JPH01219665A - Constant temperature bath for liquid chromatograph - Google Patents
Constant temperature bath for liquid chromatographInfo
- Publication number
- JPH01219665A JPH01219665A JP63046323A JP4632388A JPH01219665A JP H01219665 A JPH01219665 A JP H01219665A JP 63046323 A JP63046323 A JP 63046323A JP 4632388 A JP4632388 A JP 4632388A JP H01219665 A JPH01219665 A JP H01219665A
- Authority
- JP
- Japan
- Prior art keywords
- heat
- conductive material
- temperature
- bath
- constant temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims description 6
- 239000004020 conductor Substances 0.000 claims abstract description 17
- 238000001816 cooling Methods 0.000 abstract description 9
- 238000010438 heat treatment Methods 0.000 abstract description 9
- 238000005192 partition Methods 0.000 abstract description 8
- 230000004043 responsiveness Effects 0.000 abstract description 2
- 230000000644 propagated effect Effects 0.000 abstract 2
- 230000005855 radiation Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000012774 insulation material Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- XSOKHXFFCGXDJZ-UHFFFAOYSA-N telluride(2-) Chemical compound [Te-2] XSOKHXFFCGXDJZ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
【発明の詳細な説明】
イ、産業上の利用分野
本発明は液体クロマトグラフ用恒温槽に関するものであ
る。DETAILED DESCRIPTION OF THE INVENTION A. Field of Industrial Application The present invention relates to a constant temperature bath for liquid chromatography.
口、従来の技術
液体クロマトグラフに於て各種液体を使用する場合、カ
ラムを一定温に保つことにより分離効率を高めることが
行われている。そのため、従来恒温槽に於ては ヒータ
ーを組込んで温度を一定に保つようにしである。2. Description of the Related Art When various liquids are used in a liquid chromatograph, separation efficiency is improved by keeping the column at a constant temperature. For this reason, conventional thermostats incorporate heaters to keep the temperature constant.
ハ、解決すべき問題点
然して従来の恒温槽に於てはヒーターのみを設置したも
のであるため、恒温槽内は室温＋１０℃以上になりそれ
を下げる手段がなく、このため室温程度の温度は求めら
れなかった。最近室温程度の要求か高まり、これに対遮
すべく、クーラーを設置した恒温槽か提案されている（
特開昭８２−２０１３５９）。しかしこの場合でも、室
温以下の設定温度の場合クーラーのみで温度制御し、室
温以上の設定温度の場合ヒーターのみでの温度制御であ
った。このため応答性か悪く精度の良い制御は出来なか
った。C. Problems to be solved However, since conventional thermostatic chambers are equipped with only a heater, the temperature inside the thermostatic chamber reaches 10 degrees Celsius or more above the room temperature, and there is no way to lower the temperature. I wasn't asked for it. Recently, the demand for temperatures around room temperature has increased, and in order to meet this demand, a constant temperature chamber equipped with a cooler has been proposed (
JP 82-201359). However, even in this case, when the set temperature was below room temperature, the temperature was controlled only by the cooler, and when the set temperature was above room temperature, the temperature was controlled only by the heater. For this reason, responsiveness was poor and accurate control was not possible.
二１問題点を解決するための子役
そこで本発明に於ては、冷却加熱装置とし ゛てサーモ
モジュールを使用することにより、室温を境にしてヒー
ターとしての機悌と、クーラーとしての機能を極性反転
により交代させ精度よく温度制御を為しうると共に設定
温度と室温との差によりサーモモジュールの冷却、加熱
偉力を変更させ、条件に合った能力を与え、以って応答
性のよい冷却、加熱を為した温度制御を為さんとするも
ので、槽内の設定温度と基準温度との温度差により比較
回路を介してサーモモジュールのｔｔ力制御装置を作動
させる如くしたことを特徴とする。Therefore, in the present invention, by using a thermo module as a cooling/heating device, the flexibility of the heater and the function of a cooler can be polarized at room temperature. It is possible to control the temperature accurately by alternating by reversing the temperature, and also change the cooling and heating power of the thermo module depending on the difference between the set temperature and the room temperature, giving the ability to match the conditions, resulting in responsive cooling and heating. The device is characterized in that the tt force control device of the thermo module is operated via a comparison circuit depending on the temperature difference between the set temperature in the tank and the reference temperature.
又筐体外壁に通孔を形成し、熱伝導性材にて被覆すると
共に該熱伝導材外側にサーモモジュールを設置したこと
を特徴とするものである。Another feature of the present invention is that a through hole is formed in the outer wall of the casing, which is covered with a thermally conductive material, and a thermomodule is installed outside the thermally conductive material.
