JPH01290614A - Sebum secretion promoter - Google Patents

Abstract

PURPOSE:To obtain a sebum secretion promotor, consisting of an extract from propolis and capable of exhibiting mild improving effects on symptoms, such as skin roughening or psoriasis, caused by insufficient secretion of sebum. CONSTITUTION:A sebum secretion promoter obtained by dipping and extracting propolis which is a resinous substance collected from plants by bees and called bee resin in a mixed solution of water with a hydrophilic solvent (e.g. methanol or acetone) or the hydrophilic solvent and distilling the solvent from the resul tant propolis extract solution through distillation, etc., and using the prepared propolis extract as the sebum secretion promoter. The amount thereof in blend ing with other drugs for external use is >=1 wt.% based on the total composition and the extract is preferably blended in an amount within the range of 3-20 wt.% expressed in terms of drying residue. The above-mentioned extract is excellently permeated into the skin and the activity thereof is specifically directed only to sebaceous gland without applying any stimulus to other organs and especially suitable for improving symptoms, such as insufficient sebum scretion.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a sebum secretion promoter. More specifically, it is a sebum secretion promoter that shows a mild improvement effect on symptoms such as rough skin and psoriasis caused by insufficient secretion of sebum.

[Prior Art] Propolis is a tar-like substance collected from plants and produced by bees. Propolis has been used as a traditional folk medicine since ancient times, and in recent years its functions and effects have been elucidated mainly in Eastern European countries. There are many reports on its antibacterial, hemostatic, scarring, anti-inflammatory, antioxidant, local anesthetic, and tumor growth inhibitory effects. The main components of propolis are flavones, flavanones, aromatic alcohols, aromatic aldehydes, coumarins, etc. The composition and content of these substances vary depending on where propolis is produced, and it is said that their effects also differ. .

On the other hand, compounds that specifically act on sebaceous glands to promote sebum secretion and do not affect organs other than the sebaceous glands are used to treat symptoms such as rough skin and dry skin caused by insufficient secretion of sebum. is unknown until today.

[Problems to be Solved by the Invention] Therefore, the present inventors were researching a compound that acts specifically on sebaceous glands to promote sebum secretion and does not affect organs other than the sebaceous glands, and found that propolis The present invention was completed based on the discovery that an extract of the following can achieve this purpose.

[! i! Means for Solving the Problems] That is, the present invention is a sebum secretion promoter comprising an extract of propolis.

Hereinafter, the configuration of the present invention will be explained in detail.

As mentioned above, propolis used in the present invention is a resin-like substance collected from plants by bees, and is also called bee resin.

-When fishing by boat, a large amount of bee-keeping sticks to the frames and crevices of hives, so they are collected by scraping them off.

The above-mentioned extract or extract from propolis is produced as follows. Propolis is extracted by immersing it in a mixture of water and a hydrophilic solvent or in a hydrophilic solvent (generally, an extract having an amount of about 10 times the weight of propolis is used) to obtain a propolis extract. Examples of the hydrophilic solvent include alcohols such as methanol and ethanol, and acetone.

A propolis extract is obtained by removing the solvent from the propolis extract by distillation or other methods.

When incorporated into other external preparations as a sebum secretion promoter, the amount of the extract (residue after distilling off the extraction solvent) is generally greater than 1% (wt%) in the total composition. There is no particular upper limit to the amount of propolis and its extracts, but from the viewpoint of commercial value such as coloring and the effect of promoting sebum secretion, the amount of propolis and its extracts should be blended at a total of 3% to 20% as dry residue. is preferred.

