JPH0247700B2 - - Google Patents
Info
- Publication number
- JPH0247700B2 JPH0247700B2 JP56063160A JP6316081A JPH0247700B2 JP H0247700 B2 JPH0247700 B2 JP H0247700B2 JP 56063160 A JP56063160 A JP 56063160A JP 6316081 A JP6316081 A JP 6316081A JP H0247700 B2 JPH0247700 B2 JP H0247700B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- sample
- measurement
- blood
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 claims description 120
- 238000005259 measurement Methods 0.000 claims description 54
- 210000004369 blood Anatomy 0.000 claims description 45
- 239000008280 blood Substances 0.000 claims description 44
- 239000000243 solution Substances 0.000 claims description 19
- 239000007853 buffer solution Substances 0.000 claims description 14
- 239000012488 sample solution Substances 0.000 claims description 10
- 239000012086 standard solution Substances 0.000 claims description 6
- 239000012482 calibration solution Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 108010093096 Immobilized Enzymes Proteins 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 50
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 20
- 239000008103 glucose Substances 0.000 description 20
- 239000012895 dilution Substances 0.000 description 19
- 238000010790 dilution Methods 0.000 description 19
- 230000008859 change Effects 0.000 description 14
- 239000003146 anticoagulant agent Substances 0.000 description 13
- 229940127219 anticoagulant drug Drugs 0.000 description 13
- 101100441413 Caenorhabditis elegans cup-15 gene Proteins 0.000 description 12
- 238000005070 sampling Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000007410 oral glucose tolerance test Methods 0.000 description 4
- 238000010241 blood sampling Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 102100021851 Calbindin Human genes 0.000 description 1
- 101710196208 Fibrinolytic enzyme Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000898082 Homo sapiens Calbindin Proteins 0.000 description 1
- 101001021643 Pseudozyma antarctica Lipase B Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- -1 that is Substances 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150229—Pumps for assisting the blood sampling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Manufacturing & Machinery (AREA)
- Optics & Photonics (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56063160A JPS57178151A (en) | 1981-04-24 | 1981-04-24 | Automatic and continuous measuring apparatus of blood component |
| EP82302100A EP0064369B1 (de) | 1981-04-24 | 1982-04-23 | Vorrichtung zur automatischen und kontinuierlichen Bestimmung von Blutbestandteilen |
| DE8282302100T DE3273657D1 (en) | 1981-04-24 | 1982-04-23 | A device for automatically and continuously measuring the constituent parts of blood |
| US06/371,482 US4512348A (en) | 1981-04-24 | 1982-04-23 | Device for automatically and continuously measuring the constituent parts of blood |
| BE0/207920A BE892964A (fr) | 1981-04-24 | 1982-04-26 | Dispositif en vue de mesurer automatiquement et en continu les elements constitutifs du sang |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56063160A JPS57178151A (en) | 1981-04-24 | 1981-04-24 | Automatic and continuous measuring apparatus of blood component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57178151A JPS57178151A (en) | 1982-11-02 |
| JPH0247700B2 true JPH0247700B2 (de) | 1990-10-22 |
Family
ID=13221202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56063160A Granted JPS57178151A (en) | 1981-04-24 | 1981-04-24 | Automatic and continuous measuring apparatus of blood component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57178151A (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62186846A (ja) * | 1986-02-13 | 1987-08-15 | 日機装株式会社 | 連続採血サンプルの特定物質濃度測定装置 |
| AT389589B (de) * | 1987-04-03 | 1989-12-27 | Avl Verbrennungskraft Messtech | Einrichtung zur wahlweisen beschickung eines analysengeraetes |
| JPH0389168A (ja) * | 1989-08-31 | 1991-04-15 | Kanzaki Paper Mfg Co Ltd | フロー型測定装置及びそれを用いた測定方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53109691A (en) * | 1977-03-07 | 1978-09-25 | Hitachi Ltd | Flow cell type analysis method and apparatus liquid for specimen |
| JPS54106962A (en) * | 1978-02-09 | 1979-08-22 | Akira Yoda | Chaff crusher |
-
1981
- 1981-04-24 JP JP56063160A patent/JPS57178151A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53109691A (en) * | 1977-03-07 | 1978-09-25 | Hitachi Ltd | Flow cell type analysis method and apparatus liquid for specimen |
| JPS54106962A (en) * | 1978-02-09 | 1979-08-22 | Akira Yoda | Chaff crusher |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57178151A (en) | 1982-11-02 |
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