JPH07284507A - Thermopasting agent - Google Patents

Abstract

PURPOSE:To provide a thermopasting agent which enables even an aged man to simply, easily and surely peel a protective layer held in tight contact with tacky adhesive layers, is simple in structure free from entanglement of the tacky adhesive layers with each other at the time of use, has an excellent adhesion property to the skin, pharmacological effect and pharmacological effect sustaining property, is low in cost and is excellent in mass productivity. CONSTITUTION:This thermopasting agent has an exothermic member 2, the tacky adhesive layer 4 which is spread to one surface of this exothermic member 2 via or without via a base 3 over approximately the entire surface thereof or partially or like a frame, a releasable liner 6 which is adhered along one side part of the tacky adhesive layer 4 and the releasable protective layer 5a which is formed to cover the front surfaces of this releasable liner 6 and the tacky adhesive layer 4.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a heat-resistant patch such as a disposable body warmer, a heat-shipping agent, a heat-plaster, etc., which is used for medicine or medical treatment, home use, and leisure. More specifically, a releasable liner formed on the side or corner of the releasable protective layer adhered over substantially the entire one surface of the heat-generating agent or the entire pressure-sensitive adhesive layer spread partially or in a frame shape is used. The present invention relates to a heat-sensitive adhesive patch which has excellent convenience in that even an aged person can very easily peel the peelable protective layer from the pressure-sensitive adhesive layer by simply flipping the formed portion of the peelable liner with a fingertip.

[0002]

2. Description of the Related Art In recent years, an aging society has advanced and back pain, elbow pain,
The number of people complaining of symptoms such as knee pain and shoulder pain tends to increase. Therefore, a hyperthermia patch by symptomatic treatment is widely used. As the heat-sensitive adhesive patch, a pressure-sensitive adhesive layer is spread on a heat-generating member such as a heat-resistant ship agent, heat-plaster, disposable body warmer, etc., and a peelable protective layer such as polyethylene or polypropylene for protecting the pressure-sensitive adhesive layer. Is used. The conventional thermal patch will be described below.
FIG. 6 (a) is a perspective view of a conventional thermal patch, and FIG.
(B) is the AA sectional view taken on the line. 10 is a conventional heat-sensitive adhesive patch, 11 is a heat-generating member made of heat-resistant ship agent, heat-plaster, disposable body warmer, etc. 11a is iron powder, reduced iron powder, activated carbon, alumina, silica gel, charcoal, water-absorbing polymer, chloride A chemical exothermic agent in which exothermic raw materials such as sodium, potassium chloride, magnesium chloride, iron chloride, acetic acid, chloroacetic acid, water, and acrylic water-absorbing polymer are appropriately mixed and formulated.
b is a flat bag body containing the chemical exothermic agent 11a, 11c is a breathable base film made of synthetic resin, synthetic fiber, natural fiber or the like that constitutes the flat bag body 11b, and 11d is a breathable base film 11c. A reinforcing film for reinforcement, 12 is an adhesive layer, 13 is a support 13a adhered to one surface of the flat bag body 11b via the adhesive layer 12, and an adhesive 13b spread on the support 13a. The pressure-sensitive adhesive layer 14 is a peelable protective layer made of a film, sheet, metal foil or the like having extremely thin flexibility, which is adhered to the entire surface of the pressure-sensitive adhesive layer 13 so as to be adhered thereto. The method of using the thermal adhesive patch configured as described above will be described below. First, the corners of the heat-sensitive adhesive patch 10 are repeatedly searched with a nail so that the pressure-sensitive adhesive layer 13 and the peelable protective layer 14 can be easily peeled off, and then the peelable protective layer 14 is peeled with a nail, and then the heat-generating member. After peeling off the peelable protective layer 14 while being careful not to twist the adhesive layers 11 and entangle each other, attach the heat-generating member 11 to the affected area or attach it to the surface of underwear such as a shirt. It was used.

