JPH01128901A - Organ preserving device - Google Patents
Organ preserving deviceInfo
- Publication number
- JPH01128901A JPH01128901A JP28723987A JP28723987A JPH01128901A JP H01128901 A JPH01128901 A JP H01128901A JP 28723987 A JP28723987 A JP 28723987A JP 28723987 A JP28723987 A JP 28723987A JP H01128901 A JPH01128901 A JP H01128901A
- Authority
- JP
- Japan
- Prior art keywords
- unit
- organ
- cold storage
- storage unit
- section
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000056 organ Anatomy 0.000 title claims abstract description 25
- 230000010412 perfusion Effects 0.000 claims description 23
- 239000000082 organ preservation Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 5
- 239000002826 coolant Substances 0.000 claims description 3
- 238000003973 irrigation Methods 0.000 claims 1
- 230000002262 irrigation Effects 0.000 claims 1
- 238000001816 cooling Methods 0.000 abstract description 5
- 210000004072 lung Anatomy 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 9
- 238000004321 preservation Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 239000000110 cooling liquid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、人や動物から摘出した心臓、肝臓等の臓器を
他の患者や動物へ移植するに際し、−時的に臓器を潅流
保存するための臓器保存装置に関するものである。[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides a method for transplanting organs such as hearts and livers extracted from humans or animals to other patients or animals, by temporarily preserving the organs by perfusion. The present invention relates to an organ preservation device.
〔従来の技術］
摘出した臓器を保存するには単純冷却保存法がある。こ
れは、単に容器内で臓器を冷凍或いは冷温状態で保存す
るというものだが、この方法によると保存時間に限界が
ある。[Prior Art] There is a simple cooling preservation method for preserving extracted organs. This method simply preserves the organ in a container in a frozen or cold state, but this method has a limit to the preservation time.
このため低温潅流保冷法という方法が用いられている。For this reason, a method called low-temperature perfusion cold storage method is used.
これは潅流液の循環回路を形成して臓器を保存するとい
うものであり、米国特許筒３．６３２．４７３号、同第
３，７５３，８６５号、同第３，７７２．１５３号、同
第３，８８１，９９０号、同第４，１８６．５Ｇ５号な
どに示されている。This is to preserve organs by forming a perfusion fluid circulation circuit, and is disclosed in U.S. Patent No. 3,632,473, U.S. Pat. No. 3,881,990, No. 4,186.5G5, etc.
しかしながら、従来の低温潅流保冷法による場合、装置
の大型化が避けられず重量負担も大きいため、自動車、
飛行機、ヘリコプタ−等で緊急、事態に間に合わせるよ
うに運搬しようとしても不可能であり、装置の小さい単
純冷却保存法に依存せざるを得なかった。このため前述
のごとく保存時間に限界があり、輸送距離に限界を生じ
必要な医療行為を為し得ないという問題があった。However, when using the conventional low-temperature perfusion cooling method, the size of the equipment is unavoidable and the weight burden is large, so
Attempts to transport the materials by airplane, helicopter, etc. in time for emergency situations were impossible, and we had no choice but to rely on simple methods of cooling and preserving the small size of the equipment. For this reason, as mentioned above, there is a limit to the storage time, and there is a limit to the transportation distance, making it impossible to perform necessary medical procedures.
本発明は、このような問題を解決すべくなされたもので
、運搬に適した潅流型の臓器保存装置を提供することを
目的とする。The present invention was made to solve such problems, and an object of the present invention is to provide a perfusion type organ preservation device suitable for transportation.
上記目的を達成するため、この発明では臓器保存装置、
潅流回路およびこの潅流回路を流れる潅流液を制御する
保冷ユニットを、前記制御機器に結合される駆ｖＪ部お
よび電源部を有する駆動ユニットに着脱自在に装着する
ようにする。In order to achieve the above object, the present invention includes an organ preservation device,
A perfusion circuit and a cooling unit for controlling perfusion fluid flowing through the perfusion circuit are detachably attached to a drive unit having a drive unit and a power supply unit coupled to the control device.
（作 用〕
このような本発明の臓器保存装置においては、駆動ユニ
ットから保冷ユニットを分離できるので、輸送手段に駆
動ユニットを設け、これに分離した保冷ユニットを装着
することによって長距離輸送が可能となる。(Function) In the organ preservation device of the present invention, the cold storage unit can be separated from the drive unit, so long-distance transportation is possible by providing the drive unit in the transportation means and attaching the separate cold storage unit to it. becomes.
