JPH0249712A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic sufficiently exhibiting effects of medicinal components, excellent safety and feeling in use containing an amine oxide, beautifying agent, dandruff inhibitor and antiseborrheic. CONSTITUTION:One or more of amine oxides (e.g., dimethylllaurylamine oxide), a beautifying agent (e.g., ascorbic acid), a dandruff inhibitor (e.g., zinc pyrithione) and antiseborrheic (e.g., sulfur) are used as active ingredients, blended with conventional components and prepared by a conventional procedure to give the aimed substance. The amount of the amine oxide blended is 0.01-5wt.% and the amounts of the medicinal components of the beautifying agent, dandruff inhibitor and the antiseborrheic are 0.01-5wt.%. The aimed substance has beautifying action and skin flexibility and inhibitory effects on dandruff.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to cosmetics that fully exhibit the effects of drugs. More specifically, the present invention relates to a cosmetic containing one or more amine oxides and one or more selected from the group consisting of whitening agents, anti-dandruff agents, and antiseborrheic agents.

[Prior art] The surface of the skin is called the stratum corneum, and it originally has a physiological function as a barrier to prevent foreign substances from entering the body, so it has been commonly used in cosmetics. Merely incorporating medicinal ingredients into a base does not provide sufficient drug effects.

Problems to be Solved by the Invention] In view of the above-mentioned problems, the present inventors conducted intensive research to develop cosmetics that fully demonstrate the effects of medicinal ingredients.
The present invention has now been completed.

[Means for Solving the Problems] That is, the present invention contains one or more amine oxides and one or more selected from the group consisting of whitening agents, antidandruff agents, and antiseborrheic agents. It is a cosmetic product that is characterized by:

Hereinafter, the configuration of the present invention will be explained in detail.

Examples of the amine oxide used in the present invention include those of the following general formulas (A) to (C).

R2-N→0 (A) (wherein R1, R2, and R3 represent a straight chain or branched saturated or unsaturated hydrocarbon group having 1 to 24 carbon atoms, and at least one of R1, R2, and R3 represents a straight chain or branched saturated or unsaturated hydrocarbon group having 8 or more carbon atoms.) Specific examples of the amine oxide represented by the general formula (A) include dimethyl lauryl amine oxide, dimethyl myristyl amine oxide, dimethylcetylamine oxide, dimethylstefurylamine oxide, dimethyloleylamine oxide, dimethylbehenylamine oxide,
Examples include methyl dilaurylamine oxide.

CH2CR20H R4-N→0 (B) Represents a branched saturated or unsaturated hydrocarbon group. ) R3 R5(OCH2CH12)n N→0 (C)H
3 (wherein R5 represents a straight or branched saturated or unsaturated hydrocarbon/hydrogen group of carbon atoms IJI18 to 24, and n is 1
represents an integer from 5 to 5. ) In the present invention, one or more of these amine oxides are arbitrarily selected and used.

As the whitening agent used in the present invention, ascorbic acid,
Examples include ascorbyl civalmitate, ascorbic acid 2-sulfuric acid, saxifrage extract, placenta extract, kojic acid, and the like.

Anti-dandruff agents used in the present invention include zinc pyrithione, trichlorocarbanilide, piroctone olamine, and the like.

Examples of the antiseborrheic agent used in the present invention include sulfur, peony, botanical, pyridoxine hydrochloride, pyridoxine tribalmitate, Hypericum perforatum, and the like.

When the whitening agent, anti-dandruff agent, and anti-seborrheic agent used in the present invention are mixed with the surfactant of the present invention and applied to the skin, the effects of the agents are fully exhibited. Both medicinal ingredients intended for local action and medicinal ingredients intended for systemic action exhibit excellent effects.

The amount of the whitening agent, anti-dandruff agent, and anti-seborrheic agent used in the present invention may be sufficient as long as it has the desired medicinal effect, and it depends on the type of medicinal ingredient, the skin type and symptoms of the user, etc. -Although it cannot be said generally, approximately 0.001 to 50 amine oxide per 1% by weight of the medicinal ingredient.
Weight%.

The above-mentioned amine oxide may be used as it is after suitably mixing the medicinal ingredients, but taking into consideration the feel of use and the ease of application, for boat fishing, the constituent ingredients may be mixed into an appropriate cosmetic, such as a cream, etc. It is used by mixing it into a base such as gel, roller 3 run, milk), etc.

In that case, the amount of each component to be blended will vary depending on the type of medicinal ingredient, etc., but the following range is generally the preferred range of the amount to be blended. That is, the amount of amine oxide blended in the cosmetic is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, and the medicinal ingredient is 0.0% by weight.
01 to 10% by weight is preferable, more preferably o, oi
~5% by weight.

