JPH03161432A - Cataplasm - Google Patents

Abstract

PURPOSE:To provide a cataplasm made up of a substrate and an ointment having excellent followability even for the sites with complicate mobility such as the scruff of the neck and the flank, using, as the substrate, a stretchable one with each specified modulus and rigidity determined by the JIS general fabric test. CONSTITUTION:The objective cataplasm to be used as a plaster, etc., made up of a substrate and an ointment. The substrate is a stretchable one with a 50% modulus 0.1-2.0 (pref. 0.1-0.8)kg/5cm and a rigidity determined by the JIS general fabric test of 0.200-0.650 (pref. 0.250-0.450) in terms of drape factor. The present cataplasm is excellent in followability even for human skin of vigorously mobile or complicated sites such as the joints, the scruff of the neck and the flank, therefore, being resistant to debonding off the skin, high in adherability, and having high therapeutic effect with the good cooling effect of the ointment and the high absorbability for active ingredients.

Description

[Detailed description of the invention] Industrial application The present invention relates to a patch used as a poultice, a plaster, etc. Conventionally, the patch used as a poultice, a plaster, etc. has been used as a patch to be applied to the skin.
Plasters are frequently used. In particular, research into poultices has progressed in recent years, and hydrogel plasters with high adhesive strength have been developed, eliminating the need for fixing them to the skin with adhesive tape, etc. (Japanese Patent Laid-Open Nos. 59-110617 and 59-13718). .

However, the lint cloth and non-woven fabric used as a support for conventional poultices have almost no elasticity, so when applied once, they cannot follow the movement of the human skin and may peel off from the skin. There were many things I ended up doing.

To solve this problem, poultices using stretchable non-woven fabrics or stretchable knitted fabrics have been developed (
JP-A-63-122621, JP-A-1-1212
Publication No. 14, Publication No. 1-197434, Publication No. 1-228
Publication No. 911). However, even when these elastic supports are used, although they show some degree of tracking ability in areas such as elbows and knees, they have poor tracking ability in areas where the skin makes complex movements, such as the neck and flanks. The problem was that it peeled off easily. The purpose of the present invention is to provide a patch that exhibits excellent followability even in areas that undergo complex movements, such as the neck and flanks.

The patch of the present invention has a support part and a plaster part, and the support part has a 50% modulus of 0.
1-2.0kg/5cm, and the drape coefficient is 0.200 to 0 according to the JIS general textile test method.
．． It is characterized by using a stretchable support made of No. 650.

The present invention will be explained in more detail below.

Even in the human body, the skin on elbows, knees, neck, etc. has particularly high elasticity.
The expansion/contraction rate of these parts reaches a maximum of 1.4 to 1.5 times. Therefore, the support for the patch applied to these areas is required to have an elongation rate of up to 1.5 times its original length. Also, the load (50% modulus) to stretch the length to 1.5 times the maximum elongation (50% elongation)
Although the value of will vary depending on the adhesive strength of the plaster itself, it is desirable that it be as small as possible. But on the other hand, 5
If the 0% modulus value becomes too small, the strength will decrease and the suitability for plaster coating will deteriorate. Therefore, in the present invention, the 50% modulus is 0.1-2.0 kg/5 cm,
Preferably a support of 0.1-0.8 kg/5 cm is used. Note that even if the support of the present invention satisfies this modulus value only in the vertical direction, it can be used in both the vertical and horizontal directions (all directions).
may satisfy this value, and the latter is preferable.

The 50% modulus value is measured as follows.

That is, using a tensile strength testing machine for a 50 mm x 300 mm specimen, the test length was 200 mm, and the tensile speed was 200 mm.
/min to 100cm, this strength (kg)
is measured and taken as the 50% modulus.

However, the effects of the present invention cannot be obtained only by satisfying the above 50% modulus value. In areas where the skin is soft and makes complex movements, such as the neck and flanks, sufficient followability cannot be obtained simply by providing elasticity to the support. Therefore, in the present invention, the above-mentioned conformability is improved by imparting appropriate flexibility to the support in addition to stretchability. JIS general textile testing method (JIS L 1096-
(1979), the drape coefficient is 0. 200
~0.650, preferably 0.250-0.450 support is used. When the drape coefficient exceeds 0.650, the flexibility is poor and the followability to the skin is insufficient. On the other hand, the drape coefficient is 0. If it is less than 200, it is too soft and difficult to apply to the skin, resulting in poor usability. The type of support that satisfies the above conditions may be any of woven fabrics, knitted fabrics, nonwoven fabrics, polymer films, or laminates thereof, but nonwoven fabrics or laminates of nonwoven fabrics and polymer films are particularly preferred. The material of the nonwoven fabric is not particularly limited, but it is desirable to use thermoplastic fibers alone or a blend of thermoplastic fibers and non-thermoplastic fibers. Further, as the polymer film, a urethane polymer film is preferable.

