JPH01299211A - Dentifrice - Google Patents
DentifriceInfo
- Publication number
- JPH01299211A JPH01299211A JP12752888A JP12752888A JPH01299211A JP H01299211 A JPH01299211 A JP H01299211A JP 12752888 A JP12752888 A JP 12752888A JP 12752888 A JP12752888 A JP 12752888A JP H01299211 A JPH01299211 A JP H01299211A
- Authority
- JP
- Japan
- Prior art keywords
- granules
- water
- insoluble
- dentifrice
- granule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000551 dentifrice Substances 0.000 title claims abstract description 44
- 239000008187 granular material Substances 0.000 claims abstract description 117
- 239000011230 binding agent Substances 0.000 claims abstract description 37
- 239000002245 particle Substances 0.000 claims abstract description 34
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 18
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910021536 Zeolite Inorganic materials 0.000 claims abstract description 12
- 239000010457 zeolite Substances 0.000 claims abstract description 12
- 239000008119 colloidal silica Substances 0.000 claims abstract description 9
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims abstract description 7
- 235000019700 dicalcium phosphate Nutrition 0.000 claims abstract description 7
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 21
- 239000007921 spray Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 14
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 10
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 5
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 239000003086 colorant Substances 0.000 claims description 4
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims description 4
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 4
- 239000001095 magnesium carbonate Substances 0.000 claims description 4
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 3
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 3
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 239000000378 calcium silicate Substances 0.000 claims description 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims description 2
- 229910001701 hydrotalcite Inorganic materials 0.000 claims description 2
- 229960001545 hydrotalcite Drugs 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 2
- 239000000347 magnesium hydroxide Substances 0.000 claims description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims description 2
- 235000012245 magnesium oxide Nutrition 0.000 claims description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 2
- 239000004137 magnesium phosphate Substances 0.000 claims description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 2
- 229960002261 magnesium phosphate Drugs 0.000 claims description 2
- 235000010994 magnesium phosphates Nutrition 0.000 claims description 2
- 239000002210 silicon-based material Substances 0.000 claims description 2
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 claims description 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 claims 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims 1
- 229960003563 calcium carbonate Drugs 0.000 claims 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims 1
- 229940043256 calcium pyrophosphate Drugs 0.000 claims 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims 1
- 229910000358 iron sulfate Inorganic materials 0.000 claims 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 22
- -1 magnesium metasilicate aluminate Chemical class 0.000 abstract description 5
- 238000005498 polishing Methods 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 3
- 239000004115 Sodium Silicate Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 235000019795 sodium metasilicate Nutrition 0.000 abstract 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052911 sodium silicate Inorganic materials 0.000 abstract 1
- 230000001680 brushing effect Effects 0.000 description 25
- 238000004519 manufacturing process Methods 0.000 description 16
- 239000000606 toothpaste Substances 0.000 description 16
- 229940034610 toothpaste Drugs 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 210000000214 mouth Anatomy 0.000 description 8
- 230000035807 sensation Effects 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 208000002064 Dental Plaque Diseases 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000011164 primary particle Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241001131796 Botaurus stellaris Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-RNFDNDRNSA-N Magnesium-28 Chemical group [28Mg] FYYHWMGAXLPEAU-RNFDNDRNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000004442 acylamino group Chemical class 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000004649 discoloration prevention Methods 0.000 description 1
- YVIGPQSYEAOLAD-UHFFFAOYSA-L disodium;dodecyl phosphate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOP([O-])([O-])=O YVIGPQSYEAOLAD-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960003351 prussian blue Drugs 0.000 description 1
- 239000013225 prussian blue Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 239000004549 water soluble granule Substances 0.000 description 1
- 239000003232 water-soluble binding agent Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、顆粒の審美的効果とさらには口の中での顆粒
の感触によりよごれ落し効果を認識できる顆粒を含有す
る歯磨剤に関する。更に詳しくは、歯磨に配合した顆粒
が口の中で触知できる程の強度と大きさを保有している
にもかかわらず、歯を磨いている過程で、徐々に崩壊し
ていくために不愉快な異物感を与えない顆粒を含有する
歯磨剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a dentifrice containing granules that has an aesthetic effect and a stain-removing effect that can be recognized by the feel of the granules in the mouth. More specifically, although the granules contained in toothpaste are strong and large enough to be felt in the mouth, they gradually disintegrate during the process of brushing, which is unpleasant. This invention relates to a dentifrice containing granules that do not give a foreign body sensation.
顆粒や顆粒状の物質を配合した歯磨剤は従来から知られ
ている。かかる顆粒には、薬剤、酵素剤、研磨剤等の機
能性材料を含有させたものや、その審美的効果を目的と
し友ものがある。また従来の歯磨剤には歯磨開始直後に
は触知できるが、歯磨中に触知できなくなる顆粒剤や、
最初から触知できず、肉眼視のみでその効果を訴えるも
のがある。これら顆粒の結合剤としては各種の水溶性結
合剤や水不溶性結合剤が使われてきた。水溶性顆粒結合
剤としては、各種水溶性高分子化合物、例えば、メチル
セルロース、カルボキシメチルセルロース等が使われて
いる。しかし斯かる水溶性結合剤を用いて調製された顆
粒剤は、医薬品等の乾燥した状態で使用する場合には支
障がないが、水分が多量に存在する歯磨剤のような多水
分組成物中では強度が著しく低下し、歯磨剤製造時の混
合過程で顆粒が崩壊したり、たとえ形態を保持できたと
しても、軟化しているため、口中ではまったく触知でき
ず、顆粒の存在感、効果感を認知することができない。Dentifrices containing granules or granular substances have been known for a long time. Such granules include those containing functional materials such as drugs, enzymes, and abrasives, and those intended for aesthetic effects. In addition, conventional dentifrices include granules that are palpable immediately after brushing, but become unpalpable during tooth brushing;
There are some products that cannot be felt from the beginning and can only be seen with the naked eye. Various water-soluble and water-insoluble binders have been used as binders for these granules. As the water-soluble granule binder, various water-soluble polymer compounds such as methyl cellulose and carboxymethyl cellulose are used. However, granules prepared using such a water-soluble binder have no problems when used in a dry state such as pharmaceuticals, but they do not pose any problem when used in a dry state such as a pharmaceutical product, but when used in a high-moisture composition such as a toothpaste that contains a large amount of water. The strength of the granules decreases significantly, and the granules collapse during the mixing process during dentifrice manufacturing, and even if they retain their shape, they are softened and cannot be felt in the mouth at all, resulting in a loss of the presence and effectiveness of the granules. Unable to recognize feelings.
一方、水不溶性の結合剤として種々の有機結合剤を用い
る方法、例えば、ワックスで着色剤、研摩剤を結合した
顆粒剤とする方法(特開昭49−132249号、特開
昭50−81594号)、あるいは炭酸カルシウム等の
研摩側粉末を水不溶性でエタノール溶解性の結合剤、た
とえばエチルセルロースで造粒する方法(特開昭58−
126806号)等が知られている。しかしながらこれ
らの結合剤を用いて造粒した顆粒は、歯磨剤中では安定
であるが、触知できるほどの硬度と大きさにすると口の
中で不快な異物感として捉えられた9あるいは異物感と
ならないような低硬度にすると日中で触知できないもの
であった。On the other hand, there are methods of using various organic binders as water-insoluble binders, such as methods of forming granules in which colorants and abrasives are bound with wax (JP-A-49-132249, JP-A-50-81594). ), or a method of granulating an abrasive powder such as calcium carbonate with a water-insoluble but ethanol-soluble binder, such as ethyl cellulose (Japanese Patent Application Laid-Open No. 1983-1999)
No. 126806), etc. are known. However, although granules granulated using these binders are stable in dentifrice, when they are hard and large enough to be palpable, they can be perceived as an unpleasant foreign body sensation in the mouth9 or a foreign body sensation. If the hardness was set to such a low level that it would not become visible, it would not be palpable during the day.
