JPH0377479B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a radioisotope automatic dispensing device,
In particular, the present invention relates to an automatic radioisotope dispensing device that automatically injects a predetermined amount of radioisotope, such as technetium-99m (Tc-99m), into a labeled vial filled with an injection drug under clean conditions.

When a certain labeled drug is injected into the human body, the labeled drug selectively collects in each tissue or organ due to its characteristics. Therefore, when a radioisotope, such as technetium-99m, is mixed and injected into the human body, the radioisotope also concentrates in the organs, and by observing it with a device that detects this, the state of each tissue or organ can be determined. be able to.

Conventionally, when mixing a radioisotope into a labeled vial containing a drug, in order to prevent chemical changes, for example, nitrogen gas is first extracted with a syringe or the like from a labeled vial containing a drug sealed with nitrogen gas. Thereafter, using a syringe, a predetermined amount of radioisotope was manually injected into the drug-containing labeled vial each time various labeled drug solutions were prepared from a radioisotope vial with high radioactivity intensity.

Such manual handling of radioisotopes always poses the risk of harming the human body, especially hands and fingers, due to exposure due to work errors or cumulative exposure due to long-term handling. The dispensing of radioisotopes into labeled vials containing drugs must be done under clean conditions and with great care to avoid exposure to radioactivity, which has the disadvantage of being time consuming and extremely poor in work efficiency.

The present invention can automatically inject a predetermined amount of radioisotopes, which are dangerous to handle, into labeled vials containing drugs, while maintaining cleanliness while minimizing the danger to the human body and improving work efficiency. The purpose is to provide an automatic radioisotope dispensing device. Therefore, the radioisotope automatic dispensing device of the present invention includes a box made of a radiation shielding member, and a radioisotope vial filled with radioisotope (a radioisotope vial (except for the cap part) that is provided in the upper part of the box and is made of a radiation shielding member. A syringe needle having a needle tip placed near the spout for extracting a radioisotope from the spout of the body (encased in a material) held upside down with the spout facing downward; and a hypodermic needle for introducing air. , a needle tip is arranged near the spout of a labeled vial placed upright in the lower part of the box body, an injection needle for injecting the radioisotope from the needle tip into the labeled vial, and an injection needle for taking out the radioisotope. A tube that connects a syringe needle for injecting a radioisotope, a flow controller that is located between the tube and adjusts the flow rate of the radioisotope from a radioisotope vial flowing into the tube, and a radio. The radioisotope vial is equipped with an aspirator that creates a negative pressure in the labeled vial into which the isotope is injected through a depressurizing injection needle whose needle tip is placed near the labeled vial stopper, and the radioisotope vial is controlled by a flow rate controller. A predetermined amount of radioisotope is dispensed into a labeled vial.
It is also characterized by a structure that allows the injection needle, tube, etc. to be replaced at any time. Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 is a front view of the automatic radioisotope dispensing device according to the present invention, FIG. 2 is an internal structural diagram of the automatic radioisotope dispensing device according to the present invention, and FIG. 3 is a structural perspective view of the flow rate controller. Figure 4 is a longitudinal sectional view of the structure around the labeled vial, Figure 5 is a longitudinal sectional view of the area around the techne vial, Figure 6 is the flow path system diagram of Figure 2, and Figure 7 is the automatic radioisotope separation according to the present invention. 3A and 3B respectively show flow path system diagrams showing other embodiments of the injection device.

In FIGS. 1 and 2, reference numeral 1 is a box made of lead to shield radioactivity.
A door 3 is attached to the door 3, which can be opened and closed with a hinge 2. An operation panel 4 is provided next to the door 3, and by operating the switches on the operation panel 4, a radioisotope stored in a lead container 5, such as a solution of technetium 99m (hereinafter referred to as technetium solution), is released. ) or a saline vial 6 containing a physiological saline solution, the techne solution or physiological saline solution is injected into a labeled vial containing a drug stored in a labeled vial attachment device 7. The door 3 is designed so that a labeled vial containing a drug can be exchanged into the labeled vial attachment device 7 with the door 3 closed, and a techne vial and a saline vial 6 stored in the lead container 5 can be exchanged. Notches 8 and 9 are provided.

