JPS6164257A - Sterilization of body fluid treatment apparatus - Google Patents
Sterilization of body fluid treatment apparatusInfo
- Publication number
- JPS6164257A JPS6164257A JP59184496A JP18449684A JPS6164257A JP S6164257 A JPS6164257 A JP S6164257A JP 59184496 A JP59184496 A JP 59184496A JP 18449684 A JP18449684 A JP 18449684A JP S6164257 A JPS6164257 A JP S6164257A
- Authority
- JP
- Japan
- Prior art keywords
- body fluid
- treatment device
- fluid treatment
- circuit
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001124 body fluid Anatomy 0.000 title claims description 32
- 239000010839 body fluid Substances 0.000 title claims description 32
- 230000001954 sterilising effect Effects 0.000 title claims description 22
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 16
- 210000004369 blood Anatomy 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000002504 physiological saline solution Substances 0.000 claims description 6
- 229920000515 polycarbonate Polymers 0.000 claims description 6
- 239000004417 polycarbonate Substances 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005977 Ethylene Substances 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 239000012510 hollow fiber Substances 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920001747 Cellulose diacetate Polymers 0.000 claims description 2
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 210000001367 artery Anatomy 0.000 claims description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 229920000578 graft copolymer Polymers 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920002492 poly(sulfone) Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920002050 silicone resin Polymers 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 239000004945 silicone rubber Substances 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 description 25
- 238000000605 extraction Methods 0.000 description 5
- 230000036470 plasma concentration Effects 0.000 description 4
- 238000001802 infusion Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 235000008375 Decussocarpus nagi Nutrition 0.000 description 1
- 244000309456 Decussocarpus nagi Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- RZXDTJIXPSCHCI-UHFFFAOYSA-N hexa-1,5-diene-2,5-diol Chemical compound OC(=C)CCC(O)=C RZXDTJIXPSCHCI-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、血液中の血漿成分及び／または血漿成分中の
物質を分離する体液処理装置の滅菌方法に関するもので
、特に臨床使用前の洗浄作業のＤｉ Ｊ化を図ったもの
である。Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a method for sterilizing a body fluid treatment device that separates plasma components in blood and/or substances in plasma components, and particularly relates to a method for sterilizing a body fluid treatment device for separating plasma components in blood and/or substances in plasma components. This is an attempt to make the work DiJ.
（従来の技術）
従来から、−次フイルターと二次フィルターを用い、−
次フイルターにおいて血液中の血漿成分を分離し、さら
に二次フィルターにおいてこの血漿成分中のターゲット
物質を分離除去する装置が知られている。(Conventional technology) Conventionally, − order filters and secondary filters are used, −
An apparatus is known in which a secondary filter separates a plasma component from blood, and a secondary filter further separates and removes a target substance from the plasma component.
かかる血漿分ｇｌ装置の滅菌処理は、各フィルターにつ
いては１本体内に生理食塩水を封入した後、所定の条件
で高圧プ＾気滅菌を行ない、また、これらフィルタ一連
結される血液回路はエチンオキサイトによるガス滅菌が
なされるのが通例である。In the sterilization process of such a plasma GL device, each filter is sterilized with high-pressure air under predetermined conditions after filling the body with physiological saline, and the blood circuit connected to these filters is Gas sterilization using oxide is usually performed.
（発明が解決しようとする問題点）
しかし、前記フィルターの高圧ハス滅菌では、フィルタ
ーを収容するハウジング内に必ずしも完全に生理食塩水
が充填されるとは限られず、たとえば血液及び血漿出入
口付近に多少の空気が溜ることが多く、さらには血液回
路との連結部に空気が入ることもあって、これらの空気
の残留により凝血等を引き起すことにもなる。(Problems to be Solved by the Invention) However, in the high-pressure lotus sterilization of the filter, the housing containing the filter is not necessarily completely filled with physiological saline, and for example, some amount of saline is present near the blood and plasma entrances and exits. In many cases, air accumulates in the blood, and air may also enter the connection to the blood circuit, resulting in blood clots or the like due to residual air.
