JP7856636B2 - セレブロンタンパク質のモジュレータとしての置換ｎ－（２－（２，６－ジオキソピペリジン－３－イル）－１，３－ジオキソイソインドリン－５－イル）アリールスルホンアミド類似体 - Google Patents
セレブロンタンパク質のモジュレータとしての置換ｎ－（２－（２，６－ジオキソピペリジン－３－イル）－１，３－ジオキソイソインドリン－５－イル）アリールスルホンアミド類似体Info
- Publication number
- JP7856636B2 JP7856636B2 JP2023518170A JP2023518170A JP7856636B2 JP 7856636 B2 JP7856636 B2 JP 7856636B2 JP 2023518170 A JP2023518170 A JP 2023518170A JP 2023518170 A JP2023518170 A JP 2023518170A JP 7856636 B2 JP7856636 B2 JP 7856636B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cancer
- pharmaceutically acceptable
- och
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063082365P | 2020-09-23 | 2020-09-23 | |
| US63/082,365 | 2020-09-23 | ||
| PCT/US2021/051648 WO2022066835A1 (en) | 2020-09-23 | 2021-09-23 | Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023542930A JP2023542930A (ja) | 2023-10-12 |
| JP2023542930A5 JP2023542930A5 (cg-RX-API-DMAC10.html) | 2024-10-01 |
| JP7856636B2 true JP7856636B2 (ja) | 2026-05-11 |
Family
ID=80845797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023518170A Active JP7856636B2 (ja) | 2020-09-23 | 2021-09-23 | セレブロンタンパク質のモジュレータとしての置換ｎ－（２－（２，６－ジオキソピペリジン－３－イル）－１，３－ジオキソイソインドリン－５－イル）アリールスルホンアミド類似体 |
Country Status (14)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022066835A1 (en) | 2020-09-23 | 2022-03-31 | St. Jude Children's Research Hospital, Inc. | Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
| EP4554581A1 (en) | 2022-07-13 | 2025-05-21 | Monte Rosa Therapeutics AG | Combination therapy comprising gspt1-directed molecular glue degraders and pi3k/akt/mtor pathway inhibitors |
| US20260014133A1 (en) * | 2022-07-15 | 2026-01-15 | St. Jude's Chidren's Research Hospital, Inc. | SUBSTITUTED 3-(l-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE/2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-l,3-DIONE ANALOGS AS MODULATORS OF CEREBLON PROTEIN |
| JP2025531869A (ja) | 2022-09-09 | 2025-09-25 | イノヴォ セラピューティクス、インコーポレイテッド | ＣＫ１αおよびＤＵＡＬ ＣＫ１α／ＧＳＰＴ１分解化合物 |
| WO2024073871A1 (en) * | 2022-10-04 | 2024-04-11 | Biofront Ltd | Gspt1 degraders, compositions comprising the degrader, and methods of using the same |
| CN117917402A (zh) * | 2022-10-21 | 2024-04-23 | 暨南大学 | 异吲哚酰胺类化合物及其药物组合物和应用 |
| WO2024109918A1 (zh) * | 2022-11-24 | 2024-05-30 | 西藏海思科制药有限公司 | 一种gspt1降解剂及其在医药上的应用 |
| KR102570883B1 (ko) * | 2023-04-13 | 2023-08-29 | (주) 사이러스테라퓨틱스 | 신규한 gspt1 분해제 및 이의 용도 |
| AU2024344247A1 (en) | 2023-09-19 | 2026-05-07 | Kancure Pte. Ltd. | Survivin-targeted compounds |
| WO2025067255A1 (zh) * | 2023-09-26 | 2025-04-03 | 映恩生物制药（苏州）有限公司 | 哌啶二酮类化合物、其制备方法和用途 |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
Citations (3)
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| JP2010502627A (ja) | 2006-08-30 | 2010-01-28 | セルジーン・コーポレーション | ５−置換イソインドリン化合物 |
| US20200071291A1 (en) | 2017-05-22 | 2020-03-05 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | A class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof |
| WO2020118098A1 (en) | 2018-12-05 | 2020-06-11 | Vividion Therapeutics, Inc. | Substituted isoindolinones as modulators of cereblon-mediated neo-substrate recruitment |
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| WO1998023617A1 (en) | 1996-11-26 | 1998-06-04 | American Cyanamid Company | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents |
| BR9714142A (pt) * | 1996-12-17 | 2000-02-29 | Warner Lambert Co | Uso de inibidores de metaloproteìnases matriciais para tratamento de distúrbios neurológicos e promoção de cicatrização de feridas |
| US7091353B2 (en) * | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| PL371344A1 (en) * | 2002-02-13 | 2005-06-13 | Glaxo Group Limited | Benzenesulfonamide derivatives as antipsychotic agents |