第１図および第２図は本発明の一実施例を示すものであ
る。保冷ユニットｌには、保存ずべき臓器２を収納する
臓器保存室３、潅流液貯蔵タンク４、人工肺５、熱交換
器６、泡取り器７を設け、これらを潅流チューブ８で直
列に接続して閉ループの潅流回路を構成する。泡取り器
７には、温度センサ９、ＰＨセンサ１０．、ＰＯ，セン
サ１１を設け、これらセンサの計測データを計測部１３
を介して記録部１４に記録さるようにする。また、保冷
ユニット１には、臓器の保存条件を記憶させておく記録
部１５を設けるとともに、該記録部１５と前記記録部１
４とを駆動するための小型のバッテリー（図示しない°
）を設ける。なお、保冷ユニット１は全体を断熱材料よ
り成る保冷容器１２で覆うようにする。1 and 2 show one embodiment of the present invention. The cold storage unit 1 is provided with an organ preservation chamber 3 for storing organs 2 to be preserved, a perfusate storage tank 4, an oxygenator 5, a heat exchanger 6, and a bubble remover 7, which are connected in series with a perfusion tube 8. to form a closed-loop perfusion circuit. The bubble remover 7 includes a temperature sensor 9, a PH sensor 10. , PO, and sensors 11 are provided, and the measurement data of these sensors is sent to the measurement unit 13.
The data is recorded in the recording section 14 via the . In addition, the cold storage unit 1 is provided with a recording section 15 for storing organ preservation conditions, and the recording section 15 and the recording section 1
4 and a small battery (not shown) to drive
) will be established. The entire cold storage unit 1 is covered with a cold storage container 12 made of a heat insulating material.
駆動ユニット１６には、冷却液循環装置１７、送液ポン
プ１８および０□タンク１９に接続したガス制御装置２
０を設けるとともに、これらの駆動部を制御する制御部
２１および電源部２４を設ける。また、制御部２１には
設定部２２および表示部２３を接続して設け、設定部２
２において保存条件を設定するとともに表示部２３にお
いて臓器の保存状態を表示するようにする。なお、電源
部２４には１００■交流や１５Ｖ電源等の外部電源の他
、駆動ユニッ目６を短時間駆動可能なバックアップ用バ
ッテリーを設ける。The drive unit 16 includes a cooling liquid circulation device 17, a liquid feeding pump 18, and a gas control device 2 connected to a 0□ tank 19.
0, and also a control section 21 and a power supply section 24 for controlling these drive sections. Further, the control unit 21 is provided with a setting unit 22 and a display unit 23 connected to each other.
In step 2, preservation conditions are set, and the preservation state of the organ is displayed on the display section 23. The power supply unit 24 is provided with a backup battery capable of driving the drive unit 6 for a short time in addition to an external power source such as a 100 AC power source or a 15 V power source.
この実施例では、保冷ユニットｌを駆動ユニッ目６に着
脱自在に装着するようにする。このため駆動ユニット１
６の制御部２１と保冷ユニット１の計測部１３および記
録部１５とをそれぞれ接続する信号ケーブル２５および
２６をコネクタ２７ａおよび２７ｂを介して着脱自在に
接続する。なお、第２図では両方の信号ケーブル２５．
２６およびコネクタ２７ａ。In this embodiment, the cold storage unit 1 is detachably attached to the drive unit 6. For this reason, drive unit 1
Signal cables 25 and 26 that connect the control section 21 of No. 6 to the measurement section 13 and recording section 15 of the cold storage unit 1, respectively, are detachably connected via connectors 27a and 27b. In addition, in FIG. 2, both signal cables 25.
26 and connector 27a.
