JPH03153610A - Skin-beautifying cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin-beautifying cosmetic free from skin irritation and having an effect to suppress melanogenesis and an effect to quickly bleach dark skin by using a vitamin E derivative of azelaic acid and an L-ascorbic acid derivative as essential components. CONSTITUTION:The objective cosmetic can be prepared by compounding 0.1-5wt.% of vitamin E derivative of azelaic acid or its salt and 0.2-10wt.% (in total) of one or more substances selected from L-ascorbic acid sulfuric acid ester salts and L-ascorbic acid phosphoric acid ester salts to known cosmetic base having the form of cream, milky lotion or lotion and forming the obtained mixture in the form of cosmetic by conventional method. The cosmetic may be properly compounded with colorant, perfumery, preservative, antioxidant, surfactant, skin-nourishing agent, pigment, etc. The skin-beautifying effect can be further improved especially by applying the cosmetic quickly after the exposure to sunlight, etc.

Description

Detailed Description of the Invention (Technical Field) The present invention provides a skin-whitening cosmetic that is excellent in skin safety, has the effect of preventing skin from becoming dark-skinned, and has the effect of quickly lightening dark-skinned skin. Regarding Gi 4.

(Prior Art) Dark skin IN caused by sunburn is said to be caused by the fact that tyrosine present in one skin is oxidized to melanin pigment by the action of tyrosinase, and this melanin is produced in excess. In order to prevent or treat this pigmentation, whitening cosmetics containing L-ascorbic acid and its derivative 5 colloidal sulfur, hydrogen peroxide, hydroquinone, etc. have been developed. However, these whitening cosmetics have insufficient storage stability, or do not have sufficient whitening effects, or may have the effect of lightening dark skin, but may This poses a safety problem, and it has been difficult to obtain an excellent whitening cosmetic.

(Disclosure of the Invention) Therefore, the present inventors have aimed to: 1) rapidly eliminate melanin present in excess in the epidermis, 2) suppress new melanin generation within the skin, and 2) ensure skin safety. As a result of theoretical and oral research with the aim of creating a whitening cosmetic that satisfies the requirements such as having no sexual problems, the present invention was completed by discovering that a whitening cosmetic with a specific composition can achieve the above objectives. did.

(Object of the Invention) That is, the object of the present invention is to provide an excellent whitening cosmetic that does not cause skin irritation, has the effect of inhibiting melanin pigment formation, and has the effect of rapidly whitening dark skin.

(Structure of the Invention) The present invention provides vitamin E SA 'L form of azelaic acid and at least one of its salts, and L-ascorbine M6.
A whitening cosmetic containing at least one of gM ester salts and mono-ascorbic acid ester salts.

(Specific explanation of composition) The azelaic acid vitamine E derivative and its salts used in the present invention can be produced according to the description in JP-A-50-106965 fgr "Production method of tocopherol acidic succinate ester". , is a substance with vitamin E activity. Vitamin E has 4 or 41 forms α, β, T,
It is also possible to use isomers such as δ. In addition, as vitamin E derivatives of azelaic acid, there are monoesters and diesterols, and the bases constituting the monoester salts include sodium, potassium, calcium, magnesium, ammonium, alkano-J rare amino acids, and basic amino acids. Examples include.

Ascorbic acid sulfate ester salts and ascorbic acid phosphate ester salts are known substances, and the bases constituting the salts include sodium, potassium, calcium, magnesium, ammonium, alkanolamines, basic amino acids, etc. Can be mentioned.

The present inventors have discovered that vitamin E derivatives of azelaic acid and their salts (hereinafter abbreviated as VEAZs) are incorporated into cosmetic bases.
Toshi-ascorbic acid sulfate ester salts and L-ascorbic acid phosphate ester salts (hereinafter referred to as AC-3t, AC
The present invention was completed by confirming that the coexistence of Pt (hereinafter abbreviated as "Pt") exhibits a significantly superior oral effect compared to their individual effects.

That is, the effect of activating the skin tissue of VE-AZ, accelerating the turnover rate of the stratum corneum, and rapidly eliminating melanin together with the stratum corneum to lighten dark skin, and the above-mentioned AC. -3L-AC-PL The effect of suppressing the latent melanin-forming ability of the skin and preventing new dark-skinned skin is synergistic, and under conditions favorable to skin physiology, dark-skinned skin can be reduced. It has been newly discovered that it has the effect of lightening the skin.

Therefore, the whitening cosmetic of the present invention is intended for use on skin that has not reached a certain level of color after exposure to sunlight or skin that has become dark-skinned, and particularly for skin that has become physiologically unstable. However, it exhibits a remarkable effect in blackening the skin color or lightening dark skin without causing skin irritation.

The 1 white cosmetic of the present invention comprises VE-AZs and the above-mentioned AC-
5t-AC-P Ll is a well-known cream milk type 1
It is prepared by blending it into a cosmetic base, which is lotion tn, in a conventional manner.

The content of the VE-AZ neck is 0.1 to 5% by weight (hereinafter abbreviated as wt%) based on the total amount of the cosmetic, and the content of the above AC-3t -AC-P in the neck is 0.1 to 5% by weight (hereinafter abbreviated as wt%). The amount is
0.2 to 10.0 in total amount of each alone or in combination
It is sufficient if it is wt%. Even if the upper limit of these contents (〒) is exceeded, no effect commensurate with the higher content (frffl) can be expected, and if the content (2) is less than the lower limit, the object of the present invention cannot be achieved.

The whitening cosmetic of the present invention may contain pigments, fragrances, preservatives, antioxidants, surfactants, skin nutrients, 111 ingredients, etc. as appropriate within the scope of achieving the purpose of the present invention. .

