JPH0326881Y2 - - Google Patents
Info
- Publication number
- JPH0326881Y2 JPH0326881Y2 JP1985045590U JP4559085U JPH0326881Y2 JP H0326881 Y2 JPH0326881 Y2 JP H0326881Y2 JP 1985045590 U JP1985045590 U JP 1985045590U JP 4559085 U JP4559085 U JP 4559085U JP H0326881 Y2 JPH0326881 Y2 JP H0326881Y2
- Authority
- JP
- Japan
- Prior art keywords
- extraction
- liquid
- coil
- specimen
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000605 extraction Methods 0.000 claims description 72
- 239000007788 liquid Substances 0.000 claims description 47
- 239000003814 drug Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 19
- 238000000926 separation method Methods 0.000 claims description 9
- 239000010409 thin film Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- BGPVFRJUHWVFKM-UHFFFAOYSA-N N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] Chemical compound N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] BGPVFRJUHWVFKM-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 241000777300 Congiopodidae Species 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Extraction Or Liquid Replacement (AREA)
Description
【考案の詳細な説明】
〔産業上の利用分野〕
この考案は競走馬の尿等の検体から薬物を検出
するための薬物抽出装置に関するものである。[Detailed description of the invention] [Field of industrial application] This invention relates to a drug extraction device for detecting drugs from specimens such as racehorse urine.
第２図は従来の薬物抽出装置の断面図である。
図において、１は回転カツプで容器２内に設けら
れ、モータ３によつて回転する回転磁石４に対応
して設けられた磁石５によつて回転するようにな
つている。
FIG. 2 is a sectional view of a conventional drug extraction device.
In the figure, reference numeral 1 denotes a rotating cup, which is provided in a container 2 and is rotated by a magnet 5 provided in correspondence with a rotating magnet 4 rotated by a motor 3.
従来の薬物抽出方法は、検体６およびこの検体
６に対し難溶性で比重差の大きい抽出用液７を回
転カツプ１に入れ、モータ３を回転カツプ１を高
速回転させ、カツプ内壁に検体６および抽出用液
７の２液の膜を作り、検体６内の薬物を抽出用液
７に抽出させる。その後回転を停止し、両液を回
転カツプ１の底に留めた後、再度回転カツプ１を
高速回転させ、新たな膜で抽出を行わせる。この
ような抽出操作を十数回行うことにより薬物の抽
出量を増加させる。そして抽出終了後抽出用液７
のみをポンプにて吸引し、乾燥系に吐出する。 In the conventional drug extraction method, a sample 6 and an extraction liquid 7 that is poorly soluble with respect to the sample 6 and has a large difference in specific gravity are placed in a rotating cup 1, and the motor 3 rotates the rotating cup 1 at high speed to infuse the sample 6 and the sample 6 onto the inner wall of the cup. A two-liquid membrane of the extraction liquid 7 is made, and the drug in the specimen 6 is extracted by the extraction liquid 7. After that, the rotation is stopped and both liquids are kept at the bottom of the rotary cup 1, and then the rotary cup 1 is rotated at high speed again to perform extraction using a new membrane. By performing this extraction operation more than ten times, the amount of extracted drug is increased. After the extraction is complete, the extraction liquid 7
The liquid is sucked up using a pump and discharged into the drying system.
しかしながら、このような従来の薬物抽出装置
においては、回転カツプを高速回転させるので、
抽出装置が大掛りとなり、構造が複雑であるとと
もに、高温でかつ抽出用液としてクロロホルム等
の溶剤を用いるためベアリングの寿命が短くな
り、さらにカツプ内に大量の空気があるためエマ
ルジヨン化するなどの問題点があつた。
However, in such conventional drug extraction devices, the rotary cup is rotated at high speed.
The extraction equipment is large and has a complicated structure, and the life of the bearings is shortened due to the high temperatures and the use of solvents such as chloroform as the extraction liquid.Furthermore, there is a large amount of air inside the cup, which causes problems such as emulsion formation. There was a problem.