Examples of thermoplastic fibers include polyester fibers, polyethylene fibers, polypropylene fibers, polyamide fibers, polyvinyl chloride fibers, and polyvinyl alcohol fibers, which may be used alone or in combination of two or more. Non-thermoplastic fibers include rayon, cupola, hemp,
Examples include silk.

The method for producing a nonwoven fabric using these fibers is not particularly limited, but for example, two types of fibers with different heat shrinkage rates are pasted together and integrated by a double punch method, a spunlace method, etc. There is a method of causing thermal contraction through heat treatment to make it stretchable. In particular, in order to reduce the drape coefficient, the Suban lace method is preferable.

As the paste for the patch of the present invention, conventionally used pastes, such as those prepared by sufficiently kneading medicinal extracts, water-soluble polymers, mineral powders, hardeners, and water, can be used.

The medicinal ingredients are not particularly limited, but include, for example, methyl salicylate, glycol salicylate, indomethacin,
Ketoprofen, flurbiprofen, ibuprofen, diclofenac sodium, mefepmic acid and its derivatives, flufenamic acid and its derivatives, bufexamac, ibufenac, alclofenac, prednisolone, hydrocortisone acetate, dekitamesone, Shinichi menthol, dQ camphor, crotamiton , diphenhydramine hydrochloride, chlorpheniramine maleate, tocopherol acetate, vanillylamide nonylic acid, naproxen, piroxicam, capsaicin, powdered crude drugs such as Vasperica nigra, soft extracts of herbal medicines such as capsicum extract, dried extracts of crude drugs such as Dried extract of Macaroni spp., etc. These include herbal medicine extracts, herbal medicine tinctures such as arnica tincture, and essential oils such as peppermint oil and cinnamon bark oil.

Water-soluble polymers include gelatin, pectin, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone,
vinyl acetate copolymer, polyethylene oxide,
Examples include sodium carboxymethylcellulose, hydroxybutylated cellulose, methylcellulose, sodium alginate, xanthan gum, gum albia, gum tragacanth, gum karaya, methinolevinolether, and pyrohydric maleic acid copolymer.

Examples of the mineral powder include kaolin, bentonite, montmolystite, zinc oxide, titanium oxide, and silicic anhydride.

Examples of the hardening agent include potassium aluminum sulfate, magnesium aluminate silicate, aluminum hydroxide, magnesium alumina hydroxide, magnesium aluminate metasilicate, synthetic hydrotalcite, dihydroxyaluminum aminoacetate, and the like.

In addition, humectants such as glycerin, sorbitol, and propylene glycol, and surfactants such as polysorbate 80, polyoxyethylene hydrogenated castor oil, and glycerin fatty acid esters can be blended.

In addition, in the patch of the present invention, in order to take full advantage of the elasticity of the support, it is desirable that the adhesive strength of the plaster is sufficiently strong, and the adhesive strength by pole tack method is Nα4 or more, preferably Nα10 or more. It is desirable that

The adhesive patch of the present invention can be produced by applying a plaster to the above-mentioned support by a known method.

According to the present invention, the 50% modulus is 0.1 to 2.0k.
g/cm. And the drape coefficient is 0. 200 ~0.6
By using 50 supports, it can follow the movement of the skin even when applied to areas where the human body moves rapidly or complexly, such as joints, neck, flanks, etc.
A highly therapeutically effective patch is obtained that is difficult to peel off from the skin, has excellent adhesion, has a cooling effect as a plaster, and has excellent absorption of active ingredients.