ホ、実施例 以下図にしめず実施例につき本発明の詳細な説明する。E, Example The present invention will be described in detail below with reference to the drawings.
１は恒温槽て、夫々保温材２．２１０．を内包した壁体
３．３６８．により筐体Ａを構成し、全面には壁体３と
同構成の蓋５を開閉自在に取付けである。６．６６１．
は壁体３、好むべくは後壁に設けた通孔で、その内側は
アルミニウム板等の熱伝導性材７により被Ｙｇされてい
る。該熱伝導性材７は通孔６に充填する形てもよく、単
に覆う型でもよい。1 is a constant temperature bath, and each heat insulating material is 2.210. Wall containing 3.368. This constitutes a casing A, and a lid 5 having the same structure as the wall 3 is attached to the entire surface so as to be openable and closable. 6.661.
is a through hole provided in the wall 3, preferably the rear wall, and the inside thereof is covered with a thermally conductive material 7 such as an aluminum plate. The thermally conductive material 7 may fill the through hole 6 or may simply cover it.
該通孔６にはサーモモジュール８を設けておく、該サー
モモジュールのカブルは一例を示せば、ビスマス、テル
ル化物の半導体であるか、これに限定されるものてはな
く、ペルチュ効果を有するペルチュ素子は使用できる。A thermomodule 8 is provided in the through hole 6. For example, the thermomodule's cable is made of bismuth or telluride semiconductor, or is not limited to these, but is made of a pertschemiconductor having a pertsch effect. The element can be used.
サーモモジュール８は熱伝導性材７に接近して設けるの
が効率よい、又サーモモジュール８は通孔６か熱伝導性
材７を充填した場合には、その外側に設けておく。熱伝
導性材７としてはアルミニューム飯等金属板か適当であ
る。９は放熱フィンで、サーモモジュール８の外側に設
置して放熱作用を為すものである。１０はモーターで、
軸１１を介して恒温槽１内にファン１２を、外側にファ
ン１３を設けである。１４は仕切板で必要に応し設け、
放熱フィン９とファン１３による風の交差を防ぎ、風の
流れをよくするために設けである。１５は内仕切板で、
恒温槽１内の空気流通を図るべく、ファン１２対応位置
に穴１６を設けである。サーモモジュール８の冷却、加
熱の作動は熱伝導性材６を介して恒温槽１内に伝えられ
、ファン１２より対流せしめられ、恒温槽１内を冷却加
熱せしめる。又サーモモジュール８の作動熱は放熱フィ
ン９を経て放出される。この際仕切板１４によって外壁
に沿って放出される。一方外側のファン１３によってサ
ーモモジュール８或は通孔６に吹付けられる風は直進す
るように仕切板１４により訪導されており、放熱フィン
９より放出の熱と混合しない、このため、サーモモジュ
ール８の加熱、冷却作動は通孔６より熱伝導性材７を介
して恒温槽１内を効率よく行われる。第二図は本発明実
施例回路図で、温度センサー１７、温度設定器１８を夫
々アンプ１９．２７を介し、室温センサー２１のアンプ
３０を介した信号とともにコンパレーター２２に連結さ
せである。比較回路としての該コンパレーター２２によ
りデコーダー２４を介しサーモモジュール８の制御用リ
レー２５．２５．、、によりサーモモジュール８の作動
をさせ、且又極性の変換によりサーモモジュール８のヒ
ーターとして又クーラーとして使用するものである。そ
の他２６は電圧設定器で、アンプ２７を経て、切換スイ
ッチ２８を介し増巾アンプ２９に連結しである。切換ス
イッチ２８により電圧設定器２６か温度設定器１８を選
択的にコンパレーター２２に接続しである。３１はスイ
ッチで、ＡＮＤゲート３２．５ＳＲ３３を介してヒータ
ー３４に接続し、ＡＮＤゲート３２にはガス検知回路主
１を接続し、該ガス検知回路１５はセンサー３６とガス
濃度レベル設定器３７をコンパレーター３８に接続して
構成されツザー３９を設けておく。デコーダー２４と制
御用リレー２５．２５間には夫々リレー駆動回路４０．
４０を設け、必要に応じ遅延回路４１を組込んておく。It is efficient to provide the thermomodule 8 close to the thermally conductive material 7, and if the through hole 6 or the thermally conductive material 7 is filled, the thermomodule 8 is provided outside of the through hole 6 or the thermally conductive material 7. As the thermally conductive material 7, a metal plate such as aluminum plate is suitable. Reference numeral 9 denotes a heat dissipation fin, which is installed on the outside of the thermo module 8 and performs a heat dissipation function. 10 is the motor,
A fan 12 is provided inside the thermostatic chamber 1 via a shaft 11, and a fan 13 is provided outside. 14 is a partition plate provided as necessary,
This is provided to prevent the wind from crossing over between the radiation fins 9 and the fan 13 and to improve the flow of the wind. 15 is an internal partition board,
A hole 16 is provided at a position corresponding to the fan 12 in order to allow air to circulate inside the thermostatic chamber 1. The cooling and heating operations of the thermomodule 8 are transmitted to the thermostatic chamber 1 through the thermally conductive material 6, and convection is generated by the fan 12, thereby cooling and heating the thermostatic chamber 1. Further, the operating heat of the thermo module 8 is released through the heat radiation fins 9. At this time, the liquid is released along the outer wall by the partition plate 14. On the other hand, the air blown by the outside fan 13 into