JPS63133952A - Animal growth promotion agent - Google Patents
Animal growth promotion agentInfo
- Publication number
- JPS63133952A JPS63133952A JP61282556A JP28255686A JPS63133952A JP S63133952 A JPS63133952 A JP S63133952A JP 61282556 A JP61282556 A JP 61282556A JP 28255686 A JP28255686 A JP 28255686A JP S63133952 A JPS63133952 A JP S63133952A
- Authority
- JP
- Japan
- Prior art keywords
- animal
- fosmidomycin
- feed
- vitamin
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 29
- GJXWDTUCERCKIX-UHFFFAOYSA-N fosmidomycin Chemical compound O=CN(O)CCCP(O)(O)=O GJXWDTUCERCKIX-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229950006501 fosmidomycin Drugs 0.000 claims abstract description 18
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 239000007952 growth promoter Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 abstract description 13
- 240000007594 Oryza sativa Species 0.000 abstract description 4
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 235000009566 rice Nutrition 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 231100000053 low toxicity Toxicity 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- 239000012050 conventional carrier Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 235000019156 vitamin B Nutrition 0.000 description 6
- 239000011720 vitamin B Substances 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- 235000019733 Fish meal Nutrition 0.000 description 4
- 229930003270 Vitamin B Natural products 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 235000005822 corn Nutrition 0.000 description 4
- 239000004467 fishmeal Substances 0.000 description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 244000068988 Glycine max Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 235000019764 Soybean Meal Nutrition 0.000 description 3
- -1 amine salts Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000004455 soybean meal Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108010001478 Bacitracin Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004181 Flavomycin Substances 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 240000004658 Medicago sativa Species 0.000 description 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 229930003779 Vitamin B12 Natural products 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 229960003071 bacitracin Drugs 0.000 description 2
- 229930184125 bacitracin Natural products 0.000 description 2
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 2
- PERZMHJGZKHNGU-JGYWJTCASA-N bambermycin Chemical compound O([C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1NC(C)=O)O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@H](O1)C(=O)NC=1C(CCC=1O)=O)O)C)[C@H]1[C@@H](OP(O)(=O)OC[C@@H](OC\C=C(/C)CC\C=C\C(C)(C)CCC(=C)C\C=C(/C)CCC=C(C)C)C(O)=O)O[C@H](C(O)=O)[C@@](C)(O)[C@@H]1OC(N)=O PERZMHJGZKHNGU-JGYWJTCASA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 229910000361 cobalt sulfate Inorganic materials 0.000 description 2
- 229940044175 cobalt sulfate Drugs 0.000 description 2
- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
- 229910000365 copper sulfate Inorganic materials 0.000 description 2
- 229960000355 copper sulfate Drugs 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 235000019374 flavomycin Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 229910000358 iron sulfate Inorganic materials 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 235000006109 methionine Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960004839 potassium iodide Drugs 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- 150000003522 tetracyclines Chemical class 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- 235000019163 vitamin B12 Nutrition 0.000 description 2
- 239000011715 vitamin B12 Substances 0.000 description 2
- 229940046001 vitamin b complex Drugs 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
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- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- UOELMDIOCSFSEN-FVZZCGLESA-N 7-Dehydrositosterol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)C=C[C@H](C)C(C)C)=CC=C1C[C@@H](O)CCC1=C.C1[C@@H](O)CCC2(C)C(CC[C@@]3([C@@H]([C@H](C)C=C[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 UOELMDIOCSFSEN-FVZZCGLESA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
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- 235000013619 trace mineral Nutrition 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
Landscapes
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
星１五立五ユ旦１
この発明はホスミドマイシンまたはその塩類を含有する
ことを特徴とする動物成長促進剤に関するものである。DETAILED DESCRIPTION OF THE INVENTION This invention relates to an animal growth promoter characterized by containing fosmidomycin or a salt thereof.
８来のｔ術および当該 明が解決しようとするシ星Ａ
従来、家禽、家畜等の動物の成長促進を目的として、ペ
ニシリン、テトラサイクリン、バシトラシン等の抗生物
質が飼料に添加使用されているが必ずしも満足されるも
のではない。Conventionally, antibiotics such as penicillin, tetracycline, and bacitracin have been added to feed for the purpose of promoting the growth of animals such as poultry and livestock. It's not satisfying.
そこで、この発明者等はこのような従来使用きれている
抗生物質と化学構造、抗菌スペクトラムその他の点で全
く異なるユニークな抗生物質ホスミドマイシンまたはそ
の塩類が動物の成長を促進し、飼料要求率を改善し、動
物に対しても極めて低毒性であるという知見を得、さら
に鋭意研究の結果、この発明を完成した。Therefore, the inventors discovered that fosmidomycin, a unique antibiotic that is completely different from conventional antibiotics in terms of chemical structure, antibacterial spectrum, and other aspects, or its salts can promote animal growth and improve feed conversion rates. They obtained the knowledge that this product had improved properties and had extremely low toxicity to animals, and as a result of further intensive research, they completed this invention.
