JPH0459701A - Apparatus for storage of organ - Google Patents

Abstract

PURPOSE:To obtain the subject apparatus capable of readily watching the revolution operation of a perfusion pump while actuating the apparatus in a state where both an organ-conveying unit and a unit in a hospital are coupled by attaching a head of the perfusion pump of the organ-conveying unit to the observation plane side of the conveying unit in a state where both the units are coupled. CONSTITUTION:In a state where an organ conveying unit 2 equipped with a perfusion circuit having an organ accommodating chamber and a perfusion pump is coupled with a unit 3 in a hospital equipped with a device for adjustment of perfusion liquid components by connecting a power supply cable 4, a signal cable 5 and a perfusion tube 7 respectively to both the units, a pump head 40 of the perfuming pump is attached to the face panel 39 of a driving chamber 32 of the conveying unit 2 and an operational panel 41 is further attached to the front face of the unit 3 in the hospital in a inclined state. Indication of the operational panel 41 of the unit 3 in the hospital, indication of an operational panel 33 of the conveying unit 2 and visual confirmation of the pump head 40 can rapidly and correctly be carried out.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention provides a method for transplanting organs such as hearts and livers extracted from humans or animals to other patients or animals, by temporarily preserving the organs by perfusion. Regarding an organ preservation device for.

[Conventional technology]

A method for preserving removed organs is simple cooling preservation. This method simply preserves the organ in a container by freezing or keeping it cool, but this method has a limited storage time.

For this reason, a method called low-temperature perfusion preservation is used. This is to preserve the organ by creating a circulation circuit for perfusion fluid. When low-temperature perfusion preservation is used, the apparatus becomes larger and the weight burden increases, so it is necessary to have a structure that allows transport, and an organ transport unit that can be transported separately is formed.

For example, JP-A No. 2-69401, JP-A No. 2-12
Japanese Patent No. 4801 discloses an organ preservation device in which a transportable cold storage unit and a drive unit installed at a transportation destination can be detachably connected.

[Problem to be solved by the invention]

However, in the organ preservation device shown in the above-mentioned conventional example, the pump head of the perfusion pump for pumping the perfusion fluid into the circulation circuit is provided on the upper surface of the organ transport unit. Therefore, when the organ transport unit is connected to the in-hospital unit, the bomb head is located at a location that is not fully within the operator's observation field of view.

Therefore, there has been a problem in that the pump head cannot be monitored, which is necessary when adjusting the rotation speed of the perfusion pump depending on the type of organ to be preserved or when confirming whether the perfusion pump is performing a predetermined operation.

The present invention is proposed to solve the above-mentioned problems.
It is an object of the present invention to provide an organ preservation device that can realize proper driving of the perfusion pump by easily confirming the rotational operation of the perfusion pump.

[Means and Effects for Solving the Problems] In order to achieve the above object, the present invention provides an organ transport unit provided with a perfusion circuit having at least an organ storage chamber and a perfusion pump, and at least a perfusion solution. In an organ storage device that can be detachably connected to an in-hospital unit equipped with means for adjusting components, a perfusion pump is installed on the observation side of the organ transport unit when the organ transport unit and the in-hospital unit are connected. This is an organ preservation device equipped with a head.

In this way, since the head of the perfusion pump is provided at a position where it can be easily observed by the operator when necessary, the head can be easily and reliably monitored.

〔Example〕

Hereinafter, one embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a schematic diagram showing the overall configuration of the device. Organ storage devices can be broadly divided into organ transport units 2.
and an in-hospital unit 3, both of which can be connected and separated at will. To transport the extracted organ from the donor side hospital to the recipe end side hospital, the organ transport unit 2 is used.
Move only. To connect both, use power cable 4
and signal cable 5 are connected via a cable connector 6, respectively, and the irrigation tube 7 is connected via a tube connector 8.

