JPH0360831B2 - - Google Patents

Info

Publication number
JPH0360831B2
JPH0360831B2 JP2012779A JP1277990A JPH0360831B2 JP H0360831 B2 JPH0360831 B2 JP H0360831B2 JP 2012779 A JP2012779 A JP 2012779A JP 1277990 A JP1277990 A JP 1277990A JP H0360831 B2 JPH0360831 B2 JP H0360831B2
Authority
JP
Japan
Prior art keywords
solution
acid
mmol
hours
vacuo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP2012779A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02231483A (ja
Inventor
Jee Kuetoitsuchi Reimondo
Jii Meriro Deiuitsudo
Emu Raian Kenesu
Suretsutsuingaa Meiyaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH02231483A publication Critical patent/JPH02231483A/ja
Publication of JPH0360831B2 publication Critical patent/JPH0360831B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012779A 1981-04-08 1990-01-24 （２□ＤＳ）―テトラヒドロ―２α―メチル―６―オキソ―４β―アミノ―２□ＤＨ―ピラン―３α―カルボン酸の製造方法 Granted JPH02231483A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US252,492 1981-04-08
US06/252,492 US4360684A (en) 1981-04-08 1981-04-08 Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP57056782A Division JPS57179179A (en) 1981-04-08 1982-04-07 Manufacture of (2s)-tetrahydro-2 alpha- methyl-6-oxo-4 beta-amino-2h-pyrane-3 alpha carboxylic acid

Publications (2)

Publication Number Publication Date
JPH02231483A JPH02231483A (ja) 1990-09-13
JPH0360831B2 true JPH0360831B2 (OSRAM) 1991-09-17

Family

ID=22956238

Family Applications (2)

Application Number Title Priority Date Filing Date
JP57056782A Granted JPS57179179A (en) 1981-04-08 1982-04-07 Manufacture of (2s)-tetrahydro-2 alpha- methyl-6-oxo-4 beta-amino-2h-pyrane-3 alpha carboxylic acid
JP2012779A Granted JPH02231483A (ja) 1981-04-08 1990-01-24 （２□ＤＳ）―テトラヒドロ―２α―メチル―６―オキソ―４β―アミノ―２□ＤＨ―ピラン―３α―カルボン酸の製造方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP57056782A Granted JPS57179179A (en) 1981-04-08 1982-04-07 Manufacture of (2s)-tetrahydro-2 alpha- methyl-6-oxo-4 beta-amino-2h-pyrane-3 alpha carboxylic acid

Country Status (4)

Country Link
US (1) US4360684A (OSRAM)
EP (1) EP0062840B1 (OSRAM)
JP (2) JPS57179179A (OSRAM)
DE (1) DE3277839D1 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190404B (en) * 1982-07-30 1986-09-29 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing amino-lactone-carboxylic acid
CA1220215A (en) * 1983-03-07 1987-04-07 Yasutsugu Ueda Carbapenem intermediates
IE58243B1 (en) * 1983-12-07 1993-08-11 Lonza Ag A process for the preparation of optically-active 3-amino carboxylic acids
HU194203B (en) * 1984-08-15 1988-01-28 Richter Gedeon Rt Process for producing amino-lactone
GB8605413D0 (en) * 1986-03-05 1986-04-09 Ici Plc Chemical compounds
US4837343A (en) * 1986-09-08 1989-06-06 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Optically active β-amino acid derivatives and their salts, and processes for producing the same
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
JPH10503772A (ja) * 1994-07-29 1998-04-07 アボツト・ラボラトリーズ 置換２，５−ジアミノ−３−ヒドロキシヘキサンの製造方法
JP3726121B2 (ja) * 2000-12-21 2005-12-14 独立行政法人産業技術総合研究所 β―ラクタムの合成方法
WO2004011033A1 (en) * 2002-07-24 2004-02-05 Universite Catholique De Louvain Method for the synthesis of anthracycline-peptide conjugates
US6835841B2 (en) 2002-09-13 2004-12-28 Bristol-Myers Squibb Company Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters
KR20110049823A (ko) * 2008-07-30 2011-05-12 랜박시 래보러터리스 리미티드 카르바페넴 화합물의 제조 방법
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4282148A (en) * 1980-01-14 1981-08-04 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline

Also Published As

Publication number Publication date
EP0062840B1 (en) 1987-12-16
JPS57179179A (en) 1982-11-04
DE3277839D1 (en) 1988-01-28
US4360684A (en) 1982-11-23
JPH0254350B2 (OSRAM) 1990-11-21
EP0062840A1 (en) 1982-10-20
JPH02231483A (ja) 1990-09-13

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