JPH0359882B2 - - Google Patents
Info
- Publication number
- JPH0359882B2 JPH0359882B2 JP58170497A JP17049783A JPH0359882B2 JP H0359882 B2 JPH0359882 B2 JP H0359882B2 JP 58170497 A JP58170497 A JP 58170497A JP 17049783 A JP17049783 A JP 17049783A JP H0359882 B2 JPH0359882 B2 JP H0359882B2
- Authority
- JP
- Japan
- Prior art keywords
- sup
- animal
- salt
- mycoplasmosis
- acyl peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241001465754 Metazoa Species 0.000 claims abstract description 31
- 125000002252 acyl group Chemical group 0.000 claims abstract description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- -1 lactoyl-alanyl- Chemical group 0.000 claims abstract description 15
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 15
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 6
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 3
- 239000001257 hydrogen Substances 0.000 claims abstract description 3
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 3
- 239000007952 growth promoter Substances 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 description 18
- 239000003814 drug Substances 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 7
- 229940088710 antibiotic agent Drugs 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 108010001478 Bacitracin Proteins 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- MVTQIFVKRXBCHS-SMMNFGSLSA-N N-[(3S,6S,12R,15S,16R,19S,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone Chemical compound CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C)n2.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1 MVTQIFVKRXBCHS-SMMNFGSLSA-N 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 239000004188 Virginiamycin Substances 0.000 description 2
- 108010080702 Virginiamycin Proteins 0.000 description 2
- 229960003071 bacitracin Drugs 0.000 description 2
- 229930184125 bacitracin Natural products 0.000 description 2
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- 229960003842 virginiamycin Drugs 0.000 description 2
- 235000019373 virginiamycin Nutrition 0.000 description 2
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000272517 Anseriformes Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 239000004181 Flavomycin Substances 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 101710176384 Peptide 1 Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 235000009430 Thespesia populnea Nutrition 0.000 description 1
- 229930185202 Thiopeptin Natural products 0.000 description 1
- IXEQUEFFDUXSRS-UGJHNBEYSA-N Thiopeptin Bb Natural products CC=C1NC(=O)[C@@H](NC(=O)c2csc(n2)[C@]34CCC(=N[C@@H]3c5csc(n5)[C@@H](NC(=S)c6csc(n6)[C@H](NC(=O)[C@@H]7CN=C1S7)[C@@](C)(O)[C@H](C)O)[C@H](C)OC(=O)c8cc([C@@H](C)O)c9C=C[C@@H](N[C@H](C(C)C)C(=O)N[C@H](C)C(=O)NC(=C)C(=O)N[C@H](C)C(=O)N4)[C@@H](O)c9n8)c%10nc(cs%10)C(=O)NC(=C)C(=O)NC(=C)C(=O)O)[C@H](C)O IXEQUEFFDUXSRS-UGJHNBEYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 229940124536 anticoccidial agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- PERZMHJGZKHNGU-JGYWJTCASA-N bambermycin Chemical compound O([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1NC(C)=O)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@H](O1)C(=O)NC=1C(CCC=1O)=O)O)C)[C@H]1[C@@H](OP(O)(=O)OC[C@@H](OC\C=C(/C)CC\C=C\C(C)(C)CCC(=C)C\C=C(/C)CCC=C(C)C)C(O)=O)O[C@H](C(O)=O)[C@@](C)(O)[C@@H]1OC(N)=O PERZMHJGZKHNGU-JGYWJTCASA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229910000361 cobalt sulfate Inorganic materials 0.000 description 1