また前述のようにフィルターと血液回路を別々に滅菌す
ると、臨床使用前の準備作業がきわめて煩雑である。す
なわち、使用前には一次フイルター、二次フィルター及
び血液回路を生理食塩水で洗浄する必要があるが、その
作業は動脈側回路先端部の洗浄から始まって、動脈側回
路、静脈側回路、血漿抜取回路、血漿返５回’１８等を
一次フイルターや二次フィルターに所定の手順に従って
順次連結しつつ、洗浄を進めていくものである。このた
め各部位での連結作業やコッヘルのセットなどが複雑で
面倒であり、また連結部位が細菌に汚染される心配があ
る等の問題がある。Furthermore, if the filter and blood circuit are sterilized separately as described above, the preparation work before clinical use is extremely complicated. In other words, before use, it is necessary to wash the primary filter, secondary filter, and blood circuit with physiological saline. Washing proceeds while sequentially connecting the extraction circuit, plasma return 5 times, etc. to the primary filter and secondary filter according to a predetermined procedure. For this reason, the connection work and the setting of the Kocher at each site are complicated and troublesome, and there is also a risk that the connection sites may be contaminated with bacteria.
（問題点を解決するための手段）
本発明はこのような従来の不利欠点を解決するために検
討の結果提案されたものである。(Means for Solving the Problems) The present invention has been proposed as a result of studies to solve these conventional disadvantages.
すなわち、本発明は、血漿成分及び／または而・漿成分
中の物質を分離する体液処理装置を減菌するにあたり、
前記体液処理装置と体液循環回路内に液体を充填し、か
つこれら体液処理装置と体液循環回路とを連結した状態
で同時に高圧／′に気滅菌することにある。That is, the present invention provides a method for sterilizing a body fluid treatment device that separates substances in plasma components and/or plasma components.
The purpose is to fill the body fluid treatment device and the body fluid circulation circuit with liquid, and simultaneously perform air sterilization at high pressure /' while the body fluid treatment device and the body fluid circulation circuit are connected.
前記体液処理装置は、血液中の血漿成分を分離する一次
フイルターと血漿成分中の大分子量成分を分離排出する
二次フィルターとから構成され、これらフィルターはハ
ウジングの中に多数の中空系膜を束ねて収容したもので
ある。 −＋ｉη記中空糸膜の材質としては、セルロー
スアセテートまたはセルロースジアセテート、ポリビニ
ルアルコール、ポリエチレンまたはポリプロピレン、ポ
リスルフォン、ポリカーボネート、エチレンビニルアル
コールＢ 重合体、／リコーン樹脂の中から選定される
。The body fluid treatment device is composed of a primary filter that separates plasma components from blood and a secondary filter that separates and discharges large molecular weight components from the plasma components.These filters bundle a large number of hollow membranes in a housing. This is what was housed. -+iη The material for the hollow fiber membrane is selected from cellulose acetate or cellulose diacetate, polyvinyl alcohol, polyethylene or polypropylene, polysulfone, polycarbonate, ethylene vinyl alcohol B polymer, and silicone resin.
また前記フィルターのハウジングの材質としては、ポリ
カーボネイトまたはポリオレフィンが好ましい。Furthermore, the material of the housing of the filter is preferably polycarbonate or polyolefin.