Long and short injection needles 10 and 11 are placed in the upper part of the inside of the box 1.
Holders 12 and 13 are provided in parallel. These holders 12 and 13 are provided with slider grooves, and are fitted into the support plate 15.
Therefore, the holders 12 and 13 equipped with the long and short injection needles 10 and 11 can be taken out by pulling them out from the paper surface of FIG. 2 toward the front. holder 12,
A longer injection needle 10 provided at 13 is used for introducing air, and elastic tubes 16 and 17 made of, for example, silicone rubber are connected to the injection needle 10.
Microfilters 18 for air cleaning are attached to the ends of the filters, respectively, and are installed in the box body 1 in a removable manner. Shorter injection needle 11 provided in holders 12 and 13
Elastic tubes 19 and 20 are also attached, and the other ends thereof are connected to a coupler 21. An elastic tube 23 connected to an air cleaning microfilter 22 is also bonded to the bonder 21.
Further, the connector 21 is removably attached by sliding it from the connector 21 to the labeled vial attacher 7 provided at the lower part of the box 1 through the elastic tube 24 from the paper surface of FIG. It is connected to the longer injection needle 26 of the holder 25. The holder 25 is also provided with a short injection needle 27, and an elastic tube 28 is attached to this shorter injection needle 27, and a microfilter 29 is attached to the end thereof. The microfilter 29
The tip is connected via a trap 30 to a suction machine, ie, a vacuum pump, installed behind a partition plate 31. The trap 30 is provided to prevent the injection liquid from being drawn directly into the vacuum pump when the injection liquid is drawn from the shorter injection needle 27, and serves as a buffer.

Flow rate controllers 32, 33, and 34 are provided between the elastic tubes 19, 20, and 23 to adjust the flow rate. Next, this flow rate controller 32 will be explained using FIG. 3.

A fixing plate 321 is fixed to the partition plate 31. Behind the partition plate 31 is a drive device, such as a rotary solenoid 323, which applies rotational force to the swing shaft 322 in the direction of the arrow shown in the figure, that is, in the counterclockwise direction.
is provided. An L-shaped swing plate 324 is fixed to the swing shaft 322, and a holding member 32 for closing the elastic tube 19 is attached to one end of the L-shaped swing plate 324.
A spring 327 is secured between the other end of the L-shaped swing plate 324 and a support rod 326 protruding from the partition plate 31. Normally, the elastic tube 19 interposed between the fixing member 321 and the pressing member 325 is closed by the elastic force of the spring 327. When the rotary solenoid 323 is energized, the swing shaft 323 is
rotates counterclockwise, the L-shaped rocking plate 324 performs rocking motion, and the holding member 325 presses the elastic tube 1
9 is opened. In this way, the presser member 32
5, the elastic tube 19 is pressed or relaxed to open and close the flow path of the elastic tube 19.
The configuration of the flow rate controller 32 described above is similar to that of other flow rate controllers 3.
The same applies to 3 and 34.

Next, the structure of the labeled vial attacher 7 will be briefly described. The labeled vial attacher 7 is configured to be able to be pulled out to the front of the box body 1. Further, the upper part of the bottomless guide tube 39 is pivotally supported by the labeled vial attachment device 7 so as to be swingable. Accordingly, a labeled vial containing a drug stored in a lead container is inserted from the bottom of the guide tube 39. Note that the holder 25 equipped with the long and short injection needles 26 and 27 described above is removably provided at the upper end of the guide tube 39.

FIG. 4 shows a longitudinal cross-sectional view of the structure around the labeled vial, and a labeled vial 41 containing a drug stored in a lead container 40 is inserted from the bottom of the guide tube 39. In order to prevent chemical change of the drug 42 and the drug 42, the marker vial 41 is sealed with, for example, nitrogen gas with a stopper 43 to form a space layer 44. The labeled vial 41 containing the drug is moved to the guide tube 39 of the labeled vial attachment device 7.
When setting the injection needle, the long and short injection needles 26 and 27 provided on the holder 25 penetrate the spout 43, and both the long and short injection needles 26 and 27 remain in the space layer 44, and the mixed liquid with the injected Techne solution, That is, it is set at a position where the needle tip does not touch the labeled chemical solution.