- 229940044175 cobalt sulfate Drugs 0.000 description 1
- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 239000003224 coccidiostatic agent Substances 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- 229960000355 copper sulfate Drugs 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 230000000816 effect on animals Effects 0.000 description 1
- NJCUSQKMYNTYOW-MWUYRYRWSA-N enramicina Chemical compound O.N1C(=O)NC(=O)C(C=2C=C(Cl)C(O)=C(Cl)C=2)NC(=O)C(CO)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(CC2N=C(N)NC2)NC(=O)C(CCCNC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C(C)O)NC(=O)N(CCCCN)C(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)/C=C/C=C/CCCCC(C)CC)C(C)OC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C)NC(=O)C1CC1CNC(N)=N1 NJCUSQKMYNTYOW-MWUYRYRWSA-N 0.000 description 1
- 229950003984 enramycin Drugs 0.000 description 1
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- 150000002169 ethanolamines Chemical class 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
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- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000002766 immunoenhancing effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- SRTDKHGZQCTGBY-RVDKCFQWSA-N thiopeptin Chemical compound N1C2C(N=3)=CSC=3C(C(C)OC(=O)C=3N=C4C(O)C(NC(C(C)C)C(=O)NC(C)C(=O)NC(=C)C(=O)NC(C)C(=O)N5)C=CC4=C(C(C)O)C=3)NC(=S)C(N=3)=CSC=3C(C(C)(O)C(C)O)NC(=O)C(N=3)CSC=3C(=C/C)\NC(=O)C(C(C)O)NC(=O)C(N=3)=CSC=3C25CCC1C1=NC(C(N)=O)=CS1 SRTDKHGZQCTGBY-RVDKCFQWSA-N 0.000 description 1
- 108010030742 thiopeptin Proteins 0.000 description 1
- 229960004885 tiamulin Drugs 0.000 description 1
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
この発明は新規な動物の成長促進剤および動物
の抗マイコプラズマ症薬剤に関するものである。
この発明の動物の成長促進剤および動物の抗マ
イコプラズマ症薬剤において有効成分として使用
されるアシルペプタイドは下記の一般式（）で
示される。
（式中、R1はラクトイル−アラニル、R2はカ
ルボキシメチルアミノ、R3はカルボキシをそれ
ぞれ意味するか、R1はヘプタノイル、R2は１−
カルボキシエチルアミノ、R3はカルボキシをそ
れぞれ意味するか、またはR1はステアロイル、
R2は１−カルボキシエチルアミノ、R3は水素を
それぞれ意味する。）
上記一般式（）で示されるアシルペプタイド
およびその無毒性塩は免疫増強活性を有する化合
物として知られている（例えば特開昭56−45449
号公報参照）。
従来からある種の抗生物質（例えばペニシリ
ン、テトラサイクリン、バシトラシン、バージニ
アマイシン等）が動物の成長促進剤として使用さ
れているが、これらの抗生物質は強力な直接的な
抗菌活性を有していることが特徴であるために、
耐性菌の出現の問題がある。
この発明者等はこの問題点を解決すべく、鋭意
研究の結果、免疫増強活性を有するが、インビト
ロで抗菌活性（すなわち、直接的な抗菌活性）を
有しない前記化合物（）およびその無毒性塩が
動物の成生促進作用を有し、さらに動物の抗マイ
コプラズマ症に有効であるということを見出しこ
の発明を完成した。
この発明で有効成分として使用するアシルペプ
タイド(1)の無毒性塩としては、ナトリウム塩、カ
リウム塩、カルシウム塩、アンモニウム塩、エタ
ノールアミン塩、トリエチルアミン塩、ジシクロ
ヘキシルアミン塩等の有機または無機塩、酢酸
塩、トリフルオロ酢酸塩、乳酸塩、マレイン酸
塩、フマル酸塩、酒石酸塩、くえん酸塩、メタン
スルホン酸塩、塩酸塩、硫酸塩、硝酸塩、りん酸
塩等の有機酸または無機酸との酸付加塩が挙げら
れる。
また、アシルペプタイド(1)にはその分子中の不
斉炭素原子による１または２以上の立体異性体が
含まれ、これらの化合物も全てこの発明の有効成
分として使用できる。
この発明で有効成分として使用されるアシルペ
プタイド(1)のうち、代表的な化合物を挙げると次
のとおりである。
この発明の動物の成長促進剤および抗マイコプ
ラズマ症薬剤を動物に投与する場合には、直接ア
シルペプタイド(1)またはその無毒性塩を経口投与
してもよいが、一般には通常使用されている担体
（例えば、脂肪米ぬか、脱脂大豆粉、ふすま、カ
オリン、タルク、炭酸カルシウム、乳糖等）と混
合したものを投与するか、あるいはこのようにし
て混合したものもしくはアシルペプタイド(1)また
はその無毒性塩単独を動物飼料もしくは水と混合
して投与する方法が好ましい。
また抗マイコプラズマ症薬剤として使用する場
合には、経口投与のほかに、注射により投与する
こともできる。