[0003]

However, in the above-mentioned conventional structure, a white or white transparent pressure-sensitive adhesive layer formed on the upper surface of a one-colored support, which is mostly a thermosensitive patch, is formed, The surface is covered with a peelable protective layer made of an extremely thin and flexible transparent color film, so it is difficult to distinguish between the peelable protective layer and the pressure-sensitive adhesive layer, and the peeling position is unclear, so the peelable protective layer can be picked. It had a problem that it was difficult. Further, since the peelable protective layer and the heat-generating member have the same shape and the same size, there is a problem that the fingertip does not work well even when the fingertip is exposed at the tip of the peelable protective layer. Furthermore, since the pressure-sensitive adhesive layer uses a thickener having a thickening action, etc., the pressure-sensitive adhesive has extremely strong adhesiveness, and a thin releasable protective layer is adhered and adhered to the pressure-sensitive adhesive layer having the pressure-sensitive adhesive property. Therefore, even if the patient tries to stick it on the affected area, the peelable protective layer is difficult to peel off, and it takes time to peel off the peelable protective layer, which is often frustrating, and peeling work is difficult and difficult to use. It had the problem of inconvenience. Especially for the elderly, because the fingertips are less dexterous and the visual acuity is lower than when they are young, it is difficult to distinguish because the thin transparent peelable protective layer has the same color as the adhesive layer and is in close contact. There is a problem that peeling off the peelable protective layer from the pressure-sensitive adhesive layer imposes a great burden. In addition, when the heat-sensitive patch is a thin heat-type patch or patch, both the peelable protective layer and the heat-generating member are flexible, so the heat-generating member is twisted and the pressure-sensitive adhesive layers are entangled with each other, and the original state is restored. There was a problem that it took time.

The present invention solves the above-mentioned problems of the prior art by which the peelable protective layer adhered to the pressure-sensitive adhesive layer can be peeled easily, easily, and surely by an elderly person without any trouble. The purpose of the present invention is to provide a heat-sensitive adhesive patch that is easy to use, has a simple structure without entanglement between the adhesive layers, has excellent skin adhesion, pharmacological effect and pharmacological sustainability, and is low in cost and mass-producible. To do.

[0005]

To achieve this object, the heat-sensitive adhesive patch of the present invention has the following constitution. The heat-sensitive adhesive patch according to claim 1, a heat-generating member, and a pressure-sensitive adhesive layer that is spread on one surface of the heat-generating member with or without a support in a substantially entire surface or a partial or frame shape. A release liner adhered along one side of the pressure-sensitive adhesive layer; and a release protective layer provided on the upper surface of the release liner and the pressure-sensitive adhesive layer. ing. According to a second aspect of the present invention, in the heat-sensitive adhesive patch according to the first aspect, the peelable liner has a structure in which characters, figures, symbols and the like are printed on the surface and / or the release liner is colored. The heat-sensitive adhesive patch according to claim 3 is the heat-sensitive adhesive patch according to any one of claims 1 and 2, wherein the release liner is adhesively laminated on any one or both of the upper and lower surfaces of the release protective layer. Have a configuration. The thermal adhesive patch according to claim 4 is the thermosensitive patch according to any one of claims 1 to 3, wherein the release liner and / or the release protective layer is polypropylene, polyethylene, polyester, polyvinyl chloride, or polyvinylidene chloride. , A film or sheet of synthetic resin such as polystyrene, a silicon-treated paper, an aluminum foil, or the like. The thermal adhesive patch according to claim 5, wherein the release liner and / or the release protective layer has a thickness of 0.1 to 1000 in any one of claims 1 to 4.
.mu.m.

Here, there is no limitation on the kind of the heat generating member, and any conventionally known member having heat generation can be applied. For example, a heat-generating member using electricity, a heat-generating member using a dry cell or a solar cell, a paper-like battery, or a heat-generating body warmer having a flat bag containing a heat-generating agent that causes chemical heat generation can be used. Above all, a heat-generating body warmer is preferably used as a heat-generating member from the viewpoint of portability and the effect of heating and compressing. The composition of the exothermic agent is iron powder, reaction aid,
A substance that is composed of water and a water retention agent and generates heat in the presence of air and water is preferably used. Specifically, iron powder, reduced iron powder, activated carbon, alumina, silica gel,
Charcoal, water absorbent polymer, sodium chloride, potassium chloride,
It is a composition in which exothermic raw materials such as magnesium chloride, iron chloride, acetic acid, chloroacetic acid, water, and acrylic water-absorbing polymer are appropriately mixed and formulated. The amount of exothermic agent is 0.5 to 6 g / cm ² , preferably 1 to 3 g / cm ² . Depending on the type of exothermic agent, the heating effect tends to be lost as the amount of exothermic agent becomes less than 1 g, and the risk of low-temperature burn tends to occur as the amount of exothermic agent exceeds 3 g. Further, it is most important not to destroy the thermal stability of the pressure-sensitive adhesive layer as the temperature condition of the exothermic agent, and the temperature setting is such that the surface temperature of the pressure-sensitive adhesive layer is 60 ° C or lower, preferably 50 ° C or lower, The temperature is preferably 45 ° C. or lower, most preferably around 40 ° C. This is to prevent low temperature burns and enhance the effect of hyperthermia. Ceramic powder may be included in the heat generating composition, or a ceramic layer may be provided between the heat generating member layer and the adhesive layer. The far-infrared effect can give a thermal effect to deep inside the body.