(Leaving space below) Example Glycol esalicylate Q-Menthol dQ-Camfunorekaolin Glycerin Propylene glycol polysorbate 80 Synthetic hydrotalcite 7.0 20.0 10.0 1.0 0.06 100.0 *1) As solid content 4.0% non-woven fabric of 100% polyester fiber, 50% modulus 0.5Kg/5cm. A plaster of the above composition is kneaded on a support with a drape coefficient of 0.382 by a conventional method to form a workpiece (
The patch of the present invention was obtained by coating and cutting the adhesive to give a weight of 16 g per 140 mm x 100 mm.

Comparative Example A non-woven fabric made of 100% epoxy fiber, with a 50% modulus of 0.4 kg/5 cm. Comparative Example 1 was obtained by coating and cutting the same plaster as in Example onto a support having a drape coefficient of 0.182. Comparative Example 2 A nonwoven fabric of 95% polyester fiber and 5% rayon.
0% modulus 0.8 kg/5 cm. Comparative Example 2 was obtained by applying the same paste as in Example 5 to a support having a drape coefficient of 0.728 and cutting it in the same manner.

Comparative Example 3 Comparative Example 3 was obtained by applying the same paste as in Example 1 to a support made of a completely non-stretchable nonwoven fabric of 50% polyester fiber and 50% rayon and having a drape coefficient of 0.352, and cutting it in the same manner as in Example 1.

Experimental Example 1 (Usage Test) Select 10 healthy men and conduct Example 1, Comparative Example 1, and Comparative Example 2.
and Comparative Example 3 were sequentially applied to the left side of the neck (from the neck to the shoulder), and the ease of application was evaluated. Furthermore, the state of peeling was examined 5 hours after application, and the results are shown in Table 1 below.

Base of ease of peeling: 0 Cannot say: Δ Difficult to stick: × Base of difficulty in peeling: Does not peel off at all: O Slightly curly edges: O More than half peels off: Δ Peels off: × (blank below) Peeling: Evaluation results for resistance to peeling Experimental example 2 After completing Experimental example 1, the peeled samples were collected and the remaining amount of glycol salicylate in the plaster was measured.
The amount of glycol salicylate absorbed into the skin was compared. The results are shown in Table 2. (Space below) Table 2 From the results in Table 1 above, the adhesive patch of the present invention is easy to apply,
It can be seen that it is excellent in terms of resistance to peeling.

Furthermore, from Table 2, it was confirmed that the adhesive patch of the present invention has excellent adhesion, has good absorption to a certain extent, and exhibits high effectiveness. Comparative example ↓ had a low 50% modulus and a low drape coefficient, so it had good adhesion, but it became clear that it was too flexible and difficult to stick during use.

As described above, the effects of the present invention can only be achieved by using a support that satisfies both 50% modulus and drape coefficient, and cannot be achieved even if either one of them is lacking.

Example 2 Plasma: Indomethacin, menthol, crotamiton, polyvinyl alcohol, kaolin, glycerin, propylene glycol, polysorbate, 80% hydrotalcite water *1) 4.0% as solids 1.0 7.0 20.0 10.0 1. 0 0,05 100.0 Non-woven fabric blended with 75% polyester fiber and 25% polypropylene fiber, 50% modulus 0.48kg/5c
A patch of the present invention was obtained by coating a plaster of the above composition on a support having a thickness of 1.5 m and a drape coefficient of 0.338 so that 17 g per sheet (140 x 100 mm) was applied and cut.

When this adhesive patch was tested according to Experimental Examples 1 and 2, it showed excellent performance similar to that of Example 1.

(Left below) Example 3 Set Bufexamac Seiichi Menthol Crotamiton Glycerin Propylene Glycol Zinc oxide Glycerin Fatty acid ester Synthesis Hydrotalcite Water 20.0 10,0 5.0 1.0 0.06 100.0 *l) Solid One sheet of plaster of the above composition (60% Coating so that it is 2g per x 60mm),
It was cut to obtain a patch of the present invention.

When this patch was tested according to Experimental Examples 1 and 2, it showed the same excellent performance as Example 1.

Examples 4 to 11 A patch of the present invention was obtained by applying a plaster having the composition shown in Table 3 below to a nonwoven fabric (50% modulus, drape coefficient listed in Table 3).

Similar to Example 1, these patches were easy to apply, difficult to peel off, and had excellent adhesion (see margin below).

Claims (1)

[Claims] 1. In a patch having a support part and a plaster part, the support part has a 50% modulus of 0.1 to 2.0 kg.
/5 cm, and has a drape coefficient of 0.200 to 0.650 according to the JIS general textile test method.