JPH0363071A - Drug administration appliance assisted by ultrasonic wave - Google Patents

Abstract

PURPOSE:To easily replenish and change over a drug by mounting paper or a cloth-like article coated with the drug or a bag-like article having said drug received therein to the under surface of an ultrasonic oscillation element in a close contact state in a detachable manner. CONSTITUTION:The adhesive paper 5 bondable to an ultrasonic oscillation element 2 and a drug permeable bonding film 6 coated with a creamy or gel-like drug layer 7 are laminated to the under surface of the ultrasonic oscillation element 2 having the terminal 9 connected to an external oscillator 1 and protective paper 8 is bonded to the surface coming into contact with the skin being the lowermost surface. At the time of use, the protective paper 8 of the lowermost surface is released to bond the bonding film 6 to the affected part and the terminal 9 is connected to the external oscillator to perform administration. When a drug is replaced and changed over, release is performed at the part of the adhesive paper 5 bonded to the ultrasonic oscillation element 2 and a laminate containing a now drug layer is bonded before use.

Description

[Detailed Description of the Invention] [Industrial Field of Application] The present invention is capable of separating the drug portion of a drug administration device for administering drugs to the human body through the skin, various mucous membranes, etc. using ultrasound, and is capable of replenishing and replenishing drugs. This invention relates to an ultrasonic drug administration device that can be easily switched.

[Conventional technology]

Methods for externally administering drugs for the treatment and prevention of human diseases include injections, 9 tablets, and capsules.

Oral or parenteral administration methods such as suppositories, and transdermal administration methods such as ointments and patches have been conventionally used. Among these, in the drug administration method by transdermal absorption, since the amount of drug absorbed through the skin is extremely small, oral administration or injections have been mostly used except for direct topical drugs.

However, in the case of oral or injectable drugs, the drug concentration generally reaches a peak quickly after drug administration, and then decreases over time, making it difficult to maintain a stable blood concentration. Furthermore, even the most commonly used orally administered drugs may cause gastrointestinal disorders, liver dysfunction, etc., and the drug is inactivated during the first passage through the liver after absorption from the intestinal tract. There are only a limited number of substances that meet the conditions for use as drugs. Furthermore, in the case of injections, there are various disadvantages such as the use of needles and the direct injection of foreign substances into the body, which causes an immune reaction, and there is also the risk of shock. −
It is impossible to recover drugs that have been injected into the body by multiple injections.

Therefore, the present inventor has developed an ointment that does not have these drawbacks.

In order to solve the difficulty of drugs passing through the stratum corneum or keratin layer of the skin, which is caused by the extremely heavy absorption of transdermal drugs such as patches, we first apply trauma to the skin. We developed a method that allows drugs to penetrate into the skin using physical energy that does not cause damage, allows drugs to pass through the stratum corneum and keratin layers of the skin, and maintains sufficient blood concentration of drugs. Heading: Invention of a transdermal administration device in which a drug layer is provided close to an ultrasonic oscillation element;
It was disclosed in Publication No. 5179.

[Problem to be solved by the invention]

In the above-mentioned transdermal administration device, which is equipped with an ultrasonic oscillation element that improves transdermal permeability of the drug and a drug layer directly in front of one administration, a new drug is added and the same administration is continued. If the need arises to replace the drug layer, such as when switching to another drug and administering it continuously, a new transdermal administration device must always be prepared, and a new drug layer must be prepared at all times. There were many complications in terms of treatment, such as having to keep a large number of transdermal administration devices equipped with

[Means to solve the problem]

The present invention provides an ultrasonic drug administration device that, except for the above-mentioned drawbacks, allows only the drug part to be switched when the same drug is added and continuously administered for treatment or when switched to another drug. The present invention provides a so-called disposable ultrasonic drug administration device.

The present invention provides an administration device in which a drug-coated paper, cloth-like material, or a bag-like material containing a drug is attached to the lower surface of an ultrasonic oscillation element in a removable manner, and a rod-shaped or drug-containing capsule housing space is provided at the tip. This is an ultrasonic drug administration device in which a capsule containing a drug is removably attached to the tip of an ultrasonic oscillator in close contact with the tip.