The flat bag may be formed of two or more synthetic resin layers according to the purpose, but when selecting the material, one having heat sealability and easy heat fusion can be selected. Is preferred. In this case, when two or more synthetic resin layers cannot be heat-sealed, a hot melt adhesive film may be interposed between them to bond the synthetic resin layers. Care must be taken not to lose the breathability of the breathable film. Examples of the polymer material forming the flat bag body include polyethylene, polypropylene, nylon,
Polyester, polyvinyl chloride, polyvinylidene chloride,
Examples thereof include polyurethane, polystyrene, saponified ethylene-vinyl acetate copolymer, ethylene-vinyl acetate copolymer, natural rubber, recycled rubber, synthetic rubber and the like. It is preferable to use a breathable reinforcing film made of a woven fabric or a non-woven fabric to reinforce the flat bag body. Examples of the breathable reinforcing film include nylon, vinylon, polyester, rayon, acetate, acrylic and polyethylene. , Synthetic fibers such as polypropylene and polyvinyl chloride,
It is formed using one or more materials selected from natural fibers such as cotton, hemp, and silk.

The pressure-sensitive adhesive layer can be used as a simple adhesive agent for clothes such as shirts, water, poultice liquid, etc.
This is a layer for warming the skin as a poultice by mixing a poultice paste and a drug. The adhesive layer is spread over one surface of the support or one surface of the support when the heat-generating member is a heat-generating body, or is formed in a dotted pattern, a plurality of strips or waves, or one or more frame shapes. To be done. As the base material, those having an acrylic copolymer, an ABA type block copolymer, an alicyclic petroleum resin, and a softening agent are preferably used. By adding a chemical agent to this base material, it can be effectively used as a hot compress for external use. Further, an AB block copolymer or other polybutene rubber, butyl rubber or silicone rubber is used for this base material. Furthermore,
Tackifying agents such as terpene resins and petroleum resins, animal and vegetable oils such as liquid paraffin, olive oil, soybean oil, beef tallow, and tallow, polybutene, lower isoprene, wax and other adhesive strength / holding power regulators, titanium oxide, Fillers such as zinc oxide, aluminum metasilicate, calcium sulfate and calcium phosphate may be added. The pressure-sensitive adhesive layer thus obtained preferably contains water so as to improve heat conduction to the skin and has excellent adhesiveness. Further, it is desirable that the adhesive layer has an appropriate cohesive property so that it does not soften even at a temperature of 38 to 44 ° C. at the time of heat generation and the adhesive layer is not left on the skin. For example, as a raw material for containing water,
CMC, sodium polyacrylate, kaolin, gelatin, titanium oxide various crosslinking agents, etc. can be used,
In addition, various raw materials can be used to obtain desired physical properties such as flexibility and adhesiveness. By adding a water-absorbent polymer, perspiration sweat can be absorbed, the adhesion to the skin can be maintained, and the usability can be improved. Also,
By adding the non-transferable pressure-sensitive adhesive, the transferability can be prevented, so that the convenience can be improved and the application site can be expanded. As the A-B-A type block copolymer and the A-B type block copolymer, a block copolymer of a monovinyl-substituted aromatic compound A and a conjugated diolefin copolymer B is preferably used. Specifically, Califlex TR-1101, Califlex TR-1107, manufactured by Shell Chemical Co.,
Califlex TR-1111 and the like, Sorprene 418 and Sorprene 311 manufactured by Philippe Petroleum, etc., and the compounding amount thereof is 10 to 40 parts by weight, preferably 15 to 30 parts by weight in the pressure-sensitive adhesive composition. By adding 15 to 30 parts by weight of the AB block copolymer,
It is possible to improve the compatibility, anchoring force, and adhesive force of the medicinal component of the B-A type block copolymer, as well as improve the cohesive force of the oil component, and as it deviates from this range,
It is not preferable because it tends to reduce these effects. As water, simple water, hot spring water, sodium chloride water, glycerin, peppermint oil, methyl salicylate, glycol salicylate, etc. may be used alone or in combination, as well as liquid alcohols, liquid fatty acid esters, etc. These liquids include menthol, camphor, non-steroids, and other commonly used liquids, as well as liquids in which various qualities are dissolved and a surfactant or the like is added as a dispersion stabilizer.

