JPH01261301A - Organ preserving device - Google Patents

Abstract

PURPOSE:To obtain a small-sized device wherein an organ preserving chamber and a cold reserving container having a slow current circuit are equipped with semiconductor cooling elements so as to cool the cold preserving chamber and an organ can be preserved in a slow current state by the elements and a supplementary cooling medium in a cooling medium retaining space. CONSTITUTION:An organ 3 to be preserved is set in a slow current circuit 2 of closed loop constituted by connecting an organ preserving chamber 4, a slow current storage tank 5, an oxygenerator 6, a solution sending pump 7 and a foam remover 8 in series by slow current tubes 9 and these apparatus are put in a cold reserving container part 12 and fixed. Oxygen is sent from an oxygen tank 28 to the oxygenerator 6, the solution sending pump 7 and a temperature sensor 10 are connected to a control part 20 and water and gel are injected to a cooling medium retaining space 19. Temperature of the slow current and an amount thereof sent are set by a setting part 21 and the organ 3 is preserved by temperature on-off control of Peltier element 15 and by slow current to the organ 3 according to the setting part. Even in case that an outer electric source 23 is not used, slow current is carried out by a built-in battery 25. The device can be miniaturized and made lightweight.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides a method for transplanting organs such as hearts and livers extracted from humans or animals to other patients or animals, by temporarily preserving the organs by perfusion. The present invention relates to an organ preservation device.

[Conventional technology]

There is a simple cryopreservation method to preserve removed organs. This method simply stores the 1lia container in a frozen or cold state, but this method has a limit to the storage time.

For this reason, a method called low-temperature perfusion cold storage method is used.

This is to preserve organs by forming a perfusion fluid circulation circuit, and is disclosed in U.S. Patent No. 3.632.473, U.S. Pat. No. 3.881.990, No. 4.186.565, etc.

[Problem to be solved by the invention]

However, when using the conventional low-temperature perfusion cooling method, the size of the equipment is unavoidable and the weight burden is large, so
Even if we tried to transport them by airplane, helicopter, etc. in time for emergency situations, it would be impossible, and we would have to rely on simple methods of cooling and preserving the small size of the equipment. For this reason, as mentioned above, there is a limit to the storage time, and there is a limit to the transportation distance, making it impossible to perform necessary medical procedures.

The present invention was proposed to solve the above-mentioned problems, and an object of the present invention is to provide an organ preservation device that is small, lightweight, and portable and capable of perfusion preservation.

[Means and effects for achieving the object] In order to achieve the above object, the present invention provides a cold storage container which is housed in an organ storage device and has at least an organ storage chamber and a perfusion circuit, and which cools the inside of the cold storage container. A semiconductor cooling element is provided to obtain the desired result.

Thereby, by using a semiconductor cooling element as a cooling means for the cold storage container and supplementary use of a cooling medium, it is possible to reduce the size, weight, and improve the portability of the organ preservation device.

〔Example〕

1 and 2 show a first embodiment of the present invention. The organ preservation device includes an organ preservation chamber 4 that stores organs 3 to be preserved in a cold container 1, a perfusion fluid storage tank 5, an artificial lung 6,
A liquid pump 7 and a bubble remover 8 are provided, and these are connected in series with a perfusion tube 9 to form a closed loop perfusion circuit 2. The bubble remover 8 is provided with a temperature sensor lO, and the entire perfusion circuit is sealed with a perfusion circuit cover 11. A cold insulating container section 12 that houses the organ preservation chamber 4 and the perfusion circuit 2 is covered with a cold insulating wall 13 and a lid 14 made of a heat insulating material. A Bertier element 15 is fixed to the side wall constituting the cold insulation wall 13 so as to cool the inside of the cold insulation container part 12, and a cooling fin 17 is provided on the inside thereof, and a heat sink 16 is provided facing the outside. The inner peripheral surface 18 of the cold storage container part 12 and the perfusion circuit cover 1
1 is a cooling medium holding space 19. The temperature sensor 10, liquid feeding pump 7, and Bertier element 15 are connected to a control unit 20 provided outside the cold storage container l, and a setting unit 21 for setting the perfusion fluid temperature and liquid feeding amount, and displaying the set values and measured values. A display section 22 is also connected to the control section 20. The oxygen gas 6 constituting the perfusion circuit 2 is supplied with air from an oxygen tank 28 through an air supply/exhaust connector 27 provided on the side of the organ preservation device, and oxygen gas through an exhaust tube 29 to reduce the oxygen content of the perfusion fluid. It acts to keep the pressure constant. The power supply section 26 is connected via a connection cord 24 to an external power supply 23 such as an AClooV commercial power supply or a battery mounted on a car. It is also connected to a built-in battery 25 provided in the organ preservation device, and supplies power to the control unit 20.

To preserve the organ 3, the organ 3 to be preserved is set in the perfusion circuit 2, and then stored and fixed in the cold container section 12.