the thermo module 8 or the through hole 6 is guided by the partition plate 14 so as to travel straight, and does not mix with the heat released from the radiation fins 9. Therefore, the thermo module The heating and cooling operations of 8 are efficiently performed in the thermostatic chamber 1 through the through holes 6 and through the thermally conductive material 7. FIG. 2 is a circuit diagram of an embodiment of the present invention, in which a temperature sensor 17 and a temperature setter 18 are connected to a comparator 22 through amplifiers 19 and 27, respectively, and a signal from a room temperature sensor 21 through an amplifier 30. The comparator 22 as a comparison circuit controls the control relays 25, 25 . , to operate the thermo module 8, and by changing the polarity, the thermo module 8 can be used as a heater or a cooler. The other numeral 26 is a voltage setting device, which is connected to an amplifier 29 via an amplifier 27 and a changeover switch 28. The voltage setting device 26 or the temperature setting device 18 is selectively connected to the comparator 22 by a changeover switch 28. A switch 31 is connected to the heater 34 via an AND gate 32.5SR33, a gas detection circuit main 1 is connected to the AND gate 32, and the gas detection circuit 15 connects a sensor 36 and a gas concentration level setting device 37 to a comparator. A tether 39 configured to be connected to the controller 38 is provided. Relay drive circuits 40. between the decoder 24 and control relays 25, 25, respectively.
40 is provided, and a delay circuit 41 is incorporated as required.
制御用リレー２５とリレー駆動回路４０によりサーモモ
ジュール８の俺力制御回路を構成する。上記の構成に於
てヒーターをＰＩＤ制御することは従来と同様であるが
、サーモモジュール８．８０６．の制御は細かに設定温
度に従い、ステップ状にも、リニア状にも制御できる。The control relay 25 and the relay drive circuit 40 constitute a power control circuit for the thermo module 8. In the above configuration, PID control of the heater is the same as the conventional one, but thermo module 8.806. The control can be performed either stepwise or linearly according to the set temperature.
然もステップ状の場合にも極めて細かい温度リップルに
て制御可億である。又熱伝導性材により常に室温より高
くなる槽内温度を室内温度によく追従出来る。 上記の
如き本発明によれば、設定温を境にし・てヒーター、ク
ーラーの作動が極めて応答性よく反応作動し、室温から
の制御が極めて容易に行なえる。更に熱伝導性材を用い
ることにより一層室温からの制御が簡単に行なえる等実
用効果著大である。 −However, even in the case of a step shape, it is possible to control extremely fine temperature ripples. Also, the thermally conductive material allows the temperature inside the tank, which is always higher than room temperature, to closely follow the room temperature. According to the present invention as described above, the operation of the heater and cooler is extremely responsive once the set temperature is reached, and control from room temperature can be performed extremely easily. Furthermore, by using a thermally conductive material, control from room temperature can be performed more easily, which has great practical effects. −
第一図は本発明一実施例縦断側面図、第二図は同上実施
回路図、第三図は従来例との制御比較衣である。
１０４．恒温槽 ２００．保温材
３９０．壁体 ４９０．筐体
５１９．蓋 ６０１１通孔
７１０．熱伝導性材 ８８０．サーモモジュール９００
．放熱フィン １０． 、 、モーター１１、 、 、
軸 １２．１３． 、 、ファン１４、 、
、仕切板 Ｉｓ、 、 、内仕切板ＩＱ、 、 、
穴 １７． 、 、温度センサー１８、 、
、温度設定器 １９．２０． 、 、アンプ２１、 、
、室温センサー
２２、 、 、コンパレーター
２３、 、 、バッファー ２４． 、 、デコーダー
２５、 、 、制御用リレー
２６５．．７１！圧設定器 ２７． 、 、アンプ２８
、 、 、切換スイッチ
２９、 、 、増巾アンプ ３０． 、 、アンプ１１
、 、 、スイッチ ３２．、、ＡＮＤゲート３：１
．、、ＳＳＲ３４，、、ヒーター３５、 、 、ガス検
知回路
３６、 、 、センサー
３７、 、 、ガス濃度レベル設定器
：ｔ８． 、 、コンパレーターFig. 1 is a longitudinal sectional side view of one embodiment of the present invention, Fig. 2 is a circuit diagram of the same implementation, and Fig. 3 is a control comparison with a conventional example. 104. Constant temperature bath 200. Heat insulation material 390. Wall 490. Housing 519. Lid 6011 through hole 710. Thermal conductive material 880. thermo module 900
