JPH01275524A - Cosmetic for cleansing - Google Patents
Cosmetic for cleansingInfo
- Publication number
- JPH01275524A JPH01275524A JP10596388A JP10596388A JPH01275524A JP H01275524 A JPH01275524 A JP H01275524A JP 10596388 A JP10596388 A JP 10596388A JP 10596388 A JP10596388 A JP 10596388A JP H01275524 A JPH01275524 A JP H01275524A
- Authority
- JP
- Japan
- Prior art keywords
- cleansing
- cosmetic
- kojic acid
- effect
- cream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 21
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960004705 kojic acid Drugs 0.000 claims abstract description 11
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims description 13
- 239000006071 cream Substances 0.000 abstract description 11
- 239000000344 soap Substances 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 5
- 239000002453 shampoo Substances 0.000 abstract description 4
- 238000005406 washing Methods 0.000 abstract description 3
- 241000589220 Acetobacter Species 0.000 abstract description 2
- 241000228212 Aspergillus Species 0.000 abstract description 2
- 241000589236 Gluconobacter Species 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 238000012258 culturing Methods 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- 235000013336 milk Nutrition 0.000 abstract description 2
- 239000008267 milk Substances 0.000 abstract description 2
- 210000004080 milk Anatomy 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract 2
- 206010002198 Anaphylactic reaction Diseases 0.000 abstract 1
- 241000588722 Escherichia Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- 230000036783 anaphylactic response Effects 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 239000002781 deodorant agent Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 230000001815 facial effect Effects 0.000 description 6
- 239000008213 purified water Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229940121363 anti-inflammatory agent Drugs 0.000 description 4
- 239000002260 anti-inflammatory agent Substances 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- -1 parachlormetaxylenol Chemical compound 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- WADQOGCINABPRT-UHFFFAOYSA-N 3-chloro-2-methylphenol Chemical compound CC1=C(O)C=CC=C1Cl WADQOGCINABPRT-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- ISTASGAHDLTQRU-UHFFFAOYSA-N n-(2-hydroxyethyl)undec-10-enamide Chemical compound OCCNC(=O)CCCCCCCCC=C ISTASGAHDLTQRU-UHFFFAOYSA-N 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 1
- 229960002447 thiram Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、消臭、殺菌、消炎効果の優れた洗浄用化粧料
に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a cleaning cosmetic with excellent deodorizing, sterilizing and anti-inflammatory effects.
一般に身体を洗浄するために石鹸、シャンプー等が主と
して用いられている。これらの石鹸、シャンプー等を身
体特に顔に使用する場合は、洗顔用洗浄料例えば石鹸、
洗顔クリーム等に殺菌剤、消炎剤等を配合して、細菌に
よる悪臭の発生、病源菌の増殖の防止、皮膚の炎症の防
止等の効果を有するいわゆる薬用石鹸が各種市販されて
いる。Generally, soap, shampoo, etc. are mainly used to wash the body. When using these soaps, shampoos, etc. on the body, especially on the face, cleansing products such as soap,
Various types of so-called medicated soaps are commercially available, which are made by blending disinfectants, anti-inflammatory agents, etc. with facial cleansing creams, etc., and have effects such as preventing the generation of bad odors caused by bacteria, the proliferation of pathogenic bacteria, and preventing skin inflammation.
これら薬用石鹸に配合されている殺菌剤としは３．４，
４°−トリクロロカルバニリド（ＴＣＣ）、３−トリフ
ルオロメチル−４，４° −ジクロルカルバニリド、２
，４，４°−トリクロロ−２゛−ヒドロキシジフェニル
エーテル、テトラメチルチウラムジスルフィド、パラク
ロルメタキシレノール、クロルクレゾール、塩酸クロル
ヘキシジン、ウンデシレン酸モノエタノールアミド、塩
酸アルキルジアミノエチルグリシン、ジンクピリチオン
等が用いられている。また、消炎剤としてはアズレン、
アラントイン、グリチルリチン酸塩、コロイド硫黄、感
光素、硫化セレン、サリチル酸等が用いられている。消
炎剤として、他に、グリチルレチン酸及びその誘導体、
ε−アミノカプロン酸、塩化リゾチーム等も用いられる
。The disinfectants contained in these medicated soaps are 3.4.
