CA3200594A1 - Imidazopyridazine derivatives as il-17 modulators - Google Patents

Imidazopyridazine derivatives as il-17 modulators

Info

Publication number
CA3200594A1
CA3200594A1 CA3200594A CA3200594A CA3200594A1 CA 3200594 A1 CA3200594 A1 CA 3200594A1 CA 3200594 A CA3200594 A CA 3200594A CA 3200594 A CA3200594 A CA 3200594A CA 3200594 A1 CA3200594 A1 CA 3200594A1
Authority
CA
Canada
Prior art keywords
formula
alkyl
compound
mmol
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3200594A
Other languages
English (en)
French (fr)
Inventor
Gareth Neil BRACE
Shuyu CHU
Anne Marie Foley
James Andrew Johnson
Timothy John Norman
Joanna Rachel Quincey
James Thomas Reuberson
Robert Straker
Robert James Townsend
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Biopharma SRL
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2019702.6A external-priority patent/GB202019702D0/en
Priority claimed from GBGB2109583.1A external-priority patent/GB202109583D0/en
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of CA3200594A1 publication Critical patent/CA3200594A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3200594A 2020-12-14 2021-12-06 Imidazopyridazine derivatives as il-17 modulators Pending CA3200594A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB2019702.6A GB202019702D0 (en) 2020-12-14 2020-12-14 Therapeutic agents
GB2019702.6 2020-12-14
GBGB2109583.1A GB202109583D0 (en) 2021-07-02 2021-07-02 Therapeutic agents
GB2109583.1 2021-07-02
PCT/EP2021/084448 WO2022128584A1 (en) 2020-12-14 2021-12-06 Imidazopyridazine derivatives as il-17 modulators

Publications (1)

Publication Number Publication Date
CA3200594A1 true CA3200594A1 (en) 2022-06-23

Family

ID=79164779

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3200594A Pending CA3200594A1 (en) 2020-12-14 2021-12-06 Imidazopyridazine derivatives as il-17 modulators

Country Status (5)

Country Link
US (1) US20240140951A1 (https=)
EP (1) EP4259631A1 (https=)
JP (1) JP7827725B2 (https=)
CA (1) CA3200594A1 (https=)
WO (1) WO2022128584A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201909190D0 (en) * 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
CA3200594A1 (en) * 2020-12-14 2022-06-23 UCB Biopharma SRL Imidazopyridazine derivatives as il-17 modulators
AR126255A1 (es) 2021-07-01 2023-10-04 UCB Biopharma SRL Derivados de imidazotriazina como moduladores de il-17
WO2023025783A1 (en) 2021-08-23 2023-03-02 Leo Pharma A/S Small molecule modulators of il-17
WO2023111181A1 (en) 2021-12-16 2023-06-22 Leo Pharma A/S Small molecule modulators of il-17
WO2023166172A1 (en) 2022-03-04 2023-09-07 Leo Pharma A/S Small molecule modulators of il-17
GB202210731D0 (en) 2022-07-22 2022-09-07 UCB Biopharma SRL Therapeutic agents
TW202430165A (zh) 2022-12-02 2024-08-01 丹麥商理奧藥品公司 Il-17之小分子調節劑
WO2024138286A1 (en) * 2022-12-26 2024-07-04 Usynova Pharmaceuticals, Ltd. Il-17a modulators
CN121487927A (zh) * 2023-03-14 2026-02-06 歌礼制药(中国)有限公司 Il-17a的小分子调节剂、制备方法及其使用方法
CN121311483A (zh) * 2023-03-28 2026-01-09 詹森药业有限公司 含内酰胺的咪唑并哒嗪il-17抑制剂化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9309313B2 (en) 2008-01-09 2016-04-12 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
WO2014066726A2 (en) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Compounds for modulating il-17
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
WO2019138017A1 (en) 2018-01-15 2019-07-18 Ucb Biopharma Sprl Fused imidazole derivatives as il-17 modulators
WO2019223718A1 (zh) 2018-05-22 2019-11-28 成都先导药物开发股份有限公司 一种免疫调节剂
JP7349491B2 (ja) 2018-07-12 2023-09-22 ユーシービー バイオファルマ エスアールエル Ｉｌ－１７モジュレーターとしてのスピロ環状インダン類似体
GB201820166D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
GB201820165D0 (en) 2018-12-11 2019-01-23 Ucb Biopharma Sprl Therapeutic agents
BR112021010453A2 (pt) 2018-12-19 2021-08-24 Leo Pharma A/S Composto, e, composição farmacêutica
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
US20220162191A1 (en) 2019-03-08 2022-05-26 Leo Pharma A/S Small molecule modulators of il-17
GB201909191D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909190D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
GB201909194D0 (en) 2019-06-26 2019-08-07 Ucb Biopharma Sprl Therapeutic agents
KR20230019507A (ko) 2020-04-30 2023-02-08 얀센 파마슈티카 엔.브이. Il-17의 조절제로서의 이미다조피리다진
MX2022013649A (es) 2020-04-30 2023-02-01 Janssen Pharmaceutica Nv Métodos para identificar moduladores de la ruta de il-17.
CA3200594A1 (en) * 2020-12-14 2022-06-23 UCB Biopharma SRL Imidazopyridazine derivatives as il-17 modulators

Also Published As

Publication number Publication date
US20240140951A1 (en) 2024-05-02
JP2023552864A (ja) 2023-12-19
EP4259631A1 (en) 2023-10-18
WO2022128584A1 (en) 2022-06-23
JP7827725B2 (ja) 2026-03-10

Similar Documents

Publication Publication Date Title
CA3200594A1 (en) Imidazopyridazine derivatives as il-17 modulators
ES2963417T3 (es) Derivados de imidazol condensados como moduladores de IL-17
US11052076B2 (en) Spirocyclic indolines as IL-17 modulators
EP4363421A1 (en) Imidazotriazine derivatives as il-17 modulators
CA3137686A1 (en) Imidazopyridine derivatives as il-17 modulators
WO2020120141A1 (en) Functionalised amine derivatives as il-17 modulators
JP7682920B2 (ja) Ｉｌ－１７モジュレータとしてのジフルオロシクロヘキシル誘導体
CA3103711A1 (en) Spirocyclic indane analogues as il-17 modulators
CA3110767A1 (en) Benzimidazolone derivatives, and analogues thereof, as il-17 modulators
WO2020260425A1 (en) Fused imidazole derivatives as il-17 modulators
WO2021170631A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
WO2022096411A1 (en) Dicyclopropylmethyl derivatives as il-17 modulators
WO2021204800A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
WO2021170627A1 (en) Difluorocyclohexyl derivatives as il-17 modulators
CA3199816A1 (en) Dicyclopropylmethyl derivatives as il-17 modulators
WO2024017880A1 (en) Imidazotriazine derivatives as il-17 modulators
CN116583521A (zh) 作为il-17调节剂的咪唑并哒嗪衍生物

Legal Events

Date Code Title Description
W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20250819

U13 Renewal or maintenance fee not paid

Free format text: ST27 STATUS EVENT CODE: N-1-6-U10-U13-U300 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO MAINTENANCE FEE NOTICE

Effective date: 20251020