また上記のワックス結合剤を用いる方法は、熱溶融工程
が必須であり、エチルセルロース結合剤を有機溶媒に溶
かして使用する方法は、火災などの危険を伴うため、こ
れを防止するための設備及び厳格な操作を必要とすると
いう欠点があった。In addition, the method using the wax binder described above requires a hot melting process, and the method of dissolving the ethyl cellulose binder in an organic solvent involves risks such as fire, so equipment and strict regulations are required to prevent this. The disadvantage is that it requires a lot of manipulation.
そこで、本発明の目的は肉眼視できて、審美性があり口
腔中で触知できる程の強度と大きさを有しつつ、異物感
のない快適な顆粒触感で研摩効果感があり、かつ歯を傷
つけないで研摩力を増強するという実効果を併せもつ顆
粒を含有する歯磨剤を提供せんとするものである。Therefore, the object of the present invention is to provide granules that are visible to the naked eye, aesthetically pleasing, and have a size and strength that are palpable in the oral cavity, while providing a comfortable tactile feel and polishing effect without the sensation of a foreign body. It is an object of the present invention to provide a dentifrice containing granules that has the practical effect of increasing the abrasive power without damaging the dentifrice.
本発明者は、上記観点から歯磨用顆粒に関し、鋭意研究
した結果、水不溶性粉末材料を水不溶性の結合剤で造粒
し、一定の大きさと強度を保持した顆粒を配合した歯磨
剤は、口の中で顆粒を触知でき、効果感を認識できるに
もかかわらず、異物感をほとんど感することがなく、ま
た、歯を傷つけることなく研摩力が増強できることを見
出し、本発明を完成するに至った。As a result of extensive research into dentifrice granules from the above perspective, the present inventors found that a dentifrice containing granules of a water-insoluble powder material granulated with a water-insoluble binder that maintains a certain size and strength can be used in the mouth. Although the granules can be palpated and the effect can be recognized, there is almost no foreign body sensation, and it has been discovered that the polishing force can be increased without damaging the teeth, and in completing the invention. It's arrived.
すなわち本発明は、水不溶性粉末材料と水不溶性無機結
合剤で結着させて得られる顆粒であって、30メツシュ
篩(JIS規格、以下同じ)を通過し、かつ200メツ
シュ@(JIB規格、以下同じ)を通過しない粒径サイ
ズ(75〜500μに相当)を有し、顆粒1個当り0.
1〜10fの荷重を加えたときに崩壊する顆粒剤を含有
する歯磨剤を提供するものである。That is, the present invention provides granules obtained by binding a water-insoluble powder material with a water-insoluble inorganic binder, which pass through a 30 mesh sieve (JIS standard, hereinafter the same) and pass through a 200 mesh sieve (JIB standard, hereinafter the same). The particle diameter size (equivalent to 75 to 500 μ) does not pass through (the same), and each granule has 0.
The present invention provides a dentifrice containing granules that disintegrate when a load of 1 to 10 f is applied.
本発明の顆粒の製造に用いられる水不溶性粉末材料は、
第二リン酸カルシウム、第三リン酸カルシウム、不溶性
メタリン酸ナトリウム、シリカ、水酸化アルミニウム、
リン酸マグネシウム、炭酸カルシウム、ビロリン酸カル
シウム、ゼオライト、複合アルミノケイ酸塩、炭酸マグ
ネシウム、ベンガラ、硫酸カルシウム等、一般に歯の研
摩剤として使用されるものであれば、いずれでもよい。The water-insoluble powder material used in the production of the granules of the present invention is
Dibasic calcium phosphate, tertiary calcium phosphate, insoluble sodium metaphosphate, silica, aluminum hydroxide,
Any compound commonly used as a tooth abrasive may be used, such as magnesium phosphate, calcium carbonate, calcium birophosphate, zeolite, composite aluminosilicate, magnesium carbonate, red iron oxide, and calcium sulfate.
粒子の大きさは0.1〜20μ程度のものが用いられる
が10μ以下の低研摩性の粒子を造粒しても歯の表面に
強く吸着した着色ペリクルを除くに十分な研摩力を生じ
させて、歯を白くし、顆粒の崩壊後は、研摩力が減少し
、長時間の歯磨き操作でも歯を傷つけない(低為害性)
という特長を付与することができる。特に微細なゼオラ
イト等イオン交換性微粉は最も好適に用いられ、そのイ
オン交換性ゆえに歯垢除去、歯石予防といった効果がさ
らに付加されるという利点がある。この場合、−欠粒径
が小さい程イオン交換能が高くなり、歯垢除去効果はあ
がるが、研摩効果とのかねあいからα5〜10μ程度が
好ましい。また、10〜20μという通常研摩効果を期
待して用いられる粒径のものも、本発明の造粒により、
初期研摩力が増強されて歯のよごれ落しに著効を示し、
歯磨き操作とともに顆粒は崩壊して一次粒子となるので
歯をほとんど傷つけることはない。Particles with a size of about 0.1 to 20μ are used, but even if particles with a low abrasive property of 10μ or less are granulated, sufficient abrasive force will be generated to remove colored pellicles that are strongly adsorbed to the tooth surface. After the granules disintegrate, the abrasive force decreases and does not damage the teeth even when brushing for a long time (low toxicity).
This feature can be provided. In particular, ion-exchangeable fine powder such as fine zeolite is most preferably used, and its ion-exchangeability has the advantage of additional effects such as plaque removal and tartar prevention. In this case, the smaller the defective particle size, the higher the ion exchange ability and the higher the plaque removal effect, but in consideration of the polishing effect, α is preferably about 5 to 10 μm. In addition, particles with a particle size of 10 to 20μ, which is normally used in anticipation of a polishing effect, can also be produced by the granulation of the present invention.
The initial abrasive power is enhanced and it is highly effective in removing dirt from teeth.
As the granules disintegrate into primary particles during tooth brushing, they hardly cause any damage to the teeth.
本発明の顆粒を製造するための結合剤は、水不溶性の無
機化合物である。先行文献には水不溶性の有機結合剤が
記載されているが、水不溶性の無機結合剤を記載してい
るものはない。本発明で用いる結合剤の例として、コロ
イダルシリカ、メタケイ酸アルミン酸マグネシウム、ベ
ントナイト、モンモリロナイト、カオリン、合成ケイ酸
アルミニウム、ケイ酸カルシウム、水酸化アルミニウム
グル、アルミナゾル、炭酸マグネシウム、合成ヒドロタ
ルサイト、酸化マグネシウム、水酸化マグネシウムが挙
げられ、特にケイ素系化合物が好ましい。なかでも、噴
霧造粒法での操作性などの点からメタケイ酸アルミン酸
マグネシウム、合成’;rイ酸アルミニウム、コロイダ
ルシリカが好ましい。これら無機結合剤は学独でもしく
は組み合せて使用することができる。Binders for producing the granules of the invention are water-insoluble inorganic compounds. Prior art documents describe water-insoluble organic binders, but none describe water-insoluble inorganic binders. Examples of binders used in the present invention include colloidal silica, magnesium aluminate metasilicate, bentonite, montmorillonite, kaolin, synthetic aluminum silicate, calcium silicate, aluminum hydroxide, alumina sol, magnesium carbonate, synthetic hydrotalcite, oxidized Examples include magnesium and magnesium hydroxide, with silicon-based compounds being particularly preferred. Among these, magnesium aluminate metasilicate, synthetic aluminum sulfate, and colloidal silica are preferred from the viewpoint of operability in the spray granulation method. These inorganic binders can be used alone or in combination.
