JPH0530777Y2 - - Google Patents

Description

[Detailed description of the device] [Field of industrial application] The present invention is a device that uses ultrasonic vibration to administer drugs into the body better than through the skin, and in particular, a device that uses ultrasonic vibration to administer drugs into the body through perfusion. The present invention relates to a transdermal drug administration device that achieves efficient and stable skin absorption.

[Conventional technology]

Methods of externally administering drugs for the treatment and prevention of human diseases include oral and parenteral administration via injections, pills, capsules, suppositories, etc., as well as ointments, patches, etc. A method of administering by transdermal absorption is used. Among these, methods of administering drugs through the skin have been given little attention except for ointments and patches because the amount of drug absorbed through the skin is extremely small. However, in drug administration methods such as oral administration, injection, and suppository administration, the concentration of the drug generally reaches its peak quickly and then decreases over time.
It has been difficult to maintain a stable and constant blood concentration. In addition, even the most commonly used orally administered drugs have a number of drawbacks, including gastrointestinal disorders, inactivation of the drug after absorption from the intestinal tract, drug inactivation during the first passage through the liver, and impaired liver function, making it difficult to use as a drug. Drugs that meet the conditions are extremely limited.

Furthermore, in the case of injections, there are various drawbacks such as the use of needles and the possibility of immune reactions caused by injecting foreign substances directly into the body, making it impossible to recover the drug once it has been injected into the body. There is also the risk of being shot due to the close proximity.

Therefore, in recent years, transdermal administration has attracted attention as a drug administration method that eliminates the drawbacks of the oral and parenteral administration methods mentioned above, keeps the blood concentration of the drug relatively constant, and has less risk of immune reactions. Research into base materials for pharmaceutical agents and patches is being actively conducted.

[The problem that the idea aims to solve]

Conventional transdermal administration agents such as ointments and patches require that the drug be able to pass from the epidermis to the capillary bed, but whether the drug can pass through the stratum corneum or keratin layer of the skin depends on oil, It has been difficult to maintain a sufficient blood concentration of a drug through transdermal administration because it depends on various properties including water solubility, drug concentration, PH, molecular weight, etc.

In order to solve this problem, the inventor of the present invention made it possible for the drug to penetrate into the skin by using physical energy that does not cause trauma to the skin, and the drug effectively penetrates the stratum corneum and keratin layers of the skin. He invented and applied for a patent for a drug administration device with a built-in ultrasonic oscillation element that allows the drug to pass through the bloodstream and maintain a sufficient concentration of the drug in the blood.
−282703).

However, in this device, the concentration of the drug retained gradually decreased, and the effect of permeation into the skin was not sufficiently sustained. In addition, it was not possible to change the drug concentration or replace it with another drug during use.

[Means to solve the problem]

The inventors of the present invention have conducted extensive research into devices for improving drug absorption in the transdermal administration device, and have solved the above problems by perfusing the drug contained in the device during administration.

In the present invention, an ultrasonic oscillation element equipped with a terminal is disposed in a flat drug-containing container that has a drug-permeable skin contact layer on the lower surface, and an inlet and an inlet for the drug are provided in the drug-containing container. It is a transdermal administration device.

The transdermal administration device of the present invention will be explained with reference to the drawings.

FIG. 1 is a sectional view of the transdermal administration device of the present invention.

In the flat container 1, an ultrasonic oscillation element 2 having a terminal 7 connected to an oscillator is arranged in the drug storage part 3, and the bottom of the container 1 forms a drug-permeable layer 4 that contacts the skin. There is. And container 1
A drug inlet 5 and an outlet 6 that are open to the drug storage section 3 are provided on the top or side surface, and the tip of the inlet 5 is connected to an external drug storage section with a suitable connecting member, such as a tube, and the outlet The distal end of 6 is connected to an external drug discharge part with a suitable connecting member, such as a tube. and a device for perfusing the drug storage section, the drug storage section of the administration device, and the drug discharge section;
For example, a pump or the like is provided at an appropriate location.

In the transdermal administration device of the present invention, the drug release rate is controlled by increasing or decreasing the energy of ultrasonic vibration, and the terminal 7 is connected to a variable oscillator so that the blood drug concentration can be freely varied. Then, the ultrasonic oscillator is connected to a battery or a general power source, and the drug is brought into contact with the skin while applying ultrasonic vibrations to the drug. Furthermore, since the drug inlet 5 is connected to a new drug reservoir, and the drug outlet 6 is connected to a discharged drug storage section, while the device is in contact with the skin, a liquid perfusion device such as a pump or the like can be used. The structure is such that a liquid flow is created by the vibration energy of the oscillation device, and new drug is constantly perfused into the skin contact area.

The drugs used in the administration device of the present invention include drugs conventionally used for transdermal absorption in ointments, patches, etc., such as scopolamine, nitroglycerin, indomethacin, ketoprofen, carpronium chloride, etc., and drugs that are difficult to absorb through the skin. For example, insulin, various hormone drugs, antibiotics, anticancer drugs, antihypertensive drugs, etc.

The ultrasonic oscillation element of the present invention can use commonly used ceramics such as barium titanate and zircon lead titanate. Then, the ultrasonic oscillation device usually oscillates and administers 1,500 to 8,000 pa (pa is a pascal unit).

〔Example〕

As shown in FIG. 1, a terminal 7 is placed inside a flat container 1.
A drug accommodating part 3 is arranged on the lower surface of the disc ceramic ultrasonic oscillation element 2, and the bottom surface of the container is a contact layer 4.
It consists of A drug inlet 5 and a drug outlet 6 are provided at opposite positions in the upper part of the flat container 1, and one end of the outer side of the container is connected to a drug storage part and a discharged drug storage part, respectively, by a tube. and a pump for drug perfusion.

[Effect of idea]

The transdermal administration device of the present invention is brought into contact with an appropriate part of the skin, the ultrasonic oscillation element is operated, and the inlet and outlet of the drug are connected to the drug storage section and the discharged drug storage section, respectively, and a perfusion device such as a pump is used. By perfusing the drug into this device, new drugs can be constantly supplied, and the concentration of the drug can be changed or replaced with other drugs during use. On the other hand, it also has a cooling effect against heat generation due to ultrasonic vibration, allows the use of stronger ultrasonic waves, and has the effect that drugs are absorbed more stably than through the skin.

[Brief explanation of the drawing]

FIG. 1 is a sectional view of the transdermal administration device of the present invention. DESCRIPTION OF SYMBOLS 1... Container, 2... Ultrasonic oscillation element, 3... Drug containing section, 4... Drug permeable contact layer, 5... Drug inlet, 6... Drug outlet, 7... Terminal, 8... ...Tube.

Claims (1)

[Scope of utility model registration request] A drug characterized in that an ultrasonic oscillation element equipped with a terminal is disposed in a drug-containing flat container having a drug-permeable skin contact layer on the lower surface, and the drug-containing container is provided with an inlet and an inlet for drug irrigation. transdermal administration device.