JP7827725B2 - Ｉｌ－１７モジュレータとしてのイミダゾピリダジン誘導体 - Google Patents

Ｉｌ－１７モジュレータとしてのイミダゾピリダジン誘導体

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Publication number
JP7827725B2
JP7827725B2 JP2023535832A JP2023535832A JP7827725B2 JP 7827725 B2 JP7827725 B2 JP 7827725B2 JP 2023535832 A JP2023535832 A JP 2023535832A JP 2023535832 A JP2023535832 A JP 2023535832A JP 7827725 B2 JP7827725 B2 JP 7827725B2
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JP
Japan
Prior art keywords
methyl
formula
alkyl
imidazo
mmol
Prior art date
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Application number
JP2023535832A
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English (en)
Japanese (ja)
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JP2023552864A (ja
JPWO2022128584A5 (https=
JP2023552864A5 (https=
Inventor
ニール ブレイス、ガレス
チュウ、シュユ
マリー フォーリー、アンネ
アンドリュー ジョンソン、ジェイムズ
ジョン ノーマン、ティモシー
レイチェル クインシー、ジョアンナ
トーマス ロイバーソン、ジェイムズ
ストレイカー、ロバート
ジェイムズ タウンゼント、ロバート
Original Assignee
ユーシービー バイオファルマ エスアールエル
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Filing date
Publication date
Priority claimed from GBGB2019702.6A external-priority patent/GB202019702D0/en
Priority claimed from GBGB2109583.1A external-priority patent/GB202109583D0/en
Application filed by ユーシービー バイオファルマ エスアールエル filed Critical ユーシービー バイオファルマ エスアールエル
Publication of JP2023552864A publication Critical patent/JP2023552864A/ja
Publication of JPWO2022128584A5 publication Critical patent/JPWO2022128584A5/ja
Publication of JP2023552864A5 publication Critical patent/JP2023552864A5/ja
Application granted granted Critical
Publication of JP7827725B2 publication Critical patent/JP7827725B2/ja
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Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2023535832A 2020-12-14 2021-12-06 Ｉｌ－１７モジュレータとしてのイミダゾピリダジン誘導体 Active JP7827725B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2019702.6A GB202019702D0 (en) 2020-12-14 2020-12-14 Therapeutic agents
GB2019702.6 2020-12-14
GBGB2109583.1A GB202109583D0 (en) 2021-07-02 2021-07-02 Therapeutic agents
GB2109583.1 2021-07-02
PCT/EP2021/084448 WO2022128584A1 (en) 2020-12-14 2021-12-06 Imidazopyridazine derivatives as il-17 modulators

Publications (4)

Publication Number Publication Date
JP2023552864A JP2023552864A (ja) 2023-12-19
JPWO2022128584A5 JPWO2022128584A5 (https=) 2024-11-15
JP2023552864A5 JP2023552864A5 (https=) 2024-11-15
JP7827725B2 true JP7827725B2 (ja) 2026-03-10

Family

ID=79164779

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023535832A Active JP7827725B2 (ja) 2020-12-14 2021-12-06 Ｉｌ－１７モジュレータとしてのイミダゾピリダジン誘導体

Country Status (5)

Country Link
US (1) US20240140951A1 (https=)
EP (1) EP4259631A1 (https=)
JP (1) JP7827725B2 (https=)
CA (1) CA3200594A1 (https=)
WO (1) WO2022128584A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201909190D0 (en) * 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
CA3200594A1 (en) * 2020-12-14 2022-06-23 UCB Biopharma SRL Imidazopyridazine derivatives as il-17 modulators
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑
WO2024138286A1 (en) * 2022-12-26 2024-07-04 Usynova Pharmaceuticals, Ltd. Il-17a modulators
CN121487927A (zh) * 2023-03-14 2026-02-06 歌礼制药(中国)有限公司 Il-17a的小分子调节剂、制备方法及其使用方法
CN121311483A (zh) * 2023-03-28 2026-01-09 詹森药业有限公司 含内酰胺的咪唑并哒嗪il-17抑制剂化合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020011731A1 (en) 2018-07-12 2020-01-16 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
WO2020146194A1 (en) 2019-01-07 2020-07-16 Eli Lilly And Company Imidazo[1,2-b]pyridazine il-17a inhibitors
JP2022538519A (ja) 2019-06-26 2022-09-05 ユーシービー バイオファルマ エスアールエル Ｉｌ－１７調節剤としてのイミダゾピリジン誘導体
JP2023524018A (ja) 2020-04-30 2023-06-08 ヤンセン ファーマシューティカ エヌ．ベー． Ｉｌ－１７の調節因子としてのイミダゾリダジン
JP2023525234A (ja) 2020-04-30 2023-06-15 ヤンセン ファーマシューティカ エヌ．ベー． Ｉｌ－１７経路のモジュレータを同定する方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9309313B2 (en) 2008-01-09 2016-04-12 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
WO2019223718A1 (zh) 2018-05-22 2019-11-28 成都先导药物开发股份有限公司 一种免疫调节剂
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
BR112021010453A2 (pt) 2018-12-19 2021-08-24 Leo Pharma A/S Composto, e, composição farmacêutica
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
CA3200594A1 (en) * 2020-12-14 2022-06-23 UCB Biopharma SRL Imidazopyridazine derivatives as il-17 modulators

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019138017A1 (en) 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2020011731A1 (en) 2018-07-12 2020-01-16 UCB Biopharma SRL Spirocyclic indane analogues as il-17 modulators
WO2020146194A1 (en) 2019-01-07 2020-07-16 Eli Lilly And Company Imidazo[1,2-b]pyridazine il-17a inhibitors
JP2022538519A (ja) 2019-06-26 2022-09-05 ユーシービー バイオファルマ エスアールエル Ｉｌ－１７調節剤としてのイミダゾピリジン誘導体
JP2023524018A (ja) 2020-04-30 2023-06-08 ヤンセン ファーマシューティカ エヌ．ベー． Ｉｌ－１７の調節因子としてのイミダゾリダジン
JP2023525234A (ja) 2020-04-30 2023-06-15 ヤンセン ファーマシューティカ エヌ．ベー． Ｉｌ－１７経路のモジュレータを同定する方法

Also Published As

Publication number Publication date
US20240140951A1 (en) 2024-05-02
JP2023552864A (ja) 2023-12-19
EP4259631A1 (en) 2023-10-18
WO2022128584A1 (en) 2022-06-23
CA3200594A1 (en) 2022-06-23

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