JP7821573B2 - Ｄｏｔ１ｌディグレーダーおよびその使用 - Google Patents

Ｄｏｔ１ｌディグレーダーおよびその使用

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Publication number
JP7821573B2
JP7821573B2 JP2020571383A JP2020571383A JP7821573B2 JP 7821573 B2 JP7821573 B2 JP 7821573B2 JP 2020571383 A JP2020571383 A JP 2020571383A JP 2020571383 A JP2020571383 A JP 2020571383A JP 7821573 B2 JP7821573 B2 JP 7821573B2
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JP
Japan
Prior art keywords
alkyl
certain embodiments
unsubstituted
substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2020571383A
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English (en)
Japanese (ja)
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JPWO2020006157A5 (https=
JP2021529174A (ja
JP2021529174A5 (https=
Inventor
ジュン チィー，
スコット アームストロング，
ポール エム． パーク，
Original Assignee
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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Application filed by デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド filed Critical デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
Publication of JP2021529174A publication Critical patent/JP2021529174A/ja
Publication of JPWO2020006157A5 publication Critical patent/JPWO2020006157A5/ja
Publication of JP2021529174A5 publication Critical patent/JP2021529174A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020571383A 2018-06-27 2019-06-27 Ｄｏｔ１ｌディグレーダーおよびその使用 Active JP7821573B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690791P 2018-06-27 2018-06-27
US62/690,791 2018-06-27
PCT/US2019/039368 WO2020006157A1 (en) 2018-06-27 2019-06-27 Dot1l degrader and uses thereof

Publications (4)

Publication Number Publication Date
JP2021529174A JP2021529174A (ja) 2021-10-28
JPWO2020006157A5 JPWO2020006157A5 (https=) 2022-07-05
JP2021529174A5 JP2021529174A5 (https=) 2022-07-05
JP7821573B2 true JP7821573B2 (ja) 2026-02-27

Family

ID=67263119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020571383A Active JP7821573B2 (ja) 2018-06-27 2019-06-27 Ｄｏｔ１ｌディグレーダーおよびその使用

Country Status (6)

Country Link
US (1) US11634450B2 (https=)
EP (1) EP3814365B1 (https=)
JP (1) JP7821573B2 (https=)
AU (1) AU2019294723B2 (https=)
CA (1) CA3102856A1 (https=)
WO (1) WO2020006157A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020205665C1 (en) 2019-01-09 2025-10-02 Dana-Farber Cancer Institute, Inc. DOT1L degraders and uses thereof
US20240245787A1 (en) 2021-04-13 2024-07-25 President And Fellows Of Harvard College E3 ligase binders and uses thereof
EP4419518A1 (en) * 2021-10-18 2024-08-28 Dana-Farber Cancer Institute, Inc. Small molecules for dot1l degradation and uses thereof
WO2023215354A1 (en) * 2022-05-03 2023-11-09 Board Of Regents, The University Of Texas System Menin proteolysis targeting chimeras (protacs)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015017311A1 (en) 2013-07-29 2015-02-05 Dana-Farber Cancer Institute, Inc. Dot1l probes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9458165B2 (en) * 2014-08-27 2016-10-04 Dana-Farber Cancer Institute, Inc. DOT1L inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015017311A1 (en) 2013-07-29 2015-02-05 Dana-Farber Cancer Institute, Inc. Dot1l probes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ACS Chem. Biol., 2015, Vol. 10, p. 667-674
Chem. Eur. J., 2016, Vol. 22, p. 7824-7836

Also Published As

Publication number Publication date
WO2020006157A1 (en) 2020-01-02
AU2019294723B2 (en) 2024-06-27
CA3102856A1 (en) 2020-01-02
US11634450B2 (en) 2023-04-25
JP2021529174A (ja) 2021-10-28
EP3814365A1 (en) 2021-05-05
US20210130386A1 (en) 2021-05-06
EP3814365B1 (en) 2025-09-17
AU2019294723A1 (en) 2020-12-17

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