By adopting such a structure, the present invention allows only paper, cloth-like material coated with the drug, bag-like material containing the drug, capsule, etc., to be placed at the tip of the administration tool when adding the same drug or switching between different drugs. By pasting, fitting, and inserting the
It has the advantage that switching can be done easily with a simple operation, and that the same administration tool can always be used since only the drug part is kept at hand.

The ultrasonic drug administration device of the present invention can be of a stationary type, by selecting the type of ultrasonic oscillator and the type of power source.
It can be of various types such as portable type, regular use type, stick-on type, etc.

For example, as shown in Fig. 1, the stationary type has an ultrasonic oscillator 1 connected to a general AC power source and an ultrasonic oscillator element 2 with a rod-shaped tip provided at the bottom of a cylindrical container, connected by a conductor. It is cylindrical and can be inserted and removed from the tip of the container.
This administration device is equipped with a drug capsule 3 containing a drug, which has a hole into which a rod-shaped part of an ultrasonic oscillation element can be inserted. In this type, the shape of the ultrasonic oscillation element 2 may be such that the tip thereof has a space adapted to the shape of the drug-accommodating capsule, and the drug capsule is fitted into the tip, as shown in FIG.

In this type, a general power source can be used as the power source, so high energy can be continuously supplied. Further, the ultrasonic oscillation element can be made of commonly used ceramics such as barium titanate, zircon/lead titanate, metals, polymer soft films, and the like.

This stationary type is suitable for use in hospitals, homes, etc. by applying it to the skin for a short period of time.

When adding a new drug or switching to another drug, this can be done with a simple operation by replacing the drug capsule at the tip of the administration device at the tip of the same administration device.

For example, as shown in Figure 3, the portable type has four batteries in a cylindrical container.
In this type, an ultrasonic oscillator 1 and an ultrasonic oscillating element 2 are connected to each other by a conductive wire, and a drug capsule 3 is detachably attached to the tip of the ultrasonic oscillator 1. Although the shape of the ultrasonic oscillation element 2 is shown as a rod in FIG. 3, it may be shaped to fit into the drug-accommodating capsule shown in FIG. 2.

This portable type is relatively small and has a power source and an ultrasonic oscillator built into a single container, so it can be carried around at all times, and when needed, it can be taken out and administered by touching it to the affected area. can do. Also, additional administration of drugs,
Switching administration is extremely simple because it can be done simply by switching drug capsules.

For example, as shown in Fig. 4, the regular type is delivered in a flat container with a small battery 4 and a small ultrasonic oscillator, such as an IC oscillator 1 and an ultrasonic oscillator 2, connected with a conductor wire, and then the ultrasonic oscillation is started. It is of the type in which a drug layer 3 is provided on the lower surface of the element 2.

This type of container has bands attached to both sides of the container to keep the drug layer of the container in contact with the affected area at all times, making it suitable for affected areas where it is necessary to constantly administer drugs.

For example, as shown in FIG. 5, the adhesive type has an adhesive paper 5 attached to the ultrasonic oscillation element on the lower surface of the ultrasonic oscillation element 2 having a terminal 9 connected to an external oscillator, and a cream-like material on the drug-permeable adhesive membrane 6. , laminating drug layers coated with a gel-like drug layer 7;
This is a type of administration device with a protective paper 8 pasted on the lowermost surface that comes into contact with the skin.

When in use, the lowermost protective paper 8 is peeled off, the adhesive film 6 is applied to the affected area, and the terminal 9 is connected to an external oscillator for administration.

To replace or switch the drug, the part of the adhesive paper 5 bonded to the ultrasonic oscillation element 2 is peeled off, and a laminate containing a new drug layer is bonded and used.

In addition, when the drug is a liquid, a bag-like material containing the drug liquid is attached to the drug-permeable adhesive membrane 6 for use.