明の 成および 果
この発明で使用するホスミドマイシンは下記の化学式で
示きれ、緑膿菌に強い抗菌力を示す抗生物質として知ら
れている［例えば、特開昭５３−４０７２０号公報第２
６頁参照］。Fosmidomycin used in this invention is represented by the chemical formula below, and is known as an antibiotic that exhibits strong antibacterial activity against Pseudomonas aeruginosa [for example, JP-A-53-40720 No. 2]
See page 6].
すｈ
［３−（Ｎ−ホルミル−Ｎ−ヒドロキシアミノ）プロピ
ルホスホン酸］
ホスミドマイシンの塩類としては、例えばナトリウム塩
、カリウム塩、カルシウム塩、アルミニウム塩、アンモ
ニウム塩、マグネシウム塩、トリエチルアミン塩、エタ
ノールアミン塩、エチレンジアミン塩、Ｎ、Ｎ’ −ジ
ベンジルエチレンジアミン塩等の無機または有機塩基と
の塩類である動物薬として許容される塩類が挙げられる
。[3-(N-formyl-N-hydroxyamino)propylphosphonic acid] Examples of salts of fosmidomycin include sodium salt, potassium salt, calcium salt, aluminum salt, ammonium salt, magnesium salt, triethylamine salt, and ethanol. Examples include salts with inorganic or organic bases that are acceptable as veterinary drugs, such as amine salts, ethylenediamine salts, and N,N'-dibenzylethylenediamine salts.
この発明の動物成長促進剤を動物に投与する場合には、
直接ホスミドマイシンまたはその塩類を経口投与しても
よいが、一般には通常使用されている担体（例えば、脱
脂米ぬか、脱脂大豆粉、ふすま、カオリン、タルク、炭
酸カルシウム、乳糖等）と混合したものを投与するか、
あるいはこのようにして混合したものもしくはホスミド
マイシンまたはその塩類自体を動物飼料もしくは水と混
合して投与する方法が好ましい。When administering the animal growth promoter of this invention to animals,
Although fosmidomycin or its salts may be administered orally directly, it is generally mixed with commonly used carriers (e.g., defatted rice bran, defatted soybean flour, bran, kaolin, talc, calcium carbonate, lactose, etc.). or administer
Alternatively, it is preferable to administer the mixture or fosmidomycin or its salt itself by mixing it with animal feed or water.
この発明の動物成長促進剤の投与量は動物の種類、成長
時期等により異なるが、通常はホスミドマイシンとして
０．１〜４０ｍｇ／ ｋｇ／日の範囲内から最適投与量
が適宜選択される。The dosage of the animal growth promoter of the present invention varies depending on the type of animal, growth period, etc., but usually the optimal dosage is appropriately selected from the range of 0.1 to 40 mg/kg/day of fosmidomycin.
また、ここでホスミドマイシンまたはその塩類を動物飼
料と混合して使用する場合について詳述すると、動物用
飼料の形態は例えば配合飼料等の一般に使用きれる動物
用飼料であればいずれも使用可能である。そのような例
としては、例えばとうもろこし、米、麦、マイロ、大豆
粕、綿実粕、ふすま、脱脂米ぬか、魚粉、脱脂粉乳、乾
燥ホエー、油脂、アルファルファミール、戻酸カルシウ
ム、りん酸３カルシウム、塩化ナトリウム、塩化コリン
、ビタミン類（例えばビタミンＡ１ ビタミンＤ１ ビ
タミンＥ１ ビタミンＢ１、ビタミンＢ２、ビタミンＢ
６、ビタミンＢ１２、パントテン醋カルシウム、ニコチ
ン酸アミド、葉酸等）、アミノ酸類（例えばリジン、メ
チオニン等）、微量無機塩類（例えば硫酸マグネシウム
、硫酸鉄、硫酸銅、硫酸亜鉛、よう化カリウム、硫酸コ
バルト等）等の１部または全部を混合して調製した配合
飼料が挙げられる。さらに、この発明の動物成長促進剤
は上記のほか他の抗生物質や殺菌剤、防かび剤、駆虫剤
、抗コクシジウム剤、抗酸化剤、天然色素等を適宜添加
して使用してもよい。また、この発明の動物成長促進剤
の効果的な池の使用方法として、動物成長促進作用を有
する他の抗生物質（例えば、チオペブチン、エンラマイ
シン、バシトラシン、ミカマイシン、フラボマイシン、
フラボマイシン、パージニアマイシン、テトラサイクリ
ン、キタサマイシン、タイロシン、ケベマイシン等）を
添加併用してもよい。In addition, to explain in detail the case where fosmidomycin or its salts are mixed with animal feed, any form of animal feed that can be used in general, such as compound feed, can be used. be. Examples include corn, rice, wheat, milo, soybean meal, cottonseed meal, bran, skimmed rice bran, fishmeal, skim milk powder, dried whey, fats and oils, alfalfa meal, rehydrated calcium, tricalcium phosphate, chloride. Sodium, choline chloride, vitamins (e.g. vitamin A1, vitamin D1, vitamin E1, vitamin B1, vitamin B2, vitamin B