２７ｂを一体化して示している。また、冷却液循環装置
１７および熱交換器６を結合する送水チューブ２８およ
び排水チューブ２９はそれぞれのコネクタ３０を介して
着脱自在に接続し、ガス制御部２０および人工肺５を結
合する送気チューブ３１および排気チューブ３２も同様
にそれぞれのコネクタ３３を介し”ζ着脱自在に接続す
る。なお、潅流回路を構成する潅流チューブ８は、保冷
ユニット１を駆動ユニッＨ６に装着する際に送液ポンプ
１８に掛は渡す。27b is shown integrated. Further, a water supply tube 28 and a drainage tube 29 that connect the coolant circulation device 17 and the heat exchanger 6 are detachably connected via respective connectors 30, and an air supply tube that connects the gas control unit 20 and the oxygenator 5 31 and the exhaust tube 32 are similarly detachably connected via their respective connectors 33.The perfusion tube 8 constituting the perfusion circuit is connected to the liquid feeding pump 18 when the cold storage unit 1 is attached to the drive unit H6. Nikake hands it over.
以下、この実施例の動作を説明する。先ずドナーから摘
出した臓器２を臓器保存室３にセットすると共に、駆動
ユニット１６の設定部２２により保存温度、Ｐ Ｈ１Ｐ
Ｏ□潅流量等の保存条件を設定する。設定部２２で保存
条件が設定されると、このデータは制御部２１を会して
記録部１５に記憶され、この記憶されたデータに基づい
て制御部２１により冷却液循環装置１７、送液ポンプ１
８、ガス制御部２０が保存条件に合うように駆動制御さ
れ、摘出臓器２の潅流保存が行われる。なお、この実施
例では０□タンク１９のみを設置しているが、必要に応
じＣＯ□タンクをも設置することもできる。The operation of this embodiment will be explained below. First, the organ 2 extracted from the donor is set in the organ preservation chamber 3, and the setting unit 22 of the drive unit 16 sets the preservation temperature, P H1P
O□Set storage conditions such as perfusion rate. When the storage conditions are set in the setting section 22, this data is passed through the control section 21 and stored in the recording section 15, and based on this stored data, the control section 21 controls the cooling liquid circulation device 17 and the liquid feeding pump. 1
8. The gas control unit 20 is driven and controlled to meet preservation conditions, and perfusion preservation of the extracted organ 2 is performed. In this embodiment, only the 0□ tank 19 is installed, but a CO□ tank can also be installed if necessary.
第３図は、この実施例による臓器保存装置を用いて摘出
臓器を保存、運搬してレシピエンドへ移植するまでの流
れを説明するものである。先ず、病院３４でドナーより
摘出した臓器を、病院内用の駆動ユニット３５に接続さ
れた保冷ユニット１に保存する。次に、保冷ユニット１
を駆動ユニット３５から分離して病院３４から飛行場ま
で運ぶ運搬車３７に設置した駆動ユニット３８にセット
して運搬する。FIG. 3 explains the flow of preserving and transporting the extracted organ using the organ preservation device according to this embodiment until transplanting it to the recipe end. First, an organ extracted from a donor at a hospital 34 is stored in a cold storage unit 1 connected to a drive unit 35 for use in the hospital. Next, cold storage unit 1
is separated from the drive unit 35 and set in a drive unit 38 installed in a transport vehicle 37 for transporting from the hospital 34 to the airport.
なお、保冷ユニット１を駆動ユニット３８にセットした
後は、該駆動ユニット３８の制御部により保冷ユニット
１の記録部１５に記憶されている保存条件を読み出し、
その条件で駆動を制御する。以下同様にして、保冷ユニ
ット１を飛行機３９内の駆動ユニット３５（図示しない
）、運搬車４０の駆動ユニット４１、そして最終的に移
植の行なわれる病院４２の駆動ユニット４３へと運搬す
る。Note that after setting the cold storage unit 1 in the drive unit 38, the control section of the drive unit 38 reads out the storage conditions stored in the recording section 15 of the cold storage unit 1,
Drive is controlled under those conditions. Thereafter, in the same manner, the cold storage unit 1 is transported to the drive unit 35 (not shown) in the airplane 39, the drive unit 41 of the transport vehicle 40, and finally to the drive unit 43 of the hospital 42 where the transplantation will be performed.