In addition to the above-mentioned essential components, the cosmetics (-1) according to the present invention can contain ingredients that are generally included in cosmetics. Scutellaria scutellariae extract, ivy extract, yarrow extract, Japanese cabbage extract, birch extract,
Horse chestnut extract, loquat extract, glycyrrhizic acid, β-
Anti-inflammatory agents such as glycyrrhizic acid, monoammonium glycyrrhizinate, stearyl glyderretinate, hinokitiol, D-camphor, L-menthol, zinc oxide, calamine, allantoin, diphenhydramine hydrochloride, carrot extract, mallow extract, garlic extract, iris extract , Yokuinin extract, grape extract, loofah extract, peach extract, yeast extract, royal jelly, sodium copper chlorophyllin, γ-oryzanol, hinokitiol, β-carotene, urea, allantoin, carrageenan, ethinylestradiol, L-alanine ,DL-
Activators such as serine, disodium adenosine triphosphate, pantothenyl ethyl ether, biotin, inosit, ergocalciferol, nicotinamide, black snail, 7-oryzanol, DL-camphor, sodium textran sulfate, DL-α-riluic acid Blood circulation promoters such as tocopherol and DL-α-tocopherol acetate, keratin softeners such as resorcin and lactic acid, horsetail extract, mulberry, mulberry root, deadlock root extract, horse chestnut extract, grape wreath extract, mugwort extract, oxidized tsukuda Astringents such as lead and calamine, aloe extract, lily extract, quince seed, xanthan gum, sodium dextran sulfate, sodium chondroitin sulfate, carrageenan, sodium hyaluronate, moisturizing agents such as urocanic acid, olive oil, royal jelly oyster extract, Yeast extract, ascorbic acid, nutritional supplements such as Inojit, avocado oil, safflower oil, tea seed oil, jojoba oil, ononis extract, urea, linoleic acid, cholesterol, dehydrocholesterol,
Softeners such as dihydrocholesterol, lanosterol, glycyrrhetinyl stearate, polyhydric alcohols, oils, waxes, acids, alkalis, other surfactants, powders, pigments, dyes, preservatives, antioxidants, ultraviolet absorbers, Examples include chelating agents, water-soluble polymers, montmorillonite, alcohols, solvents, fragrances, and the like.

[Examples] Next, the present invention will be specifically explained with reference to Examples, but the present invention is not limited only to these Examples. The blending amount is in weight%.

Example 1 Cream (1) Ascorbic acid 2-sulfuric acid (2) Propylene glycol (3) Glycerin (4) Liquid paraffin (5) Diisopropyl adipate (6) Stearyl dimethylamine oxide (7) Glycerin monofatty acid ester (8) Preservative 1.0 8. 0 5.0 1.0 3.0 0.8 1.5 Adequate amount (9) Clay mineral (bentonite) 6.0 (10)
Purified water Remaining comparative example 1 Cream (1 Ascorbic acid 2-sulfuric acid 1.0 (2 Propylene glycol 8.0 (3 Glycerin)
5.0 (4 Liquid paraffin 1,0 (5 Diisopropyl adipate 3.0 (6 Glycerin monofatty acid ester 1.5 (7) Preservative appropriate amount (8)
Clay mineral (bentonite) 6.0 (9) Purified water
The skin whitening effects of the remaining rnicreams prepared in Example 1 and Comparative Example 1 were compared. The test method and evaluation method are shown below.

That is, the creams prepared in Example 1 and Comparative Example 1 were continuously applied to the faces of 20 female melasma patients for 4 weeks, and evaluations were made before and after that.

The criteria for evaluation are: ``significant improvement effect on melasma'' (score 2) ``obvious improvement effect'' (score 1) ``slight improvement effect'' (score 0.5) ``no change''
(Score O) An average score was determined for each base side.

As is clear from Table 1, it can be seen that the cream of Example 1 has excellent whitening effect.

Example 2 Cream (1) Kojic acid (2) Dehydrocholesterol (3) Tea seed oil 2.0 0.5 0.2 (4) Glycerin monofatty acid ester (5) Lauryldihydroxydiethylamine oxide (6) Liquid paraffin 7 ) Setanol 8) Preservative 9) Clay mineral (bentonite) 10) Fragrance 11) Ion exchange water 1.4 1.2 4.0 1.0 Appropriate amount 5.0 Appropriate amount remainder (8) Clay mineral (bentonite) (9) Fragrance (10) Ion-exchanged water 5.0 Appropriate amount Remaining Example 2 and Comparative Example 2 were tested for whitening effect in the same manner. The results are shown in Table-2.

Comparative Example 3 Cream (1) Kojic acid (2) Dehydrocholesterol (3) Tea seed oil (4) Glycerin monofatty acid ester (5) Liquid paraffin (6) Setanol (7) Preservative 2.0 0.5 0.2 1.4 4.0 1.0 Appropriate Amount As is clear from Table 2, it can be seen that the cream of Example 2 has excellent whitening effect. It also showed excellent effects on skin flexibility.

