CN114929719A - 大规模制备5-溴吡啶-3-基-3-脱氧-3-[4-(3,4,5-三氟苯基)-1H-1,2,3-三唑-1-基]-1-硫代-α-D-吡喃半乳糖苷及其结晶形式的方法 - Google Patents

大规模制备5-溴吡啶-3-基-3-脱氧-3-[4-(3,4,5-三氟苯基)-1H-1,2,3-三唑-1-基]-1-硫代-α-D-吡喃半乳糖苷及其结晶形式的方法 Download PDF

Info

Publication number
CN114929719A
CN114929719A CN202080085867.5A CN202080085867A CN114929719A CN 114929719 A CN114929719 A CN 114929719A CN 202080085867 A CN202080085867 A CN 202080085867A CN 114929719 A CN114929719 A CN 114929719A
Authority
CN
China
Prior art keywords
compound
formula
organic solvent
base
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080085867.5A
Other languages
English (en)
Chinese (zh)
Inventor
L·格拉韦勒
F·塞特贝里
A·蒂勒尔
C·金奈尔特
A·韦茅斯-威尔逊
R·克拉克森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galecto Biotech AB
Original Assignee
Galecto Biotech AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galecto Biotech AB filed Critical Galecto Biotech AB
Priority to CN202510684688.8A priority Critical patent/CN120699068A/zh
Publication of CN114929719A publication Critical patent/CN114929719A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN202080085867.5A 2019-12-16 2020-12-16 大规模制备5-溴吡啶-3-基-3-脱氧-3-[4-(3,4,5-三氟苯基)-1H-1,2,3-三唑-1-基]-1-硫代-α-D-吡喃半乳糖苷及其结晶形式的方法 Pending CN114929719A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510684688.8A CN120699068A (zh) 2019-12-16 2020-12-16 大规模生产方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19216405.1A EP3838909A1 (en) 2019-12-16 2019-12-16 Large scale process for the preparation of 5-bromopyridin-3-yl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1h-1,2,3-triazol-1-yl]- 1-thio-alpha-d-galactopyranoside
EP19216405.1 2019-12-16
PCT/EP2020/086385 WO2021122719A1 (en) 2019-12-16 2020-12-16 Large scale process for the preparation of 5-bromopyridin-3-yl-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1h-1,2,3-triazol-1-yl]- 1-thio-alpha-d-galactopyranoside and a crystalline form thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510684688.8A Division CN120699068A (zh) 2019-12-16 2020-12-16 大规模生产方法

Publications (1)

Publication Number Publication Date
CN114929719A true CN114929719A (zh) 2022-08-19

Family

ID=69024098

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080085867.5A Pending CN114929719A (zh) 2019-12-16 2020-12-16 大规模制备5-溴吡啶-3-基-3-脱氧-3-[4-(3,4,5-三氟苯基)-1H-1,2,3-三唑-1-基]-1-硫代-α-D-吡喃半乳糖苷及其结晶形式的方法
CN202510684688.8A Pending CN120699068A (zh) 2019-12-16 2020-12-16 大规模生产方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202510684688.8A Pending CN120699068A (zh) 2019-12-16 2020-12-16 大规模生产方法

Country Status (7)

Country Link
US (1) US20230063538A1 (https=)
EP (2) EP3838909A1 (https=)
JP (2) JP7839730B2 (https=)
KR (1) KR20220114597A (https=)
CN (2) CN114929719A (https=)
CA (1) CA3160971A1 (https=)
WO (1) WO2021122719A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108558974B (zh) * 2018-04-28 2023-05-23 浙江树人学院 一种糖衍生吡啶三氮唑镍催化剂的制备及应用
WO2025180907A1 (en) 2024-02-26 2025-09-04 Galecto Biotech Ab Specific galactoside inhibitor of galectin-1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406478A (zh) * 2015-01-30 2017-11-28 格莱克特生物技术公司 半乳糖凝集素的α‑D‑半乳糖苷抑制剂
WO2018011094A1 (en) * 2016-07-12 2018-01-18 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406478A (zh) * 2015-01-30 2017-11-28 格莱克特生物技术公司 半乳糖凝集素的α‑D‑半乳糖苷抑制剂
WO2018011094A1 (en) * 2016-07-12 2018-01-18 Galecto Biotech Ab Alpha-d-galactoside inhibitors of galectins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘凤华 等: "《化学制药工艺学》", vol. 01, 31 March 2014, 沈阳：东北大学出版社, pages: 35 - 36 *

Also Published As

Publication number Publication date
JP2025111532A (ja) 2025-07-30
US20230063538A1 (en) 2023-03-02
JP7839730B2 (ja) 2026-04-02
EP4077343A1 (en) 2022-10-26
WO2021122719A1 (en) 2021-06-24
JP2023506066A (ja) 2023-02-14
KR20220114597A (ko) 2022-08-17
CN120699068A (zh) 2025-09-26
EP3838909A1 (en) 2021-06-23
CA3160971A1 (en) 2021-06-24

Similar Documents

Publication Publication Date Title
JP7279057B6 (ja) Ｐｄ１／ｐｄ－ｌ１活性化の阻害剤としてのピリミジン誘導体
JP7279063B2 (ja) Ｐｄ１／ｐｄ－ｌ１相互作用／活性化の阻害剤としての二環式化合物
CN106456643B (zh) 用于trail诱导的药效团
JP2025111532A (ja) ５－ブロモピリジン－３－イル－３－デオキシ－３－［４－（３，４，５－トリフルオロフェニル）－１ｈ－１，２，３－トリアゾール－１－ｙｌ］－１－チオ－アルファ－ｄ－ガラクトピラノシド及びその結晶形を調製するための大規模方法
KR20190039086A (ko) Bet 저해제의 결정질 고체 형태
KR102331013B1 (ko) 퀴나졸리논 유도체, 이의 제조방법, 약학 조성물 및 적용
CA2958139A1 (en) Solid state forms of ibrutinib
JP7280695B2 (ja) Ｎｕｃ‐１０３１の単一異性体がリッチな組成物及びその製造方法並びに用途
US20170166602A1 (en) Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
CA3173661A1 (en) Stereoselective manufacture of selected purine phosphoramidates
EP3009435B1 (en) Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban
EP3101020B1 (en) Deuterated quinazolinone compound and pharmaceutical composition comprising same
CA3050061A1 (en) Process for preparing purine derivatives
WO2020206367A1 (en) Processes for the preparation of deuterated d-serine
JP2019131532A (ja) 酸無水物、および該酸無水物を用いたｌ−カルノシンの製造方法
EP4238961A1 (en) Method of producing 3-methyl-4-halo-indole derivative
WO2022171561A1 (en) Novel galactoside inhibitor of galectins
TW202535414A (zh) 製造kras g12c抑制劑之方法
EP4281076A1 (en) Processes for purification of bictegravir intermediates
CN102766165A (zh) 合成钼蝶呤前体z衍生物的方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20220819

WD01 Invention patent application deemed withdrawn after publication