In addition to propolis extract, the present invention contains sulfur, hinokitiol, triclosan, trichlorocarbanilide, chlorhexidine hydrochloride, chlorhexidine gluconate, halocarpan, chlorophenesine, benzethonium chloride, benzalkonium chloride, lysozyme chloride, alkyl hydrochloride. Antibacterial agents such as diaminoethylglycine, isopropylmethylphenol, benzoic acid, Photosensor No. 201, thymol, hexachlorophene, berberine, and thioxolone, and vitamins such as vitamin A% C, B2, B6, B1°, E1 biotin, and nicotinic acid. Exfoliating agents such as salicylic acid and resorcinol, clycyrrhetinic acid, clycyrrhizic acid, allantoin, epsilon aminocaproic acid, butyl flufenamate, azulene, camphor, zinc chloride, zinc white, menthol, indomethacin, ibuprofen piconol, mefenamic acid, and their Anti-inflammatory agents such as derivatives, γ-oryzanol, zinc and its metal compounds, lactic acid, and although it varies depending on the properties, oils, surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, etc. can be used in the present invention. It can be blended as appropriate within a range that does not impair the effects of.

[Example] Next, the present invention will be explained in more detail with reference to Examples.

The sebum secretion enhancer of the present invention was incorporated into a lotion and its effectiveness was investigated using clinical examples.

(Medicine used) A lotion-type sebum secretion stimulant obtained by the following formulation and manufacturing method was used.

1) Propolis extract 5.0g2
) P OE (60 mol) Hydrogenated castor oil 2
．． 0g3) Glycerin 9.0
g4) Dipropylene glycol 9.0g5
) 1.3-Butylene glycol 5.0g6) Polyethylene glycol 1500 5.0g7) Cetyl isooctanaate 10.0g8) Squalane 5.0g9) Methylparaben 1.0 glo) Carboxyvinyl polymer 0.3g11) Sodium hexametaphosphate 0. 08g12) Ion exchange water 11.0g13) Potassium hydroxide 0.12 g14) Ion exchange water 37.5g1)2)3)4
) 5) Dissolve 6) by heating at 60°C. To this 7) 8) 9
) was added and mixed by heating to <60°C, and processed with a homomixer to form a gel. Next, add 1 to this gel.
0) Gradually add 11) dissolved in 12) and disperse with a homomixer, then add and mix 13) dissolved in 14), emulsify with a homomixer, and release sebum into the lotion. Contains accelerator.

(Targets for Use and Observation Period) The product was used for 4 weeks on 20 patients between the ages of 30 and 40 with rough skin due to obvious lack of sebum secretion.

(How to use) Apply the above-mentioned lotion-type sebum secretion promotion rules on the face.
It was applied at least 3 times a day.

(Measurement of sebum) The total amount of sebum before use and after 4 weeks of use was measured by collecting sebum using the glass cup method and using the gravimetric method [Ohokawa, H., et al.
l.

Anal, Biochem, 95.351358 (1
979)].

The amount of sebum was expressed as a relative ratio as shown in the following formula.

(Left below) (Results) Case number Age Gender Sebum increase rate 1 30 Female 12 2 32 Male 10 3 40 Female 8 4 36 Male 9 5 35 Female 5 6 36 Female 11 7 38 Female 9 8 36 Female 13 9 31 Female 8 10 33 Female 6 11 30 Female 1112 3
0 Male 1513 32 Female
5 Case number Age Sex Skin increase rate 14 36 Male 1115 3
3 men 1216 32 men
1017 30 Male 518
35 Female 3 19 36 Female 320 3
6 Female 2 The results of a clinical test conducted on 20 people (7 males and 13 females) showed that the average sebum increase rate was 8.4%, proving the effectiveness of the sebum secretion promoter of the present invention.

Next, a formulation example in which the product of the present invention is blended into an ointment will be shown.

1) Solid paraffin 10.0g
2) Peace wax 10.0g
3) Squalane 10.0g
4) Propolis extract 4.0g
5) Resorcinol 0.1g6
) Perfume Appropriate amount 7) Vaseline 65.9g The above ingredients were mixed, the mixture was heated and dissolved at 80°C, and then cooled with stirring to obtain an ointment.

[Effects of the Invention] The sebum secretion promoting agent of the present invention exhibits a very good sebum secretion promoting effect. In addition, it penetrates the skin very well, and its activity is specifically directed only to the sebaceous glands and does not irritate any other organs, making it particularly suitable for improving symptoms of insufficient sebum secretion.

Patent applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] Sebum secretion stimulant made from propolis extract