アシルペプタイド(1)またはその無毒性塩を動物
成長促進剤として使用する場合の投与量は動物の
種類、成長時期等により異なるが、通常は0.01〜
10mg／Kg／日の範囲内で最適投与量が選択され
る。また、抗マイコプラズマ症薬剤として使用す
る場合の投与量は動物の種類、疾病の程度により
異なるが、一般的には成長促進剤として使用する
場合とだいたい同程度の範囲内で最適投与量が選
択される。
ここでアシルペプタイド(1)またはその無毒性塩
を動物飼料と混合して使用する場合について詳述
すると、動物飼料の形態は例えば配合飼料等の一
般に使用される動物用飼料であればいずれも使用
可能である。その１例としては、例えばとうもろ
こし、米、麦、マイロ、大豆粕、綿実油、ふす
ま、脱脂米ぬか、魚粉、脱脂粉乳、乾燥ホエー、
油脂、アルフアルフアミール、炭酸カルシウム、
りん酸３カルシウム、塩化ナトリウム、塩化コリ
ン、ビタミン類（例えばビタミンＡ、ビタミン
Ｄ、ビタミンＥ、ビタミンB1、ビタミンB2、ビ
タミンB6、ビタミンB12、パントテン酸カルシウ
ム、ニコチン酸アミド、葉酸等）、アミノ酸類
（例えばリジン、メチオニン等）、微量無機塩類
（例えば硫酸マグネシウム、硫酸鉄、硫酸銅、硫
酸亜鉛、よう化カリウム、硫酸コバルト等）等の
１部または全部を混合して調製した配合飼料が挙
げられる。
この発明の動物の成長促進剤および抗マイコプ
ラズマ症薬剤は上記のほか抗生物質や殺菌剤、防
かび剤、駆虫剤、抗コクシジウム剤、抗酸化剤、
天然色素等を適宜添加して使用してもよい。また
他の動物成長促進剤、例えばチオペプチン、エン
ラマイシン、バシトラシン、ミカマイシン、フラ
ジオマイシン、フラボマイシン、バージニアマイ
シン等を主成分とする動物成長促進剤と併用して
もよい。
また、飼料中のアシルペプタイド(1)またはその
無毒性塩の含有量は通常0.01ppm〜100ppm好ま
しくは0.1ppm〜10ppmの範囲内で適宜選択され
る。
この発明の動物成長促進剤および抗マイコプラ
ズマ症薬剤は動物一般に使用でき、その例として
例えば鶏、七面鳥、あひる、うずら、牛、馬、
豚、羊、やぎ、うさぎ、犬、ねこ、ミンク等の家
きんおよび家畜が挙げられる。
また、この発明の動物成長促進剤および抗マイ
コプラズマ症薬剤を動物飼料と混合して用いる場
合における動物飼育法は、一般の動物飼育法がそ
のまま適用される。
この発明の動物成長促進剤は動物の成長を促進
するのみならず動物の飼料要求率を改善するとい
う効果に加えてアシルペプタイド(1)およびその無
毒性塩が直接的な抗菌活性を有しないため、抗生
物質に対する耐性菌の出現を伴わなず、安全に使
用できるという従来の抗生物質を使用する動物成
長促進剤には見られない優れた効果を有する。
またアシルペプタイド(1)またはその無毒性塩を
抗マイコプラズマ症薬剤として使用する場合、こ
の薬剤はマイコプラズマ症の治療剤および予防剤
の双方の薬剤として使用することができるが、通
常は予防剤として使用するのが好ましい。
このアシルペプタイド(1)を抗マイコプラズマ症
薬剤として使用する場合、抗生物質（例えば、タ
イロシン、テトラサイクリン、クロラムフエニコ
ール、チアムリン、スペクチノマイシン等）と併
用すると、相乗効果を示すという新知見が得られ
た。
この発明の抗マイコプラズマ症薬剤を上記抗生
物質と併用する場合、アシルペプタイド１と該抗
生物質とを同様に動物に投与してもよいが、先づ
アシルペプタイド(1)またはその無毒性塩を投与し
た後ある一定期間（例えば１週間）後に、該抗生
物質を投与した方が好ましい。
また、このアシルペプタイド(1)またはその無毒
性塩と抗生物質とを併用する場合の両者の投与量
比は動物の種類、疾病の程度等によつて異なる
が、一般的にはアシルペプタイド(1)またはその無
毒性塩１に対して抗生物質50程度の割合で投与す
ればよい。
この発明の抗マイコプラズマ症薬剤は抗生物質
に対する耐性菌の出現を伴わず、安全に使用でき
るという従来の抗生物質を使用する薬剤には見ら
れない優れた効果を有する。
次にこの発明の効果を試験例により説明する。
試験例 １
７日令の肉用種鶏ひな（雄）（チヤンキー）を
１群４羽ずつ、すなわちアシルペプタイド(1)投与
群（処理群）と対照群に分け、下記飼料組成を
飼育開始日から４週令まで、飼料組成を５週令
から８週令まで不断に投与し、常法により飼育し
た後、増体重および飼料要求率を調べた。結果は
下記表のとおりである。
This invention relates to novel animal growth promoters and animal anti-mycoplasmosis agents. The acyl peptide used as an active ingredient in the animal growth promoter and animal anti-mycoplasmosis drug of the present invention is represented by the following general formula (). (In the formula, R 1 means lactoyl-alanyl, R 2 means carboxymethylamino, R 3 means carboxy, R 1 means heptanoyl, R 2 means 1-
carboxyethylamino, R 3 means carboxy or R 1 is stearoyl,
R 2 means 1-carboxyethylamino, and R 3 means hydrogen. ) Acyl peptides represented by the above general formula () and their non-toxic salts are known as compounds having immunoenhancing activity (for example, Japanese Patent Application Laid-open No. 56-45449
(see publication). Traditionally, certain antibiotics (e.g. penicillin, tetracycline, bacitracin, virginiamycin, etc.) have been used as growth promoters in animals, and these antibiotics have strong direct antibacterial activity. Because it is characterized by