Example 3 Hair tonic (1) Piroctone olamine (2) DL-α-tocopherol acetate (3) Lily extract 1.0 0.3 0.05 (4) Pyridoxine hydrochloride 0.07
(5) Hinoki teal 0.03
(6) Oleyl dimethylamine oxide 0.7 (7) Polyoxyethylene (40 mol addition) hydrogenated castor oil derivative 0.5 (8) Ethyl alcohol 50.0 (
9) Buffering agent appropriate amount (10) Flavoring agent appropriate amount (11) Purified water
Residue Comparative Example 3 Hair tonic (1 Piroctone olamine 1.0 (2 Acetate DL-α-tocopherol 0.3 (3 Lily extract)
0.05 (pyridoxine 4-hydrochloride
0.07 (5 hinokitiru
0.03 (6 polyoxyethylene (40 mol addition) hydrogenated castor oil derivative 0.5 (7) Ethyl alcohol 50.0 (
8) Mild (÷i agent (9) Fragrance (10) Appropriate amount of purified water Appropriate amount of remainder A dandruff suppression test was conducted for Example 3 and Comparative Example 3.

The test method and evaluation method are shown below.

Twelve men between the ages of 22 and 36 with relatively heavy dandruff were selected as subjects, and each sample was tested on six men for a total of twelve men. Before the start of the test, the hair was washed with a normal shampoo, the accumulated dandruff was collected for 3 days after the hair washing, and the weight of the collected dandruff was calculated using the hair tonic prepared in Example 3 and Comparative Example 3 for one month. The weight of dandruff accumulated during the three days after the last hair wash at the end of the test period was compared. Accumulated dandruff was collected by suctioning the head using a suction device with a filter cloth.

The reduction in dandruff due to the use of hair tonic was calculated using the following formula.

The results are shown in Table-3.

As is clear from Table 3, the hair tonic of Example 3 has an excellent dandruff suppressing effect.

Example 4 Emulsion (1 pyridoxine hydrochloride (2 salicylic acid) 3 loquat extract (4' L-menthol (5 cetanol (6 vaseline P Oxide 10 Glycerin monostearate 11 Glycerin 12) Dipropy 1/N glycol 3 Carboxyvinyl polymer 4KOH 0,05 0,1 0,02 0,2 1,0 2,0 4,0 2,0 1,2 2, 0 5,0 4,0 0,3 0,1 (15) Preservative (16) Fragrance (17) Ion exchange water Comparative example 4 Emulsion (1 Pyridoxine hydrochloride (2 Salicylic acid (3) Loquat extract (4L, -Menthol ( 5) Setanol (6 Vaseline P (7 Squalane (8 Dimethylpolysiloxane) .05 0.1 0.02 0.2 1.0 2.0 4.0 2.0 2.0 5.0 4.0 0.3 0.1 Appropriate amount i!i amount (16) Remaining ion exchange water The acne-improving effects of the emulsions prepared in Example 4 and Comparative Example 4 were compared.The test method and evaluation method are shown below.

That is, the emulsions prepared in Example 4 and Comparative Example 4 were continuously applied to the faces of 20 healthy women suffering from acne for 4 weeks, and evaluations were made before and after.

The judgment criteria are: ``Remarkable improvement effect on acne'' (Score 2) ``Clear improvement effect'' (Score 1) ``Weak improvement effect'' (Score 0.5) ``No change''
(Score O) An average score was determined for each base. The results are shown in Table-4.

Table 4 The hair liquid of Example 5 showed an excellent dandruff suppressing effect.

As is clear from Table 4, it can be seen that the emulsion of Example 4 has an excellent acne-improving effect.

Example 5 Hair liquid (1) Trichlorocarbanilide (2) DL-α-tocopherol acetate (3) Polyoxypropylene (40 mol addition) Butyl ether (4 Ethyl alcohol (5) Oleyl dimethylamine oxide (6) Stearyl dimethylamine oxide ( 7 Fragrance (8 Ion-exchanged water 0.3 0.1 15.0 50.0 1.2 0.4 Appropriate amount remaining Example 6 Lotion ■) Ascorbic acid 2-sulfuric acid 2 Placenta extract 3 Pantothenyl ethyl ether 4 Di Lauryl methylamine oxide 5 Behenyldimethylamine oxide (6 Glycerin (71,3-butylene glycol) 8 Ethyl alcohol (9 Preservative (10) Buffer (11) Ion exchange water 0.3 0.2 0.2 0.2 0.4 2.0 1.0 10.0 Appropriate amount Appropriate amount Residual The lotion of Example 6 exhibited an excellent whitening effect and also exhibited a skin revitalizing effect.

[Effects of the Invention] The cosmetic according to the present invention is a cosmetic that fully exhibits the effects of medicinal ingredients, and is safe and feels good when used.

Claims (1)

[Claims] (1) one or more amine oxides and a whitening agent,
A cosmetic comprising one or more selected from the group consisting of an anti-dandruff agent and an anti-seborrheic agent.