Next, the air supply/exhaust tube 29 to the oxygenator 6 is connected to the air supply/exhaust connector 27, and the power cord 30 of the liquid supply pump 7 and the connection cable 31 of the temperature sensor IO are connected via connectors (not shown), respectively. Connect to the control unit 20. Water or a gel-like substance is injected into the cooling medium holding space 19. The setting unit 21 sets the irrigation fluid temperature and the irrigation fluid delivery amount, and turns the Vertier element 15 ON or OFF according to the setting position.
Organ 3 is heated by temperature control by FF and perfusion to organ 3.
Save. In this case, the lower power supply 23 can be supplied from hospitals, moving cars, and airplanes, but for example, while driving from the hospital to the hospital, the external power source 23 can be used for a short time (generally less than 10 minutes). You will no longer be able to receive supplies from 23. At this time, the liquid feed pump 7 is connected to the built-in battery 25.
Electric power is supplied so that driving can be performed, and the Bertier element 15 is turned off. Note that when power is being supplied from the external power supply 23 for all driving and control, the built-in battery 2
5 is charged.

In this way, in this embodiment, since the Vertier element is used as the cooling means of the cold storage container, the ratio of the cooling means to the entire apparatus is small, and the apparatus can be made smaller and lighter. This Bertier element consumes a large amount of power, but by using an external power supply, there is no need to incorporate a large battery into the device, which also helps reduce the size of the device.
It can be made lighter. Even if power is not supplied from an external power supply, the cooling medium acts and low-temperature preservation is possible to some extent, and the small built-in battery continues to perfuse the perfusion circuit, so there is no adverse effect on organs. rare.

If a bimorph pump is used as the liquid pump, stable perfusion can be achieved because it has extremely flat pressure characteristics, is small, lightweight, and generates almost no heat. If the organ is a kidney, it does not require oxygen during cryopreservation, so an oxygen tank is not required, and air can be supplied.

FIG. 3 shows a second embodiment of the present invention, in which a pump chamber 32 separated from the cooling medium holding space 19 is provided in the cold storage container, a liquid pump 33 is disposed therein, and a perfusion tube 34 is connected to the pump chamber 32. Some of them are also brought here. 35 is ice as a cooling medium. To preserve organs, first set them in the perfusion circuit, then store them in the cold container section 12.
Then, the perfusion tube 34 is attached to the liquid feeding pump 33 (rotor pump) to perform perfusion. Other operations are the same as in the first embodiment. This embodiment is economically advantageous because the liquid pump can be reused even when the perfusion circuit is replaced.

〔Effect of the invention〕

As described above, according to the present invention, since the semiconductor cooling element is used as the cooling means in the cold storage container, the entire device can be made smaller and lighter, and its portability can be improved. Moreover, even if the semiconductor cooling element is turned off, the cooling medium can keep the body cool and the built-in battery can provide perfusion, so there is almost no effect on the internal organs within a short period of time.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing a first embodiment of the organ preservation device according to the present invention, FIG. 2 is an external perspective view of the same, and FIG. 3 is a sectional view showing a second embodiment. 1...Cold container part 2...Perfusion circuit 3...
Organ 4...Organ preservation chamber 15...Peltier element 19...Cooling medium holding space Patent applicant Olympus Optical Industry Co., Ltd. Written by: August 17, 1983 Director General of the Japan Patent Office Yoshi 1) Mr. Moon Takeshi■, Indication of the case 1988 Patent Application No. 88131 2, Name of the invention Organ Preservation Device 3, Relationship with the person making the amendment Patent application Person (037) Olympus Optical Industry Co., Ltd. 4, Agent 5, Subject of amendment ``Claims'' of the specification ``Claims on page 1, lines 3 to 10 of the Detailed Explanation of the Invention are as follows: Correct as follows: ``2.Claim 1. A cold storage container that is housed in an organ storage device and has at least an organ storage chamber and a first-flow circuit is equipped with a semiconductor cooling device to cool the inside of the cold storage container. 2. The organ preservation device according to claim 1, characterized in that a space for holding a cooling medium for cooling at least the old method circuit is provided inside the cold storage container. "Perfusion preservation" on page 1, line 15 of the specification is corrected to "perfusion preservation." 3. Correct "perfusion" to "perfusion" in lines 2, 3, 9, and 18 of page 2. 4, page 3, line 3, line 13, line 15, line 16,
Correct "perfusion" in line 17 (two places) and line 19 to "perfusion". 5. On page 4, line 4, line 8, line 1O, line 13, and line 20, "perfusion" is corrected to "perfusion." 6. Corrected "perfusion" in line 8 (2 places) of page 5 to "perfusion", corrected "setting position" in lines 8 to 9 of the same page to "set value", and corrected "setting value" in line 10 of the same page. Correct "perfusion" in the row to "irrigation amount control" and correct "lower power supply 23" in line 12 of the same page to "external power supply 23." 7. "Perfusion" in lines 10-11 of the same page was corrected to "perfusion", "perfusion" in line 11 of the same page was corrected to "perfusion j", and "perfusion" in line 11 of the same page was corrected to "perfusion j"
Correct "perfusion" in line 5 to "perfusion". 8. Corrected "perfusion" in lines 2, 4, 5, 8, and 17 on page 7 to "perfusion," and changed "perfusion" in line 6 of the same page.
Correct "(low coupon pump)" to "(roller pump)". 9. Change "2...perfusion circuit" in the 4th line of page 8 to "2...
・Corrected to "perfusion circuit".

Claims (1)

[Claims] 1. A cold storage container that is housed in an organ storage device and has at least an organ storage chamber and a perfusion circuit is provided with a semiconductor cooling element so as to cool the inside of the cold storage container. organ storage device. 2. The organ preservation device according to claim 1, further comprising a space for holding a cooling medium for cooling at least the perfusion circuit inside the cold storage container.