JPH01240196A - 新規グリコペプチド系抗生物質pa−45052 - Google Patents
新規グリコペプチド系抗生物質pa−45052Info
- Publication number
- JPH01240196A JPH01240196A JP63084652A JP8465288A JPH01240196A JP H01240196 A JPH01240196 A JP H01240196A JP 63084652 A JP63084652 A JP 63084652A JP 8465288 A JP8465288 A JP 8465288A JP H01240196 A JPH01240196 A JP H01240196A
- Authority
- JP
- Japan
- Prior art keywords
- culture
- compound
- nocardia
- formula
- hci
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010015899 Glycopeptides Proteins 0.000 title abstract description 11
- 102000002068 Glycopeptides Human genes 0.000 title abstract description 11
- 230000003115 biocidal effect Effects 0.000 title abstract description 8
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title description 2
- 241000894006 Bacteria Species 0.000 claims abstract description 21
- 241001465754 Metazoa Species 0.000 claims abstract description 21
- 241001430312 Amycolatopsis orientalis Species 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- 241000187654 Nocardia Species 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
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- 238000012258 culturing Methods 0.000 claims description 7
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- 239000003429 antifungal agent Substances 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
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- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 10
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
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- 239000008363 phosphate buffer Substances 0.000 description 5
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 235000019733 Fish meal Nutrition 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
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- 240000007594 Oryza sativa Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
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- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
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- 240000004658 Medicago sativa Species 0.000 description 3
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- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 3
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- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 description 3
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- 238000004809 thin layer chromatography Methods 0.000 description 1
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- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
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Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63084652A JPH01240196A (ja) | 1987-04-16 | 1988-04-05 | 新規グリコペプチド系抗生物質pa−45052 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-94742 | 1987-04-16 | ||
JP9474287 | 1987-04-16 | ||
JP62-287616 | 1987-11-13 | ||
JP63084652A JPH01240196A (ja) | 1987-04-16 | 1988-04-05 | 新規グリコペプチド系抗生物質pa−45052 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH01240196A true JPH01240196A (ja) | 1989-09-25 |
JPH0428278B2 JPH0428278B2 (zh) | 1992-05-13 |
Family
ID=26425647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63084652A Granted JPH01240196A (ja) | 1987-04-16 | 1988-04-05 | 新規グリコペプチド系抗生物質pa−45052 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH01240196A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009081958A1 (ja) | 2007-12-26 | 2009-07-02 | Shionogi & Co., Ltd. | グリコペプチド抗生物質配糖化誘導体 |
US8778874B2 (en) | 2004-11-29 | 2014-07-15 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
US8933012B2 (en) | 2006-05-26 | 2015-01-13 | Shionogi & Co., Ltd. | Glycopeptide antibiotic derivative |
-
1988
- 1988-04-05 JP JP63084652A patent/JPH01240196A/ja active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8778874B2 (en) | 2004-11-29 | 2014-07-15 | National University Corporation Nagoya University | Glycopeptide antibiotic monomer derivatives |
US8933012B2 (en) | 2006-05-26 | 2015-01-13 | Shionogi & Co., Ltd. | Glycopeptide antibiotic derivative |
WO2009081958A1 (ja) | 2007-12-26 | 2009-07-02 | Shionogi & Co., Ltd. | グリコペプチド抗生物質配糖化誘導体 |
RU2481354C2 (ru) * | 2007-12-26 | 2013-05-10 | Шионоги Энд Ко., Лтд. | Гликозилированные гликопептидные антибиотические производные |
US8481696B2 (en) | 2007-12-26 | 2013-07-09 | Shionogi & Co., Ltd. | Glycosylated glycopeptide antibiotic derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPH0428278B2 (zh) | 1992-05-13 |
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