The alicyclic petroleum resin is a petroleum resin having a cyclic skeleton, specifically, Alcon P-85,
Archon P-100, Archon P-125 (manufactured by Arakawa Chemical), Quinton (manufactured by Nippon Zeon), Escoletz 30
00 (manufactured by Exxon) and the like are blended in an amount of 10 to 50 parts by weight, preferably 25 to 45 parts by weight. This is for adjusting the flexibility of the base material.

As the softening agent, higher fatty acid, liquefied rubber,
Mineral oil or the like is used, and the compounding amount thereof is 10 to 50 parts by weight, preferably 25 to 45 parts by weight. 2 softeners
By adding 5 to 45 parts by weight, it is possible to prevent the base material from softening, sagging or flowing, and adjust the flexibility, depending on the heat generation temperature of the heat generating agent. There is a tendency that these effects are not obtained as the value deviates from this range.

The water-absorbent polymer is one that absorbs 10 times or more of its own weight of water and gels and swells. For example, a water-absorbent polymer obtained by introducing a light crosslinking bond into a water-soluble polymer is
It is prescribed alone or as a mixture of two or more kinds.
Specifically, Sunwet IM-300, Sunwet I
M-300MPS, Sunwet IM-1000, Sunwet IM-1000MPS (manufactured by Sanyo Chemical Co., Ltd.), Aquakeep 4S, Aquakeep 4SH (manufactured by Steel Chemical), etc.,
Sumika gel SP-520, Sumika gel N-1040 (manufactured by Sumitomo Chemical Co., Ltd.), KI gel 201-K, KI gel-201
K-F2 (manufactured by Kuraray Co., Ltd.), Arasoap 800, Arasoap 800F (manufactured by Arakawa Chemical Co., Ltd.), etc., among which, Sunwet IM-300MPS, Sunwet IM-1000M
PS, Sumika gel NP-1020, Sumika gel NP-1
040, KI gel-201K-F2, ALASORP 800
F and the like are particularly preferable. The blending amount is 1 to 10 parts by weight, preferably 2 to 8 parts by weight in the pressure-sensitive adhesive composition. When the amount of the water-absorbent polymer is less than 2 parts by weight, the sweat absorption tends to be insufficient, and when it exceeds 8 parts by weight, the skin drying phenomenon occurs, which is not preferable. In addition, a conventionally known antiaging agent, an inorganic filler such as talc or tankal, and an antioxidant are appropriately mixed in appropriate amounts according to the purpose of use.