4°-trichlorocarbanilide (TCC), 3-trifluoromethyl-4,4°-dichlorocarbanilide, 2
, 4,4°-trichloro-2′-hydroxydiphenyl ether, tetramethylthiuram disulfide, parachlormetaxylenol, chlorcresol, chlorhexidine hydrochloride, undecylenic acid monoethanolamide, alkyldiaminoethylglycine hydrochloride, zinc pyrithione, and the like. Also, as an anti-inflammatory agent, azulene,
Allantoin, glycyrrhizinate, colloidal sulfur, photosensitizer, selenium sulfide, salicylic acid, etc. are used. Other anti-inflammatory agents include glycyrrhetinic acid and its derivatives,
ε-aminocaproic acid, lysozyme chloride, etc. are also used.
上述のような従来の薬用石鹸は配合する殺菌剤、消炎剤
は何れもその安全性に問題があり、また殺菌、消炎の効
果を達成するためには、それぞれの活性を有する薬剤を
数種組合せて石鹸中に配合する必要があった。その場合
、殺菌性物質と消炎活性物質との任意の組合せは、相互
の併用禁忌等の調査、検討をし、更にその皮膚に対する
障害等を検討しなければならない等の非常に困難な点が
多々あった。Conventional medicated soaps as mentioned above have safety issues with the bactericidal agents and anti-inflammatory agents that they contain, and in order to achieve bactericidal and anti-inflammatory effects, it is necessary to combine several types of agents that have the respective activities. Therefore, it was necessary to incorporate it into soap. In that case, any combination of a bactericidal substance and an anti-inflammatory active substance is very difficult, as it is necessary to investigate and consider contraindications for mutual use, and also to consider possible harm to the skin. there were.
本発明はこのような欠点のない優れた殺菌、消炎、更に
色白効果をもたらす洗浄用化粧料を提供することを目的
とするものである。The object of the present invention is to provide a cleansing cosmetic that does not have these drawbacks and provides excellent sterilization, anti-inflammatory, and skin whitening effects.
本発明はコウジ酸を含有する洗浄用化粧料である。 The present invention is a cleaning cosmetic containing kojic acid.
この洗浄用化粧料は石＃ｉ類、洗顔料類、クレンジング
クリーム、クレンジングローション及ヒホディンヤンプ
ーなどが含まれる。The cleaning cosmetics include stone #i types, facial cleansers, cleansing creams, cleansing lotions, Hihodinyanpu, and the like.
本発明の有効成分であるコウジ酸はアスペルギルス属、
ペニンリウム属、エスカリキア属、アセトバクター属、
グルコノバクタ−属等の菌を培養して得られる公知物質
で、メラニン生成抑制作用を有するもので色白化粧料な
どに使用されている。Kojic acid, which is the active ingredient of the present invention, is derived from Aspergillus spp.
Peninrium spp., Escalichia spp., Acetobacter spp.
It is a known substance obtained by culturing bacteria such as Gluconobacter, which has a melanin production inhibiting effect and is used in skin-fairing cosmetics.
そして、この物質は極めて毒性が低く、マウス、ラント
を用いた急性毒性は経口、腹腔投与によりＬＤｓｏが約
２．５〜３．５ ｇ／Ｋｇで、皮膚に対しても一次刺激
及び累積刺激がなく、アレルギー反応も全く認められな
い安全な物質である。This substance has extremely low toxicity, with an LDso of approximately 2.5 to 3.5 g/Kg when administered orally or intraperitoneally in mice and runts, and causes both primary and cumulative irritation to the skin. It is a safe substance with no allergic reactions.
本発明はコウジ酸を洗浄用化粧料例えば洗顔クリーム、
洗顔パウダー、石鹸、クレンジングミルク、クレンジン
グクリーム、ボディシャンプーに、これらの洗浄用化粧
料の全量に対し０．０１〜５．０ ％重遣配合した洗浄
用化粧料である。そして、コウジ酸の配合は上記洗浄用
化粧料に通常使用される基剤及び助剤に所定量を配合し
て本発明の洗浄用化粧料とする。The present invention uses kojic acid in cleansing cosmetics, such as facial cleansing creams.
This is a cleaning cosmetic that is blended with facial cleansing powder, soap, cleansing milk, cleansing cream, and body shampoo in an amount of 0.01 to 5.0% based on the total amount of these cleaning cosmetics. Then, kojic acid is blended in a predetermined amount into the base and auxiliary agents commonly used in the above-mentioned cleaning cosmetics to obtain the cleaning cosmetics of the present invention.
