JP7829895B2 - Ｃａｒをコードする核酸分子とそれを含むベクター、ｃａｒ、ｃａｒを含む免疫細胞とその細胞を含む医薬組成物、並びにｃａｒを含む免疫細胞の製造方法 - Google Patents

Ｃａｒをコードする核酸分子とそれを含むベクター、ｃａｒ、ｃａｒを含む免疫細胞とその細胞を含む医薬組成物、並びにｃａｒを含む免疫細胞の製造方法

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JP7829895B2
JP7829895B2 JP2024551314A JP2024551314A JP7829895B2 JP 7829895 B2 JP7829895 B2 JP 7829895B2 JP 2024551314 A JP2024551314 A JP 2024551314A JP 2024551314 A JP2024551314 A JP 2024551314A JP 7829895 B2 JP7829895 B2 JP 7829895B2
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amino acid
encoding
nucleotide sequence
seq
sequence encoding
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JPWO2024084852A5 (https=
JPWO2024084852A1 (https=
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洋 珠玖
泰 赤堀
真吾 前田
淳 福永
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Sysmex Corp
Mie University NUC
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Sysmex Corp
Mie University NUC
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • A—HUMAN NECESSITIES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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JP2024551314A 2022-10-20 2023-09-07 Ｃａｒをコードする核酸分子とそれを含むベクター、ｃａｒ、ｃａｒを含む免疫細胞とその細胞を含む医薬組成物、並びにｃａｒを含む免疫細胞の製造方法 Active JP7829895B2 (ja)

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JP2022168686 2022-10-20
JP2022168686 2022-10-20
PCT/JP2023/032627 WO2024084852A1 (ja) 2022-10-20 2023-09-07 Ｃａｒをコードする核酸分子とそれを含むベクター、ｃａｒ、ｃａｒを含む免疫細胞とその細胞を含む医薬組成物、並びにｃａｒを含む免疫細胞の製造方法

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JPWO2024084852A5 JPWO2024084852A5 (https=) 2025-06-05
JP7829895B2 true JP7829895B2 (ja) 2026-03-16

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JP (1) JP7829895B2 (https=)
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019500394A (ja) 2015-12-30 2019-01-10 ノバルティス アーゲー 有効性が増強された免疫エフェクター細胞治療
JP2019524100A (ja) 2016-07-18 2019-09-05 へリックス バイオファーマ コーポレーション がんを治療するための癌胎児性抗原関連細胞接着分子６を標的とするｃａｒ免疫細胞
CN113980137A (zh) 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含CD3ε胞内碱性氨基酸富集区基序的嵌合抗原受体及其用途
JP2022102539A (ja) 2020-12-25 2022-07-07 シスメックス株式会社 抗体の抗原に対する親和性を向上させる方法及びその利用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
WO2018225732A1 (ja) 2017-06-05 2018-12-13 国立大学法人三重大学 Ｍａｇｅ－ａ４由来ペプチドを認識する抗原結合性タンパク質

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019500394A (ja) 2015-12-30 2019-01-10 ノバルティス アーゲー 有効性が増強された免疫エフェクター細胞治療
JP2019524100A (ja) 2016-07-18 2019-09-05 へリックス バイオファーマ コーポレーション がんを治療するための癌胎児性抗原関連細胞接着分子６を標的とするｃａｒ免疫細胞
CN113980137A (zh) 2020-07-27 2022-01-28 中国科学院分子细胞科学卓越创新中心 一种包含CD3ε胞内碱性氨基酸富集区基序的嵌合抗原受体及其用途
JP2022102539A (ja) 2020-12-25 2022-07-07 シスメックス株式会社 抗体の抗原に対する親和性を向上させる方法及びその利用

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JPWO2024084852A1 (https=) 2024-04-25
CN119998452A (zh) 2025-05-13
WO2024084852A1 (ja) 2024-04-25

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