なお、これらの中で比較的顆粒の賦型剛的に働く結合剤
(例えば、メタケイ酸アルミン酸マグネシウム、合成ケ
イ酸アルミニウム)と、接着性が強くて顆粒の強度を著
しく上昇させる結合剤(例えば、コロイダルシリカ、ア
ルミナゾル)を組み合せて使用すれシ、所定の強度を維
持しつつ、粉末材料の種類、量を自在に変化させた、種
々の顆粒を得ることができる。Among these, there are binders that work relatively rigidly to shape the granules (e.g., magnesium aluminate metasilicate, synthetic aluminum silicate), and binders that have strong adhesive properties and significantly increase the strength of the granules (e.g., , colloidal silica, and alumina sol), various types of granules can be obtained by freely changing the type and amount of powder materials while maintaining a predetermined strength.
これら無機結合剤は顆粒中10%以上、80%以下とな
るよう使用されるのが好ましい。These inorganic binders are preferably used in an amount of 10% or more and 80% or less in the granules.
従って水不溶性粉末材料は20%以上、90%以下存在
するのが好ましいが、これら配合比率は水不溶性粉末材
料の種類、無機結合剤 ・の種類及び製造方法により適
宜選択される。Therefore, it is preferable that the water-insoluble powder material is present in an amount of 20% or more and 90% or less, but the blending ratio is appropriately selected depending on the type of water-insoluble powder material, the type of inorganic binder, and the manufacturing method.
これら無機結合剤で造粒した顆粒は、有機結合剤のそれ
とは異なり、最初、触知できるものの、みぞれ状の感触
(シャリシャリ感)を与え、徐々に崩壊していき、効果
感を認知できるという特徴を持っている。なお、上記水
不溶性無機結合剤以外の結合剤を本発明の効果を損わな
い範囲で添加することができる。。Unlike organic binders, granules made with these inorganic binders are palpable at first, but give a sleet-like feel (crunchy feeling), and gradually disintegrate, making it possible to perceive the effect. It has characteristics. Note that binders other than the water-insoluble inorganic binder described above may be added within a range that does not impair the effects of the present invention. .
また、本顆粒は酸化チタン、群青等、着色剤も存在させ
ることができ、着色顆粒による審美的効果を歯磨剤に付
加できる。着色剤は顆粒中、0.01〜10重量%配合
されるのが適当である。Furthermore, the present granules can also contain a coloring agent such as titanium oxide or ultramarine blue, and the aesthetic effect of the colored granules can be added to the dentifrice. It is appropriate that the coloring agent is incorporated in the granules in an amount of 0.01 to 10% by weight.
本発明の顆粒の粒径はメツシュ111kL35篩は通過
するがメツシュNn2QO@は通過しないもの(75μ
〜500μ)であることを要する。肉眼的に認知し、口
腔内で触知するには75μ以上の顆粒であることが必要
である。The particle size of the granules of the present invention is such that it passes through a mesh 111kL35 sieve but not through a mesh Nn2QO@ (75μ
~500μ). Granules need to be 75μ or larger to be visible to the naked eye and palpable in the oral cavity.
一般に歯磨用研摩剤は粒径が大きくなるに従って研摩力
は高くなる(30μ程度以上は余り変らないといわれる
)ので、研摩力は十分に高い。しかし、500μを越え
るような大粒子はざらつきが強く、使用感が悪い。In general, the abrasive power of toothpaste abrasives increases as the particle size increases (it is said that the difference does not change much above about 30 μm), so the abrasive power is sufficiently high. However, large particles exceeding 500 μm have a strong rough texture and are unpleasant to use.
また、本発明の顆粒は歯磨き中のブラッシング操作によ
って崩壊する必要があり、その顆粒の強度も重要である
。Furthermore, the granules of the present invention need to be disintegrated by the brushing operation during tooth brushing, and the strength of the granules is also important.
顆粒の強度(硬さ)が−個あたり0.1を以下の荷重で
崩壊してしまう場合、顆粒を認知することができない。If the strength (hardness) of the granules collapses under a load of -0.1 per piece or less, the granules cannot be recognized.
また顆粒の強度が102以上の荷重で崩壊しない場合、
これを歯磨剤に配合した時、異物感としてしか感じられ
ず、ブラッシングによってもまったく崩壊せず、歯のエ
ナメル質を傷つける恐れがある。In addition, if the strength of the granules does not collapse under a load of 102 or more,
When this is added to toothpaste, it only feels like a foreign body, and it does not disintegrate at all even when brushing, potentially damaging tooth enamel.
上記のごとく本発明の顆粒の強度は、顆粒−個あたり0
.1〜10fの荷重で崩壊するものであり、好ましくは
1〜51の荷重で崩壊するものである。顆粒の形状は球
状が好ましいう崩壊性であっても角ばった形状の顆粒は
歯を傷つけるおそれがあり、歯肉への影響はさらに大き
い。As mentioned above, the strength of the granules of the present invention is 0 per granule.
.. It collapses under a load of 1 to 10 f, preferably under a load of 1 to 51 f. Although spherical granules are preferable for caries disintegration, angular granules may damage the teeth and have a greater impact on the gums.
上記したような粒径及び強度を有する顆粒は、無機結合
剤の種類と組合せと配合量および顆粒の製造条件によっ
て変化させることができる。The granules having the particle size and strength as described above can be changed depending on the type, combination and amount of the inorganic binder and the manufacturing conditions of the granules.
本発明の顆粒は公知の造粒法により製造することができ
る。なかでも噴霧造粒法は造粒物の形状はほとんど真球
となり、ハンドリングも容易であって、本発明の顆粒の
製法として好適である。押し出し造粒法等の場合、角ば
った粒子が得られ、球状粒子とするにはマルメライザー
などによる球状化操作を要する。The granules of the present invention can be manufactured by a known granulation method. Among these, the spray granulation method is suitable as a method for producing the granules of the present invention because the granules are almost perfectly spherical in shape and are easy to handle. In the case of extrusion granulation, etc., angular particles are obtained, and a spheroidization operation using a marmerizer or the like is required to obtain spherical particles.
なお、噴霧造粒法の場合、前記の賦型性結合剤は良好な
噴霧状態を得るために水不溶性粉末材料に対し30重量
%以上配合するのが好ましく、接着性結合剤は噴霧スラ
リー粘度を著しく上昇させるため、噴霧不良やノズル閉
塞の問題を起すので顆粒全量に対し0.5〜30重量%
の範囲で添加するのが好ましい。In the case of the spray granulation method, the above-mentioned shape-forming binder is preferably blended in an amount of 30% by weight or more based on the water-insoluble powder material in order to obtain a good spray condition, and the adhesive binder is used to control the viscosity of the spray slurry. 0.5 to 30% by weight based on the total amount of granules, as it causes problems such as poor spraying and nozzle clogging.
It is preferable to add it within the following range.
藺〈シて得られた本発明の顆粒は、練り歯磨、粉歯磨な
ど各種歯磨剤に配合できるが、顆粒の審美性を表現でき
る上で特に練り歯磨剤に配合することが好適である。The granules of the present invention obtained by this process can be incorporated into various dentifrices such as toothpaste and powdered toothpaste, but it is particularly suitable to incorporate them into toothpastes since the granules can express their aesthetic properties.
