JP7864826B2 - インターロイキン２変異体およびその融合タンパク質 - Google Patents

インターロイキン２変異体およびその融合タンパク質

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Publication number
JP7864826B2
JP7864826B2 JP2024518144A JP2024518144A JP7864826B2 JP 7864826 B2 JP7864826 B2 JP 7864826B2 JP 2024518144 A JP2024518144 A JP 2024518144A JP 2024518144 A JP2024518144 A JP 2024518144A JP 7864826 B2 JP7864826 B2 JP 7864826B2
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amino acid
seq
acid sequence
cells
fragment
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Japanese (ja)
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JP2024534545A5 (enExample
JP2024534545A (ja
Inventor
カイチエ ホー
フォンケン フー
ウェイウェイ ウー
ショアイシアン チョウ
チエン コアン
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フォートビタ バイオロジクス（シンガポール）プライベート リミティド
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Publication of JP2024534545A publication Critical patent/JP2024534545A/ja
Publication of JP2024534545A5 publication Critical patent/JP2024534545A5/ja
Priority to JP2026020040A priority Critical patent/JP2026097838A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2024518144A 2021-09-22 2022-09-21 インターロイキン２変異体およびその融合タンパク質 Active JP7864826B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026020040A JP2026097838A (ja) 2021-09-22 2026-02-10 インターロイキン２変異体およびその融合タンパク質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202111110032 2021-09-22
CN202111110032.3 2021-09-22
PCT/CN2022/120265 WO2023045977A1 (zh) 2021-09-22 2022-09-21 白介素2突变体以及其融合蛋白

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026020040A Division JP2026097838A (ja) 2021-09-22 2026-02-10 インターロイキン２変異体およびその融合タンパク質

Publications (3)

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JP2024534545A JP2024534545A (ja) 2024-09-20
JP2024534545A5 JP2024534545A5 (enExample) 2025-11-11
JP7864826B2 true JP7864826B2 (ja) 2026-05-25

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JP2024518144A Active JP7864826B2 (ja) 2021-09-22 2022-09-21 インターロイキン２変異体およびその融合タンパク質
JP2026020040A Pending JP2026097838A (ja) 2021-09-22 2026-02-10 インターロイキン２変異体およびその融合タンパク質

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JP2026020040A Pending JP2026097838A (ja) 2021-09-22 2026-02-10 インターロイキン２変異体およびその融合タンパク質

Country Status (14)

Country Link
US (2) US20240391973A1 (enExample)
EP (1) EP4406965A4 (enExample)
JP (2) JP7864826B2 (enExample)
KR (1) KR20240082364A (enExample)
CN (1) CN118119635A (enExample)
AU (2) AU2022350407B2 (enExample)
CA (1) CA3233075A1 (enExample)
CL (1) CL2024000834A1 (enExample)
CO (1) CO2024004910A2 (enExample)
IL (1) IL311643A (enExample)
MX (1) MX2024003535A (enExample)
PE (1) PE20241994A1 (enExample)
TW (1) TWI858393B (enExample)
WO (1) WO2023045977A1 (enExample)

Families Citing this family (12)