．． Heat radiation fin 10. , ,Motor 11, , ,
Axis 12.13. , ,Fan 14, ,
, partition plate Is, , , internal partition plate IQ, , ,
Hole 17. , , temperature sensor 18, ,
, temperature setting device 19.20. , ,Amplifier 21, ,
, room temperature sensor 22, , comparator 23, , buffer 24. , , decoder 25, , , control relay 265. ．． 71! Pressure setting device 27. , , amplifier 28
, , , selector switch 29 , , amplifier 30. , , amplifier 11
, , , switch 32. ,,AND gate 3:1
．． , SSR34, , Heater 35, , Gas detection circuit 36, , Sensor 37, , Gas concentration level setter: t8. , , comparator
Claims (2)
を介してサーモモジュールの能力制御装置を作動させる
如くしたことを特徴とする液体クロマトグラフ用恒温槽
。(1) A constant temperature bath for a liquid chromatograph, characterized in that a temperature difference between the temperature inside the bath and a set temperature is used to operate a thermo module capacity control device via a comparison circuit.
ると共に該熱伝導材外側にサーモモジュールを設置した
ことを特徴とする液体クロマトグラフ用恒温槽。(2) A constant temperature bath for a liquid chromatograph, characterized in that a through hole is formed in the outer wall of the casing, the outer wall of the casing is covered with a thermally conductive material, and a thermomodule is installed outside the thermally conductive material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63046323A JPH01219665A (en) | 1988-02-29 | 1988-02-29 | Constant temperature bath for liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63046323A JPH01219665A (en) | 1988-02-29 | 1988-02-29 | Constant temperature bath for liquid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01219665A true JPH01219665A (en) | 1989-09-01 |
Family
ID=12743953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63046323A Pending JPH01219665A (en) | 1988-02-29 | 1988-02-29 | Constant temperature bath for liquid chromatograph |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01219665A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012013560A (en) * | 2010-07-01 | 2012-01-19 | Shimadzu Corp | Liquid chromatographic system |
| CN104034831A (en) * | 2014-06-08 | 2014-09-10 | 华东理工大学 | Super-long protein and polypeptide separation capillary liquid chromatography column system with automatic temperature control |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54122190A (en) * | 1978-03-15 | 1979-09-21 | Kankiyou Rikagaku Kenkiyuushiy | Column oven for chromatography |
| JPS58115363A (en) * | 1981-12-28 | 1983-07-09 | Showa Denko Kk | Temperature controlling method |
| JPS62201359A (en) * | 1986-02-28 | 1987-09-05 | Fumiya Ishido | Thermostatic column chamber for high-performance liquid chromatograph |
| JPS631967A (en) * | 1986-06-23 | 1988-01-06 | Hitachi Ltd | Thermostatic tank for column of chromatograph |
-
1988
- 1988-02-29 JP JP63046323A patent/JPH01219665A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54122190A (en) * | 1978-03-15 | 1979-09-21 | Kankiyou Rikagaku Kenkiyuushiy | Column oven for chromatography |
| JPS58115363A (en) * | 1981-12-28 | 1983-07-09 | Showa Denko Kk | Temperature controlling method |
| JPS62201359A (en) * | 1986-02-28 | 1987-09-05 | Fumiya Ishido | Thermostatic column chamber for high-performance liquid chromatograph |
| JPS631967A (en) * | 1986-06-23 | 1988-01-06 | Hitachi Ltd | Thermostatic tank for column of chromatograph |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012013560A (en) * | 2010-07-01 | 2012-01-19 | Shimadzu Corp | Liquid chromatographic system |
| CN104034831A (en) * | 2014-06-08 | 2014-09-10 | 华东理工大学 | Super-long protein and polypeptide separation capillary liquid chromatography column system with automatic temperature control |
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