There is a problem with the emergence of resistant bacteria. In order to solve this problem, the present inventors conducted intensive research and found that the above compound () and its non-toxic salts have immune-enhancing activity but do not have antibacterial activity (i.e., direct antibacterial activity) in vitro. This invention was completed based on the discovery that the present invention has a growth-promoting effect on animals and is also effective against mycoplasmosis in animals. Non-toxic salts of acyl peptide (1) used as active ingredients in this invention include organic or inorganic salts such as sodium salt, potassium salt, calcium salt, ammonium salt, ethanolamine salt, triethylamine salt, dicyclohexylamine salt, acetic acid salt, etc. With organic or inorganic acids such as salts, trifluoroacetates, lactates, maleates, fumarates, tartrates, citrates, methanesulfonates, hydrochlorides, sulfates, nitrates, phosphates, etc. Examples include acid addition salts. Furthermore, acyl peptide (1) includes one or more stereoisomers due to asymmetric carbon atoms in its molecule, and all of these compounds can also be used as active ingredients in the present invention. Among the acyl peptides (1) used as active ingredients in this invention, representative compounds are as follows. When administering the animal growth promoter and anti-mycoplasmosis agent of this invention to animals, the acyl peptide (1) or its non-toxic salt may be directly administered orally, but in general, commonly used carriers may be used. (e.g., fatty rice bran, defatted soybean flour, bran, kaolin, talc, calcium carbonate, lactose, etc.) or acyl peptide (1) or its non-toxic salt. A method in which the drug is administered alone in combination with animal feed or water is preferred. When used as an anti-mycoplasmosis drug, it can be administered by injection in addition to oral administration. When using acyl peptide (1) or its non-toxic salt as an animal growth promoter, the dosage varies depending on the type of animal, growth period, etc., but is usually 0.01~
The optimal dosage is selected within the range of 10 mg/Kg/day. In addition, the dosage when used as an anti-mycoplasmosis drug varies depending on the type of animal and the severity of the disease, but in general, the optimal dosage is selected within the same range as when used as a growth promoter. Ru. Here, we will discuss in detail the case where acyl peptide (1) or its non-toxic salt is used in combination with animal feed.The form of animal feed can be any commonly used animal feed such as compound feed. It is possible. Examples include corn, rice, wheat, milo, soybean meal, cottonseed oil, bran, skim rice bran, fish meal, skim milk powder, dry whey,
fats and oils, alpha alpha amil, calcium carbonate,
Tricalcium phosphate, sodium chloride, choline chloride, vitamins (e.g. vitamin A, vitamin D, vitamin E, vitamin B 1 , vitamin B 2 , vitamin B 6 , vitamin B 12 , calcium pantothenate, nicotinamide, folic acid, etc.) ), amino acids (e.g. lysine, methionine, etc.), trace inorganic salts (e.g. magnesium sulfate, iron sulfate, copper sulfate, zinc sulfate, potassium iodide, cobalt sulfate, etc.), etc. Feed is an example. In addition to the above, the animal growth promoter and anti-mycoplasmosis agent of this invention include antibiotics, bactericides, fungicides, anthelmintic agents, anti-coccidial agents, antioxidants,