(Example) The present invention will be explained below with reference to Examples.

In addition, 1) skin irritation test, 2) stratum corneum turnover rate measurement test, 2) skin color brightness recovery test, and 2) whitening practical test described in Examples are shown below.

■ Skin irritation test: Exposure to sunlight for 6 hours (3 hours a day for 2 days) in summer? Sample 0.05 was applied to the anterior arm flexor skin of 25 II examiners.
g is the diameter 1. After applying an occlusive patch for 24 hours using a batch test bandage with a circular lint cloth of Qcm,
According to the following criteria, each sample was evaluated for the condition of the skin of 25 subjects, and the 0 result was determined by taking the stronger reaction between 1 hour and 24 hours after the removal of the bandage.
It is indicated by the number of people who gave an evaluation of (±) or higher.

■ Test for measuring the turnover rate of the stratum corneum. An ointment containing 5 wt% of the fluorescent dye danzyl chloride in white petrolatum was prepared, and an ointment was applied to the skin of the anterior arm of 20 subjects for 24 hours. Penetrates and binds danzyl chloride to the stratum corneum. After that, the test sample was applied to the same area twice a day (twice in the morning), and the fluorescence of danzyl chloride was detected every day.The number of days until the fluorescence disappeared was determined as the turnover rate of the skin stratum corneum. . The measurement results were shown as the average value of the number of days for each subject.

Note that the normal turnover rate of the stratum corneum of the skin is 14
~16th.

■ Skin color brightness recovery test The back skin of 820 test subjects was irradiated with ultraviolet light in the UV-B region at twice the minimum amount of erythema, and after one week, sample application areas and non-application areas were set in the irradiated areas. Then, the reference brightness (Vo (a-Vo' value)) of each skin was measured.Subsequently, a sample Vi was applied to the application site once a day for 3 months for 38.13 weeks. The brightness (Vn value, Vn' value) of the skin at the application site and non-application site after application was measured, and recovery of skin color was evaluated based on the following measurement criteria.

In addition, the brightness of the skin (Munsell color system V (direct) was calculated from X, Y, Z (direct) obtained by measurement with a high-speed spectrocolorimeter.

The evaluation was based on the judgment of 20 test subjects. ■ Whitening Practical Test 1 Exposure to direct sunlight for 3 hours (1.5 hours a day for 2 days) I
The skin on the lateral side of the forearm of 20 examiners was tested. Seven days later, each sample was applied with Vt once in the morning and once in the evening for 13 weeks.

The evaluation was expressed by the number of subjects who answered that the area of the skin to which the sample was applied became fairer (lightening) than other areas of the skin.

Example 1. 2 Comparative Example 1.2 [Skin lotion] In the following composition, each skin lotion was prepared by changing the content of VE-AZ and AC-3L/AC-Pt as shown in Table 1. This test was carried out using a model. The results are shown in Table 1.

In addition, the calcium salt of vitamin E-azelaic acid monoester is V B -AZ + -Ca, and the vitamin E-azelaic acid diester is VE-AZ, , L-
Ascorbic acid-2-sulfate ester sodium salt as AC
-2-3L-Na, L-ascorbic acid-3-sulfate ester triethanolamine salt with AC-3-3t-TEA
, L-ascorbic acid 2-phosphate ester magnesium salt, AC-2-Pt-Mg, and L-ascorbic acid M
-3-phosphate ester lysine salt is AC-3-Pt-Lg
It is abbreviated as follows.

0) 11 years old +21 jl manufacturing method After uniformly dissolving all the raw material components in 7 volumes, fill them into a container.

(31 characteristics As shown in Table 1, the skin lotion W agent contains
The skin lotion containing He Z or AC-3t-AC-P Lfft alone (Comparative Example 1.2) has the effect of slightly increasing the turnover rate of the stratum corneum and reducing the number of days, but the skin color In the brightness recovery test and whitening practical test, sufficient effects were not obtained.In fact, Examples 1~
20 The whitening cosmetics of the present invention have good 5F value of Xu, and especially from the day after the mouth has been exposed to sunlight, excess melanin is formed in the skin f5, so the sample is applied to Φ1. The skin on the left forearm has been clearly shown to be effective in preventing dark skin, and has an improved whitening effect compared to the right forearm.

Examples 3-8. Comparative Example 3 [Skin Cream] In the same manner as in Example 1, skin creams of each type were prepared with the following compositions, and after various formulaic experiments, (1) After bringing the composition to 80°C, ( Inject the component (B) into the component C) and mix with stirring. Then, while stirring (↑), cool the temperature to 30°C.

In addition, among the (A) components, oil-soluble ones are included in the (B) component,
The other components are yy);・3 in component (C).

(3) Properties As shown in Table 2, in contrast to Comparative Example 3, Examples 3 to B, which are whitening cosmetics t4 of the present invention, showed good results in all tests and had excellent whitening effects. It was clear that there were. In addition, especially in the whitening practical test, the effect of preventing the skin of the applied area on the left forearm from becoming dark skin was found to be desirable2) Preparation method (B) and (C) ingredients were heated uniformly. , 3. Temperature (Effects of the Invention) As described above, the whitening cosmetic of the present invention has high dermatotoxicity, has the effect of suppressing melanin pigment formation, and has the effect of rapidly lightening the skin color. It is clear that by using the product immediately after exposure to sunlight, etc.
Furthermore, it was observed that the whitening effect was further improved.

Claims (1)

[Claims] A whitening cosmetic comprising at least one of azelaic acid vitamin E derivatives and salts thereof, and at least one of L-ascorbic acid sulfate ester salts and L-ascorbic acid phosphate ester salts.