| CA2822094C (en) | 2005-08-31 | 2015-10-27 | Celgene Corporation | Isoindole-imide compounds and compositions comprising and methods of using the same |
| US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
| CN101578277A (zh) * | 2006-08-30 | 2009-11-11 | 细胞基因公司 | 5-取代的异二氢吲哚化合物 |
| US7938952B2 (en) | 2008-05-20 | 2011-05-10 | Institute Francais Du Petrole | Process for multistage residue hydroconversion integrated with straight-run and conversion gasoils hydroconversion steps |
| CA2957226C (en) | 2008-10-29 | 2018-08-14 | Celgene Corporation | Isoindoline compounds for use in the treatment of cancer |
| JP5944823B2 (ja) | 2010-07-02 | 2016-07-05 | あすか製薬株式会社 | 複素環化合物及びｐ２７Ｋｉｐ１分解阻害剤 |
| UA116544C2 (uk) | 2012-08-09 | 2018-04-10 | Селджин Корпорейшн | Спосіб лікування раку з використанням 3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
| CA2908954C (en) | 2013-04-17 | 2021-08-03 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer |
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| TWI782395B (zh) | 2016-01-08 | 2022-11-01 | 美商西建公司 | 抗增生化合物，及其醫藥組合物及用途 |
| SG11201809501PA (en) * | 2016-06-06 | 2018-12-28 | Celgene Corp | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
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| WO2022066835A1 (en) | 2020-09-23 | 2022-03-31 | St. Jude Children's Research Hospital, Inc. | Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
-
2021
- 2021-09-23 WO PCT/US2021/051648 patent/WO2022066835A1/en not_active Ceased
- 2021-09-23 CN CN202180065415.5A patent/CN116209439B/zh active Active
- 2021-09-23 MX MX2023003114A patent/MX2023003114A/es unknown
- 2021-09-23 EP EP21873389.7A patent/EP4217352A4/en active Pending
- 2021-09-23 AU AU2021347238A patent/AU2021347238A1/en active Pending
- 2021-09-23 BR BR112023005344A patent/BR112023005344A2/pt unknown
- 2021-09-23 KR KR1020227017575A patent/KR102499522B1/ko active Active
- 2021-09-23 IL IL301588A patent/IL301588A/en unknown
- 2021-09-23 JP JP2023518170A patent/JP7856636B2/ja active Active
- 2021-09-23 PE PE2023001201A patent/PE20230847A1/es unknown
- 2021-09-23 CA CA3196278A patent/CA3196278A1/en active Pending
-
2022
- 2022-05-09 US US17/740,148 patent/US12454518B2/en active Active
-
2023
- 2023-02-07 CL CL2023000394A patent/CL2023000394A1/es unknown
- 2023-04-21 ZA ZA2023/04644A patent/ZA202304644B/en unknown
- 2023-09-14 US US18/368,497 patent/US12454519B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502627A (ja) | 2006-08-30 | 2010-01-28 | セルジーン・コーポレーション | ５−置換イソインドリン化合物 |
| US20200071291A1 (en) | 2017-05-22 | 2020-03-05 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | A class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof |
| WO2020118098A1 (en) | 2018-12-05 | 2020-06-11 | Vividion Therapeutics, Inc. | Substituted isoindolinones as modulators of cereblon-mediated neo-substrate recruitment |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023542930A (ja) | 2023-10-12 |
| AU2021347238A1 (en) | 2023-06-01 |
| IL301588A (en) | 2023-05-01 |
| EP4217352A1 (en) | 2023-08-02 |
| KR20220080003A (ko) | 2022-06-14 |
| MX2023003114A (es) | 2023-03-23 |
| BR112023005344A2 (pt) | 2023-05-09 |
| US20240132463A1 (en) | 2024-04-25 |
| ZA202304644B (en) | 2025-11-26 |
| US12454518B2 (en) | 2025-10-28 |
| CN116209439B (zh) | 2026-05-26 |
| PE20230847A1 (es) | 2023-05-23 |
| US12454519B2 (en) | 2025-10-28 |
| EP4217352A4 (en) | 2024-04-10 |
| CN116209439A (zh) | 2023-06-02 |
| WO2022066835A1 (en) | 2022-03-31 |
| US20220274948A1 (en) | 2022-09-01 |
| KR102499522B1 (ko) | 2023-02-13 |
| CL2023000394A1 (es) | 2023-08-18 |
| CA3196278A1 (en) | 2022-03-31 |
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