Natural pigments and the like may be appropriately added and used. It may also be used in combination with other animal growth promoters, such as animal growth promoters whose main ingredients are thiopeptin, enramycin, bacitracin, micamicin, fradiomycin, flavomycin, virginiamycin, and the like. Further, the content of acyl peptide (1) or its nontoxic salt in the feed is normally selected as appropriate within the range of 0.01 ppm to 100 ppm, preferably 0.1 ppm to 10 ppm. The animal growth promoter and anti-mycoplasmosis agent of this invention can be used for animals in general, such as chickens, turkeys, ducks, quail, cows, horses, etc.
Examples include poultry and livestock such as pigs, sheep, goats, rabbits, dogs, cats, and mink. Furthermore, when the animal growth promoter and anti-mycoplasmosis drug of the present invention are used in combination with animal feed, general animal breeding methods can be applied as they are. The animal growth promoter of the present invention not only promotes the growth of animals but also improves the feed conversion rate of animals, and in addition, the acyl peptide (1) and its nontoxic salts do not have direct antibacterial activity. It has excellent effects not seen in conventional animal growth promoters that use antibiotics, such as being safe to use without the emergence of antibiotic-resistant bacteria. Furthermore, when acyl peptide (1) or its non-toxic salt is used as an anti-mycoplasmosis drug, this drug can be used as both a therapeutic agent and a prophylactic agent for mycoplasmosis, but it is usually used as a prophylactic agent. It is preferable to do so. New findings have shown that when this acyl peptide (1) is used as an anti-mycoplasmosis drug, it exhibits a synergistic effect when used in combination with antibiotics (e.g., tylosin, tetracycline, chloramphenicol, tiamulin, spectinomycin, etc.). It was done. When the anti-mycoplasmosis drug of this invention is used in combination with the above antibiotic, acyl peptide 1 and the antibiotic may be administered to animals in the same way, but acyl peptide (1) or its non-toxic salt is administered first. It is preferable to administer the antibiotic after a certain period of time (for example, one week). Furthermore, when acyl peptide (1) or its nontoxic salt is used in combination with an antibiotic, the dosage ratio of the two will vary depending on the type of animal, the severity of the disease, etc., but in general, acyl peptide (1) ) or its nontoxic salt at a ratio of about 50 parts antibiotic. The anti-mycoplasmosis drug of the present invention is safe to use without the emergence of antibiotic-resistant bacteria, and has an excellent effect not found in conventional drugs using antibiotics. Next, the effects of this invention will be explained using test examples. Test Example 1 7-day-old meat breeder chicks (male) (Chyanki) were divided into groups of 4, that is, an acyl peptide (1) administration group (treated group) and a control group, and the following feed composition was administered to the 4 chicks from the start of rearing. The feed composition was constantly administered from 5 weeks of age to 8 weeks of age, and after rearing in a conventional manner, body weight gain and feed conversion rate were examined. The results are shown in the table below.