本発明の洗浄用化粧料は消臭、殺菌効果並びに過敏症、
炎症性の人の皮膚に適用しても消炎効果が浸れている。The cleaning cosmetic of the present invention has deodorizing and sterilizing effects as well as hypersensitivity,
It is also soaked in anti-inflammatory effects when applied to inflammatory people's skin.
次に本発明の実施例及び洗浄用化粧料として使用した場
合の効果の試験例を示す。Next, examples of the present invention and test examples of effects when used as a cleaning cosmetic will be shown.
例１ （洗顔クリーム）
Ｎ−ラウロイル−し−グルタミン酸ナトリウム２２．０
ｇ、Ｎ−７シルーし一グルタミン酸ナトリウム３．０ｇ
、ポリエチレングリコール４００１６．Ｏｇ、 ａグ
リセリン８．０ｇを加温、溶解し、この液にジステアリ
ン酸ポリエチレングリコール（１５０Ｅ、Ｏ，） １．
５ｇ 及びモノステアリン酸ポリエチレングリコール（
１５０Ｅ。Example 1 (Facial cleansing cream) Sodium N-lauroyl-glutamate 22.0
g, N-7 monosodium monoglutamate 3.0g
, polyethylene glycol 40016. Og, a Heat and dissolve 8.0 g of glycerin, and add polyethylene glycol distearate (150E, O,) to this solution.
5g and polyethylene glycol monostearate (
150E.
０、）４．５ｇを加温、溶解した液を加え攪拌し冷却す
る。かくして得られたクリームにエデト酸二ナトリウム
０１ｇ１コウジ酸１．０ｇ Ｓ精製水４３．９ｇを加え
、攪拌混合して冷却後容器に充填して製品とする。0,) 4.5g was heated, the dissolved liquid was added, stirred, and cooled. To the thus obtained cream were added 01 g of disodium edetate, 1.0 g of kojic acid, and 43.9 g of S purified water, stirred and mixed, cooled, and then filled into a container to obtain a product.
例２（石鹸）
Ｎ−アシル−し−グルタミン酸ナトリウム８０．０ｇ及
び精製水３．４ｇを加温、溶解し、この液にセタノール
８、Ｏｇｌ ピログルタミン酸イソステアリン酸ポリオ
キシエチレングリセリル（２５Ｂ、 ０． ）２．０ｇ
及びヤシ油脂肪酸ジェタノールアミド０．５ｇを加温、
溶解した液を加え、攪拌し冷却する。Example 2 (Soap) 80.0 g of sodium N-acyl-glutamate and 3.4 g of purified water were heated and dissolved, and in this solution were added cetanol 8, Ogl pyroglutamic acid isostearate polyoxyethylene glyceryl (25B, 0.0 g). 2.0g
and 0.5 g of coconut oil fatty acid jetanolamide,
Add the dissolved liquid, stir and cool.
かくして得られた石鹸にエデト酸二ナトリウム０．１ｇ
、コウジ酸１．０ｇ及び精製水５．０ｇを加え、攪拌混
合した後冷却固化し、切断し乾燥成型して製品とする。Add 0.1 g of disodium edetate to the soap thus obtained.
, 1.0 g of kojic acid and 5.0 g of purified water were added, stirred and mixed, cooled and solidified, cut and dried to form a product.
