JPH0242504B2 - - Google Patents
Info
- Publication number
- JPH0242504B2 JPH0242504B2 JP62261650A JP26165087A JPH0242504B2 JP H0242504 B2 JPH0242504 B2 JP H0242504B2 JP 62261650 A JP62261650 A JP 62261650A JP 26165087 A JP26165087 A JP 26165087A JP H0242504 B2 JPH0242504 B2 JP H0242504B2
- Authority
- JP
- Japan
- Prior art keywords
- ether
- resin composition
- soft resin
- medical
- glycerin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 110
- 239000011342 resin composition Substances 0.000 claims description 75
- 210000004369 blood Anatomy 0.000 claims description 62
- 239000008280 blood Substances 0.000 claims description 62
- -1 ether compound Chemical class 0.000 claims description 57
- 150000002430 hydrocarbons Chemical group 0.000 claims description 45
- 229920005989 resin Polymers 0.000 claims description 32
- 239000011347 resin Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 25
- 125000001033 ether group Chemical group 0.000 claims description 25
- 239000001301 oxygen Substances 0.000 claims description 25
- 229910052760 oxygen Inorganic materials 0.000 claims description 25
- 229920002635 polyurethane Polymers 0.000 claims description 22
- 239000004814 polyurethane Substances 0.000 claims description 22
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 21
- 229920001577 copolymer Polymers 0.000 claims description 21
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 239000004014 plasticizer Substances 0.000 claims description 19
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 17
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 14
- 229920000573 polyethylene Polymers 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 150000002170 ethers Chemical class 0.000 claims description 7
- 229920000728 polyester Polymers 0.000 claims description 7
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 7
- 239000004800 polyvinyl chloride Substances 0.000 claims description 7
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 229920002959 polymer blend Polymers 0.000 claims description 5
- 229920001169 thermoplastic Polymers 0.000 claims description 5
- 239000004416 thermosoftening plastic Substances 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 36
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 35
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 18
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 18
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 15
- 206010018910 Haemolysis Diseases 0.000 description 15
- 230000008588 hemolysis Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 210000003743 erythrocyte Anatomy 0.000 description 14
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 10
- 210000002381 plasma Anatomy 0.000 description 9
- 239000000306 component Substances 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 6
- 108010054147 Hemoglobins Proteins 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 210000004623 platelet-rich plasma Anatomy 0.000 description 4
- QGCFQTWMBUKZFW-UHFFFAOYSA-N 1-butoxy-16-methylheptadecane Chemical compound C(CCC)OCCCCCCCCCCCCCCCC(C)C QGCFQTWMBUKZFW-UHFFFAOYSA-N 0.000 description 3
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 3
- HDSGGLDPANXUOY-UHFFFAOYSA-N 16-methyl-1-propan-2-yloxyheptadecane Chemical compound CC(C)CCCCCCCCCCCCCCCOC(C)C HDSGGLDPANXUOY-UHFFFAOYSA-N 0.000 description 2
- YHCCCMIWRBJYHG-UHFFFAOYSA-N 3-(2-ethylhexoxymethyl)heptane Chemical compound CCCCC(CC)COCC(CC)CCCC YHCCCMIWRBJYHG-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- CIDHFUQBCBSBRO-UHFFFAOYSA-N 1-[2,3-bis(2-methylpropoxy)propoxy]-2-methylpropane Chemical compound CC(C)COCC(OCC(C)C)COCC(C)C CIDHFUQBCBSBRO-UHFFFAOYSA-N 0.000 description 1
- FJUBOZROYNKIMV-UHFFFAOYSA-N 1-[2,3-bis(3-methylbutoxy)propoxy]-3-methylbutane Chemical compound CC(C)CCOCC(OCCC(C)C)COCCC(C)C FJUBOZROYNKIMV-UHFFFAOYSA-N 0.000 description 1
- FJJACTGBBKXRDK-UHFFFAOYSA-N 1-[2-(2-butoxyethoxy)ethoxy]-3-methylbutane Chemical compound CCCCOCCOCCOCCC(C)C FJJACTGBBKXRDK-UHFFFAOYSA-N 0.000 description 1
- NMLLTHLOSVNFMY-UHFFFAOYSA-N 1-butoxy-3-methylbutane Chemical compound CCCCOCCC(C)C NMLLTHLOSVNFMY-UHFFFAOYSA-N 0.000 description 1
