JPH0137115B2 - - Google Patents

Info

Publication number
JPH0137115B2
JPH0137115B2 JP57122799A JP12279982A JPH0137115B2 JP H0137115 B2 JPH0137115 B2 JP H0137115B2 JP 57122799 A JP57122799 A JP 57122799A JP 12279982 A JP12279982 A JP 12279982A JP H0137115 B2 JPH0137115 B2 JP H0137115B2
Authority
JP
Japan
Prior art keywords
medium
cells
serum
production
imr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP57122799A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5865219A (ja
Inventor
Bohatsuku Zubi
Kadori Abinoamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of JPS5865219A publication Critical patent/JPS5865219A/ja
Publication of JPH0137115B2 publication Critical patent/JPH0137115B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP57122799A 1981-07-15 1982-07-14 プラスミノ−ゲン賦活体の製造法 Granted JPS5865219A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL63317A IL63317A (en) 1981-07-15 1981-07-15 Production of plasminogen activator
IL63317 1981-07-15

Publications (2)

Publication Number Publication Date
JPS5865219A JPS5865219A (ja) 1983-04-18
JPH0137115B2 true JPH0137115B2 (enrdf_load_stackoverflow) 1989-08-04

Family

ID=11052764

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57122799A Granted JPS5865219A (ja) 1981-07-15 1982-07-14 プラスミノ−ゲン賦活体の製造法

Country Status (6)

Country Link
JP (1) JPS5865219A (enrdf_load_stackoverflow)
DE (1) DE3226320A1 (enrdf_load_stackoverflow)
FR (1) FR2510604B1 (enrdf_load_stackoverflow)
GB (1) GB2104081B (enrdf_load_stackoverflow)
IL (1) IL63317A (enrdf_load_stackoverflow)
IT (1) IT1195939B (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
JPS60259187A (ja) * 1984-04-19 1985-12-21 マイルス・ラボラトリ−ス・インコ−ポレ−テツド プラスミノーゲン活性化因子を増収する方法
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
EP0163751B1 (en) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
AU3364589A (en) * 1988-03-22 1989-10-16 Invitron Corporation Method to enhance tpa production
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
DE4128953A1 (de) * 1991-08-30 1993-03-04 Basf Ag Verfahren zur kultivierung von saeugerzellen im fliessbettreaktor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
JPS55144887A (en) * 1979-04-26 1980-11-12 Asahi Chem Ind Co Ltd Preparation of physiologically active substance

Also Published As

Publication number Publication date
IL63317A (en) 1985-05-31
DE3226320A1 (de) 1983-02-10
IT1195939B (it) 1988-11-03
IL63317A0 (en) 1981-10-30
JPS5865219A (ja) 1983-04-18
FR2510604A1 (fr) 1983-02-04
FR2510604B1 (fr) 1985-07-12
IT8222392A0 (it) 1982-07-14
GB2104081B (en) 1985-06-12
GB2104081A (en) 1983-03-02
DE3226320C2 (enrdf_load_stackoverflow) 1989-08-17

Similar Documents

Publication Publication Date Title
Ossowski et al. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses: II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses
Bowman et al. Primary culture of microvascular endothelial cells from bovine retina: selective growth using fibronectin coated substrate and plasma derived serum
US20080009064A1 (en) Temperature-Responsive Microcarrier
US4473647A (en) Tissue culture medium
HU197766B (en) Process for producing cell lines independent of serum
JPH0137115B2 (enrdf_load_stackoverflow)
Giard Routine heat inactivation of serum reduces its capacity to promote cell attachment
CN102191220B (zh) 一种从脂肪组织中分离纯化许旺细胞的方法
Chiplonkar et al. Applications of alkaline protease from Conidiobolus in animal cell culture
KR100683429B1 (ko) 생물학적 제제를 생산하기 위한 세포의 제조
IE47060B1 (en) Process for the cultivation of viruses
Luria et al. Differentiation of hepatic and hematopoietic cells and synthesis of blood serum proteins in organ cultures of the liver
CN110982783A (zh) 精原干细胞的培养方法及其应用
EP0350714B1 (en) Tissue immobilization and cell culturing system and method for affixing biologically active moieties to a substrate
KR101639454B1 (ko) Ｐｅｒ．ｃ6 세포의 배양에 대한 확장가능 방법 및 그 방법으로 생산된 산물
JPS63196595A (ja) 抗腫瘍活性物質の製造方法
JP6956984B1 (ja) 胚盤胞の調製方法
Paranjpe et al. Selective growth of malignant cells by in vitro incubation on Teflon
CN120249177B (zh) 一种Sf9细胞饲养层制备方法
US20050142660A1 (en) Conditioned medium for culturing Schwann cells
RU2036233C1 (ru) Питательная среда для выращивания первичных и перевиваемых клеток
Pakkanen Bovine colostrum ultrafiltrate supplemented with adult bovine serum and transferrin: an effective fbs substitute for cultivation of Vero and CHO-K1 cells
JPS60231612A (ja) ヒト細胞株の無血清培養培地及び無血清培養法
CA1177424A (en) Composition for cell culture
WO1992009686A1 (en) Supplement for hybridoma cell growth medium