本発明の顆粒は歯磨剤中に1〜50fi量係、好ましく
は3〜3 Ofi量係配合される。本発明の顆粒は製造
時に75μ以下の顆粒も伴なう場合はそのまま歯磨剤に
配合することができるが、500μ以上の顆粒を伴なう
場合は、これを30メツンユ篩にかけて取り除いた上配
合することが好ましい。また、本発明の顆粒は単独で研
摩成分となり得るが、通常使用される歯磨用研摩剤を併
用することができる。The granules of the present invention are incorporated into a dentifrice in an amount of 1 to 50 fi, preferably 3 to 3 Ofi. If the granules of the present invention contain granules of 75 μm or less during production, they can be blended into dentifrices as they are, but if they contain granules of 500 μm or more, they are removed by passing them through a 30-meter sieve before blending. It is preferable. Further, the granules of the present invention can be used alone as an abrasive component, but a commonly used abrasive for toothpaste can be used in combination.
歯磨剤の調製は常法に従っておこなわれ、通常の歯磨剤
に利用される他の成分を配合することができる。例えば
粘結剤としてはカル〆キシメチルセルロースナトリウム
、?リアクリル酸ナトリウム、ヒドロキシエチルセルロ
ース、増粘性シリカ、モンモリロナイト、カラギーナン
、アルギン酸ナトリウム、グアガム、ペクチンなどが使
用出来る。また、界面活性剤としてはアシルグルタミン
酸ナトリウムやアシルサルコシン酸ナトリウムなどのア
シルアミノ酸の塩類、ラウリルリン酸ナトリウムなどの
アルキルリン酸の塩類、蔗糖脂肪酸エステル、ソルビタ
ン脂肪酸エステル、?リオキシエチレン脂肪酸エステル
などが使用出来る。また薬用成分上してアラントイン、
トラネキサム酸、ビタミンE1 ビタミンC1塩化ナト
リウム、ニガリ、フッ化ナトリウム、フッ化錫、カルパ
ゾクロム、プローリス、グリチルレチン酸、クロルヘキ
シシン、塩化セチル−リゾニウムなどが使用できる。そ
の他、湿潤剤、甘味剤、防腐剤、香料等が配合され得る
。The dentifrice can be prepared according to conventional methods and may contain other ingredients commonly used in dentifrices. For example, sodium carboxymethyl cellulose as a binder? Sodium acrylate, hydroxyethyl cellulose, thickening silica, montmorillonite, carrageenan, sodium alginate, guar gum, pectin, etc. can be used. In addition, as surfactants, salts of acyl amino acids such as sodium acylglutamate and sodium acylsarcosinate, salts of alkyl phosphates such as sodium lauryl phosphate, sucrose fatty acid ester, sorbitan fatty acid ester, etc. Lioxyethylene fatty acid ester etc. can be used. In addition, the medicinal ingredients include allantoin,
Tranexamic acid, vitamin E1, vitamin C1, sodium chloride, bittern, sodium fluoride, tin fluoride, carpazochrome, prolis, glycyrrhetinic acid, chlorhexicine, cetyl-rizonium chloride, etc. can be used. In addition, humectants, sweeteners, preservatives, fragrances, etc. may be added.
本発明の顆粒入り歯磨を使用した場合、口の中で顆粒を
触知し、異物感をほとんど感じずによごれ落し効果を認
知できる。そして事実、顆粒の存在は初期研摩力を大き
くしてよごれ落し効果に寄与し、またブラッシング操作
により、この顆粒が徐々に崩壊していく過程で粒子径が
小さくなって研摩力が低下し、長時間層いた時やブラッ
シング圧が強すぎた場合に起こる横状欠損等の為害性を
防止するとともできる。更に1水不溶性粉末材料として
ゼオライト等イオン交換性微粉を用いて調製した歯磨剤
は、高い歯石予防効果と歯の着色防止効果を兼ね備えた
有利なものとなる。When using the toothpaste containing granules of the present invention, the granules can be palpated in the mouth and the dirt-removing effect can be recognized with almost no foreign body sensation. In fact, the presence of granules increases the initial abrasive force and contributes to the dirt removal effect, and as the granules gradually disintegrate during the brushing operation, the particle size becomes smaller and the abrasive force decreases, resulting in a long-lasting It can also prevent harm such as horizontal defects that occur when brushing for a long time or when brushing pressure is too strong. Furthermore, a dentifrice prepared using an ion-exchangeable fine powder such as zeolite as a water-insoluble powder material is advantageous in that it has both a high tartar prevention effect and a tooth discoloration prevention effect.
次に実施例を挙げ、本発明を更に詳しく説明する。 Next, the present invention will be explained in more detail with reference to Examples.
実施例1
ω 固形分としてゼオライト(4A型;10μ以下の粒
子径を有するものが99.9 wt%。Example 1 ω The solid content was zeolite (type 4A; 99.9 wt% of zeolite having a particle size of 10μ or less).
平均粒径2μ)を60重景部、無水ケイ酸(コロイダル
シリカ)を10重量部、酸化チタンを2重量部及びメタ
ケイ酸アルミン酸マグネシウム28重量部を含有する水
スラリー(水の含有量は約60重量%)から噴霧造粒機
により、顆粒を製造した。製造工程中、噴霧状態は極め
て安定であった。このものは、なめらかか球面を有する
球状体であって、30メツシュ篩を通過し、200メツ
シュ篩を通過しないものが全体の92重量%を占めた。An aqueous slurry containing 60 parts by weight of particles with an average particle size of 2μ, 10 parts by weight of silicic anhydride (colloidal silica), 2 parts by weight of titanium oxide, and 28 parts by weight of magnesium aluminate metasilicate (the water content is approx. 60% by weight) using a spray granulator. During the manufacturing process, the spray condition was extremely stable. This product was a spherical body with a smooth or spherical surface, and 92% by weight of the product passed through a 30-mesh sieve but did not pass through a 200-mesh sieve.
残り8%は200メツシュ篩を通過するものであった。The remaining 8% passed through a 200 mesh sieve.
なお、顆粒強度は、得られた顆粒をふるいで分別し、同
じ大きさ(約200μ)の顆粒を一定個数(100〜2
00個)、アクリルセルの中に図1のごとく顆粒が1層
になるように入れ、上部にアクリル板をのせ、その上か
らデッシュデルグーゾで荷重をかけ、顆粒の崩壊時の荷
重を測定した。この荷重を試験に用いた顆粒数で割り、
顆粒1個あたりの荷重をもとめ、これを顆粒強度とした
。The granule strength was measured by separating the obtained granules with a sieve and dividing them into a certain number (100 to 2 granules) of the same size (about 200μ).
00 pieces), the granules are placed in a single layer in an acrylic cell as shown in Figure 1, an acrylic plate is placed on top, a load is applied from above with a dish delguso, and the load when the granules disintegrate is measured. did. Divide this load by the number of granules used in the test,
The load per granule was determined, and this was taken as the granule strength.
(1)次にこの顆粒(約200μ)の水系での安定性(
強度)を検討するため、その3.Ofを30dのサンプ
ル瓶に入れ、蒸留水25affを加えて栓をして1日放
置した。その後、サンプル瓶に鉄球を(直径7 mmで
質量3,6fを1個)入れ、栓をしたままで振とう機に
より5分間振とうした(この操作を「粉化虐待」と称す
る)。その後、200メツシュの篩にサンプル瓶の内容
物を移し、鉄球を取り除いてから、流水中にて75μ以
下の粒状物を取り除いた。そして、このふるいの上に残
った粒状物を110℃で2時間乾燥してか4ら、その重
量を測定した。この結果は後記衣3に示す。(1) Next, the stability of this granule (approximately 200μ) in an aqueous system (
In order to examine the strength), Part 3. Of was placed in a 30d sample bottle, 25ml of distilled water was added, the bottle was stoppered, and the bottle was left for one day. Thereafter, an iron ball (one piece with a diameter of 7 mm and a mass of 3.6 f) was placed in the sample bottle, and the sample bottle was shaken for 5 minutes using a shaker with the stopper closed (this operation is referred to as "pulverization abuse"). Thereafter, the contents of the sample bottle were transferred to a 200-mesh sieve to remove iron balls, and then granules of 75 μm or less were removed under running water. Then, the granules remaining on the sieve were dried at 110° C. for 2 hours, and then their weight was measured. The results are shown in Section 3 below.
