアビジン固定化精密ろ過膜を、クリーンベ
ンチ内で、1日1回水道水を1ろ過する操作を5日間
くり返した後、実施例1と同様の方法で培養したが、微
生物のコロニーはみられなかった。Example 3 The avidin-immobilized microfiltration membrane of Example 1 was cultured in the same manner as in Example 1 after repeating the operation of once filtering tap water once a day for 5 days in a clean bench. No microbial colonies were found.
実施例4 キトサン製精密ろ過膜(孔径0.1μm、厚さ0.2mm)
を、0.5%アビジン水溶液中に、4℃で1時間浸漬した
後、引き上げて25℃で1時間風乾した。次に、これを2
%グルタルアルデヒド水溶液中に10分間浸漬し、水洗し
た。Example 4 Chitosan microfiltration membrane (pore diameter 0.1 μm, thickness 0.2 mm)
Was immersed in a 0.5% avidin aqueous solution at 4 ° C. for 1 hour, pulled up, and air-dried at 25 ° C. for 1 hour. Next, this is 2
% Glutaraldehyde aqueous solution for 10 minutes and washed with water.
このようにしてアビジンを固定化させた精密ろ過膜に
ついて、実施例1と同様の大気透過および実施例2と同
様の水道水ろ過をそれぞれ実施し、培養評価したが、い
ずれも微生物のコロニーはみられなかった。The microfiltration membrane on which avidin was immobilized in this manner was subjected to the same atmospheric permeation as in Example 1 and the same tap water filtration as in Example 2, and the culture was evaluated. I couldn't.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6,DB名) B01D 61/00 - 71/82 WPI(DIALOG)──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. 6 , DB name) B01D 61/00-71/82 WPI (DIALOG)
Claims (1)
微生物膜。1. An antimicrobial membrane comprising avidin immobilized on a filtration membrane surface.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2293976A JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2293976A JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04166221A JPH04166221A (en) | 1992-06-12 |
JP2990786B2 true JP2990786B2 (en) | 1999-12-13 |
Family
ID=17801633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2293976A Expired - Fee Related JP2990786B2 (en) | 1990-10-31 | 1990-10-31 | Antimicrobial membrane |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2990786B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170001580A (en) * | 2015-06-26 | 2017-01-04 | 고려대학교 산학협력단 | 3D-mesh structure and impeller having 3D-mesh structure |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5855788A (en) * | 1996-02-07 | 1999-01-05 | Kimberly-Clark Worldwide, Inc. | Chemically charged-modified filter for removing particles from a liquid and method thereof |
KR20130080451A (en) * | 2010-06-01 | 2013-07-12 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Coated porous materials |
CN108310983B (en) * | 2018-02-02 | 2021-02-02 | 山西大学 | Preparation and regeneration method of antibacterial and anti-pollution PVDF ultrafiltration membrane |
CN114377554B (en) * | 2022-01-11 | 2023-04-28 | 浙江工业大学 | Preparation method of antibacterial polytetrafluoroethylene air filtering membrane |
-
1990
- 1990-10-31 JP JP2293976A patent/JP2990786B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170001580A (en) * | 2015-06-26 | 2017-01-04 | 고려대학교 산학협력단 | 3D-mesh structure and impeller having 3D-mesh structure |
KR101869350B1 (en) * | 2015-06-26 | 2018-07-23 | 고려대학교 산학협력단 | 3D-mesh structure and impeller having 3D-mesh structure |
Also Published As
Publication number | Publication date |
---|---|
JPH04166221A (en) | 1992-06-12 |
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