このようにすれば、臓器を低温潅流状態で運搬でき、し
かも保存条件が記録部により記憶されているため、駆動
ユニットが変っても一定の保存条件が維持できる。した
がって、保冷ユニットの移動に医師等の専門家の付き添
いの必要もなく、簡単な操作を行なえる人がいれば充分
である。なお、駆動ユニット間の保冷ユニットの移動の
間、潅流が行われないが、この時間は極めて短時間であ
るので、臓器に与える影響はほとんどない。In this way, the organ can be transported in a low-temperature perfusion state, and since the storage conditions are stored in the recording section, constant storage conditions can be maintained even if the drive unit is changed. Therefore, there is no need for a specialist such as a doctor to be present when moving the cold storage unit, and it is sufficient to have someone who can perform simple operations. Note that perfusion is not performed while the cold storage unit is being moved between the drive units, but this time is extremely short and has little effect on the organs.
また、自動車等の輸送手段に設置する駆動ユニッ１−は
、それぞれに適した形のものを使用できるため、無理な
く効率的な運搬ができる。Further, since the drive unit 1- installed in a means of transportation such as an automobile can be of a shape suitable for each type, transportation can be carried out easily and efficiently.
更に、保冷ユニットのみを移動すればよいので、運搬終
了後に元の病院へ返却する場合も、筒便に行なえる。Furthermore, since only the cold storage unit needs to be moved, returning it to the original hospital after transportation can be done in a timely manner.
以上の実施例では送液ポンプ１８を駆動ユニット１６に
設けたが、この発明の他の実施例においては送液ポンプ
を保冷ユニットに設けるとともにこの保冷ユニットに送
液ポンプを所定時間、例えば約１５分程駆動できるバッ
テリーを設け、保冷ユニットを駆動ユニットに装着した
状態では送液ポンプを駆動ユニットにより駆動して潅流
を行なわせ、保冷ユニットを駆動ユニットから外した場
合つまり駆動ユニット間の保冷ユニットの移動の間は、
保冷ユニット内のバッテリーにより送液ポンプを駆動し
て潅流を行なわせる。このようにすれば臓器の潅流を継
続的に行なうことができるので、より良好な臓器保存が
できる。また、駆動ユニットからの保冷ユニットの取り
出し、取り付けの際の送液ポンプへの潅流チューブの着
脱が不要となるので、その分作業時間を短縮できる。In the above embodiment, the liquid pump 18 is provided in the drive unit 16, but in another embodiment of the present invention, the liquid pump 18 is provided in the cold storage unit, and the liquid pump is connected to the cold storage unit for a predetermined period of time, for example, about 15 minutes. A battery that can be driven for several minutes is provided, and when the cold storage unit is attached to the drive unit, the liquid feeding pump is driven by the drive unit to perform perfusion, and when the cold storage unit is removed from the drive unit, that is, the cold storage unit between the drive units is During the move,
The battery inside the cold storage unit drives the liquid pump to perform perfusion. In this way, the organ can be perfused continuously, so that the organ can be better preserved. Further, since it is not necessary to take out the cold storage unit from the drive unit and to attach and detach the perfusion tube to the liquid feeding pump when installing it, the working time can be shortened accordingly.
以上のごとく、本発明によれば装置全体を保冷ユニット
と駆動ユニットに２分割してそれらを着脱自在に装着す
るようにしたため、運搬手段に駆動ユニットのみを設け
ることにより、保冷ユニットだけを分離して輸送手段の
駆動ユニットに装着でき、従って長距離輸送を迅速に行
なうことができるので臓器移植という緊急を要する医療
行為に支障をきたすことがない。As described above, according to the present invention, the entire device is divided into two parts, the cold storage unit and the drive unit, and these are detachably attached. Therefore, by providing only the drive unit on the transportation means, only the cold storage unit can be separated. The device can be attached to the drive unit of a transport means, and therefore long-distance transportation can be carried out quickly, so there is no hindrance to urgent medical procedures such as organ transplantation.
第１図は、本発明の一実施例を示す説明図、第２図は、
同外観斜視図、
第３図は、運搬状況を示す説明図である。
■・・・保冷ユニット ３・・・臓器保存室５・・
・人工肺 ６・・・熱交換器１２・・・保冷
容器 １４・・・記録部１６・・・駆動ユニッ
ト１７・・・冷却液循環装置２０・・・ガス制御装置
２１・・・制御駆動部２４・・・電源部
特許出願人 オリンパス光学工業株式会社手 続
補 正 書
昭和６３年 ３月 ２日
特許庁長官 小 川 邦 夫 殿１、事
件の表示
昭和６２年特許願第２８７２３９号
２、発明の名称
臓器保存装置
３゜補正をする者
事件との関係 特許出願人
（０３７） オリンパス光学工業株式会社４、代理人FIG. 1 is an explanatory diagram showing one embodiment of the present invention, and FIG. 2 is an explanatory diagram showing an embodiment of the present invention.