(−)顆粒の感触を評価するため製造した顆粒をそのま
ま表1の配合からなる歯磨剤に配合した。歯磨剤は、香
料の安定化のため製造後1週間放置した。その後20人
の、Qネラーにこの歯磨剤を使用してもらいその直後に
顆粒の感触について評価した。ハプラシは通常のラウン
ドカットハプラシを用いた。顆粒の口腔内の認知度は、
■・・・歯を磨き始めてから磨き終わる1で触知した。(-) In order to evaluate the feel of the granules, the manufactured granules were directly blended into a dentifrice having the formulation shown in Table 1. The dentifrice was left for one week after production to stabilize the fragrance. Thereafter, 20 Q-naires were asked to use this toothpaste and immediately thereafter evaluated the feel of the granules. A regular round-cut toothpaste was used. The visibility of the granules in the oral cavity is
■...I felt it in 1 after I started brushing my teeth and when I finished brushing.
■・・・歯磨初期には顆粒を触知したが、歯磨中に触知
できなくなった、■・・・顆粒を触知できなかった。に
分類した。■... Granules were palpable at the beginning of tooth brushing, but became palpable during tooth brushing; ■... Granules could not be palpated. classified into.
顆粒の感触については5段階評価とし、■・・・良い、
(?)・・・やや良い、■・・・どちらでもない、■・
・・ややわるい、■・・・悪い、とした。この結果も後
記衣3に示す。The feel of the granules was evaluated on a five-point scale: ■...Good;
(?)... Fairly good, ■... Neutral, ■・
It was rated as ...somewhat poor, ■...poor. The results are also shown in Section 3 below.
表 1
実施例2
固形分としてリン酸水素カルシウム(10μ以下の粒子
径を有するものが85重t%平均粒径6μ)を60重量
部、無水ケイ酸(コロイダルシリカ)を10重量部、酸
化チタンを2重量部及びメタケイ酸アルミン酸マグネシ
ウム28重量部を含有する水スラリーから噴霧造粒機に
より顆粒剤を製造した。製造工程中、噴霧状態は極めて
安定であった。このものはなめらかな球面を有する球状
体であって、30メツシュ篩を通過し、200メツシュ
篩を通過しないものが全体の90%を占め、残り10%
は200メツシュ篩を通過した。Table 1 Example 2 Solid contents include 60 parts by weight of calcium hydrogen phosphate (85% by weight and t% average particle size of 6 μm having a particle size of 10 μ or less), 10 parts by weight of silicic anhydride (colloidal silica), and titanium oxide. Granules were produced using a spray granulator from an aqueous slurry containing 2 parts by weight of magnesium aluminate metasilicate and 28 parts by weight of magnesium aluminate metasilicate. During the manufacturing process, the spray condition was extremely stable. This object is a spherical body with a smooth spherical surface, and 90% of the object passes through a 30-mesh sieve but does not pass through a 200-mesh sieve, and the remaining 10%.
passed through a 200 mesh sieve.
この顆粒剤についても実施例1と同様に顆粒の強度、水
系での安定性(強度)、歯磨に配合した時の感触につい
て評価した。This granule was also evaluated in the same manner as in Example 1 regarding the strength of the granule, the stability (strength) in an aqueous system, and the feel when added to toothpaste.
実施例3
固形分としてゼオライト(AA型;10μ以下の粒子径
を有するものが85重量%、平均粒径8μ)を60重量
部、メタケイ酸アルミン酸マグネシウム38重量部及び
酸イヒチタン2重量部を含有する水スジ1ノー(水の含
有量は約60重量係である)から噴霧造粒機により顆粒
を製造した。製造工程中、噴霧状態はきわめて安定であ
った。このものは、なめらかな球面を有する球状体でめ
って、30メyシュvBt通過し、200メツシュ篩を
通過しないものが全体の87重量%を占め、残り13重
量%は200メツシュ篩を通過した。Example 3 Contains 60 parts by weight of zeolite (AA type; 85% by weight having a particle size of 10 μ or less, average particle size 8 μ), 38 parts by weight of magnesium aluminate metasilicate, and 2 parts by weight of hihititanium acid as solid content. Granules were produced using a spray granulator from a water streak of 10 (water content is approximately 60% by weight). During the manufacturing process, the spray condition was extremely stable. This material is a spherical body with a smooth spherical surface that rarely passes through 30 mesh vBt, and 87% by weight does not pass through a 200 mesh sieve, and the remaining 13% by weight passes through a 200 mesh sieve. did.
この顆粒剤についても実施例1と同様に顆粒の強度、水
系での安定性(強度)、歯磨に配合した時の感触につい
て評価した。This granule was also evaluated in the same manner as in Example 1 regarding the strength of the granule, the stability (strength) in an aqueous system, and the feel when added to toothpaste.
実施例4
固形分としてシリカ(粒子径20μ以下が67%、平均
粒径16μ)を40重量部、アルミナツル10重量部、
合成ケイ酸アルミニウム49重量部、紺青1重量部を含
有する水スラリー(水の含有量は約50重量%)から噴
霧造粒機により、顆粒剤を製造した。製造工程中、噴霧
状態は極めて安定であった。このものは30メツシュ篩
を通過し、2ooメツシュ篩を通過しないものが全体の
70重量%をしめた。また、200メツシュを通過する
ものが残りの30%であった。これを実施例1と同様に
顆粒の強度及び粉化虐待後、残存する顆粒量〔初期3.
0〕を測定した。また顆粒の感触全評価するため、上記
の顆粒を表2の配合からなる歯磨剤に配合した。歯磨剤
は、香料の安定化のため製造後1週間放置した。外観は
、白いペースト中に青い顆粒が表面に浮きでるように見
え、好ましいものであった。Example 4 As solid contents, 40 parts by weight of silica (67% particles with a particle size of 20 μm or less, average particle size of 16 μm), 10 parts by weight of alumina vine,
Granules were produced from a water slurry containing 49 parts by weight of synthetic aluminum silicate and 1 part by weight of Prussian blue (water content approximately 50% by weight) using a spray granulator. During the manufacturing process, the spray condition was extremely stable. This material passed through a 30-mesh sieve, and 70% by weight of the material did not pass through a 20-mesh sieve. The remaining 30% passed through 200 meshes. The strength of the granules and the amount of remaining granules after being subjected to powdering treatment in the same manner as in Example 1 [Initial 3.
0] was measured. In addition, in order to fully evaluate the feel of the granules, the above granules were blended into a dentifrice having the formulation shown in Table 2. The dentifrice was left for one week after production to stabilize the fragrance. The appearance was favorable, as blue granules appeared to be floating on the surface of the white paste.
表 2
比較例1
固形分として第二リン酸カルシウム(10μ以下の粒子
径を有するものが85重′!jk%、平均粒径6μ)6
0重量部、メタケイ酸アルミン酸マグネシウム35重量
部およびカルボキシメチルセルロース塩5重量部を含有
する水スラリーから噴霧造粒機により顆粒を製造した。Table 2 Comparative Example 1 Dibasic calcium phosphate as solid content (85 weight'!jk% with particle size of 10 μ or less, average particle size 6 μ) 6
Granules were produced using a spray granulator from a water slurry containing 0 parts by weight of magnesium aluminate metasilicate, 35 parts by weight of magnesium aluminate metasilicate, and 5 parts by weight of carboxymethylcellulose salt.