この考案は以上のような問題点を解決するため
のもので、簡単な装置および操作により、エマル
ジヨン化を防止して、効率よく薬物の抽出を行う
ことができる薬物抽出装置を提供することを目的
としている。 The purpose of this invention is to solve the above-mentioned problems, and the purpose is to provide a drug extraction device that can prevent emulsion and efficiently extract drugs using a simple device and operation. It is said that
この考案は、検体が管内壁に付着して薄膜を形
成可能な細いチユーブからなる抽出コイルと、こ
の抽出コイルに検体および抽出用液をこの順序で
供給して、検体を抽出コイルの内壁に付着させて
その内側を抽出用液が進行するように往復動させ
て抽出を行うポンプと、前記抽出コイルで抽出を
行つた液を分離する分離槽とを備えた薬物抽出装
置である。
This device consists of an extraction coil consisting of a thin tube that allows the specimen to adhere to the inner wall of the tube and form a thin film, and a specimen and extraction liquid to be supplied to this extraction coil in this order so that the specimen adheres to the inner wall of the extraction coil. This drug extraction device is equipped with a pump that performs extraction by reciprocating the inside of the pump so that the extraction liquid advances, and a separation tank that separates the liquid extracted by the extraction coil.
薬物抽出方法は、ポンプにより検体および抽出
用液をこの順序で抽出コイルに供給して、検体を
抽出コイルの内壁に付着させ、その内側を抽出用
液が進行するように吸引、吐出を繰返えして液を
往復動させ、２液を接触させて抽出を行い、その
後液を分離槽において分離する。
The drug extraction method involves supplying the sample and extraction liquid to the extraction coil in this order using a pump, allowing the sample to adhere to the inner wall of the extraction coil, and repeating suction and ejection so that the extraction liquid advances inside the coil. The liquids are reciprocated to bring the two liquids into contact for extraction, and then the liquids are separated in a separation tank.
これにより連続したフロー系の中で抽出が効率
よく行われ、エマルジヨンの発生や故障もない。 This allows efficient extraction in a continuous flow system, without the generation of emulsions or malfunctions.
以下、この考案を図面の実施例により説明す
る。第１図はこの考案の実施例を示す系統図であ
る。図において、１１は検体容器で、中に検体６
が収容されている。１２は抽出用液容器で、クロ
ロホルム等の検体６に対して難溶性でかつ比重差
の大きい抽出用液７が収容されている。V1は四
方弁で、管１３，１４，１５，１６を介して検体
容器１１、抽出用液容器１２、ポンプP1および
四方弁V2に連絡している。四方弁V2はさらに管
１７，１８，１９を介してポンプP2、抽出コイ
ル２０および洗浄液容器２１に連絡している。
This invention will be explained below with reference to embodiments of the drawings. FIG. 1 is a system diagram showing an embodiment of this invention. In the figure, 11 is a sample container with 6 samples inside.
is accommodated. Reference numeral 12 denotes an extraction liquid container, which contains an extraction liquid 7, such as chloroform, which is poorly soluble in the specimen 6 and has a large difference in specific gravity. V 1 is a four-way valve that communicates via pipes 13, 14, 15, and 16 with the sample container 11, the extraction liquid container 12, the pump P 1 , and the four-way valve V 2 . The four-way valve V 2 further communicates via pipes 17, 18, 19 with a pump P 2 , an extraction coil 20 and a washing liquid container 21 .