【表】【table】
【表】【table】
【表】
(注)
利用された飼料
飼料要求率＝[Table] (Note)
feed utilized
Feed conversion rate =
Claims (1)
ルボキシメチルアミノ、R3はカルボキシをそれ
ぞれ意味するか、R1はヘプタノイル、R2は１−
カルボキシエチルアミノ、R3はカルボキシをそ
れぞれ意味するか、またはR1はステアロイル、
R2は１−カルボキシエチルアミノ、R3は水素を
それぞれ意味する。） で示されるアシルペプタイドまたはその無毒性塩
を含有する新規な動物の成長促進剤。[Claims] 1. General formula (In the formula, R 1 means lactoyl-alanyl, R 2 means carboxymethylamino, R 3 means carboxy, R 1 means heptanoyl, R 2 means 1-
carboxyethylamino, R 3 means carboxy or R 1 is stearoyl,
R 2 means 1-carboxyethylamino, and R 3 means hydrogen. ) A novel animal growth promoter containing an acyl peptide or a non-toxic salt thereof.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8227513 | 1982-09-27 | ||
| GB8227513 | 1982-09-27 | ||
| GB8228988 | 1982-10-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5973527A JPS5973527A (en) | 1984-04-25 |
| JPH0359882B2 true JPH0359882B2 (en) | 1991-09-12 |
Family
ID=10533190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58170497A Granted JPS5973527A (en) | 1982-09-27 | 1983-09-14 | Novel growth-promoting agent and antimycoplasmotic drug for animal |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4504471A (en) |
| EP (1) | EP0104630B1 (en) |
| JP (1) | JPS5973527A (en) |
| KR (1) | KR910002420B1 (en) |
| AT (1) | ATE22525T1 (en) |
| AU (1) | AU558679B2 (en) |
| CA (1) | CA1221865A (en) |
| DE (1) | DE3366612D1 (en) |
| ES (1) | ES8501210A1 (en) |
| MX (1) | MX7546E (en) |
| NZ (1) | NZ205737A (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO109035B1 (en) * | 1991-12-21 | 1994-11-30 | Hoechst Ag | Pre mixture of active substances with role of medicines and fodder on an active substance |
| CA2388244C (en) * | 1999-10-19 | 2009-02-03 | Hironari Koyama | Agents for promoting fattening of animals and method of promoting fattening |
| AU2005209901A1 (en) * | 2004-01-30 | 2005-08-18 | The Texas A & M University System | Compositions, methods and uses for a novel family of peptides |
| US9668500B2 (en) | 2012-04-24 | 2017-06-06 | Purina Animal Nutrition Llc | Feeding methods and systems for young livestock animals using sensory compounds |
| KR101437119B1 (en) * | 2013-01-25 | 2014-09-11 | 대한뉴팜(주) | Pellet Type Composition for Growth Promoting of Cattle Using Melengestrol |
| US11213051B2 (en) * | 2014-07-02 | 2022-01-04 | Purina Animal Nutrition Llc | Milk replacer products containing halides and sources of hydrogen peroxide and methods of feeding same |
| CA2957790A1 (en) * | 2014-08-13 | 2016-02-18 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
| US10653658B2 (en) | 2015-08-11 | 2020-05-19 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| WO2017027742A1 (en) | 2015-08-11 | 2017-02-16 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| RU2611716C1 (en) * | 2016-03-18 | 2017-02-28 | Вячеслав Михайлович Спиридонов | Bfv fodder additive |