これら−次フイルター及び二次フィルターに接続される
動脈側回路、静ｒ＠個回路、血漿抜取回路、血漿濃縮回
路等の各血液回路の材質としてはポリ塩化ビニル、ポリ
エチレンとアクリル酸アルキルエステル共重合体、ポリ
塩化ビニルとポリウレタンエラストマーの共重合体、塩
化ビニルとエチレン・酢酸ビニル共重合体のグラフト共
重合体、１１！化ビニルとエチレン・酢酸ビニル・一酸
化炭素共重合体の組成物、ポリオレフイノ、ポリカーボ
ネート、シリコーンゴム、ラテックスの中から選ばれる
。The materials of the blood circuits connected to these secondary filters and secondary filters, such as the arterial side circuit, the static r@individual circuit, the plasma extraction circuit, and the plasma concentration circuit, are polyvinyl chloride, polyethylene, and acrylic acid alkyl ester copolymer. Coalescence, copolymer of polyvinyl chloride and polyurethane elastomer, graft copolymer of vinyl chloride and ethylene/vinyl acetate copolymer, 11! The material is selected from a composition of vinyl chloride and ethylene/vinyl acetate/carbon monoxide copolymer, polyolefin, polycarbonate, silicone rubber, and latex.
こうした−次フイルター、二次フィルター及び血液回路
は滅菌前あらかじめ連結されるとともに、各フィルター
及び血液回路の内部には生理食塩水または蒸留水が充填
される。そしてこの状態で高圧蒸気減菌がなされるが、
この滅菌温度は８０−１３０℃、圧力は１〜３ｋｇ／ｃ
ゴが好ましい。These secondary filters, secondary filters, and blood circuits are connected in advance before sterilization, and each filter and blood circuit is filled with physiological saline or distilled water. In this state, high-pressure steam sterilization is performed.
The sterilization temperature is 80-130℃ and the pressure is 1-3kg/c.
Go is preferred.
（実施例）
第１図は本発明が適用される二重口過型血漿分離交換装
置の一例であり、８は一次フイルター、１５は二次フィ
ルター、３は動脈側回路、ｌＯは血漿抜取回路 ２１は
静脈側回路、２５は血漿返還回路、２６は血漿ｅ縮回路
、２７は補充液ラインである。(Example) Fig. 1 is an example of a double-port plasma separation and exchange device to which the present invention is applied, in which 8 is a primary filter, 15 is a secondary filter, 3 is an artery side circuit, and IO is a plasma extraction circuit. 21 is a venous circuit, 25 is a plasma return circuit, 26 is a plasma e-contraction circuit, and 27 is a replenisher line.
そして、動脈側シャント接続部から採血された血液は動
脈側回路３を通って一次フイルター８に導かれ４内部の
中空糸膜を介して血球と血漿に分離される。血球は静脈
側回路２１を通って静脈側シャント接続部２４から思考
に返還され、血漿は血漿抜取回路ｌＯを通って二次フィ
ルター１５に導かれる。この二次フィルター１５では、
血漿成分中の大分子量物質と低分子賃物質とが分離され
、大分子量物質は血漿濃縮回路２６を通って排液バック
２０に排出される。また低分子物質は、血漿返還回路２
５を通り、静脈側回路２１を通って患者に返還されると
同時に、補液容器１８から大分子量物質の排出量に応じ
て補液が静脈側回路２１に送液されるようになっている
。The blood collected from the arterial shunt connection is guided through the arterial circuit 3 to the primary filter 8 and separated into blood cells and plasma via the hollow fiber membrane 4 inside. The blood cells are returned to the brain via the venous shunt connection 24 through the venous circuit 21, and the plasma is led to the secondary filter 15 through the plasma withdrawal circuit IO. In this secondary filter 15,
Large molecular weight substances and low molecular weight substances in the plasma components are separated, and the large molecular weight substances are discharged into the drainage bag 20 through the plasma concentration circuit 26. In addition, low molecular weight substances are
5 and is returned to the patient through the venous circuit 21. At the same time, the replacement fluid is sent to the venous circuit 21 according to the amount of large molecular weight substances discharged from the replacement fluid container 18.
その他、：ＪＳ１図で５は圧力モニターライン。Others: 5 in the JS1 diagram is the pressure monitor line.
６はドリップチャンバー、２はヘパリン注入ラインであ
る。6 is a drip chamber, and 2 is a heparin injection line.
