JPH0225406Y2 - - Google Patents

Description

[Detailed description of the invention] (Field of industrial application) The invention consists of a first membrane module that separates blood cell components and plasma components from blood, and a second membrane module that removes high molecular weight substances from the separated plasma components. The present invention relates to a double-pass type blood processing device consisting of modules.

(Prior Art) As shown in FIG. 2, in a conventional double-pass type blood processing device, low molecular weight substances separated by a second membrane module 2 are sent to a blood reservoir 11 through a derivation circuit 6. After combining with the blood cell components sent from the first membrane module 1 through the derivation circuit 4, it is returned to the patient's body. Further, in order to supplement the plasma removed by the second membrane module 2, a replacement fluid such as albumin or HES is sent from the replacement fluid container 12 to the blood reservoir 11 through the introduction circuit 7 via the pump 10.
3 is a blood introduction circuit, 5 is a plasma circuit, 8 is a blood pump, and 9 is a plasma pump. (Refer to Japanese Patent Publication No. 60-40302) [Problems to be solved by the invention] However, in the method of returning the replacement fluid to the patient by mixing blood cell components and low molecular weight substances in the blood reservoir 11, the replacement fluid introduction circuit 7 becomes long. In addition to the inconvenience of a delay in the supply of replacement fluid when starting the replacement fluid supply,
It is inevitable that the circuit will become complicated.

(Means for Solving the Problems) The present inventors have arrived at the present invention as a result of intensive studies to solve the above-mentioned problems.

That is, the present invention includes a first membrane module that separates blood drawn from the body into blood cell components and plasma components, and a second membrane module that separates the separated plasma components into high molecular weight substances and low molecular weight substances. In the double-pass type blood processing device, the blood cell components separated by the first membrane module are returned to the body after adding a low molecular weight substance and a replacement fluid separated by the second membrane module. 2 membrane modules are arranged substantially in the vertical direction, and a plasma inlet is provided at the bottom of the plasma chamber of the membrane module, a high molecular weight substance outlet is provided at the top of the plasma chamber, and a high molecular weight substance outlet is provided at the bottom of the purified plasma chamber. This is a double-pass type blood processing device characterized by providing a low molecular weight substance outlet and a replacement fluid inlet in the upper part of the purified plasma chamber.

(Function) According to the present invention, the replacement fluid introduction circuit can be shortened by connecting the replacement fluid introduction circuit to the second membrane module and mixing the replacement fluid and the low molecular weight substance in the second membrane module. Supply delays at the start of replacement fluid supply can be reduced. Further, during priming, the priming liquid is supplied into the membrane module from the upper part of the purified plasma chamber of the second membrane module, so that the outer walls of all the hollow fiber membranes can be cleaned.

(Example) Next, an example of the device of the present invention will be described with reference to the drawings. In Fig. 1, the patient's blood taken out from the blood introduction part (the part that can communicate with a normal blood collection device such as a shunt or a syringe needle or a blood storage device) attached to the tip of the blood introduction circuit 3 is transferred to the blood pump. 8 enters the arterial pressure chamber 16, and then,
introduced into the first membrane module 1 from its upper side,
It is separated into blood cell components and plasma components. The first membrane module 1 accommodates a plasma separation membrane, for example, a flat, tube-shaped, or hollow-type separation membrane made of a polyvinyl alcohol (PVA) copolymer. Usually, a collection of a large number of hollow separation membranes is used.

The blood cell components separated by the first membrane module 1 are transferred to a venous pressure chamber 1 provided in the derivation circuit 4.
The blood is returned to the patient's body from the blood outlet part (a part that can be connected to a shunt, an intravenous drip set, etc.).