| US10940172B2 (en) | 2017-01-03 | 2021-03-09 | Purina Animal Nutrition Llc | Methods of feeding animals phytogenic products |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645449A (en) * | 1979-07-31 | 1981-04-25 | Fujisawa Pharmaceut Co Ltd | Novel peptide, its pharmaceutically acceptable salt and preparation of the same |
| JPS56100777A (en) * | 1980-01-17 | 1981-08-12 | Taiho Yakuhin Kogyo Kk | Sulfide compound and its preparation |
| JPS56123977A (en) * | 1980-02-15 | 1981-09-29 | Taiho Yakuhin Kogyo Kk | Sulfonium compound and its preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322341A (en) * | 1980-05-13 | 1982-03-30 | Fujisawa Pharmaceutical Co | Peptide, process for preparation thereof and use thereof |
| FR2460290A1 (en) * | 1979-06-29 | 1981-01-23 | Rhone Poulenc Ind | NOVEL TETRA- OR PENTAPEPTIDES, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM |
-
1983
- 1983-09-06 US US06/529,680 patent/US4504471A/en not_active Expired - Fee Related
- 1983-09-07 AU AU18779/83A patent/AU558679B2/en not_active Ceased
- 1983-09-14 JP JP58170497A patent/JPS5973527A/en active Granted
- 1983-09-23 ES ES525915A patent/ES8501210A1/en not_active Expired
- 1983-09-24 AT AT83109514T patent/ATE22525T1/en not_active IP Right Cessation
- 1983-09-24 DE DE8383109514T patent/DE3366612D1/en not_active Expired
- 1983-09-24 EP EP83109514A patent/EP0104630B1/en not_active Expired
- 1983-09-26 NZ NZ205737A patent/NZ205737A/en unknown
- 1983-09-26 CA CA000437575A patent/CA1221865A/en not_active Expired
- 1983-09-26 MX MX8310804U patent/MX7546E/en unknown
- 1983-09-27 KR KR1019830004522A patent/KR910002420B1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645449A (en) * | 1979-07-31 | 1981-04-25 | Fujisawa Pharmaceut Co Ltd | Novel peptide, its pharmaceutically acceptable salt and preparation of the same |
| JPS56100777A (en) * | 1980-01-17 | 1981-08-12 | Taiho Yakuhin Kogyo Kk | Sulfide compound and its preparation |
| JPS56123977A (en) * | 1980-02-15 | 1981-09-29 | Taiho Yakuhin Kogyo Kk | Sulfonium compound and its preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| AU558679B2 (en) | 1987-02-05 |
| EP0104630A3 (en) | 1984-06-06 |
| KR840006128A (en) | 1984-11-22 |
| JPS5973527A (en) | 1984-04-25 |
| KR910002420B1 (en) | 1991-04-22 |
| ATE22525T1 (en) | 1986-10-15 |
| NZ205737A (en) | 1987-01-23 |
| ES525915A0 (en) | 1984-11-16 |
| EP0104630A2 (en) | 1984-04-04 |
| EP0104630B1 (en) | 1986-10-01 |
| ES8501210A1 (en) | 1984-11-16 |
| MX7546E (en) | 1989-09-14 |
| DE3366612D1 (en) | 1986-11-06 |
| CA1221865A (en) | 1987-05-19 |
| AU1877983A (en) | 1984-04-05 |
| US4504471A (en) | 1985-03-12 |
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