As the drug, a drug which can be absorbed transdermally is contained and can be used as a patch for medical thermotherapy. For example, as skin irritants and analgesic and anti-inflammatory agents, salicylic acid, methyl salicylate, glycol salicylate, l-menthol, camphor, peppermint oil, thymol, nicotinic acid benzyl ester, capsicum extract, capsaicin,
Nonylic acid vaniamide, flupinac, flufenamic acid pentyl, piroxicam, indomethacin, ketoprofen, pranoprofen, feprazone, loxoprofen, amphenac sodium, oxaprozin, emorfazone, fenthiazac, fentiazac, diclofenac sodium, diflunisal, ibuprofen piconol, bendafen Zac, suprofen, felbinac, tenidap, ketorolac, and ester derivatives thereof, or publenorphine hydrochloride, pentazocine, putorphanol tartrate, etc. are used. Central nervous system agents (sleep sedatives, antiepileptic agents, neuropsychiatric agents) include fluphenazine, thioridazine, diazepam, chlorpromazine, nitrazepam, estazolam, triazolam, nimetazepam, flunitrazepam,
Haloxexazolam, flurazepam, clonazepam, propericiadine, prochlorperazine, alprazolam,
Oxazepam, oxazolam, cloxazolam, prazepam, flutazolam, mexazolam, lorazepam, fludiazepam, promazepam, metazepam, nicotine and the like are used. As diuretics, hydrothiazide,
Pendrofluna thiazide, ethiazide, cyclopenthiazide, hydrochlorothiazide, penflutide, meticlotiazide, furosemide, metolazone, polythiazide, bendroflumethiazide, etc. are used. Antihypertensive agents include clonidine, arseroxilone, resinamine, dihydroergotoxin mesylate, reserpine,
Prazosin, captopril, pindolol, enalapril maleate, etc. are used. As a coronary vasodilator,
Nitroglycerin, nitroglycol, dipyridamole, efloxat, trimethazine, nicorandil, cinnarizine, niridone, molcide minifedipine, etc. are used. Antitussive expectorants (including bronchodilators and antiallergic agents) include codin phosphate, dihydrocodin phosphate, ephedrine hydrochloride, chlorprenaline hydrochloride,
Fenoterol hydrobromide, sartamol sulfate, dimemorphan phosphate, azelastine hydrochloride, clenpterol hydrochloride, tulopterol hydrochloride, trimethoquinol hydrochloride,
Procaterol hydrochloride, promhexine hydrochloride, tranilast, tibepidine hibenzate, ketotifen fumarate, formoterol fumarate, benzproperin phosphate, glycyrrhetinic acid and the like are used. As the antihistamine, diphenhydramine hydrochloride, triprolidine hydrochloride, isothibenzyl hydrochloride, promethazine hydrochloride, chlorpheniramine maleate, cyproheptadine hydrochloride, clemastine fumarate, carbinoxamine maleate, dimethindene maleate, etc. are used. Examples of the antiarrhythmic agent include alprenolol, oxprenolol, pcumolol, bupranolol, pindolol, indenolol, carteolol, bufetrol, propranolol, timolol and the like. As cardiotonics, digitalis, ubidecarenone, digoxin, methyldigoxin, destranoside and the like are used. As the sex hormone, estradiol enanthate, estradiol cypinate, levonorgestrel, estradiol and the like are used. Adrenal skin hormone agents include hydrocortisone acetate, hydrocortisone, prednisolone, triamcinolone acetonide, dexamethasone phosphate, methylprednisolone, dichlorine acetonide acetate, dexamethasone acetate, dexamethasone, fluorometholone, betamethasone phosphate sodium, betamethasone, betamethasone valerate. , Beclomethasone propionate, fludroxycortide, hydrocortisone acetate, betamethasone dipropionate, fluoxynonide, clobetasol propionate, diflucortron valerate, halcinonide, amcinonide, prednisolone valerate, etc. are used. As the local anesthetic, lidocaine, ethyl aminobenzoate, procaine hydrochloride, dipcaine, procaine and the like are used. These medicinal components are used alone or in admixture of two or more if necessary. The compounding amount is preferably an amount capable of expecting a medicinal effect, and when the total amount of the pressure-sensitive adhesive is 100 parts by weight, it is appropriately prescribed within the range of 0.001 to 20 parts by weight. Naturally, Chinese herbal medicine extracts, powders and the like that can be used as a warming medicine can also be used.

As the non-transferable adhesive, an organic solvent type adhesive such as a rubber type, an acrylic type, a vinyl acetate type or an aqueous type adhesive is used, and a reactive functional group is introduced therein to increase the internal cohesive force. For example, an acrylic monomer in which a functional monomer is mixed in an amount of 1 to 10% by weight is used. As the functional monomer, one having 1 to 4% by weight of the following general formula I is preferably added.

[Chemical 1] (Wherein R ₁ represents a lower alkyl group having 1 to 4 carbon atoms and R ₂ represents a hydrogen atom or a methylol group.) Alternatively, 6 to 10% by weight of the following general formula II is added. With the addition of an acid catalyst,

[Chemical 2] (In the formula, R ₁ represents a hydrogen atom or a methyl group, R ₂ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an allyl group, and R ₃ represents an alkyl group having 1 to 18 carbon atoms.) Are those added with 1 to 8% by weight of the functional monomer according to the following general formula III, and 1 to 5% by weight of the water-soluble or dispersible epoxy compound added to the outside. These non-sticking adhesives are Both are known.

[Chemical 3] (However, in the formula, R ₁ represents a hydrogen atom or a methyl group.
R ₂ and R ₃ represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. )