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CN112105634B (zh) 2018-09-21 2024-03-12 信达生物制药(苏州)有限公司 新型白介素2及其用途
KR20220155316A (ko) * 2020-03-19 2022-11-22 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 인터루킨-2 돌연변이 및 이의 용도
WO2025007037A1 (en) * 2023-06-28 2025-01-02 Dragonfly Therapeutics, Inc. Variant il-2 proteins
WO2025031434A1 (zh) * 2023-08-08 2025-02-13 北京志道生物科技有限公司 经修饰的细胞因子与cd40激动剂的联用组合物及其抗肿瘤用途
AU2024411090A1 (en) 2023-12-28 2026-07-16 Fortvita Biologics (Singapore) Pte. Ltd. Pd-1/il-2r bispecific antibody fusion protein, and use and usage method thereof
WO2025151752A1 (en) 2024-01-10 2025-07-17 Xilio Development, Inc. Masked il-2 cytokines and methods of use thereof
CN118373896B (zh) * 2024-04-19 2025-07-29 上海科棋药业科技有限公司 抗pd-1抗体与il-2突变体的双功能融合蛋白
WO2025252212A1 (zh) * 2024-06-07 2025-12-11 福佑泰生物制药公司 抗pd-1抗体与细胞因子il-12突变蛋白的免疫缀合物以及其应用
WO2026012466A1 (en) * 2024-07-12 2026-01-15 Vibrant Pharma Limited Interleukin-2 muteins and uses thereof
CN118546233B (zh) * 2024-07-30 2024-10-18 成都微芯新域生物技术有限公司 白介素-21突变体及其应用
WO2026083295A1 (en) * 2024-10-16 2026-04-23 Bright Peak Therapeutics Ag Trispecific compositions comprising il-2, vegf binding domains, and pd-1 binding domains
CN121293311B (zh) * 2025-08-01 2026-07-24 合肥天港免疫药物有限公司 Il-2变体及其应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2018531986A (ja) 2015-08-10 2018-11-01 イノベント バイオロジックス （スウツォウ） カンパニー，リミテッド Ｐｄ−１抗体
WO2020057645A1 (zh) 2018-09-21 2020-03-26 信达生物制药(苏州)有限公司 新型白介素2及其用途
JP2020515275A (ja) 2017-04-03 2020-05-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗ｐｄ−１抗体と突然変異ｉｌ−２とまたはｉｌ−１５とのイムノコンジュゲート

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US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
NZ234674A (en) * 1989-08-02 1992-02-25 Seragen Inc Mutant interleukin-2,dna encoding it, host cells, cytotoxic and toxin-mutant il-2 conjugates
DZ2788A1 (fr) 1998-05-15 2003-12-01 Bayer Ag Agonistes et antagonistes selectifs à IL-2.
US6955807B1 (en) * 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
JP7148539B2 (ja) * 2017-04-03 2022-10-05 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 免疫抱合体
JP7765181B2 (ja) * 2017-12-19 2025-11-06 ゼンコア インコーポレイテッド 改変されたｉｌ－２ ｆｃ融合タンパク質
CN111868079B (zh) * 2017-12-27 2025-06-17 协和麒麟株式会社 Il-2变体
CA3143034A1 (en) * 2019-06-14 2020-12-17 Cugene Inc. Novel interleukin-2 variants for the treatment of cancer
WO2020252421A2 (en) * 2019-06-14 2020-12-17 Cugene, Inc. Novel interleukin-2 variants and bifunctional fusion molecules thereof
KR20220155316A (ko) * 2020-03-19 2022-11-22 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 인터루킨-2 돌연변이 및 이의 용도
WO2021185362A1 (zh) * 2020-03-19 2021-09-23 信达生物制药(苏州)有限公司 白介素2突变体及其用途

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Publication number Priority date Publication date Assignee Title
JP2018531986A (ja) 2015-08-10 2018-11-01 イノベント バイオロジックス （スウツォウ） カンパニー，リミテッド Ｐｄ−１抗体
JP2020515275A (ja) 2017-04-03 2020-05-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 抗ｐｄ−１抗体と突然変異ｉｌ−２とまたはｉｌ−１５とのイムノコンジュゲート
WO2020057645A1 (zh) 2018-09-21 2020-03-26 信达生物制药(苏州)有限公司 新型白介素2及其用途

Also Published As

Publication number Publication date
TW202320862A (zh) 2023-06-01
US20260053898A1 (en) 2026-02-26
EP4406965A1 (en) 2024-07-31
AU2025275202A1 (en) 2026-02-19
CO2024004910A2 (es) 2024-07-08
CA3233075A1 (en) 2023-03-30
WO2023045977A1 (zh) 2023-03-30
US20240391973A1 (en) 2024-11-28
CL2024000834A1 (es) 2024-09-06
EP4406965A4 (en) 2025-12-17
TWI858393B (zh) 2024-10-11
KR20240082364A (ko) 2024-06-10
JP2024534545A (ja) 2024-09-20
AU2022350407B2 (en) 2025-09-04
JP2026097838A (ja) 2026-06-16
AU2022350407A1 (en) 2024-05-02
CN118119635A (zh) 2024-05-31
MX2024003535A (es) 2024-05-07
PE20241994A1 (es) 2024-09-27
IL311643A (en) 2024-05-01

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