抽出コイル２０は内径２〜３mmの細いチユーブ
をコイル状に巻いたもので、注入される検体が完
全に管内壁に付着して膜を形成できる程度の長さ
を有している。洗浄液容器２１には水等の洗浄液
２２が収容されている。２３は分離槽で、管２
４，２５，２６を介して抽出コイル２０、二方弁
V3および三方弁V4に連絡している。二方弁V3に
は加圧系２７が連絡し、三方弁V4には乾燥系２
８およびドレン系２９が連絡している。 The extraction coil 20 is a thin tube with an inner diameter of 2 to 3 mm wound into a coil, and has a length that allows the sample to be injected to completely adhere to the inner wall of the tube and form a film. The cleaning liquid container 21 contains a cleaning liquid 22 such as water. 23 is a separation tank, pipe 2
Extraction coil 20 through 4, 25, 26, two-way valve
Connecting to V 3 and three-way valve V 4 . A pressurizing system 27 is connected to the two-way valve V3 , and a drying system 2 is connected to the three-way valve V4 .
8 and drain system 29 are in communication.
以上の構成において、薬物の抽出方法は、まず
弁V1，V2を図のようにしてポンプP2により検体
容器１１から検体６を吸引し、弁V1，V2間にセ
ツトする。次に弁V1を切替えてポンプP1により
抽出用液容器１２から抽出用液７を吸引し、ポン
プP1内に留めておく。そして弁V1，V2を切換え、
ポンプP1より内部に留めた抽出用液を吐出し、
弁V1，V2間の検体を抽出用液で抽出コイル２０
に押出す。 In the above configuration, the method for extracting the drug is to first aspirate the sample 6 from the sample container 11 with the pump P2 with the valves V 1 and V 2 as shown in the figure, and then set the sample 6 between the valves V 1 and V 2 . Next, the valve V 1 is switched, and the extraction liquid 7 is sucked from the extraction liquid container 12 by the pump P 1 and kept in the pump P 1 . Then, switch valves V 1 and V 2 ,
The extraction liquid retained inside is discharged from pump P1 ,
Extract the sample between valves V 1 and V 2 with extraction liquid using coil 20
Extrude to.
このとき一定の内径を持つたチユーブ内に入つ
ている検体に接して抽出用液を送り込むと、管内
壁より中心部分の流速が速いため、検体の一部を
管内壁に残して抽出用液が中心部を進み、検体は
管１６および抽出コイル２０の管内壁に付着して
薄膜を形成し、その内側を抽出用液が進行して２
液の接触面が増大し、検体中の薬物が抽出用液側
に移行し、抽出が効率よく行われる。 At this time, when the extraction liquid is sent in contact with the sample contained in a tube with a certain inner diameter, the flow rate in the center part is faster than the inner wall of the tube, so some of the sample remains on the inner wall of the tube and the extraction liquid flows. Proceeding through the center, the sample adheres to the inner walls of the tube 16 and the extraction coil 20 to form a thin film, and the extraction liquid advances inside the tube to form a thin film.
The contact surface of the liquid is increased, the drug in the specimen is transferred to the extraction liquid side, and extraction is performed efficiently.
ポンプP1で抽出用液を吐出後、同じ状態で吸
引を行い、この操作を繰返えして液を往復動さ
せ、検体と抽出用液を十分接触させて抽出を行
う。 After discharging the extraction liquid with the pump P1 , suction is performed in the same state, and this operation is repeated to move the liquid back and forth, bringing the specimen into sufficient contact with the extraction liquid to perform extraction.
抽出終了後ポンプP1により管１６および抽出
コイル２０内の液を分離槽２３に吐出する。この
とき必要により抽出用液容器１２から追加の抽出
用液を吸引して分離槽２３に吐出してもよい。分
離槽２３に吐出された液は静置により分離するの
で、加圧系２７を用いて分離した抽出用液のみを
乾燥系２８に吐出し、抽出用液を蒸発させて薬物
を濃縮する。分離した検体は弁V4を切換えてド
レン系２９に排出する。 After the extraction is completed, the liquid in the pipe 16 and the extraction coil 20 is discharged into the separation tank 23 by the pump P1 . At this time, additional extraction liquid may be sucked from the extraction liquid container 12 and discharged into the separation tank 23 if necessary. Since the liquid discharged into the separation tank 23 is separated by standing still, only the extraction liquid separated using the pressurizing system 27 is discharged into the drying system 28, and the extraction liquid is evaporated to concentrate the drug. The separated specimen is discharged into the drain system 29 by switching the valve V4 .
以上の操作終了後、弁V1，V2を切換え、洗浄
液容器２１からポンプP1および（または）P2に
より洗浄液２２を吸引し、管１６および抽出コイ
ル２０を通して分離槽２３に吐出し、さらにドレ
ン系２９に排出して洗浄を行い、管内壁等に付着
した検体を洗い流す。 After the above operations are completed, the valves V 1 and V 2 are switched, the cleaning liquid 22 is sucked from the cleaning liquid container 21 by the pump P 1 and/or P 2 , and is discharged into the separation tank 23 through the pipe 16 and the extraction coil 20. The sample is discharged into the drain system 29 for cleaning, and the specimen adhering to the inner wall of the pipe is washed away.
上記の薬物抽出装置では連続したフロー系で抽
出が行われるため、装置の構造および操作が簡単
であり、駆動部分がないため故障もなく、また空
気の入る余地がないためエマルジヨン化を防ぐこ
とができ、接触効率の高いため、効率よく抽出を
行うことができる。 The drug extraction device described above performs extraction using a continuous flow system, so the structure and operation of the device is simple, there is no driving part, so there is no failure, and there is no room for air to enter, which prevents emulsion formation. Since the contact efficiency is high, extraction can be carried out efficiently.
以上のとおり、本考案によれば、抽出コイルの
内壁に検体を付着させ、その内側を抽出用液が進
行するように往復動させて薬物の抽出を行うよう
にしたので、簡単な装置および操作により、エマ
ルジヨン化を防止して、効率よく薬物の抽出を行
うことができる。
As described above, according to the present invention, the sample is attached to the inner wall of the extraction coil, and the drug is extracted by reciprocating the inside of the coil so that the extraction liquid advances. This prevents emulsion and enables efficient drug extraction.
第１図はこの考案の実施例の系統図、第２図は
従来の薬物抽出装置の断面図である。各図中、同
一符号は同一部分を示し、６は検体、７は抽出用
液、２０は抽出コイル、２３は分離槽、P1，P2
はポンプである。
FIG. 1 is a system diagram of an embodiment of this invention, and FIG. 2 is a sectional view of a conventional drug extraction device. In each figure, the same reference numerals indicate the same parts, 6 is the specimen, 7 is the extraction liquid, 20 is the extraction coil, 23 is the separation tank, P 1 , P 2
is a pump.
Claims (1)
チユーブからなる抽出コイルと、この抽出コイル
に検体および抽出用液をこの順序で供給して、検
体を抽出コイルの内壁に付着させその内側を抽出
用液が進行するように往復動させて抽出を行うポ
ンプと、前記抽出コイルで抽出を行つた液を分離
する分離槽とを備えた薬物抽出装置。 The extraction coil consists of a thin tube that allows the specimen to adhere to the inner wall of the tube and form a thin film, and the specimen and extraction liquid are supplied to this extraction coil in this order so that the specimen adheres to the inner wall of the extraction coil and the inside of the tube is coated. A drug extraction device comprising: a pump that performs extraction by reciprocating the extraction liquid so that it advances; and a separation tank that separates the liquid extracted by the extraction coil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1985045590U JPH0326881Y2 (en) | 1985-03-28 | 1985-03-28 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1985045590U JPH0326881Y2 (en) | 1985-03-28 | 1985-03-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61163003U JPS61163003U (en) | 1986-10-09 |
| JPH0326881Y2 true JPH0326881Y2 (en) | 1991-06-11 |
Family
ID=30559220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1985045590U Expired JPH0326881Y2 (en) | 1985-03-28 | 1985-03-28 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0326881Y2 (en) |
-
1985
- 1985-03-28 JP JP1985045590U patent/JPH0326881Y2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61163003U (en) | 1986-10-09 |
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