6. Vitamin B12, calcium pantothene, nicotinamide, folic acid, etc.), amino acids (e.g. lysine, methionine, etc.), trace mineral salts (e.g. magnesium sulfate, iron sulfate, copper sulfate, zinc sulfate, potassium iodide, cobalt sulfate) etc.), etc.), etc.). Furthermore, the animal growth promoter of the present invention may be used by appropriately adding other antibiotics, bactericides, fungicides, anthelmintic agents, anti-coccidial agents, antioxidants, natural pigments, etc. in addition to those mentioned above. In addition, as an effective method for using the animal growth promoter of the present invention, other antibiotics having animal growth promoting effects (for example, thiopebutin, enramycin, bacitracin, micamycin, flavomycin,
flavomycin, parginiamycin, tetracycline, kitasamycin, tylosin, kebemycin, etc.) may be added in combination.
また、飼料中のホスミドマイシンまたはその塩類の含有
量は飼料１ｔにつき、通常０．１〜５００ｇ。Further, the content of fosmidomycin or its salts in feed is usually 0.1 to 500 g per 1 ton of feed.
好ましくは１〜１００ｇの範囲内で適宜選択きれる。Preferably, the amount can be appropriately selected within the range of 1 to 100 g.
この発明の動物成長促進剤は動物一般に使用でき、その
例として例えば鶏、七面鳥、あひる、うずら、牛、馬、
豚、羊、やぎ、うさぎ、ミンク等の家禽および家畜が挙
げられる。The animal growth promoter of the present invention can be used for animals in general, such as chickens, turkeys, ducks, quail, cows, horses, etc.
Examples include poultry and livestock such as pigs, sheep, goats, rabbits, and mink.
この発明の動物成長促進剤を動物飼料と混合して用いる
場合における動物飼育法は、一般の動物飼育法がそのま
ま適用される。When the animal growth promoter of this invention is used in combination with animal feed, general animal breeding methods can be applied as they are.
この発明の動物成長促進剤は動物の成長を促進するのみ
ならず動物の飼料要求率を改善し、さらにホスミドマイ
シンが動物に対し、低毒性である等の特徴を有し、従来
のものに比較し優れている。The animal growth promoter of this invention not only promotes the growth of animals but also improves the animal's feed conversion rate, and has features such as low toxicity of fosmidomycin to animals, and is superior to conventional ones. Excellent in comparison.
次に、この発明の効果を試験例により説明する。Next, the effects of this invention will be explained using test examples.
試験例１
生後４０日令の子豚（ランドレース種）を１群２０頭（
雄１０頭、雌１０頭）ずつホスミドマイシン投与量（ホ
スミドマイシンを含有する飼料給与区）および対照区（
ホスミドマイシンを含有しない飼料給与区）に分けて、
下記組成の飼料を不断給与し、常法により飼育し、成育
状態を観察した。Test Example 1 A group of 20 piglets (Landrace breed) aged 40 days (
(10 males and 10 females) were administered fosmidomycin (fosmidomycin-containing feed feeding group) and control group (
Feeding areas that do not contain fosmidomycin)
The animals were fed a diet with the following composition ad libitum, reared in a conventional manner, and their growth status was observed.
結果を次表に示す。The results are shown in the table below.