As the ultrasonic oscillation element 2, there are electric strain vibrators made of piezoelectric ceramics, magnetic strain vibrators using ferrite, etc.
Further, it may be a ceramic or a soft film type.

The administration device of the present invention can be used not only on the skin but also in the mouth by appropriately selecting its shape, material, and drug.

Drugs can be administered through various mucous membranes such as the gastrointestinal tract.

The drugs used in the present invention include drugs conventionally used for percutaneous absorption in ointments, patches, etc., such as scopolamine, nitroglycerin, and indomethacin.

For continuous administration of drugs such as ketoprofen and carpronium chloride, which are difficult to absorb through the skin using conventional ointments and patches, such as insulin, which is a polymer, various hormones, antibiotics, anticancer drugs, antihypertensive drugs, etc. Can be used.

It is also suitable for administering vasopressors to severe emergency patients in whom it is difficult to secure blood vessels.

〔Example〕

Example 1 As shown in FIG. 1, an ultrasonic oscillation element 2 is placed between the inner surface of the holder and a sponge-like cushioning material 10 in a cylindrical holder made of synthetic resin having an opening at the tip into which a drug-containing capsule 3 can be inserted. A terminal 9 connected to the oscillation element 2 by a conductive wire is provided on the top surface of the holder, and a drug-containing capsule 3 with an open top surface is removably inserted into the opening at the tip of the holder. This is a stationary drug administration device in which the rod-shaped tip of the oscillation element 2 is inserted into a capsule.

The terminal 9 of this administration device is used by being connected to a variable ultrasonic oscillator 1 connected to a general power source.

Example 2 As shown in FIG. 5, on the bottom surface of a disc-shaped ceramic oscillation element 2 equipped with a terminal 9, an adhesive paper 5 that adheres to the ultrasonic oscillation element 2 as the top layer, a cream-like drug layer 7, and a drug permeable A drug-coated paper-like material laminated with a manufactured adhesive film 6 is pasted on the oscillation element 2,
It is a pasted drug administration device in which a protective paper 8 is pasted on the lower surface of the drug-permeable pasted membrane 6 during storage. The terminal 9 of this administration device is used by being connected to a variable ultrasonic oscillator connected to a power source. It can also be used by connecting to a small portable ultrasonic oscillator.

〔Effect of the invention〕

As described above, the present invention uses ultrasonic vibrations to penetrate and absorb drugs from the skin, various mucous membranes, the inside of the mouth, and external organs such as the gastrointestinal tract, and controls the release of the drug by outputting ultrasonic waves. This is an extremely useful drug administration device that can be used to perform drug administration by changing the amount of the drug.Furthermore, it is a very useful drug administration device that allows the drug storage portion to be replaced at any time and can be replaced extremely easily.

[Brief explanation of drawings]

FIG. 1 is a sectional view of a stationary drug administration device of the present invention using a rod-shaped ultrasonic oscillation element. FIG. 2 is a cross-sectional view of the stationary drug administration device shown in FIG. 1, which uses an ultrasonic oscillation element in which the tip of the ultrasonic oscillation element is molded into a shape compatible with a drug containing capsule. FIG. 3 is a cross-sectional view of the portable drug administration device of the present invention. FIG. 4 is a cross-sectional view of the conventional drug administration device of the present invention. FIG. 5 is a sectional view of the adhesive-type drug administration device of the present invention. 1: Ultrasonic oscillator 2: Ultrasonic oscillator 3: Drug-containing capsule 4: Battery 5: Adhesive paper 6: Drug-permeable pasting membrane 7: Drug layer 8: Protective paper 9: Terminal 10: Cushioning material

Claims (1)

[Scope of Claims] 1. Ultrasonic waves characterized in that a paper, cloth-like material coated with a drug, or a bag-like material containing a drug is removably attached to the lower surface of an ultrasonic oscillation element. Drug administration device by. 2. An ultrasonic drug administration device comprising a rod-shaped ultrasonic oscillation element having a drug-containing capsule accommodation space at its tip, and a capsule containing a drug in close contact with the ultrasonic oscillation element detachably attached thereto. .