On the other hand, a long and short injection needle 1 provided in the upper part of the box body 1
In the holder 12 equipped with 0 and 11, a techne vial 45 containing a radioisotope stock solution delivered in the lead container 5, that is, a radioisotope with high radioactivity intensity, is set, and in the holder 13, a saline vial 6 is set, respectively. is set.

FIG. 5 shows a longitudinal cross-sectional view of the structure around the Techne Vial. The Techne Vial 45 is housed in a lead container 5 as shown in the figure, and in an upside down state, a long and short injection can be inserted into the spout 46 of the Techne Vial 45. needle 1
0,11 are shot.

Next, the operation of the automatic radioisotope dispensing apparatus of the present invention will be explained using the flow path diagram shown in FIG.
Note that in FIG. 6, the holders 12, 13, and 25 are omitted for clarity.

Prior to starting the operation, the techne vial 45 and saline vial 6 housed in the lead container 5 are set in predetermined positions. A labeled vial 41 containing a drug is also set in the guide tube 39 of the labeled vial attachment device 7 via the lead container 40. At this point, the flow controllers 32, 33, 34 are connected to each elastic tube 1.
9, 20, and 23 are closed, and the flow of the techne solution and physiological saline solution is blocked. Further, the volume of the techne vial 45 is preset by a switch of the preset counter 53.

When the main power switch 49 is turned on, all the logic of the electrical circuits (not shown) are reset. At this time, by setting the manual switch 50 to the "normal" position, the numbers preset in the preset counter 53,
In other words, the volume of the techne vial 45 is displayed on the display 54.
will be displayed. When dispensing the Techne solution into the drug-containing labeled vial 41, the selection switch 55 is turned on. As a result, the vacuum pump 47 is activated, and the inside of the marker vial 4 containing the drug is brought to negative pressure via the trap 30. When a certain period of time has elapsed after the selection switch 55 is turned on, the flow rate controller 32 operates for a time corresponding to the flow rate set by the flow rate setting switch 68. In other words, the swing shaft 322 of the flow rate controller 32
rotates counterclockwise, and the L-shaped swing plate 324 swings in the same direction against the elastic force of the spring 327.
Accordingly, the pressing force of the presser member 325 against the elastic tube 19 is removed, the elastic tube 19 opens its flow path, and the Techne solution flows from the Techne vial 45 to the injection needle 11, the elastic tube 19, the coupler 21,
It flows through the elastic tube 24 and the injection needle 26 into the labeled vial 41 containing the drug. The amount of Techne solution flowing into the drug-containing labeled vial 41 is determined by the flow rate setting switch 68 provided on the operation panel 4.
(These values are not shown on the operation panel 4 to complicate the illustration). That is, the set value selected by the flow rate setting switch 68 corresponds to the control time of the flow rate controller 32, and when the control time elapses, the swing shaft 32
The power supply to the rotary solenoid 323 connected to the rotary solenoid 323 is cut off. This causes the spring 327 to act, causing the L-shaped swing plate 324 to swing clockwise. Accordingly, the holding member 325 closes the elastic tube 19 again and blocks the flow path. Subsequently, the flow rate controller 33 is activated for a very short time to allow air to wash through the elastic tube 24. Then further flow controller 3
4 is activated, and a small amount (for example, about 0.2 ml) of physiological saline solution is poured from the saline vial 6 to clean the inside of the elastic tube 24. Then, the flow rate controller 33 is activated again to wash the inside of the elastic tube 24. Eventually, the vacuum pump 47 stops, and the dispensing of the techne solution into the drug-containing labeled vial 41 is completed. In this way, a predetermined amount of Techne solution set by the flow rate setting switch 68 is mixed into the labeled vial 41 containing the drug. The amount of techne solution remaining in the techne vial 45 is then displayed on the display 54.