飼料（人工乳）組成：
組 成 含有率（％）とうも
ろこし ６２．１５きな粉
７．０魚粉
５．０脱脂粉乳
１０．０大豆粕
１０．０グルコース
４．２燐酸カルシウム ０．５炭
酸カルシウム ０．３塩化ナトリ
ウム ０．２５リジン
０・１ビタミンＡＤ３Ｅ複合剤
０．２ビタミンＢ群複合剤
０．２微量無機塩類００，１
（＊ビタミンＢ拝復合剤組成：ビタミンＢ１、ビタミン
Ｂ ビタミンＢ ビタミンＢ１２、ビオチ２ゝ
６ ゝ
ン、葉酸およびパントテン酸カルシウム、以下同し；本
＊微量無機塩類組成：硫酸鉄、硫酸マンガン、硫酸亜鉛
、硫酸銅、硫酸コバルトおよびよう化カリウム、以下同
じ）
試験例２
肉用鶏初生びな（チャンキ一種）を１群２００羽（雄１
００羽、雌１００羽）ずつホスミドマイシン投与区（ホ
スミドマイシンを含有する飼料給与区）および対照区（
ホスミドマイシンを含有しない飼料給与区）に分け、下
記組成の飼料を不断給与し、常法により飼育し成育状態
を観察した。Feed (artificial milk) composition: Composition Content (%) Corn 62.15 Soybean flour
7.0 fishmeal
5.0 skimmed milk powder
10.0 Soybean meal
10.0 glucose
4.2 Calcium phosphate 0.5 Calcium carbonate 0.3 Sodium chloride 0.25 Lysine
0.1 Vitamin AD3E complex 0.2 Vitamin B complex complex
0.2 trace inorganic salts 00.1 (*Vitamin B compound composition: vitamin B1, vitamin B, vitamin B, vitamin B12, biotin 2.
6. Folic acid and calcium pantothenate, the same hereinafter; this *Trace inorganic salt composition: iron sulfate, manganese sulfate, zinc sulfate, copper sulfate, cobalt sulfate, and potassium iodide, the same hereinafter) Test Example 2 First-year chicken for meat A group of 200 Bina (a type of Chunki) (1 male)
00 birds and 100 females) in the fosmidomycin administration group (fed feed containing fosmidomycin) and in the control group (
The animals were divided into feed groups (feed containing no fosmidomycin), fed ad libitum with the following feed composition, reared in a conventional manner, and observed for growth.
結果は次表のとおりである。The results are shown in the table below.
飼料組成：
組 成 含有率（％）とうも
ろこし ５１．４０マイロ
１４．００大豆粕
２０．００魚粉
８，００アルフアルフア・ミール
３・００炭酸カルシウム
１．５０リン酸３カルシウム
１．００塩化ナトリウム ０．
５０ビタミンＡＤ３Ｅ複合剤 ０．
１０ビタミンＢ群複合剤” ０．２
０微量無機塩類”０．１０
ＤＬ−メチオニン ０．２０（率
ビタミン８拝復合剤組成：試験例１のそれに同じ、＊率
微量無機塩類組成：試験例１のそれに同じ）
次に、この発明の実施例を示す。Feed composition: Composition Content (%) Corn 51.40 mi
14.00 Soybean meal
20.00 fishmeal
8,00 Alfa Meal
3.00 Calcium carbonate
1.50 tricalcium phosphate
1.00 Sodium chloride 0.
50 vitamin AD3E complex 0.
10 vitamin B complex complex” 0.2
0 trace inorganic salts" 0.10 DL-methionine 0.20 (composition of vitamin 8 combination agent: same as that of Test Example 1, * composition of trace inorganic salts: same as that of Test Example 1) An example is shown.
実施例１
とうもろこし ６０１ｋｇ脱
脂大豆 ２５０に乙アルフ
ァルファ・ミール ２０ｋｇ魚粉
８０ｋｇ植物性油脂
２５ｋｇ炭酸カルシウム
１０ｋｇリン酸カルシウム
５ｋｇ塩化ナトリウム
３ｋｇビタミンＡＤ３Ｅ複合剤
１ｋｇビタミンＢ群複合剤
３ｋｇ微量微量塩類
１ｋｇＤＬ−メチオニン
２ｋｇホスミドマイシンのモノナトリウム塩
１０ｇ以上の成分を均一に混合して配合飼料とする。Example 1 Corn 601kg defatted soybeans 250 and Otsu alfalfa meal 20kg fishmeal
80kg vegetable oil
25kg calcium carbonate
10kg calcium phosphate
5kg sodium chloride
3kg vitamin AD3E complex
1kg vitamin B group complex
3kg trace salts
1kgDL-Methionine
2kg fosmidomycin monosodium salt
Mix 10g or more of the ingredients uniformly to make a compound feed.
Claims (1)
とする動物成長促進剤。An animal growth promoter characterized by containing fosmidomycin or a salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61282556A JPS63133952A (en) | 1986-11-26 | 1986-11-26 | Animal growth promotion agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61282556A JPS63133952A (en) | 1986-11-26 | 1986-11-26 | Animal growth promotion agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63133952A true JPS63133952A (en) | 1988-06-06 |
Family
ID=17654010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61282556A Pending JPS63133952A (en) | 1986-11-26 | 1986-11-26 | Animal growth promotion agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63133952A (en) |
-
1986
- 1986-11-26 JP JP61282556A patent/JPS63133952A/en active Pending
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