このような構成において、各フィルター及び回路内に生
理食塩水または蒸留水を充填し。In such a configuration, each filter and circuit is filled with saline or distilled water.
° ンヤント接続部ｌ、２４等の開口部を蓋等で密封し
高圧蒸気滅菌を行なうものである。The openings of the joints l, 24, etc. are sealed with lids, etc., and high-pressure steam sterilization is performed.
この場合、血漿濃縮回路２６及び排液へツク２０はあえ
て滅菌する必要もないので、取外しておいてもよい、ま
た、補充液ライン２７も必要に応じて省略してもよい。In this case, there is no need to sterilize the plasma concentration circuit 26 and the drain tube 20, so they may be removed, and the replenisher line 27 may also be omitted if necessary.
さらに、前記動脈側回路３に輸液ライン９と生理食塩水
またはｌに留水等の洗浄液が封入された容器７を装着し
ておくと、臨床使用前の洗浄の際、これら容器７及び輸
液ライン９の接続作業が不要となり、便利である。Furthermore, if an infusion line 9 and a container 7 filled with a washing liquid such as physiological saline or distilled water are attached to the arterial side circuit 3, these containers 7 and the infusion line can be used for cleaning before clinical use. This eliminates the need for the connection work in step 9, which is convenient.
さらにまた、第２図に示すごとく、動脈何ンヤント接ｂ
ｃｌｌと０脈側シャント接続部２４を適当なコネクター
１１を介して接続し、密封系路を形成した状！凪で高圧
蒸気減菌をすると、使用前の洗浄の際、密封系路内に洗
節液を鰻り返し循環させることができ、効率的な洗ｆｉ
＋を行なうことができる。この場合、コネクター１１の
内部にドリップチャンバー６のフィルターよりボアーサ
イズの小さい、たとえば２００色以下のフィルター１２
を設けておくと、微細なゴミ等をそのフィルター１２で
除去することがＩＩ）能となる。Furthermore, as shown in Figure 2, the arterial junction b
cll and the 0 pulse side shunt connection part 24 are connected via an appropriate connector 11 to form a sealed system path! When high-pressure steam sterilization is performed in Nagi, the cleaning solution can be circulated repeatedly in the sealed system when cleaning before use, resulting in efficient cleaning.
+ can be done. In this case, a filter 12 with a smaller bore size than the filter of the drip chamber 6, for example, 200 colors or less, is installed inside the connector 11.
By providing the filter 12, it becomes possible to remove fine dust etc. with the filter 12.
なお、本発明では一次フイルター８と二次フィルター１
５を分離して、たとえば−次フイルター８に５ｈ脈何回
路３．静脈側回路２１、及び血漿抜取回路１０を接続し
、これらフィルター及び回路に液体を充填した状態で品
用ノ入気滅菌を行なってもよい。In addition, in the present invention, the primary filter 8 and the secondary filter 1
For example, the 5h pulse circuit 3.5 is separated into the second filter 8. The venous side circuit 21 and the plasma extraction circuit 10 may be connected, and the items may be sterilized with inlet air while these filters and circuits are filled with liquid.
（効果）
以上説明した本発明によれば、体液処理ＪＡ置と体液循
環回路を同時に蒸気滅菌することができるので、個々に
滅菌する場合に比較して滅菌作業の手間が省けることは
もちろんのこと、これら装置と回路内には静体が充填さ
れているので、空気の侵入を防ぐことができ、このため
凝血等も減少する。(Effects) According to the present invention explained above, since the body fluid processing JA station and the body fluid circulation circuit can be steam sterilized at the same time, it goes without saying that the effort of sterilization work can be saved compared to the case where they are sterilized individually. Since these devices and circuits are filled with static matter, it is possible to prevent air from entering, thereby reducing blood clots and the like.
