JPH0223825B2 - - Google Patents
Info
- Publication number
- JPH0223825B2 JPH0223825B2 JP55039557A JP3955780A JPH0223825B2 JP H0223825 B2 JPH0223825 B2 JP H0223825B2 JP 55039557 A JP55039557 A JP 55039557A JP 3955780 A JP3955780 A JP 3955780A JP H0223825 B2 JPH0223825 B2 JP H0223825B2
- Authority
- JP
- Japan
- Prior art keywords
- coagulation
- scattered light
- blood coagulation
- light
- intensity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012360 testing method Methods 0.000 claims description 32
- 230000023555 blood coagulation Effects 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 21
- 102000009123 Fibrin Human genes 0.000 claims description 19
- 108010073385 Fibrin Proteins 0.000 claims description 19
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 19
- 229950003499 fibrin Drugs 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 230000003287 optical effect Effects 0.000 claims description 8
- 230000001678 irradiating effect Effects 0.000 claims description 3
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000010355 oscillation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 description 36
- 230000015271 coagulation Effects 0.000 description 35
- 239000000523 sample Substances 0.000 description 19
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- 230000035945 sensitivity Effects 0.000 description 12
- 238000005259 measurement Methods 0.000 description 11
- 238000001556 precipitation Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 230000005856 abnormality Effects 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000007711 solidification Methods 0.000 description 5
- 230000008023 solidification Effects 0.000 description 5
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 4
- 108010049003 Fibrinogen Proteins 0.000 description 4
- 102000008946 Fibrinogen Human genes 0.000 description 4
- 239000003114 blood coagulation factor Substances 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 229940012952 fibrinogen Drugs 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 230000002250 progressing effect Effects 0.000 description 3
- 108010000499 Thromboplastin Proteins 0.000 description 2
- 102000002262 Thromboplastin Human genes 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- 206010005133 Bleeding tendencies Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3955780A JPS56137140A (en) | 1980-03-27 | 1980-03-27 | Optical measuring method of blood coagulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3955780A JPS56137140A (en) | 1980-03-27 | 1980-03-27 | Optical measuring method of blood coagulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56137140A JPS56137140A (en) | 1981-10-26 |
| JPH0223825B2 true JPH0223825B2 (fr) | 1990-05-25 |
Family
ID=12556364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3955780A Granted JPS56137140A (en) | 1980-03-27 | 1980-03-27 | Optical measuring method of blood coagulation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56137140A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011257156A (ja) * | 2010-06-04 | 2011-12-22 | Kohata Toru | ゲル粒子測定装置 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766083A (en) * | 1982-04-04 | 1988-08-23 | Wako Pure Chemical Industries, Ltd. | Method for the photometric determination of biological agglutination |
| JPS606871A (ja) * | 1983-06-24 | 1985-01-14 | Ono Pharmaceut Co Ltd | 血液の凝固点検出方法 |
| US6766187B1 (en) * | 2000-09-18 | 2004-07-20 | Lumenis Inc. | Method for detecting coagulation in laser treatment of blood vessels |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5057483A (fr) * | 1973-09-20 | 1975-05-19 | ||
| JPS5190883A (fr) * | 1975-01-29 | 1976-08-09 | ||
| JPS5467496A (en) * | 1977-11-09 | 1979-05-30 | Itoman Kk | Device for measuring solidification of blood plasma |
| JPS5469497A (en) * | 1977-11-12 | 1979-06-04 | Kyoto Daiichi Kagaku Kk | Method and device for measuring blood solidification time |
-
1980
- 1980-03-27 JP JP3955780A patent/JPS56137140A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5057483A (fr) * | 1973-09-20 | 1975-05-19 | ||
| JPS5190883A (fr) * | 1975-01-29 | 1976-08-09 | ||
| JPS5467496A (en) * | 1977-11-09 | 1979-05-30 | Itoman Kk | Device for measuring solidification of blood plasma |
| JPS5469497A (en) * | 1977-11-12 | 1979-06-04 | Kyoto Daiichi Kagaku Kk | Method and device for measuring blood solidification time |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011257156A (ja) * | 2010-06-04 | 2011-12-22 | Kohata Toru | ゲル粒子測定装置 |
| US8980180B2 (en) | 2010-06-04 | 2015-03-17 | Toru Obata | Gel particle measurement device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56137140A (en) | 1981-10-26 |
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