The connected perfusion circuit includes an organ storage chamber 9 for storing the excised organ, a reservoir 10 for storing perfusion fluid, a perfusion pump 11 for delivering perfusion fluid, and one for maintaining the perfusion fluid at an appropriate temperature. heat exchanger 12, and 0□, CO,
It is formed by connecting an oxygenator 13 for adding gas and a bubble trap 14 for removing air from the perfusion fluid. Of these, the heat exchanger 12 and the artificial lung I3 are provided on the in-hospital unit 3 side, and the others are provided on the organ transport unit 2 side.

The heat exchanger I2 cools the perfusate to bring it to an appropriate temperature, and the oxygenator 13 cools the perfusate to keep it at an appropriate temperature.
is added to perform oxygenation and pH adjustment,
In order to monitor these conditions, a temperature sensor 15 and a PH sensor 16 are provided between the bubble trap 14 and the organ storage chamber 9. Based on the measured values here, the perfusion fluid is cooled, oxygenated, and pH adjusted via the control unit 17. Furthermore, a pressure sensor 18 is provided, and the perfusion pump 11 is controlled to obtain a desired perfusion pressure based on the measured value.

Therefore, 0□ cylinder 19 and Cot cylinder 2 were added to oxygenator lung 13.
0 is connected, and these are also connected to the control section 17. Further, a refrigerant pump 21 and a refrigerant tank 22 are connected to the heat exchanger 12, and a control unit 1 is connected to the refrigerant pump 21.
7 is connected.

On the other hand, the detected values of various sensors are displayed on the display meter 23 on the organ transport unit 2 side, and are displayed on the display meter 24 of the three hospital units in the organ storage device as a whole, and are recorded on the recorder 25. It has become. The entire device is driven by connecting it to an AC power source 27, but since the organ unit 2 is driven by a DC power source, the in-hospital unit 3 is equipped with an A/D converter 28.
is provided so that direct current can be supplied to the organ transport unit 2. Further, the perfusion pump 11 is driven by the output from the operating section 29, and the in-hospital unit 3
The control section 17 is operated by the output from the operation section 30.

FIG. 2 shows a state in which the organ transport unit 2 is made independent, and is a case where the organ 1 is transported.

In order to make them separate and independent in this way, the cable connector 6,
The tube connectors 8 are separated, and the cable connector 6 on the side connected to the power source is connected to the DC power source 26, and the tube connectors 8 are connected to each other to form a perfusion circuit. Therefore, the perfusion circuit consists of organ storage chamber 9, reservoir 1
0, the perfusion pump Ik has a bubble trap 14, but has no means for adjusting perfusion liquid components. Therefore, in order to keep the perfusion fluid in a cooled state, the body of the organ transport unit 2 is formed of a heat insulating container, and a cooling material is provided in the internal space.

FIG. 3 shows the appearance of the configuration shown in FIG. 1. The in-hospital unit 3 and the organ transport unit 2 are connected to the power cable 4,
They are connected by connecting a signal cable 5 and a perfusion tube 7. An organ storage chamber, a reservoir, and a bubble trap are provided inside the cold storage container 31 having a heat insulating effect of the transport unit 2, and a perfusion pump is provided in the drive container 32, as well as temperature and pressure display needles, an operation part of the perfusion pump, etc. ing. The top panel 34 of this drive container 32 is provided with a pressure sensor 18 having a drip-proof structure, and an operation panel 33 having a display needle and an operation section is provided one step higher than the top panel surface. Therefore, even if the top panel 34 gets wet, water can be prevented from penetrating into the operation panel 33. The operation panel 33 is covered with a transparent drip-proof cover 35 that can be opened and closed freely, and a drip-proof pressure 36 is provided above the connectors of the power cable 4 and signal cable 5, and a drip-proof pressure 36 is provided above the protective cover 37 of the cooling fan. A drip-proof pressure 38 is also provided.

The front panel 39 of the driving container 32 corresponds to the operator's observation surface, and a pump head 4° of the perfusion pump is provided here. Furthermore, an operation panel 4 is provided on the front of the in-hospital unit 3.
1 is tilted to make it easier to observe.

FIG. 4 is a cross-sectional view of the vicinity of the pump head 40. As shown here, the irrigation fluid flowing through the irrigation tube 7 is pumped by the pump head 4o having the roller 42 while squeezing the surface of the irrigation tube. pump head 4
0 is designed to be rotated by an ultrasonic motor 43. In order to suppress the temperature rise of the ultrasonic motor 43, cooling fins 44 are attached to the ultrasonic motor 43, a cooling fan 46 is provided near these fins, and an air passage 47 is provided.
An airflow control plate 45 is provided so as to form an airflow control plate 45. With this configuration, when the cooling fan 44 rotates, air flows as shown by the arrow, passes through the protective cover 37 via the other cooling fan 46, and is discharged, thereby cooling the ultrasonic motor 44. It can be performed.

The organ preservation device of this embodiment configured as described above is
When transporting the extracted organ l from the hospital where the donor is located to the hospital where the recipient is located, the transport unit 2 is transported as a single unit. In this case, a DC power source such as an automobile battery is used as the power source.

At the destination hospital, the transportation unit 2 will be connected to the in-hospital unit 3 and an AC power source will be used.

In this case, the entire apparatus is driven in the state shown in FIG. 3, but the surgeon can control the display on the operation panel 41 of the in-hospital unit or the operation panel 33 on the transport unit side.
The operation of the perfusion pump is adjusted while visually checking the operation of the pump head 40.

In this case, all the parts that the operator must visually observe are within a range that is easy for the operator to visually observe, so quick and appropriate visual monitoring is possible.

Therefore, the operation can be performed accurately, and damage, slack, leakage, etc. in the perfusion tube can be easily detected, and maintenance and inspection of the perfusion tube can also be facilitated.

Furthermore, since the operation panels 33 of the two organ transport units are not shaded by the pump head 40 or the perfusion tube 7, it goes without saying that visual observation is easy.

FIG. 5 shows an embodiment in which the structure of the organ storage chamber and reservoir is modified. In this embodiment, a Peltier element 49 is provided outside the organ storage chamber 9 and the reservoir 10 via an elastic material or viscous filler having excellent heat transfer characteristics, and a heat sink 48 is provided outside the Peltier element 49. Therefore, a heat exchanger is not required. A current is supplied to the Peltier element 49 via the operating section 29, and by controlling the current, the temperature of the irrigation fluid can be adjusted. Control in this case may be performed using the operating section 29 while looking at the displayed value of the display hand, or may be performed automatically by feeding back the measured value of the temperature sensor 18.

With this configuration, the temperature can be set and controlled in minute steps compared to the method of adjusting the temperature of the organ preservation solution using a heat exchanger.

Furthermore, if it is desired to preserve a plurality of organs under different temperature conditions, the temperature in the organ storage chamber or reservoir may be set individually and the temperature may be monitored. Therefore, research on organ preservation conditions, etc. is also possible.

〔Effect of the invention〕

In the present invention, when an organ transport unit and an in-hospital unit are connected and used as described above, the head of the perfusion pump is located within the operator's observation range in addition to various indicators and operation parts. Therefore, the rotational operation of the perfusion pump can be easily monitored.

[Brief explanation of the drawing]

FIG. 1 is a schematic diagram of the entire device according to an embodiment of the present invention, FIG. 2 is a schematic diagram of only the organ transport unit, and FIG.
FIG. 4 is a cross-sectional view of the vicinity of the pump head, and FIG. 5 is a modification of the above embodiment. Engineering... Organ 2... Organ transport unit 3... Hospital unit 7... Perfusion tube 9... Organ storage room Engineering 0... Reservoir 11... Perfusion pump 12... Heat exchanger 13...Artificial lung 14...Bubble trap 17...Control unit Fig. 3

Claims (1)

[Claims] 1. An organ transport unit provided with a perfusion circuit having at least an organ storage chamber and a perfusion pump, and an in-hospital unit provided with at least means for adjusting perfusion fluid components can be detachably connected. An organ preservation device as described above, characterized in that a perfusion pump head is provided on the observation surface side of the organ transportation unit in a state where the organ transportation unit and the in-hospital unit are connected.