JP7839730B2 - ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法 - Google Patents

５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法

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JP7839730B2
JP7839730B2 JP2022536675A JP2022536675A JP7839730B2 JP 7839730 B2 JP7839730 B2 JP 7839730B2 JP 2022536675 A JP2022536675 A JP 2022536675A JP 2022536675 A JP2022536675 A JP 2022536675A JP 7839730 B2 JP7839730 B2 JP 7839730B2
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formula
compound
base
organic solvent
temperature
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JP2023506066A5 (https=
JP2023506066A (ja
Inventor
グラヴェル、リーセ
ゼッターベルグ、フレドリク
ティレル、アンドリュー
キンネルト、クリスティーン
－ ウィルソン、アレクサンダー ウェイマス
クラークソン、ロバート
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ガレクト バイオテック エービー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2022536675A 2019-12-16 2020-12-16 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法 Active JP7839730B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025066488A JP2025111532A (ja) 2019-12-16 2025-04-14 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19216405.1A EP3838909A1 (en) 2019-12-16 2019-12-16 Large scale process for the preparation of 5-bromopyridin-3-yl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1h-1,2,3-triazol-1-yl]- 1-thio-alpha-d-galactopyranoside
EP19216405.1 2019-12-16
PCT/EP2020/086385 WO2021122719A1 (en) 2019-12-16 2020-12-16 Large scale process for the preparation of 5-bromopyridin-3-yl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1h-1,2,3-triazol-1-yl]- 1-thio-alpha-d-galactopyranoside and a crystalline form thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025066488A Division JP2025111532A (ja) 2019-12-16 2025-04-14 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法

Publications (3)

Publication Number Publication Date
JP2023506066A JP2023506066A (ja) 2023-02-14
JP2023506066A5 JP2023506066A5 (https=) 2023-12-19
JP7839730B2 true JP7839730B2 (ja) 2026-04-02

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Family Applications (2)

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JP2022536675A Active JP7839730B2 (ja) 2019-12-16 2020-12-16 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法
JP2025066488A Pending JP2025111532A (ja) 2019-12-16 2025-04-14 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法

Family Applications After (1)

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JP2025066488A Pending JP2025111532A (ja) 2019-12-16 2025-04-14 ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法

Country Status (7)

Country Link
US (1) US20230063538A1 (https=)
EP (2) EP3838909A1 (https=)
JP (2) JP7839730B2 (https=)
KR (1) KR20220114597A (https=)
CN (2) CN114929719A (https=)
CA (1) CA3160971A1 (https=)
WO (1) WO2021122719A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558974B (zh) * 2018-04-28 2023-05-23 浙江树人学院 一种糖衍生吡啶三氮唑镍催化剂的制备及应用
WO2025180907A1 (en) 2024-02-26 2025-09-04 Galecto Biotech Ab Specific galactoside inhibitor of galectin-1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018503660A (ja) 2015-01-30 2018-02-08 ガレクト・バイオテック・エイビイ ガレクチンの新規なガラクトシド阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3025867A1 (en) * 2016-07-12 2018-01-18 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018503660A (ja) 2015-01-30 2018-02-08 ガレクト・バイオテック・エイビイ ガレクチンの新規なガラクトシド阻害剤

Also Published As

Publication number Publication date
JP2025111532A (ja) 2025-07-30
US20230063538A1 (en) 2023-03-02
EP4077343A1 (en) 2022-10-26
WO2021122719A1 (en) 2021-06-24
CN114929719A (zh) 2022-08-19
JP2023506066A (ja) 2023-02-14
KR20220114597A (ko) 2022-08-17
CN120699068A (zh) 2025-09-26
EP3838909A1 (en) 2021-06-23
CA3160971A1 (en) 2021-06-24

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