The water-retaining agent is not particularly limited as long as it has high water-retaining property and eliminates stickiness in the heat-generating composition, and specifically, for example, vermiculite, silica powder, wood powder, At least one of water-absorbent polymers and the like can be mentioned. For the peelable protective layer and the peelable liner, films or sheets made of synthetic resin such as polypropylene, polyethylene, polyester, polyvinyl chloride, polyvinylidene chloride, polystyrene, etc., colorless or colored such as silicon processed paper, aluminum foil, etc. are used. .
It is desirable that the peelable protective layer and the peelable liner be colored in different colors, or that one side thereof be printed with characters, symbols or codes. This is because the peeling position can be easily identified. The peelable liner is formed on the entire surface of at least one side of the peelable protective layer or on the side thereof in a scattered manner or at one or a plurality of corners of either side. When the peelable protective layer has a large shape or is made of a thin synthetic resin having a low rigidity, it may be formed on both sides. When the releasable liner is formed on the entire surface of one side of the releasable protective layer, it is 2% to 50%, preferably 4% to 4% of the area of the releasable protective layer.
The width is preferably 0%, more preferably 6% to 30%. Specifically, the size of the release liner is 0.
3-5 cm, preferably 0.5-4 cm, more preferably 1
It is formed with a width of ~ 3 cm. Although it depends on the material of the release liner, it tends to weaken the waist strengthening force of the release protective layer as it becomes less than 1 cm, and the release liner of the release protective layer becomes too wide as it exceeds 3 cm and the affected area is affected. It is not preferable because it tends to be difficult to peel when the peelable protective layer is peeled off while the heat-sensitive adhesive patch is being applied. In addition, the shape of the release liner is not limited to the strip shape, and if the release protective layer or the like is easily flipped, one having an uneven portion such as a corrugated shape, a round shape, a square shape, a triangle shape or the like It may be formed in the size described above. This is because the peelable protective layer can be peeled off smoothly, and an indication of the peeling position can be printed on the surface of the peelable liner, which improves convenience. The thickness of the peelable protective layer or the reinforcing material is 0.1 to 1000 μm, preferably 1 to 500 μm,
More preferably, it is formed in the range of 5 to 100 μm. The peelable liner can be easily turned up and the conventional production line can be used as it is, just by making the peelable protective layer firm and rubbing the end of the peelable liner forming part of the heat-sensitive patch with a fingertip. Also, it is preferable in terms of releasability and manufacturing process. Further, when the peelable liner is made of a laminated material that is adhesively laminated on the peelable protective layer, the laminated material may be formed of the same or different material as the peelable protective layer and adhered by an adhesive, In the case of a resin, it is preferable to use the same kind of material, because it can be easily adhered and laminated by thermal adhesion. When the peelable protective layer is thin and has a low rigidity, the laminated material is preferably formed to be thicker than the peelable protective layer or formed of a synthetic resin having rigidity higher than that of the peelable protective layer. When the peelable protective layer is made of a strong synthetic resin, it may be formed to have the same thickness or thinner. It is because the peeling protective layer can be easily peeled off.

[0015]

With this structure, since a flexible and peelable liner having a strong elasticity is formed at the end portion of the peelable protective layer, the end portion of the heat-sensitive adhesive patch in the portion reinforced by the peelable liner is rubbed with a fingertip. The peelable protective layer and the support can be easily flipped over just by doing. Further, by simply touching the end of the peelable protective layer reinforced by the peelable liner with a fingertip, peeling from the adhesive layer at that portion can be easily performed, so a part of the heat-sensitive adhesive patch can be picked, Further, the peelable protective layer can be peeled off from the pressure-sensitive adhesive layer very easily only by picking up and opening the reinforced end portion of the peelable protective layer. Further, since the strippable liner formed on the side of the strippable protective layer can prevent the strippable protective layer from sagging, the strippable protective layer can prevent the sag of the pressure-sensitive adhesive layer having good tracking property. The adhesive layer surfaces can be peeled without being entangled with each other and without wrinkling. An existing production line can be utilized by forming the peelable liner separately from the peelable protective layer by laminating with a laminate material. The heat-sensitive adhesive patch thus obtained is used for diseases such as stiff shoulders, low back pain, bruises, and sprains, and the therapeutic effect due to heat can be expected sufficiently, and there is a particular problem in use. The occurrence of touch can be remarkably suppressed by making the thermal patch of the present invention absorb sweat. Since the adhesive layer containing the medicinal component is provided, the heat-sensitive adhesive patch sufficiently absorbs sweat, which is considered to be a cause of contact, even when it is applied for a long period of time, so that the generation thereof is significantly suppressed. Further, it also has a heating effect, the transdermal absorption of the drug into human skin is further improved, the drug effect is rapidly exhibited, and the therapeutic effect is also preferable. Since it is a chemical exothermic body warmer type in which a heat generating agent is contained in a flat bag, it is excellent in portability. By providing a poultice layer on the other surface side of the heat-generating member composed of the flat bag body enclosing the heat-generating composition, that is, on the layer (background) opposite to the breathable film side, it can also be used as a thermal poultice. .