製造工程中、噴霧状態はきわめて安定であった。このも
のは、なめらがな球面を有する球状体であって、3oメ
ツシュ篩を通過し、200メツシュ篩を通過しないもの
が全体の87重量%を占め、残り13重量%は200メ
ツシュ篩を通過した。比較例についても以下、実施例と
同じ評価を行った。During the manufacturing process, the spray condition was extremely stable. This product is a spherical body with a smooth spherical surface, and 87% by weight of the product passes through a 3o mesh sieve but does not pass through a 200 mesh sieve, and the remaining 13% by weight passes through a 200 mesh sieve. did. The comparative examples were also evaluated in the same way as the examples.
比較例2
固形分としてゼオライト(4A型;10μ以下の粒子径
を有するものが99.9重量%、平均粒径2μ)を30
重量部、メタケイ酸アルミン酸マグネシウム30重量部
、アルミナゾル20重量部および無水ケイ酸(コロ2イ
ダルシリカ)20重量部を含有する水スラリーから噴霧
造粒機により顆粒剤を製造した。Comparative Example 2 Zeolite (type 4A; 99.9% by weight having a particle size of 10 μ or less, average particle size 2 μ) was used as a solid content of 30
Granules were produced using a spray granulator from a water slurry containing 30 parts by weight of magnesium aluminate metasilicate, 20 parts by weight of alumina sol, and 20 parts by weight of silicic anhydride (colloidal silica).
製造工程中に、噴霧状態は徐々に悪化し、噴霧ノズルが
つまり、噴霧?ンゾのモーターが故障したので製造を中
止しな。製造中止前に得られた顆粒はなめらかな球面を
有する球状体であって、30メツシュ篩を通過し、20
0メツシュ篩を通過しないものが全体の87重量%を占
め、残り13重量%¥′1200メツシュを通過するも
のであった。During the manufacturing process, the spray condition gradually deteriorated, and the spray nozzle became clogged, resulting in a spray problem. Nzo's motor has broken down, so production has to be discontinued. The granules obtained before production discontinuation were spherical bodies with smooth spherical surfaces, passed through a 30-mesh sieve, and passed through a 20-mesh sieve.
Those that did not pass through the 0 mesh sieve accounted for 87% by weight of the total, and the remaining 13% by weight passed through the ¥1,200 mesh.
比較例3
固形分として第二リン酸カルシウム(10μ以下の粒子
径を有するものが855重量部平均粒径6μ)60重量
部、エチルセルロース3重量部とこれに対して適量のア
七トンを加え、混れんし、その後押し出し造粒機で顆粒
を試作した。このものはおよそ円柱状の角ばった粒子で
、30メツシュ篩を通過し、200メツシュ篩を通過し
ないものが全体の844重量部上であり、残り166重
量部200メツシュ篩を通過するものであった。Comparative Example 3 60 parts by weight of dibasic calcium phosphate (855 parts by weight having a particle size of 10 μ or less, average particle size 6 μ), 3 parts by weight of ethyl cellulose, and an appropriate amount of a7ton were added to this, and the mixture was mixed. Then, a prototype of granules was produced using the push-out granulator. These particles were approximately cylindrical and angular, and passed through a 30-mesh sieve, with 844 parts by weight of the total not passing through a 200-mesh sieve, and the remaining 166 parts by weight passing through a 200-mesh sieve. .
以下余白
実験例1
本発明品の顆粒入り歯磨の研摩性について粉末品と比較
した。すなわち図2にしめずようなアクリル板をブラッ
シングマシーンにセットした。歯磨剤は、蒸留水でうす
め、50%溶液とし念後、この溶液150dをブラッシ
ングマシーンに注入し、荷重640tでブラッシングを
行った。一定時間後、ブラッシング後アクリル板の摩損
量を微量天秤で測定した。実験にもちいた歯磨剤は表4
Kl、めす通りである。この結果は図3の通りである。Margin Experiment Example 1 The abrasiveness of the toothpaste containing granules of the present invention was compared with that of a powdered product. That is, an acrylic plate like the one shown in Figure 2 was set in a brushing machine. The dentifrice was diluted with distilled water to make a 50% solution, and then 150 d of this solution was poured into a brushing machine and brushing was performed with a load of 640 t. After a certain period of time, the amount of wear and tear on the acrylic plate after brushing was measured using a microbalance. Table 4 shows the toothpaste used in the experiment.
Kl, that's right. The results are shown in FIG.
以下余白
表 4
原料粉末”
実施例30顆粒剤と同様の組成の粉末品である。すなわ
ち顆粒の原料粉末を単にまぜあわせたもの。Table 4: Raw material powder This is a powder product with the same composition as the granules in Example 30. In other words, it is simply a mixture of the raw material powders for the granules.
図3の結果から明らかなように本発明品(顆粒品)の場
合、粉末品に比べ初期の研摩力が強く、顆粒がブラッシ
ングにより崩壊するにつれて、その研摩力が減少し、粉
末品と同程度になっていることがわかる。As is clear from the results in Figure 3, in the case of the product of the present invention (granule product), the initial abrasive force is stronger than that of the powder product, and as the granules are disintegrated by brushing, the abrasive force decreases to the same level as the powder product. You can see that it is.
実験例2
表4KLめす組成の歯磨を調製し、その清浄作用を調べ
た。その作用は、黒のマジックインキを塗布したガラス
板を、被験組成物1tを用いハグラシでブラッシングし
、肉眼的に見てガラス板上の黒のマジックインキが完全
に除去された時のブラッシング回数で判定した。仁の結
果を表5に示す。Experimental Example 2 A toothpaste having the composition of Table 4 KL female was prepared and its cleaning effect was investigated. The effect is determined by brushing a glass plate coated with black marker ink with a tooth brush using 1 ton of the test composition, and measuring the number of brushings until the black marker ink on the glass plate is completely removed when seen with the naked eye. I judged it. The results are shown in Table 5.
この実験結果は、本発明の顆粒剤が、粉末原料であるゼ
オライトが有しないような高い研摩力を持ち、清浄効果
に優れていることを示している。This experimental result shows that the granules of the present invention have a high abrasive power that zeolite, which is a powder raw material, does not have, and have excellent cleaning effects.
実験例3
市販歯磨剤A(リン酸水素カルシウムを研摩剤として配
合)と、試験品として実施例1の歯磨剤を用い、同じノ
・ブラシを使用して、被験者4名について歯磨剤使用前
後の歯垢量を測定することにより歯垢除去率を求めた。Experimental Example 3 Using commercially available dentifrice A (containing calcium hydrogen phosphate as an abrasive) and the dentifrice of Example 1 as a test product, using the same brush, 4 test subjects were tested before and after using the dentifrice. Plaque removal rate was determined by measuring the amount of plaque.
歯垢量の測定は、銘木の方法(口腔衛生会誌、20,9
.1970)に準じた。即ち被験歯として、上下顎6歯
を用い、歯垢顕示剤で歯垢を染色後、歯肉辺縁よりの歯
垢の高さ(moI)を?ケットゾロープで測定し、測定
部位は、1歯あたり唇側5カ所、舌ロ蓋側5カ所の計1
0カ所とし、各々の部位の合計をその歯垢量とした。歯
垢除去率は下の式を用い歯垢除去率とした。The amount of plaque is measured using the precious wood method (Journal of Oral Hygiene, 20, 9).
.. (1970). That is, six teeth in the upper and lower jaws were used as test teeth, and after staining the plaque with a plaque revealer, what was the height of the plaque from the gingival margin (moI)? Measurements are taken with a ketzo rope, and the measurement sites are 1 in total: 5 labial areas and 5 lingual lid areas per tooth.