Furthermore, on the upstream side of the blood pump 8, a pillow sensor 21 consisting of a bag-like body that can be expanded and contracted is provided.
is provided, and when it becomes difficult to remove blood,
It operates upon detecting the negative pressure in the blood introduction circuit 3, stops the blood pump 8, and restarts the blood pump when the negative pressure disappears. Also, connected to the arterial pressure chamber 16 are a heparin injector 22 that mixes a small amount of heparin into the blood to prevent blood from coagulating during treatment, and an arterial pressure sensor 23. An overpressure sensor 24 is connected to the module 1, and a venous pressure sensor 26 is connected to the venous pressure chamber 18. Further, an air bubble detector 27 is installed near the blood lead-out portion of the blood lead-out circuit 4.
is provided.

The plasma component separated in the first membrane module 1 is pressurized by the plasma pump 9 of the plasma circuit 5, enters the secondary membrane pressure chamber 32, and is introduced into the second membrane module 2 from below, Separated into high molecular weight substances and low molecular weight substances. This second membrane module 2 accommodates a plasma processing membrane, for example, a flat, tube-shaped, or hollow separation membrane made of an ethylene vinyl alcohol (EVA) copolymer. Usually, a collection of a large number of hollow fiber separation membranes is used.

The high molecular weight substance separated by the second membrane module 2 is discharged from above the second membrane module to the outside through a drain opening by a drain pump 13. On the other hand, the low molecular weight substances are returned from the plasma derivation circuit 6 to the human body via the blood derivation circuit 4.

In the second membrane module 2, a replacement fluid introduction part (a part that can be connected to an intravenous drip set, etc.) is connected to a replacement fluid container 1 that supplies replacement fluid such as albumin or HES through the drain pump 13 and the bubble detector 40.
2, and the replacement fluid is sent into the second membrane module 2 by the drain pump 13, where it is mixed with the low molecular weight substances that have passed through the membrane in the purified plasma chamber of the module.

Here, the drain pump 13 serves both to discharge high molecular weight substances and to supply replacement fluid, but unlike this, the discharge of high molecular weight substances and the supply of replacement fluid are performed separately as shown in FIG. A pump may also be used. However, if the dual-use structure is adopted as in this embodiment, the discharge amount of the high molecular weight substance and the supply amount of the replacement fluid are always equal to each other without any particular control, which is advantageous.

The second membrane module 2 is arranged substantially vertically. Here, "substantially" means that the plasma inlet a and the low molecular weight substance outlet b of the second membrane module are located at the bottom, and the high molecular weight substance outlet c and the replacement fluid inlet d are located at the bottom of the second membrane module.
This also includes an embodiment in which the holder is arranged at an angle so that the top is at the top. In short, as long as the replacement fluid introduced into the second membrane module is collected at the lower part of the second membrane module and led out from the low molecular weight substance outlet b, it may be arranged approximately horizontally.

(Effects of the invention) As explained above, according to the invention, the replacement fluid introduction circuit can be shortened compared to the conventional method. Accordingly, the residence time of the replacement fluid in the circuit is shortened, and the delay in the replacement fluid supply at the time of starting the replacement fluid supply can be reduced. Furthermore, during priming, it has the excellent effect of cleaning the outer wall of the hollow fibers of the second membrane module.

[Brief explanation of the drawing]

FIG. 1 is a flowchart showing an embodiment of the double-pass type blood processing device of the present invention, and FIG. 2 is a flowchart of a conventional device. 1...First membrane module, 2...Second membrane module, 7...Replacement fluid introduction circuit.

Claims (1)

[Scope of utility model registration request] a first membrane module that separates blood drawn from the body into blood cell components and plasma components; and a second membrane module that separates the separated plasma components into high molecular weight substances and low molecular weight substances; In a double-pass type blood processing device in which low molecular weight substances and replacement fluid separated by the second membrane module are added to blood cell components separated by the first membrane module and then returned to the body, the second membrane module are arranged substantially vertically, a plasma inlet is provided at the bottom of the plasma chamber of the membrane module, a high molecular weight substance outlet is provided at the top of the plasma chamber, and a low molecular weight substance is introduced at the bottom of the purified plasma chamber. 1. A double-pass type blood processing device, characterized in that an outlet and a replacement fluid inlet are provided in the upper part of the purified plasma chamber.