[0016]

DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to the drawings. (Example 1) FIG. 1 is a perspective view of a thermal adhesive patch of the first embodiment of the present invention, and FIG. 2 is a state in which a peelable protective layer of the thermal adhesive patch of the first embodiment of the present invention is bent. Is a side view showing
FIG. 3 is a perspective view thereof. Reference numeral 1a is the heat-sensitive adhesive patch of the first embodiment, 2 is a heat-generating member made of a flat bag containing a chemical heat-generating agent, 3 is a support which is bonded or integrally laminated on one surface of the heat-generating member 2, 4 Is a pressure-sensitive adhesive layer spread on the entire surface of one side of the support 3, 5 is a peelable protective layer attached on the entire surface of the pressure-sensitive adhesive layer 4, and 6 is a whole surface of one side of the pressure-sensitive adhesive layer 4. Releasable liner having corrugated irregularities on the side of the adhesive layer 4 formed, 7 is a display portion on the surface of the releasable liner 6 where the peeling position and the like are displayed in an easy-to-understand manner, and 8 is an irregular shape of the releasable liner 6. It is the formed end. The pressure-sensitive adhesive layer 4 was prepared by the following formulation. Styrene-isoprene-styrene teleblock copolymer 100 parts, styrene-isoprene copolymer 1
0 part, liquid paraffin 150 parts, and rosin-modified maleic acid resin 50 parts are heated to 140 to 150 ° C. in a nitrogen gas stream to dissolve. The melt (about 150 ° C.) was cooled to about 120 ° C., and then 30 parts of methyl salicylate and 21 parts of 1-menthol were added and mixed to make a uniform mixture. This was spread on a support with a spreading machine to a thickness of about 1 mm. Regarding the heat-sensitive adhesive patch of the first example configured as described above,
The usage method will be described below. Since the peelable protective layer 5 and the peelable liner 6 are not adhered to each other, the user grips the peelable liner 6 side of the peelable protective layer 5 and slightly peels it off, and then the display portion 7 of the peelable liner 6 is placed outside. When the heat-sensitive adhesive patch 1 is slightly bent, the convex portion of the end portion 8 of the peelable liner 6 is easily turned over and peeled off a little from the adhesive layer 4, so the end portion 8 is picked and the peelable liner 6 is peeled off. Then, the exposed pressure-sensitive adhesive layer 4 is applied to the affected area and attached, and then the peeling protective layer 5 is peeled by picking up the end of the peeled protective protective layer 5 and the heat generating member 2 in the peeled portion is touched. By pressing and holding, the heat-sensitive adhesive patch can be appropriately and easily applied to the affected area without soiling the hands.

FIG. 4 is a perspective view of a thermal patch of the second embodiment of the present invention. 2 is a heat generating member, 3 is a support, 4 is an adhesive layer, 6 is a releasable liner, 7 is a display portion on the surface of the releasable liner 6 where the peeling position and the like are easily displayed by printing, and 8 is a releasable liner 6. Since these are the same as the thermal adhesive patch of the first embodiment, the same reference numerals are given and the description thereof is omitted. The thermal patch 1b of the second embodiment is different from that of the first embodiment in that a release liner is attached to both sides of the adhesive layer 4 and a release protective layer 5b is attached to the upper surface thereof. It is a point. Since it is configured as described above, the user can peel off and attach the peelable protective layer 5b from any of them.

(Experimental Example) Next, using the thermosensitive patch of Examples 1 and 2, a test for confirming peeling time, skin adhesion and duration of pharmacological effect was conducted on 10 female panelists in their 50s to 70s. I went. The results are shown in (Table 1).

[Table 1] In the table, the peeling time is the time until 5 pieces of the heat-sensitive adhesive patch of this example are passed to each panelist and the protective layer of the heat-sensitive adhesive patch is peeled off. The skin adhesion was judged by the presence or absence of spontaneous peeling, the feeling of pain during peeling, the amount of adhesive residue, etc., and evaluated as good, normal, or bad. As a comparative example, a peeling test was performed under the same conditions as in Examples 1 and 2 using a commercially available heat-sensitive adhesive patch.
As is clear from this (Table 1), the peeling time of Examples 1 and 2 was extremely short, that is, 1/4 to 1/7, as compared with the comparative example, and it was found that even an elderly person could peel it very easily. In addition, compared with the comparative example by the adhesive formulation of the present example,
The duration of the pharmacological effect was 1.5 times or more excellent, and the skin adhesion was also excellent. From the comparison between Examples 1 and 2, it was found that a wider reinforcing material formed in the pressure-sensitive adhesive layer facilitates peeling. .