The amount of dental plaque was determined as 0, and the total amount of each site was determined as the amount of plaque. The plaque removal rate was determined using the formula below.
図4に示すように、本発明の歯磨剤は、市販歯磨剤に比
べ、有意に高い(p<α05)歯垢除去率を示した。こ
れは、顆粒が特定粒径のため、歯垢の付着しやすい歯間
部に入りやすくなり、歯磨動作と共に、崩れて顆粒成分
中のゼオライトが一次粒子となって、歯垢中に入り込む
ため、歯垢中のCaが減少して、刷掃時に歯垢が除去さ
れやすくなっていることが考えられる。As shown in FIG. 4, the dentifrice of the present invention showed a significantly higher plaque removal rate (p<α05) than the commercially available dentifrice. This is because the granules have a specific particle size, so they easily enter the interdental area where dental plaque tends to adhere, and when you brush your teeth, they break down and become primary particles of zeolite in the granule component, which penetrates into the dental plaque. It is thought that the Ca content in dental plaque is reduced, making it easier to remove dental plaque during brushing.
図1は、顆粒強度を測定するために用いた装置の模式図
である。
図2は、実験例1で用いたブラッシングマシーンの斜視
図である。
図3は、アクリル板の摩損量とブラッシング回数の関係
を示す図面である。
図4は、市販歯磨剤と本発明の実施例1の歯磨剤との歯
垢除去率の比較を示す図面である。
以上FIG. 1 is a schematic diagram of the apparatus used to measure granule strength. FIG. 2 is a perspective view of the brushing machine used in Experimental Example 1. FIG. 3 is a diagram showing the relationship between the amount of wear and tear on the acrylic plate and the number of times of brushing. FIG. 4 is a drawing showing a comparison of the plaque removal rate between a commercially available dentifrice and the dentifrice of Example 1 of the present invention. that's all
Claims (1)
て得られる顆粒であつて、 30メッシュ篩を通過するが、200メッシュ篩を通過
しない粒径サイズを有し、 顆粒1個当り0.1〜10gの荷重を加えたときに崩壊
する顆粒を含有することを特徴とする歯磨剤。 2、水不溶性粉末材料が第二リン酸カルシウム、第三リ
ン酸カルシウム、不溶性メタリン酸ナトリウム、シリカ
、水酸化アルミニウム、リン酸マグネシウム、炭酸カル
シウム、ピロリン酸カルシウム、ゼオライト、複合アル
ミノケイ酸塩、炭酸マグネシウム、ベンガラ、硫酸カル
シウム及びそれらの混合物からなる群より選ばれたもの
である特許請求の範囲第1項記載の歯磨剤。 3、水不溶性粉末材料の粒径が0.1〜20μである特
許請求の範囲第1項記載の歯磨剤。 4、水不溶性粉末材料がゼオライトである特許請求の範
囲第1項記載の歯磨剤。 5、水不溶性無機結合剤がコロイダルシリカ、メタケイ
酸アルミン酸マグネシウム、ベントナイト、モンモリロ
ナイト、カオリン、合成ケイ酸アルミニウム、ケイ酸カ
ルシウム、水酸化アルミニウムゲル、アルミナゾル、炭
酸マグネシウム、合成ヒドロタルサイト、酸化マグネシ
ウム、水酸化マグネシウム及びそれらの混合物からなる
群より選ばれたものである特許請求の範囲第1項記載の
歯磨剤。 6、水不溶性無機結合剤がケイ素系化合物である特許請
求の範囲第1項記載の歯磨剤。 7、水不溶性無機結合剤がメタケイ酸アルミン酸マグネ
シウム又は合成ケイ酸アルミニウムとコロイダルシリカ
の併用系である特許請求の範囲第1項記載の歯磨剤。 8、顆粒が更に着色剤を存在せしめたものである特許請
求の範囲第1項記載の歯磨剤。 9、顆粒の形状が実質的に球状である特許請求の範囲第
1項記載の歯磨剤。 10、顆粒が噴霧造粒法により得られたものである特許
請求の範囲第1項記載の歯磨剤。11、顆粒量が1〜5
0重量%である特許請求の範囲第1項記載の歯磨剤。[Scope of Claims] 1. Granules obtained by binding water-insoluble powder materials with a water-insoluble inorganic binder, which have a particle size that passes through a 30 mesh sieve but does not pass through a 200 mesh sieve. , A dentifrice containing granules that disintegrate when a load of 0.1 to 10 g is applied to each granule. 2. Water-insoluble powder materials include dibasic calcium phosphate, tribasic calcium phosphate, insoluble sodium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, calcium carbonate, calcium pyrophosphate, zeolite, composite aluminosilicate, magnesium carbonate, red iron sulfate, calcium sulfate The dentifrice according to claim 1, which is selected from the group consisting of: and mixtures thereof. 3. The dentifrice according to claim 1, wherein the water-insoluble powder material has a particle size of 0.1 to 20μ. 4. The dentifrice according to claim 1, wherein the water-insoluble powder material is zeolite. 5. The water-insoluble inorganic binder is colloidal silica, magnesium aluminate metasilicate, bentonite, montmorillonite, kaolin, synthetic aluminum silicate, calcium silicate, aluminum hydroxide gel, alumina sol, magnesium carbonate, synthetic hydrotalcite, magnesium oxide, The dentifrice according to claim 1, which is selected from the group consisting of magnesium hydroxide and mixtures thereof. 6. The dentifrice according to claim 1, wherein the water-insoluble inorganic binder is a silicon-based compound. 7. The dentifrice according to claim 1, wherein the water-insoluble inorganic binder is a combination system of magnesium aluminate metasilicate or synthetic aluminum silicate and colloidal silica. 8. The dentifrice according to claim 1, wherein the granules further contain a coloring agent. 9. The dentifrice according to claim 1, wherein the granules have a substantially spherical shape. 10. The dentifrice according to claim 1, wherein the granules are obtained by a spray granulation method. 11, granule amount is 1-5
The dentifrice according to claim 1, which contains 0% by weight.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63127528A JPH0621053B2 (en) | 1988-05-25 | 1988-05-25 | Toothpaste |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63127528A JPH0621053B2 (en) | 1988-05-25 | 1988-05-25 | Toothpaste |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH01299211A true JPH01299211A (en) | 1989-12-04 |
JPH0621053B2 JPH0621053B2 (en) | 1994-03-23 |
Family
ID=14962248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63127528A Expired - Lifetime JPH0621053B2 (en) | 1988-05-25 | 1988-05-25 | Toothpaste |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0621053B2 (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH03271215A (en) * | 1990-03-20 | 1991-12-03 | Kao Corp | Drug-containing granule and dentifrice containing the same |
JPH0421624A (en) * | 1990-05-14 | 1992-01-24 | Nippon Zeora Kk | Dentifrice composition |
JPH04243816A (en) * | 1991-01-28 | 1992-08-31 | Kao Corp | Granule agent and composition for oral cavity containing the same agent |
JPH04243815A (en) * | 1991-01-25 | 1992-08-31 | Kao Corp | Composition for oral cavity |
JPH05163126A (en) * | 1991-12-16 | 1993-06-29 | Kao Corp | Composition for oral cavity |
JP2001089342A (en) * | 1999-09-22 | 2001-04-03 | Lion Corp | Masticatory composition |
WO2002015857A1 (en) * | 2000-08-23 | 2002-02-28 | Lion Corporation | Oral composition |
JP2004250456A (en) * | 2004-04-28 | 2004-09-09 | Kao Corp | Dentifrice |
WO2005000260A1 (en) * | 2003-06-27 | 2005-01-06 | Lion Corporation | Dentifrice composition |