The series of movements of the flow rate controllers 32, 33, 34 and the vacuum pump 47 described above are controlled by an electric path (not shown).

On the other hand, when diluting the concentration of the techne solution, the amount to be diluted is set in advance with the flow rate setting switch 69, and then the selection switch 52 is turned on. The vacuum pump 47 operates to create a negative pressure in the labeled vial 41 containing the labeled drug solution (the radioisotope is injected into the labeled vial 41 containing the drug), and after a predetermined period of time, the flow rate controller 34 is operated.
A predetermined amount of physiological saline solution set by the flow rate setting switch 69 is caused to flow from the saline vial 6 via the flow rate controller 34 into the labeled vial 41 containing the labeled drug solution. That is, using the same principle as the flow rate controller 32 described above, the physiological saline solution is passed from the saline vial 6 through the injection needle 11, the elastic tube 20, the coupler 21, the elastic tube 24, and the injection needle 26 into the marker vial 41 containing the marker liquid. Injected. In this way, the physiological saline solution is injected into the labeled vial 41 containing the labeled drug solution, thereby diluting it.

After the flow controller 34 is activated, the flow controller 33 is activated for a very short time, and the elastic tube 24
Air cleans the inside. After that, the vacuum pump 47 stops.

In embodiments of the invention, the elastic tube, particularly the elastic tube 24 below the coupler 21 and the injection needle 26, can be cleaned. That is, the elastic tube 19, which is the flow path for the techne solution, is shut off, and the switches 70 and 71 are turned on to operate the flow rate controllers 33 and 34. As a result, the elastic tubes 20 and 23 allow the physiological saline solution and air to flow through them. The air becomes bubbles and mixes with the saline solution, and these are drained from the injection needle 26 while cleaning the inside of the elastic tube 24.

Although the rotary solenoid 323 is used as the drive device in the above embodiment, it goes without saying that the control can be performed using a motor.

FIG. 7 shows a flow path system diagram of another embodiment of the radioisotope automatic dispensing device according to the present invention. The operation of this embodiment is exactly the same as the embodiment described above except that the flow rate controller is different. Therefore, the same reference numerals in FIGS. 6 and 7 correspond to those in FIG.

Reference numerals 56, 57, and 58 are flow rate controllers. The flow rate controllers 56, 57, 58 are elastic tubes 19,
23, 20, and the stopcock 59,
By rotating the rotation levers 62, 63, 64 of 60, 61, each elastic tube 19, 23,
20 channels are opened and closed. For example, to explain the flow rate controller 56 in more detail, a driving motor 65 is fixedly installed behind a partition plate (not shown). A working rod 66 is attached to the motor 65, and an elongated hole 67 is provided at the tip of the working rod 66. Rotating lever 6 of stopcock 59
A pin 68 implanted in the stopper 2 is inserted into the elongated hole 67 of the working rod 66, and as the working rod 66 swings, the rotary lever 62 is rotated to open and close the stopcock 59. The opening time of this stopcock 59 corresponds to the amount set by the flow rate setting switch 68, as in the embodiment shown in FIG.

The other flow rate controllers 57 and 58 are also connected to the flow rate controller 5.
6 and its structure and operation are the same, and the automatic radioisotope dispensing device shown in FIG. 7 performs exactly the same operation as the automatic radioisotope dispensing device shown in FIG. Techne solution is injected or diluted with saline solution.

Holders 12 and 13 to which long and short injection needles 10 and 11 are attached, coupler 21, and long and short injection needle 2
As mentioned above, the holder 25 to which the holders 6 and 27 are attached and each elastic tube connected thereto are structured so that they can be removed from the box body 1 and replaced at any time, and can be sterilized if necessary. These sets can then be replaced with sterile packs.

Note that the meter 72 on the operation panel 4 measures the radioactivity intensity, and its sensor (not shown)
is installed, for example, at a certain distance from the bottom of the marker vial 41, and constantly monitors the radioactivity intensity to ensure its safety.