(Example 3) FIG. 5 (a) is a side view of a heat-sensitive adhesive patch of the third embodiment of the present invention, and FIG. 5 (b) shows the peelable protective layer and the end portions of the peelable liner. FIG. 5 is a side view showing the unfolded state, and FIG. 5 (c) is a perspective view of FIG. 5 (b).
Reference numeral 2 is a heat generating member, 3 is a support, and 4 is a pressure-sensitive adhesive layer. Since these are the same as those of the thermal adhesive patch of the first embodiment, the same reference numerals are given and the description thereof is omitted. The thermal patch 1c of the third embodiment is different from that of the first embodiment in that a release liner 6 is bent on both sides of the pressure-sensitive adhesive layer 4 on the side of the pressure-sensitive adhesive layer 4 to form a bending piece 6 '. It is formed and adhered, and the peelable protective layer 5b is adhered on the upper surface thereof. With the above-described structure, the user can peel off the peelable protective layer 5c from any of them, and the peelable liner 6 can be peeled off by simply grasping the bending piece 6'by hand, and the portion can be attached to the affected area. Then, the peelable protective layer 5c can be easily attached while being peeled off.

[0020]

As described above, in the present invention, the peelable protective layer is adhered over the entire surface of the pressure-sensitive adhesive layer, and the peelable liner is formed on one side or corner of the peelable protective layer. The release liner is colored or has characters printed on it, so even the user, especially the elderly, can very easily confirm the release part and its position and reinforce it with the release liner. By rubbing the end portion of the peelable protective layer with a fingertip, the end portion of the peelable protective layer and a part of the heat-sensitive adhesive patch can be easily flipped over, so pick that portion and make sure both After separating in a short time, it can be immediately applied to the affected area. Moreover, since the peeling liner has letters, symbols, and codes printed on it, the peeling position can be easily confirmed, and the heat-sensitive adhesive patch can be applied to the affected area without bothering the peeling work and soiling the hands. It is possible to realize a heat-sensitive adhesive patch that can be applied and is extremely convenient and low in cost and suitable for mass production.

[Brief description of drawings]

FIG. 1 is a perspective view of a thermal patch according to a first embodiment of the present invention.

FIG. 2 is a side view showing a state in which the peelable protective layer of the heat-sensitive adhesive patch of the first embodiment of the present invention is bent.

FIG. 3 is a perspective view of FIG.

FIG. 4 is a perspective view of a thermal patch according to a second embodiment of the present invention.

FIG. 5 (a) is a side view of the thermal adhesive patch of the third embodiment of the present invention (b) is a side view showing a state in which the ends of the peelable protective layer and the peelable liner are widened (c) FIG. 5 ( b) perspective view

FIG. 6 (a) is a perspective view of a conventional thermal patch, and (b) is a sectional view taken along the line AA of FIG. 6 (a).

[Explanation of symbols]

 1, 1a, 1b, 1c Thermal adhesive patch 2 Exothermic member 3 Support 4 Adhesive layer 5, 5b, 5c Releasable protective layer 6 Releasable liner 6'Folding piece 7 Display part 8 End of releasable protective layer 10 Conventional thermal adhesive patch 11 Heating member 11a Chemical heating agent 11b Flat bag 11c Breathable base film 11d Reinforcing film 12 Adhesive layer 13 Adhesive layer 13a Support 13b Adhesive 14 Releasable protective layer

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Mitsumasa Kabashima 408 Tadai Daikancho, Tosu City, Saga Prefecture, Hisamitsu Pharmaceutical Co., Ltd. (72) Inventor Akira Kawada 408, Tashiro Daikancho, Tosu City, Saga Prefecture Hisamitsu Pharmaceutical Co., Ltd. Within the corporation

Claims (5)

[Claims] 1. A heat-generating member, a pressure-sensitive adhesive layer that is spread on one surface of the heat-generating member substantially or entirely or partially or in a frame shape with or without a support, and one side of the pressure-sensitive adhesive layer. A releasable liner adhered along a portion, and a releasable protective layer provided on the upper surface of the releasable liner and the pressure-sensitive adhesive layer. 2. The heat-sensitive adhesive patch according to claim 1, wherein the release liner has characters, figures, symbols and the like printed and / or colored on the surface thereof. 3. The heat treatment according to claim 1, wherein the peelable liner is adhesively laminated on one or both of the upper and lower surfaces of the peelable protective layer. Sex patch. 4. The peelable liner and / or the peelable protective layer is a film or sheet of synthetic resin such as polypropylene, polyethylene, polyester, polyvinyl chloride, polyvinylidene chloride, polystyrene, or siliconized paper, aluminum foil, etc. The thermal adhesive patch according to any one of claims 1 to 3, which is selected from the following. 5. The thermal adhesive patch according to claim 1, wherein the thickness of the peelable liner and / or the peelable protective layer is 0.1 to 1000 μm.