WO2005089703A1 (en) * | 2004-03-19 | 2005-09-29 | Kao Corporation | Composition for toothbrushing |
JP2006008651A (en) * | 2004-05-21 | 2006-01-12 | Kao Corp | Composition for toothbrushing |
JP2006069983A (en) * | 2004-09-03 | 2006-03-16 | Kao Corp | Tooth-brushing composition |
WO2006038318A1 (en) * | 2004-09-30 | 2006-04-13 | Kobayashi Pharmaceutical Co., Ltd. | Gingivitis remedial or preventive agent |
JP2007238634A (en) * | 2007-06-25 | 2007-09-20 | Kao Corp | Dentifrice |
JP2009242241A (en) * | 2007-11-21 | 2009-10-22 | Kao Corp | Dentifrice |
JP2010070458A (en) * | 2008-09-16 | 2010-04-02 | Kao Corp | Method for producing dentifrice granules |
JP2010173986A (en) * | 2009-01-30 | 2010-08-12 | Kao Corp | Process for producing dentifrice granule |
JP2010275260A (en) * | 2009-05-29 | 2010-12-09 | Kao Corp | Toothpaste |
JP2011011998A (en) * | 2009-06-30 | 2011-01-20 | Kao Corp | Granule for dentifrice |
JP2011084530A (en) * | 2009-10-19 | 2011-04-28 | Kao Corp | Method for producing granule for dentifrice |
JP2013155165A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2013155164A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2013155160A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2014015437A (en) * | 2012-07-11 | 2014-01-30 | Lion Corp | Dentifrice composition |
JP2014024837A (en) * | 2012-06-20 | 2014-02-06 | Kao Corp | Producing method of dentifrice granule |
JP2014125440A (en) * | 2012-12-26 | 2014-07-07 | Lion Corp | Composition for oral cavity |
JP2014237619A (en) * | 2013-06-10 | 2014-12-18 | 花王株式会社 | Dentifrice |
JP2015010044A (en) * | 2013-06-27 | 2015-01-19 | 花王株式会社 | Dentifrice |
JP2015089873A (en) * | 2013-11-05 | 2015-05-11 | 花王株式会社 | Dentifrice |
JP2015105258A (en) * | 2013-12-02 | 2015-06-08 | 花王株式会社 | Method for producing granules for dentifrices |
JP2015117205A (en) * | 2013-12-18 | 2015-06-25 | 花王株式会社 | Dentifrice composition |
JP2015117206A (en) * | 2013-12-18 | 2015-06-25 | 花王株式会社 | Dentifrice composition |
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JP2015124161A (en) * | 2013-12-26 | 2015-07-06 | 花王株式会社 | Dentifrice |
JP2018104294A (en) * | 2016-12-22 | 2018-07-05 | 花王株式会社 | Granules for dentifrices, and dentifrice composition containing the same |
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Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03271215A (en) * | 1990-03-20 | 1991-12-03 | Kao Corp | Drug-containing granule and dentifrice containing the same |
JPH0421624A (en) * | 1990-05-14 | 1992-01-24 | Nippon Zeora Kk | Dentifrice composition |
JPH04243815A (en) * | 1991-01-25 | 1992-08-31 | Kao Corp | Composition for oral cavity |
JPH04243816A (en) * | 1991-01-28 | 1992-08-31 | Kao Corp | Granule agent and composition for oral cavity containing the same agent |
JPH05163126A (en) * | 1991-12-16 | 1993-06-29 | Kao Corp | Composition for oral cavity |
JP2001089342A (en) * | 1999-09-22 | 2001-04-03 | Lion Corp | Masticatory composition |
WO2002015857A1 (en) * | 2000-08-23 | 2002-02-28 | Lion Corporation | Oral composition |
WO2005000260A1 (en) * | 2003-06-27 | 2005-01-06 | Lion Corporation | Dentifrice composition |
WO2005089703A1 (en) * | 2004-03-19 | 2005-09-29 | Kao Corporation | Composition for toothbrushing |
EP2548547A1 (en) * | 2004-03-19 | 2013-01-23 | Kao Corporation | Composition for toothbrushing |
JP2004250456A (en) * | 2004-04-28 | 2004-09-09 | Kao Corp | Dentifrice |
JP2006008651A (en) * | 2004-05-21 | 2006-01-12 | Kao Corp | Composition for toothbrushing |
JP2006069983A (en) * | 2004-09-03 | 2006-03-16 | Kao Corp | Tooth-brushing composition |
WO2006038318A1 (en) * | 2004-09-30 | 2006-04-13 | Kobayashi Pharmaceutical Co., Ltd. | Gingivitis remedial or preventive agent |
JP2006096711A (en) * | 2004-09-30 | 2006-04-13 | Kobayashi Pharmaceut Co Ltd | Gingivitis ameliorating or preventing agent |
JP2007238634A (en) * | 2007-06-25 | 2007-09-20 | Kao Corp | Dentifrice |
JP2009242241A (en) * | 2007-11-21 | 2009-10-22 | Kao Corp | Dentifrice |
JP2010070458A (en) * | 2008-09-16 | 2010-04-02 | Kao Corp | Method for producing dentifrice granules |
JP2010173986A (en) * | 2009-01-30 | 2010-08-12 | Kao Corp | Process for producing dentifrice granule |
JP2010275260A (en) * | 2009-05-29 | 2010-12-09 | Kao Corp | Toothpaste |
JP2011011998A (en) * | 2009-06-30 | 2011-01-20 | Kao Corp | Granule for dentifrice |
JP2011084530A (en) * | 2009-10-19 | 2011-04-28 | Kao Corp | Method for producing granule for dentifrice |
JP2013155165A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2013155164A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2013155160A (en) * | 2012-01-31 | 2013-08-15 | Kao Corp | Dentifrice |
JP2014024837A (en) * | 2012-06-20 | 2014-02-06 | Kao Corp | Producing method of dentifrice granule |
JP2014015437A (en) * | 2012-07-11 | 2014-01-30 | Lion Corp | Dentifrice composition |
JP2014125440A (en) * | 2012-12-26 | 2014-07-07 | Lion Corp | Composition for oral cavity |
JP2014237619A (en) * | 2013-06-10 | 2014-12-18 | 花王株式会社 | Dentifrice |
JP2015010044A (en) * | 2013-06-27 | 2015-01-19 | 花王株式会社 | Dentifrice |
JP2015089873A (en) * | 2013-11-05 | 2015-05-11 | 花王株式会社 | Dentifrice |
JP2015105258A (en) * | 2013-12-02 | 2015-06-08 | 花王株式会社 | Method for producing granules for dentifrices |
JP2015117205A (en) * | 2013-12-18 | 2015-06-25 | 花王株式会社 | Dentifrice composition |
JP2015117206A (en) * | 2013-12-18 | 2015-06-25 | 花王株式会社 | Dentifrice composition |
WO2015092885A1 (en) * | 2013-12-18 | 2015-06-25 | 花王株式会社 | Dentifrice |
CN105828781A (en) * | 2013-12-18 | 2016-08-03 | 花王株式会社 | Dentifrice |
JPWO2015092885A1 (en) * | 2013-12-18 | 2017-03-16 | 花王株式会社 | Dentifrice |
TWI633894B (en) * | 2013-12-18 | 2018-09-01 | 日商花王股份有限公司 | Dentifrice |
JP2015124161A (en) * | 2013-12-26 | 2015-07-06 | 花王株式会社 | Dentifrice |
JP2018104294A (en) * | 2016-12-22 | 2018-07-05 | 花王株式会社 | Granules for dentifrices, and dentifrice composition containing the same |
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---|---|
JPH0621053B2 (en) | 1994-03-23 |
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