また、臨床使用前の洗浄作業をする場合、装置と回路内
にはすでに液体が充填されているため、これら装置と回
路を所定の位置にセットした後、血液ポンプを駆動させ
るだけで直ちに洗浄することができ、従来のような連結
作業等が不要となるため、細菌汚染の心配もなく、衛生
的である等の効果が得られる。In addition, when performing cleaning work before clinical use, the devices and circuits are already filled with liquid, so after setting these devices and circuits in place, you can immediately clean them by simply driving the blood pump. Since there is no need for the conventional connection work, there is no need to worry about bacterial contamination, and benefits such as hygiene can be obtained.
第１図は本発明が適用される体液処理装置及びその回路
の一例を示す概略図、第２図は動脈側及び静脈側シャン
ト接続部を連結した状態を示す断面図である。
図中３は動脈側回路、７は洗浄液容器、８は一次フイル
ター、９は輸液ライン、１０は血漿抜取口路、１１はコ
ネクター、１５は二次フィルター、２１は静脈側回路、
２５は血漿返還回路、２６は血漿濃ｔｉｔ回路、２７は
補充液ラインを各示す。FIG. 1 is a schematic diagram showing an example of a body fluid treatment device and its circuit to which the present invention is applied, and FIG. 2 is a sectional view showing a state in which the arterial and venous shunt connections are connected. In the figure, 3 is the arterial side circuit, 7 is the washing liquid container, 8 is the primary filter, 9 is the infusion line, 10 is the plasma extraction port, 11 is the connector, 15 is the secondary filter, 21 is the venous side circuit,
25 is a plasma return circuit, 26 is a plasma concentration circuit, and 27 is a replenisher line.
Claims (9)
を分離する体液処理装置を滅菌するにあたり、前記体液
処理装置と体液循環回路内に液体を充填し、かつこれら
体液処理装置と体液循環回路とを連結した状態で、同時
に高圧蒸気滅菌することを特徴とする体液処理装置の滅
菌方法。(1) When sterilizing a body fluid treatment device that separates plasma components in blood and/or substances in plasma components, the body fluid treatment device and the body fluid circulation circuit are filled with liquid, and the body fluid treatment device and the body fluid circulation circuit are filled with liquid. A method for sterilizing a body fluid treatment device, characterized in that high-pressure steam sterilization is performed at the same time while the device is connected to a circuit.
を分離する体液処理装置を滅菌するにあたり、前記体液
処理装置と体液循環回路内に液体を充填し、かつこれら
体液処理装置と体液循環回路と連結するとともに、前記
体液循環回路の動脈側回路のシャント接続部と静脈側回
路のシャント接続部を連結して、密封回路を形成した状
態で高圧蒸気滅菌することを特徴とする体液処理装置の
滅菌方法。(2) When sterilizing a body fluid treatment device that separates plasma components in blood and/or substances in plasma components, the body fluid treatment device and the body fluid circulation circuit are filled with liquid, and the body fluid treatment device and the body fluid circulation circuit are filled with liquid. A body fluid treatment device characterized in that the body fluid treatment device performs high-pressure steam sterilization in a state in which the shunt connection portion of the arterial side circuit and the shunt connection portion of the venous side circuit of the body fluid circulation circuit are connected to form a sealed circuit. sterilization method.
またはセルロースジアセテート、ポリビニルアルコール
、ポリエチレンまたはポリプロピレン、ポリスルフォン
、ポリカーボネート、エチレンビニルアルコール共重合
体、シリコーン樹脂の中から選ばれた材質であることを
特徴とする前記第１項または第２項記載の発明。(3) The hollow fiber membrane of the body fluid treatment device is made of a material selected from cellulose acetate or cellulose diacetate, polyvinyl alcohol, polyethylene or polypropylene, polysulfone, polycarbonate, ethylene vinyl alcohol copolymer, and silicone resin. The invention as described in item 1 or 2 above.