- FLWPLEJBOIQGBW-UHFFFAOYSA-N 16-methyl-1-(2-methylpropoxy)heptadecane Chemical compound C(C(C)C)OCCCCCCCCCCCCCCCC(C)C FLWPLEJBOIQGBW-UHFFFAOYSA-N 0.000 description 1
- OVZBYIWZUUXJMN-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethanol Chemical compound OCCOCCO.OCCOCCO OVZBYIWZUUXJMN-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- PEFIQBVQMPKANX-UHFFFAOYSA-N 3-(1,3-dibutoxypropan-2-yloxymethyl)heptane Chemical compound CCCCOCC(COCCCC)OCC(CC)CCCC PEFIQBVQMPKANX-UHFFFAOYSA-N 0.000 description 1
- JWSYJZKEPKDXHA-UHFFFAOYSA-N 3-(2,5-dimethylhexan-2-yloxy)propane-1,2-diol Chemical compound C(C)(C)CCC(C)(C)OCC(O)CO JWSYJZKEPKDXHA-UHFFFAOYSA-N 0.000 description 1
- DWYVJBPOMVHFKW-UHFFFAOYSA-N 3-(2-methyloctan-2-yloxy)propane-1,2-diol Chemical compound CCCCCCC(C)(C)OCC(O)CO DWYVJBPOMVHFKW-UHFFFAOYSA-N 0.000 description 1
- CBWPGKXHWQUERP-UHFFFAOYSA-N 3-(2-propan-2-yloxyethoxymethyl)heptane Chemical compound CCCCC(CC)COCCOC(C)C CBWPGKXHWQUERP-UHFFFAOYSA-N 0.000 description 1
- AEQSRSXWZJFUTF-UHFFFAOYSA-N 3-(20-methylhenicosan-5-yloxy)propane-1,2-diol Chemical compound OCC(O)COC(CCCC)CCCCCCCCCCCCCCC(C)C AEQSRSXWZJFUTF-UHFFFAOYSA-N 0.000 description 1
- GQQHEKOOHGFEED-UHFFFAOYSA-N 3-(propan-2-yloxymethyl)heptane Chemical compound CCCCC(CC)COC(C)C GQQHEKOOHGFEED-UHFFFAOYSA-N 0.000 description 1
- QRIIMZADASNLNI-UHFFFAOYSA-N 3-[2-(2-ethylhexoxy)ethoxymethyl]heptane Chemical compound CCCCC(CC)COCCOCC(CC)CCCC QRIIMZADASNLNI-UHFFFAOYSA-N 0.000 description 1
- NZXXOEAWMQEZPZ-UHFFFAOYSA-N 3-[2-(2-ethylhexoxy)propoxymethyl]heptane Chemical compound CCCCC(CC)COCC(C)OCC(CC)CCCC NZXXOEAWMQEZPZ-UHFFFAOYSA-N 0.000 description 1
- ZVEHYXJFLMJYKE-UHFFFAOYSA-N 3-[2-(2-propan-2-yloxyethoxy)ethoxymethyl]heptane Chemical compound CCCCC(CC)COCCOCCOC(C)C ZVEHYXJFLMJYKE-UHFFFAOYSA-N 0.000 description 1
- KDEPTIZYSPUNAD-UHFFFAOYSA-N 3-[2-[2-(2-ethylhexoxy)ethoxy]ethoxymethyl]heptane Chemical compound CCCCC(CC)COCCOCCOCC(CC)CCCC KDEPTIZYSPUNAD-UHFFFAOYSA-N 0.000 description 1
- QRIUEZQNQVVNQK-UHFFFAOYSA-N 3-methyl-1-[2-(2-propan-2-yloxyethoxy)ethoxy]butane Chemical compound CC(C)CCOCCOCCOC(C)C QRIUEZQNQVVNQK-UHFFFAOYSA-N 0.000 description 1
- 102000007347 Apyrase Human genes 0.000 description 1
- 108010007730 Apyrase Proteins 0.000 description 1
- 101710131215 Apyrase 2 Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- AQZGPSLYZOOYQP-UHFFFAOYSA-N Diisoamyl ether Chemical compound CC(C)CCOCCC(C)C AQZGPSLYZOOYQP-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 229920003314 Elvaloy® Polymers 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920001944 Plastisol Polymers 0.000 description 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical group CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- ROPXFXOUUANXRR-YPKPFQOOSA-N bis(2-ethylhexyl) (z)-but-2-enedioate Chemical compound CCCCC(CC)COC(=O)\C=C/C(=O)OCC(CC)CCCC ROPXFXOUUANXRR-YPKPFQOOSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000010101 extrusion blow moulding Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004999 plastisol Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920003225 polyurethane elastomer Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62261650A JPH01104268A (ja) | 1987-10-19 | 1987-10-19 | 医療用軟質樹脂組成物および医療用具 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62261650A JPH01104268A (ja) | 1987-10-19 | 1987-10-19 | 医療用軟質樹脂組成物および医療用具 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01104268A JPH01104268A (ja) | 1989-04-21 |
| JPH0242504B2 true JPH0242504B2 (US06559137-20030506-C00112.png) | 1990-09-25 |
Family
ID=17364852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62261650A Granted JPH01104268A (ja) | 1987-10-19 | 1987-10-19 | 医療用軟質樹脂組成物および医療用具 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01104268A (US06559137-20030506-C00112.png) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006326226A (ja) * | 2005-05-30 | 2006-12-07 | Nipro Corp | ガイディングカテーテル |
-
1987
- 1987-10-19 JP JP62261650A patent/JPH01104268A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01104268A (ja) | 1989-04-21 |
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