JP7904250B2 - セレブロン結合化合物、その組成物及びそれによる治療方法 - Google Patents

セレブロン結合化合物、その組成物及びそれによる治療方法

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Publication number
JP7904250B2
JP7904250B2 JP2023579304A JP2023579304A JP7904250B2 JP 7904250 B2 JP7904250 B2 JP 7904250B2 JP 2023579304 A JP2023579304 A JP 2023579304A JP 2023579304 A JP2023579304 A JP 2023579304A JP 7904250 B2 JP7904250 B2 JP 7904250B2
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Prior art keywords
mmol
trans
alkyl
cyclohexyl
phenyl
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JP2023579304A
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English (en)
Japanese (ja)
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JP2024526191A5 (enExample
JP2024526191A (ja
Inventor
ディ アレキサンダー，マシュー
ディ コレア，マシュー
ダルビー，ディーパク
ヘザー シャロン グラント，バージニア
ハンセン，ジョシュア
サード，ロイ エル ハリス，ザ
ジェイ ホーン，エバン
ホアン，デフア
メイン，クリストファー
ノリス，スティーブン
プラントヴァン－クレニツキー，ヴェロニク
ジェイ サピエンザ，ジョン
テラニ，リダ
ダブリュー ホワイトフィールド，ブランドン
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Celgene Corp
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Celgene Corp
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Publication of JP2024526191A5 publication Critical patent/JP2024526191A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023579304A 2021-06-25 2022-06-24 セレブロン結合化合物、その組成物及びそれによる治療方法 Active JP7904250B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163215243P 2021-06-25 2021-06-25
US63/215,243 2021-06-25
PCT/US2022/034921 WO2022272074A1 (en) 2021-06-25 2022-06-24 Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Publications (3)

Publication Number Publication Date
JP2024526191A JP2024526191A (ja) 2024-07-17
JP2024526191A5 JP2024526191A5 (enExample) 2025-06-30
JP7904250B2 true JP7904250B2 (ja) 2026-08-12

Family

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JP2023579304A Active JP7904250B2 (ja) 2021-06-25 2022-06-24 セレブロン結合化合物、その組成物及びそれによる治療方法

Country Status (6)

Country Link
US (1) US20240368118A1 (enExample)
EP (1) EP4359407A4 (enExample)
JP (1) JP7904250B2 (enExample)
KR (1) KR20240026939A (enExample)
CN (1) CN117561249A (enExample)
WO (1) WO2022272074A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240146608A (ko) * 2023-03-29 2024-10-08 주식회사 아이비스바이오 세레블론 결합 활성을 가지는 저분자 화합물 및 이의 용도
KR20260041885A (ko) 2023-07-25 2026-03-27 몬테 로사 테라퓨틱스 아게 표적화된 단백질 분해를 위한 치환된 피페리딘디온
WO2026099466A1 (en) * 2024-11-08 2026-05-15 Monte Rosa Therapeutics Ag Targeted protein degradation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019504836A (ja) 2016-01-11 2019-02-21 ヤンセン ファーマシューティカ エヌ．ベー． アンドロゲン受容体アンタゴニストとしての置換チオヒダントイン誘導体
JP2020506922A (ja) 2017-01-31 2020-03-05 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． セレブロンリガンド、およびセレブロンリガンドを含有する二官能性化合物
US20200199073A1 (en) 2018-12-19 2020-06-25 Celgene Corporation Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
JP2020528918A (ja) 2017-07-28 2020-10-01 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． アンドロゲン受容体の標的化分解のための化合物および方法
WO2021053495A1 (en) 2019-09-16 2021-03-25 Novartis Ag Bifunctional degraders and their methods of use
WO2021262810A1 (en) 2020-06-24 2021-12-30 Celgene Corporation Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6817962B2 (ja) * 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019504836A (ja) 2016-01-11 2019-02-21 ヤンセン ファーマシューティカ エヌ．ベー． アンドロゲン受容体アンタゴニストとしての置換チオヒダントイン誘導体
JP2020506922A (ja) 2017-01-31 2020-03-05 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． セレブロンリガンド、およびセレブロンリガンドを含有する二官能性化合物
JP2020528918A (ja) 2017-07-28 2020-10-01 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． アンドロゲン受容体の標的化分解のための化合物および方法
US20200199073A1 (en) 2018-12-19 2020-06-25 Celgene Corporation Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith
WO2021053495A1 (en) 2019-09-16 2021-03-25 Novartis Ag Bifunctional degraders and their methods of use
WO2021262810A1 (en) 2020-06-24 2021-12-30 Celgene Corporation Cereblon binding compounds, compositions thereof, and methods of treatment therewith

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACS OMEGA，2018年，Vol.3(9)，p.11163-11171

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US20240368118A1 (en) 2024-11-07
CN117561249A (zh) 2024-02-13
WO2022272074A1 (en) 2022-12-29
EP4359407A4 (en) 2025-04-30
KR20240026939A (ko) 2024-02-29
EP4359407A1 (en) 2024-05-01
JP2024526191A (ja) 2024-07-17

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