特徴とする前記第１項または第２項記載の発明。(4) The invention according to item 1 or 2 above, wherein the high-pressure steam sterilization temperature is 80 to 130°C.
が、生理食塩水または蒸留水であることを特徴とする前
記第１項または第２項記載の発明。(5) The invention described in item 1 or 2 above, wherein the liquid filled in the body fluid treatment device and the body fluid circulation circuit is physiological saline or distilled water.
あることを特徴とする前記第１項または第２項記載の発
明。(6) The invention according to item 1 or 2 above, wherein the pressure during high-pressure steam sterilization is 1 to 3 kg/cm^2.
容器が接続されていることを特徴とする前記第１項また
は第２項記載の発明。(7) The invention as set forth in item 1 or 2 above, wherein a container filled with cleaning fluid is connected to the artery side circuit of the body fluid circulation circuit.
たはポリオレフィンから構成されていることを特徴とす
る前記第１項、第２項、第３項または第５項記載の発明
。(8) The invention according to item 1, 2, 3 or 5, wherein the housing of the body fluid treatment device is made of polycarbonate or polyolefin.
アクリル酸アルキルエステル共重合体、ポリ塩化ビニル
とポリウレタンエラストマーの共重合体、塩化ビニルと
エチレン・酢酸ビニル共重合体のグラフト共重合体、塩
化ビニルとエチレン・酢酸ビニル・一酸化炭素共重合体
の組成物、ポリオレフィン、ポリカーボネイト、シリコ
ーンゴム、ラテックスの中から選ばれた材質であること
を特徴とする前記第１項、第２項、第５項または第７項
記載の発明。(9) Body fluid circulation circuit made of polyvinyl chloride, polyethylene and acrylic acid alkyl ester copolymer, polyvinyl chloride and polyurethane elastomer copolymer, vinyl chloride and ethylene/vinyl acetate copolymer graft copolymer, vinyl chloride Items 1, 2, and 5 above, characterized in that the material is selected from among a composition of ethylene/vinyl acetate/carbon monoxide copolymer, polyolefin, polycarbonate, silicone rubber, and latex. Or the invention described in item 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59184496A JPS6164257A (en) | 1984-09-05 | 1984-09-05 | Sterilization of body fluid treatment apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59184496A JPS6164257A (en) | 1984-09-05 | 1984-09-05 | Sterilization of body fluid treatment apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6164257A true JPS6164257A (en) | 1986-04-02 |
| JPS6324700B2 JPS6324700B2 (en) | 1988-05-21 |
Family
ID=16154197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59184496A Granted JPS6164257A (en) | 1984-09-05 | 1984-09-05 | Sterilization of body fluid treatment apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6164257A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015027444A (en) * | 2013-07-05 | 2015-02-12 | 日機装株式会社 | Connector, and blood purification device therewith |
| JP2015054092A (en) * | 2013-09-12 | 2015-03-23 | 日機装株式会社 | Connection device |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0210000U (en) * | 1988-06-29 | 1990-01-23 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55129067A (en) * | 1979-03-28 | 1980-10-06 | Terumo Corp | Device for moving hollow thread type substance |
| JPS58165865A (en) * | 1982-03-26 | 1983-09-30 | 川澄化学工業株式会社 | Body liquid treating apparatus |
-
1984
- 1984-09-05 JP JP59184496A patent/JPS6164257A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55129067A (en) * | 1979-03-28 | 1980-10-06 | Terumo Corp | Device for moving hollow thread type substance |
| JPS58165865A (en) * | 1982-03-26 | 1983-09-30 | 川澄化学工業株式会社 | Body liquid treating apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015027444A (en) * | 2013-07-05 | 2015-02-12 | 日機装株式会社 | Connector, and blood purification device therewith |
| JP2015054092A (en) * | 2013-09-12 | 2015-03-23 | 日機装株式会社 | Connection device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6324700B2 (en) | 1988-05-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |