JPH03227908A - Enzyme-formulated toiletry product - Google Patents

Abstract

PURPOSE:To obtain the title product with the enzyme stabilized, capable of promoting protein-degradative activity by incorporating a powdery or granular enzyme-formulated toiletry product composition with a peptide such as collagen, albumin or elastin. CONSTITUTION:The objective product can be obtained by incorporating (A) powdery or granular enzyme-containing toiletry product composition with (B) pref. 001-20.0 (esp. 0.05-10.0)wt.% of a peptide such as collagen, albumin or elastin. The present product is stabilized in the enzyme contained and capable of promoting protein degradative activity, also having favorable use feeling with the effects unique to the enzyme induced. Incorporation of the peptide plays a role of promoting the performance of the present toiletry product. The present products include bath agents, cleansing bases, powdery detergents for clothes, body powder, tooth powder, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application The present invention relates to an enzyme-containing toiletry product containing an enzyme and having a powdered or granular dosage form.

(b) Conventional technology It has been known that enzymes with proteolytic ability are added to toiletry products to promote the action of toiletry products by releasing the dissolution of skin keratin and promoting the decomposition of dirt. ing.

(c) Problems to be solved by the invention However, due to the inherent properties of enzymes, it is difficult to maintain and stabilize their activity over a long period of time in toiletry products. The decomposition ability was lowered, and the skin cleansing effect touted as an effective effect could not be obtained sufficiently. In addition, simply incorporating enzymes into toiletry products will not protect the skin by dissolving and removing the skin keratin, and furthermore, conventional powdered and granular toiletry products will not leave the skin feeling moisturized after use. Compared to liquid toiletry products containing base ingredients such as polyhydric alcohols, the feeling of use is not superior, but powdered and granular products with satisfactory long-term stabilization of enzyme activity and a good feeling of use. J. Development of elementary products is desired.

For example, in Japanese Patent Publication No. 59-341.12, the immobilization of enzymes with collagen was reported for the purpose of long-term stabilization of enzymes. However, since it forms a collagen membrane and stabilizes enzyme activity over a long period of time, it has poor reactivity with substrates and has a slow initial activation rate, making it difficult to use toiletry products. In addition, special manufacturing methods are required, and enzyme activity may decrease during the manufacturing process. In order to obtain the desired enzyme activity in toiletry products, it is difficult to obtain the desired enzyme activity. It was also extremely expensive.

(d) Means for solving the problems In the present invention, as a result of continuous research and development aimed at long-term stabilization of practical enzymes in toiletry products having dosage forms such as powder and granules, Peptides such as collagen, albumin, elastin, etc. are added to the composition of enzyme-containing toiletry products in the form of powders, granules, etc. for 08 to 20 minutes. Ow/v% preferably 0.05 to L0. Ow
/w% stabilizes the enzyme, promotes proteolytic action, provides a good feeling of use that is not found in conventional powdered or granular toiletry products, produces effects unique to enzymes, and furthermore By blending peptides such as collagen, albumin, and elastin into powdered toiletry products that have proteolytic power, the peptides such as collagen, albumin, and elastin form a film on the skin after washing, and each toiletry product is The aim is to provide toiletry products containing enzymes that enhance the action of the product.

For example, in order to promote the action of bath additives, bath additive base ingredients such as inorganic salts act on the skin that has been cleansed through keratolysis by enzymes, promoting blood circulation, and collagen and collagen are added to the body, which has an increased heat retention effect. Peptides such as albumin and elastin form a film that maintains the heat retention effect and prevents the water from getting cold.

In addition, in order to promote the action of cleansing toiletry products such as facial cleansing powder, peptides such as collagen, albumin, and elastin form a film on the skin that has been purified by keratin decomposition by enzymes. It prevents skin irritation, skin roughness and cracking caused by degreasing, and maintains normal skin.

Here, examples of toiletry products in the form of powder, granules, etc. include bath salts, facial cleansers, powdered laundry detergents,
Refers to toiletry products such as body powder and powdered toothpaste.

Enzymes with proteolytic activity include proteases of microbial origin such as ASP protease, B, sub protease, and actinomycete protease, and proteases of plant or animal origin such as papain, promelain, and pancreatin. Depending on the purpose, one or more can be used, but the invention is not limited to these.

In addition, the peptide used as the stabilizer varies depending on the intended toiletry product, but any one or more of collagen, albumin, and elastin can be used, but the stabilizer is not limited thereto.

The base ingredients of Toy 1 Notari products are not particularly limited as long as they have a dosage form such as powder or granules, and can be arbitrarily selected depending on the purpose of each toiletry product. For example, in the case of powdered bath agent bases, sodium bicarbonate, thorium carbonate,
Inorganic salts such as sodium sesquicarbonate, sodium sulfate, thorium thiosulfate, and borax;
Spruce, Angelica, Jasmine, Gingerbread,
Carrot, Keihi, Peony, Scutellariae, Zanshishi,
Herbal medicines such as Bukuriyou, Dokukat, Gaiyo, Matsubusa, Biyaku, Jyuyaku, Chinpi, Calamus, Lavender, Zaffron, Auricularia, Fennel, Chamomile, Campifolia, Glycerin as a pigment solubilizer, 11,3-butylene glycol, propylene glycol, etc. A powdered bath agent base can be prepared by mixing polyhydric alcohols, coloring agents, and fragrances, but the bath agent base components are not limited to these.

In the case of facial cleansing powder bases, colorants such as talc, corn starch, calcium carbonate, crystalline cellulose, lactose, dextrin, maltose, maltitol, sodium lauryl sulfate, sodium acylglutamate, carboxymethyl cellulose, and sodium polyacrylate are used. , fragrances, preservatives, etc. can be mixed to form the base component of the facial cleansing powder, but the base component is not limited to these facial cleansing powder base components.

(e) Actions and Effects The enzyme-containing toiletry product described above can provide the following effects.

- By incorporating peptides such as collagen, albumin, and elastin, enzymes with proteolytic ability can be stabilized for a long time.

- By incorporating peptides such as collagen, albumin, and elastin, it is possible to obtain a good feeling of use that is not found in conventional toiletry products such as powdered and granular forms.

■The technology of the present invention does not require special manufacturing methods and can be used for all powdered and granular toiletry products.

- By incorporating peptides such as collagen, albumin, and elastin, a film can be formed on the skin and the effects of each toiletry product can be enhanced.

(f) Examples Hereinafter, specific examples of the present invention will be described.

[First Example] The feeling of use and the stability of enzyme activity of a powdered control enzyme bath additive having the ingredient composition shown in Table 1 and the enzyme bath additive according to the present invention were compared.

Table 2 shows the test results for the feeling of use, and FIG. 1 shows the results for the stability of enzyme activity.

Here, the evaluation test method for enzyme activity is to color allyl-amino acid calculated by substrate reaction using Folin reaction, and compare the colors at an absorbance of 13BOnm, with a coloration degree equivalent to 1 μg of tyrosine per minute. is considered as 1 unit, and the titer is evaluated.

Table 1 (w/w%) Table 2 As is clear from Table 2, the enzyme bath additive according to the present invention has the following properties: skin cleansing and heat retention (heat retention), which determines its suitability as a bath additive. ) Furthermore, it has better skin moisturizing properties than the control enzyme bath additive.

Regarding the stability of the enzyme, as is clear from FIG. 1, the enzyme bath additive according to the present invention exhibits sufficient and long-term stable enzyme activity compared to the control enzyme bath additive.

[Second Example] A powdered control enzyme facial cleansing powder having the ingredient composition shown in Table 3 was compared with the enzyme facial cleansing powder according to the present invention in terms of feeling of use and stability of enzyme activity. Table 4 shows the test results for the feeling of use, and FIG. 2 shows the results for the activity stability of the enzyme.

Here, the enzyme activity evaluation test method was performed in the same manner as in the first example.

Table 3 (w/w%) Table 4 As is clear from Table 4, the enzyme facial cleansing powder according to the present invention has cleansing power and skin irritation, which determine whether it is good or bad as a facial cleansing powder, and also It has better properties than the control enzyme facial cleansing powder in terms of skin normalization and moisture.

Regarding enzyme stability, as is clear from FIG. 2, the enzyme facial cleansing powder according to the present invention exhibits sufficient and long-term stable enzyme activity compared to the control enzyme facial cleansing powder.

As mentioned above, by incorporating peptides such as collagen, albumin, and elastin into powdered toiletry products with proteolytic ability, long-term enzyme stabilization is achieved, which is not found in conventional powdered or granular toiletry products. , and enhance the effectiveness of each toiletry product, making it possible to obtain a product with a good feeling of use.

This combines the cleaning power of enzymes with collagen, albumin,
Peptides such as elastin are stabilized for a long period of time, and peptides such as collagen, albumin, and elastin form a film on the skin after washing, thereby enhancing the effectiveness of each toiletry product.

In addition, since other toiletry products may have similar thread compositions, the preferred component compositions of these toiletry products are shown below.

1) 19 actinomycete proteases (80,000 units/g) in 100g of body powder wood invention product 4.0
0g2, collagen 1.5
0g3, albumin 1.50
g4, magnesium stearate 5.50g
5. Talc 84.1
0g6, clove oil 3・o
og7, fragrance 0.40
g total
100.00g2) Powdered laundry detergent 1 in 100g of the invention product, actinomycete protease (80,000 units/g) 2. o
og2, Promeline (100,000 units/g)
a, oog3, bacterial lipase (20,000 units/g)
1.50g4, elastin
1.70g5, albumin
0.90g 6, sodium α-olefin sulfonate 7, sodium carbonate 8, sodium sulfate 9, fragrance total 33.20g 22.00g 34.70g 1.00g 1oo, oog [margin below] 3) Powder toothpaste present invention 2.20g in 100g of product 2.00g 1.50g 1, oOg 82.34g 10.30g 0.20g 0.01g 0.45g 100.00g ■, Papain (60,000 units/g) 2, Promeline (120,000 units/g) Units/g) 3. Lysozyme chloride 4, Collagen 5, Calcium hydrogen phosphate 6, Sodium lauryl sulfate 7, Saccharin 8, Blue No. 1 9, Flavor total [Margin below]

[Brief explanation of drawings]

FIG. 1 is a graph showing the stability of the enzyme according to the first example of the toiletry product according to the present invention, and FIG. 2 is a graph showing the stability of the enzyme according to the second example among the toiletry products according to the present invention. This is a graph showing the characteristics.

Claims (1)

[Claims] 1) Enzyme-containing toiletry products in powdered, granular, or other dosage forms, which are characterized by containing enzymes with proteolytic ability and peptides such as collagen, elastin, and albumin.