In addition, when this device is not in use, a dummy alcohol-containing vial or the like is stored in the guide tube 39 of the marked vial holder 7 to prevent contamination of the long and short injection needles 26 and 27 to prevent contamination of the long and short injection needles 26 and 27. Protect and maintain cleanliness.

As explained above, according to the present invention, the radioisotope can be injected into the labeled vial by external operation, so there is no risk of radiation exposure to the human body, such as hands and fingers. In addition, radioisotopes can be automatically injected into labeled vials in preset amounts, and can be dispensed by simply exchanging labeled vials one after another and pressing a switch on the operation panel, increasing the efficiency of dispensing work. improves. This device has a structure in which all of the parts into which the radioisotope and physiological saline solution flow, such as the injection needle and elastic tube, can be removed from the box, so these injection needles and elastic tubes should be sterilized in the sterilization pack. cleanliness can be maintained.

[Brief explanation of drawings]

FIG. 1 is a front view of the automatic radioisotope dispensing device according to the present invention, FIG. 2 is an internal structural diagram of the automatic radioisotope dispensing device according to the present invention, and FIG. 3 is a structural perspective view of the flow rate controller. Figure 4 is a longitudinal sectional view of the structure around the labeled vial, Figure 5 is a longitudinal sectional view of the area around the techne vial, Figure 6 is the flow path system diagram of Figure 2, and Figure 7 is the automatic radioisotope separation according to the present invention. FIG. 7 shows a flow path system diagram showing another embodiment of the injection device. In the figure, 1 is a box, 10, 11, 26, 27 are injection needles, 16, 17, 19, 20, 23, 24, 2
8 is an elastic tube, 21 is a splicer, 32, 33,
34, 56, 57, 58 are flow rate controllers, 59, 6
0 and 61 are stopcocks, 65 is a motor, 321 is a fixed member, 322 is a swing shaft, 323 is a rotary solenoid, 324 is an L-shaped swing plate, 325 is a holding member,
326 represents a support rod, and 327 represents a spring.

Claims (1)

[Scope of Claims] 1. A box made of a radiation shielding member, and a radioisotope vial filled with a radioisotope, which is provided in the upper part of the box and is held upside down with the cap facing down. A syringe needle with a needle tip placed near the stopper to take out the radioisotope from the body, an syringe needle for introducing air, and a needle tip near the stopper of a labeled vial placed upright at the bottom of the box. is arranged, an injection needle for injecting the radioisotope from the needle tip into the labeled vial, a tube connecting between the injection needle for taking out the radioisotope and the injection needle for injecting the radioisotope, and an injection needle for injecting the radioisotope, and an injection needle for injecting the radioisotope from the needle tip into the labeled vial. A flow controller that adjusts the flow rate by intermittent flow of the radioisotope from the radioisotope vial flowing into the tube, and a needle tip placed in the labeled vial into which the radioisotope is injected near the labeled vial stopper. and an aspirator to create a negative pressure through a syringe needle for depressurization, and a predetermined amount of radioisotope is dispensed from the radioisotope vial into a labeled vial under the control of a flow rate controller. Radioisotope automatic dispensing device. 2 The flow rate controller includes a fixing member and a presser member, and the tube connecting the injection needles is interposed between the fixing member and the presser member, and the tube is pressed or relaxed by the presser member. 2. The automatic radioisotope dispensing device according to claim 1, further comprising a drive device for controlling the flow of the radioisotope by opening and closing the channel of the tube. 3. A patent claim in which the flow rate controller is provided with a stopcock in the middle of the tube connecting the injection needles, and is equipped with a drive device that opens and closes the stopcock, and controls the flow of the radioisotope by opening and closing the flow path of the tube. The radioisotope automatic dispensing device according to item 1. 4. According to any one of claims 1 to 3, the inflow path combining the injection needles and the tube connecting the injection needles has a structure that is detachable from the box body. Radioisotope automatic dispensing device.