例３ （クレンジングクリーム）
カルボキシビニルポリマー０．１ｇ 、 １．３−ブチ
レングリコール７．０ｇ、バラオキシ安息香酸エチル０
．３ｇ及び精製水１８．７ｇ を加温、溶解する。この
液にモノステアリン酸ポリオキシエチレンソルビタン（
２０日、ｏ、）３．３ｇ、親油型モノステアリン酸グリ
セリン１．７ｇ、サラシラロウ１．９ｇ、ステアリン酸
２．８ｇ、、 トリオクタン酸グリセリル２１．０ｇ
、流動ハラフィン３７．０ｇ及び天然ビタミンＥ Ｏ
，０４ｇ を加温、溶解した液を加え、攪拌、乳化し後
冷却する。かくして得られたクリームに炭酸カリウムの
適量、エデト酸二ナトリウム０１ｇ、コウジ酸１．０ｇ
及び精製水５、Ｏｇを加え、攪拌混合する。これを冷却
し後容器に充填し製品とする。Example 3 (Cleansing cream) Carboxyvinyl polymer 0.1g, 1,3-butylene glycol 7.0g, ethyl roseoxybenzoate 0
．． 3g and 18.7g of purified water are heated and dissolved. Add polyoxyethylene sorbitan monostearate (
20th, o, ) 3.3 g, lipophilic glyceryl monostearate 1.7 g, Sarashiro 1.9 g, stearic acid 2.8 g, glyceryl trioctanoate 21.0 g
, liquid halafine 37.0g and natural vitamin E O
,04g was heated, a dissolved solution was added, stirred, emulsified, and then cooled. To the cream thus obtained, add an appropriate amount of potassium carbonate, 01 g of disodium edetate, and 1.0 g of kojic acid.
Add 5.0 g of purified water and mix with stirring. This is cooled and then filled into a container to produce a product.
試験例 にキビ改善試験）
１）供試試料
実施例１の洗顔クリーム
２）試験方法
ニキビ肌の人１０人をパネラ−として、供試試料を使用
し洗顔した場合と、供試々料を使用しないで洗顔した場
合（コントロール）とで、各人のニキビの改善程度を評
価した。Test Example: Millet improvement test) 1) Test sample Facial cleansing cream of Example 1 2) Test method A panel of 10 people with acne-prone skin wash their faces using the test sample, and a case using the test sample. The degree of improvement in each person's acne was evaluated based on when they washed their face without washing (control).
３）試験結果 試験結果は下記表１の通りであった。3) Test results The test results are shown in Table 1 below.
表１
以上の結果より明らかな通り、本発明の洗浄用化粧料は
ニキビの改善に著しい効果があった。Table 1 As is clear from the above results, the cleaning cosmetic of the present invention had a remarkable effect on improving acne.
本発明の洗浄用化粧料は殺菌、消炎の効果を毒性の殆ど
無い安全な成分により達成し、皮膚に対 −′−する刺
激性がなく、しかも使用後、本成分本来の効果の色白効
果も奏する極めて優れた有用な洗浄用化粧料である。The cleaning cosmetic of the present invention achieves sterilization and anti-inflammatory effects using safe ingredients with almost no toxicity, has no irritation to the skin, and furthermore, after use, the skin whitening effect of this ingredient is maintained. It is an extremely useful cleaning cosmetic with excellent cleansing properties.
Claims (1)
。1. A cleaning cosmetic characterized by containing kojic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63105963A JP2549148B2 (en) | 1988-04-27 | 1988-04-27 | Cleaning cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63105963A JP2549148B2 (en) | 1988-04-27 | 1988-04-27 | Cleaning cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01275524A true JPH01275524A (en) | 1989-11-06 |
| JP2549148B2 JP2549148B2 (en) | 1996-10-30 |
Family
ID=14421449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63105963A Expired - Lifetime JP2549148B2 (en) | 1988-04-27 | 1988-04-27 | Cleaning cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2549148B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082884A1 (en) * | 2000-05-03 | 2001-11-08 | Unilever Plc | Detergent bar composition with benefit agents |
| US6710076B2 (en) | 1994-10-24 | 2004-03-23 | Physician's Choice Of Arizona, Inc. | Hydroxy-kojic acid skin peel |
| CN105326733A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Pore-fining liquid facial cleanser and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS533538A (en) * | 1976-06-28 | 1978-01-13 | Sansho Seiyaku Kk | Skin bleach cosmetics |
-
1988
- 1988-04-27 JP JP63105963A patent/JP2549148B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS533538A (en) * | 1976-06-28 | 1978-01-13 | Sansho Seiyaku Kk | Skin bleach cosmetics |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710076B2 (en) | 1994-10-24 | 2004-03-23 | Physician's Choice Of Arizona, Inc. | Hydroxy-kojic acid skin peel |
| WO2001082884A1 (en) * | 2000-05-03 | 2001-11-08 | Unilever Plc | Detergent bar composition with benefit agents |
| CN105326733A (en) * | 2015-10-29 | 2016-02-17 | 青岛海之源智能技术有限公司 | Pore-fining liquid facial cleanser and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2549148B2 (en) | 1996-10-30 |
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