JPH03504729A - マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド - Google Patents

マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド

Info

Publication number
JPH03504729A
JPH03504729A JP50532590A JP50532590A JPH03504729A JP H03504729 A JPH03504729 A JP H03504729A JP 50532590 A JP50532590 A JP 50532590A JP 50532590 A JP50532590 A JP 50532590A JP H03504729 A JPH03504729 A JP H03504729A
Authority
JP
Japan
Prior art keywords
protein
polypeptide
hybrid
male
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP50532590A
Other languages
English (en)
Japanese (ja)
Inventor
クルマン，ジヤン‐マリー
オフヌン，モーリス
スメルクマン，セベ
Original Assignee
アンステイテユ・パストウール
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アンステイテユ・パストウール filed Critical アンステイテユ・パストウール
Publication of JPH03504729A publication Critical patent/JPH03504729A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP50532590A 1989-03-17 1990-03-16 マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド Pending JPH03504729A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8903557A FR2644463A1 (pt) 1989-03-17 1989-03-17
FR89/03557 1989-03-17

Publications (1)

Publication Number Publication Date
JPH03504729A true JPH03504729A (ja) 1991-10-17

Family

ID=9379821

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50532590A Pending JPH03504729A (ja) 1989-03-17 1990-03-16 マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド

Country Status (4)

Country Link
EP (1) EP0426787A1 (pt)
JP (1) JPH03504729A (pt)
FR (1) FR2644463A1 (pt)
WO (1) WO1990011360A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US6004811A (en) * 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US5843728A (en) * 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2615528B1 (fr) * 1987-05-18 1991-05-24 Pasteur Institut Procede de production d'un polypeptide ayant des proprietes choisies determinees, dans un organisme-hote transforme par un adn recombinant contenant des sequences nucleiques codant pour ce polypeptide et pour une proteine affine d'ose

Also Published As

Publication number Publication date
FR2644463A1 (pt) 1990-09-21
EP0426787A1 (fr) 1991-05-15
WO1990011360A1 (fr) 1990-10-04

Similar Documents

Publication Publication Date Title
Fiedler et al. Bimodal interaction of coatomer with the p24 family of putative cargo receptors
US4822606A (en) Immunosuppressive synthetic peptides and analogs thereof based on retroviral envelope sequences
JPH07501698A (ja) 二価特異性ヘテロ二量体
JPS60222429A (ja) 形質転換宿主細胞中にハイブリッド・ポリペプチドを発現させるｄｎａ発現ベクター
JPH04501051A (ja) 組換え型ｄｎａ由来ボルデテラ毒素サブユニット類似体
JP2635035B2 (ja) Ｃｙｓコドン修飾ＤＮＡ
US7504483B2 (en) α-β C4BP-type recombinant heteromultimeric proteins
KR20220116516A (ko) 변이형 rsv f 단백질 및 그 이용
KR960005181B1 (ko) 재조합 htlv-ⅲ 단백질 및 이의 용도
WO2019109954A1 (zh) PD-1-Fc融合蛋白及其制备方法和用途
EP0372352B1 (en) Aequorin fused with a protein having a specific-binding activity, its preparation, its purification and detection method by its use
JPH03504729A (ja) マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド
JP4307838B2 (ja) Ｇｐ１２０ウイルスタンパク質に対して親和性を示すペプチド、およびその使用
JPH10509038A (ja) 免疫、精製及び検出適用のためのたんぱく質、ペプチド及び複合物の高い水準の発現と容易な精製
JP2718827B2 (ja) 分泌Ｍａｃ−２結合糖タンパク質
JPS63502000A (ja) エイズウイルス遺伝子発現
EP0303625B1 (en) Polypeptide competitor for immunoglobulin e
JPH03155787A (ja) Ｅｂｚｄ蛋白質発現系
CN115057938B (zh) 抗新型冠状病毒人源化多价结合蛋白及其应用
JPH01206998A (ja) 細胞接着活性ポリペプチド
Gupta et al. Recombinant fusion proteins for haemagglutination-based rapid detection of antibodies to HIV in whole blood
JPH04506605A (ja) トランス活性化作用を有するタンパク質、前記タンパク質を発現させるベクター、セルラインおよびその使用
JPS61233700A (ja) 分子クロ−ンされたエイズ関連ポリペプチド
Radford et al. Antibodies against an inter‐domain segment of polypeptide chain inhibit active‐site coupling in the pyruvate dehydrogenase multienzyme complex
CN110759975B (zh) 一种多肽以及具有强adcc效应的抗体和应用