The same external perspective view and FIG. 3 are explanatory diagrams showing the transportation situation. ■...Cold storage unit 3...Organ preservation room 5...
- Artificial lung 6... Heat exchanger 12... Cold container 14... Recording section 16... Drive unit 17... Coolant circulation device 20... Gas control device
21... Control drive section 24... Power supply section Patent applicant: Olympus Optical Industry Co., Ltd. Procedural amendments March 2, 1988 Director-General of the Patent Office Kunio Ogawa 1. Indication of the case 1988 patent Application No. 287239 2, Name of the invention: Organ preservation device 3. Relationship with the amended case Patent applicant (037) Olympus Optical Industry Co., Ltd. 4, Agent
Claims (1)
潅流液を制御する機器を有する保冷ユニットと、この保
冷ユニットに着脱自在に装着され前記制御機器に結合さ
れる駆動部および電源部を有する駆動ユニットとを具え
ることを特徴とする臓器保存装置。 ２、前記保冷ユニットに、前記潅流液の温度を制御する
熱交換器および人工肺を設け、前記駆動ユニットには前
記熱交換器に結合される冷却液循環装置および前記人工
肺に結合されるガス制御装置を設け、前記潅流液を潅流
させる送液ポンプを保冷ユニット又は駆動ユニットのい
ずれかに配設したことを特徴とする特許請求の範囲第１
項記載の臓器保存装置。 ３、前記保冷ユニットには保存条件を記憶させておく記
憶部を設け、前記駆動ユニットには前記記憶部からの信
号を読み取って前記駆動部を制御する制御部を設けたこ
とを特徴とする特許請求の範囲第１又は第２項記載の臓
器保存装置。[Scope of Claims] 1. A cold storage unit having an organ storage chamber, a perfusion circuit, and a device for controlling the perfusion fluid flowing through the perfusion circuit, and a drive section that is detachably attached to the cold storage unit and coupled to the control device. and a drive unit having a power supply section. 2. The cold storage unit is provided with a heat exchanger for controlling the temperature of the perfusion fluid and an oxygenator, and the drive unit is provided with a coolant circulation device coupled to the heat exchanger and a gas coupled to the oxygenator. Claim 1, characterized in that a control device is provided, and a liquid sending pump for perfusing the irrigation fluid is disposed in either a cold storage unit or a drive unit.
Organ preservation device as described in Section. 3. A patent characterized in that the cold storage unit is provided with a storage section for storing storage conditions, and the drive unit is provided with a control section that reads signals from the storage section and controls the drive section. An organ preservation device according to claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28723987A JPH01128901A (en) | 1987-11-16 | 1987-11-16 | Organ preserving device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28723987A JPH01128901A (en) | 1987-11-16 | 1987-11-16 | Organ preserving device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01128901A true JPH01128901A (en) | 1989-05-22 |
Family
ID=17714835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28723987A Pending JPH01128901A (en) | 1987-11-16 | 1987-11-16 | Organ preserving device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01128901A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0616501A (en) * | 1992-05-06 | 1994-01-25 | Tonokura Ika Kogyo Kk | Method and device for carrying organ and pump for organ-carrying device |
| JP2019048776A (en) * | 2017-09-08 | 2019-03-28 | 株式会社ジェイ・エム・エス | Transport device of organs and biological tissues |
| JP2019048652A (en) * | 2017-09-08 | 2019-03-28 | 株式会社ジェイ・エム・エス | Transport device for organ and biological tissue |
-
1987
- 1987-11-16 JP JP28723987A patent/JPH01128901A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0616501A (en) * | 1992-05-06 | 1994-01-25 | Tonokura Ika Kogyo Kk | Method and device for carrying organ and pump for organ-carrying device |
| JP2019048776A (en) * | 2017-09-08 | 2019-03-28 | 株式会社ジェイ・エム・エス | Transport device of organs and biological tissues |
| JP2019048652A (en) * | 2017-09-08 | 2019-03-28 | 株式会社ジェイ・エム・エス | Transport device for organ and biological tissue |
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