CA3102856A1 - Dot1l degraders and uses thereof - Google Patents

Dot1l degraders and uses thereof Download PDF

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Publication number
CA3102856A1
CA3102856A1 CA3102856A CA3102856A CA3102856A1 CA 3102856 A1 CA3102856 A1 CA 3102856A1 CA 3102856 A CA3102856 A CA 3102856A CA 3102856 A CA3102856 A CA 3102856A CA 3102856 A1 CA3102856 A1 CA 3102856A1
Authority
CA
Canada
Prior art keywords
compound
certain embodiments
alkyl
unsubstituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3102856A
Other languages
English (en)
French (fr)
Inventor
Jun Qi
Scott Armstrong
Paul M. PARK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of CA3102856A1 publication Critical patent/CA3102856A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3102856A 2018-06-27 2019-06-27 Dot1l degraders and uses thereof Pending CA3102856A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690791P 2018-06-27 2018-06-27
US62/690,791 2018-06-27
PCT/US2019/039368 WO2020006157A1 (en) 2018-06-27 2019-06-27 Dot1l degrader and uses thereof

Publications (1)

Publication Number Publication Date
CA3102856A1 true CA3102856A1 (en) 2020-01-02

Family

ID=67263119

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3102856A Pending CA3102856A1 (en) 2018-06-27 2019-06-27 Dot1l degraders and uses thereof

Country Status (6)

Country Link
US (1) US11634450B2 (https=)
EP (1) EP3814365B1 (https=)
JP (1) JP7821573B2 (https=)
AU (1) AU2019294723B2 (https=)
CA (1) CA3102856A1 (https=)
WO (1) WO2020006157A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020205665C1 (en) 2019-01-09 2025-10-02 Dana-Farber Cancer Institute, Inc. DOT1L degraders and uses thereof
US20240245787A1 (en) 2021-04-13 2024-07-25 President And Fellows Of Harvard College E3 ligase binders and uses thereof
EP4419518A1 (en) * 2021-10-18 2024-08-28 Dana-Farber Cancer Institute, Inc. Small molecules for dot1l degradation and uses thereof
WO2023215354A1 (en) * 2022-05-03 2023-11-09 Board Of Regents, The University Of Texas System Menin proteolysis targeting chimeras (protacs)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014296532B2 (en) 2013-07-29 2019-05-16 Dana-Farber Cancer Institute, Inc. DOT1L probes
US9458165B2 (en) * 2014-08-27 2016-10-04 Dana-Farber Cancer Institute, Inc. DOT1L inhibitors

Also Published As

Publication number Publication date
WO2020006157A1 (en) 2020-01-02
AU2019294723B2 (en) 2024-06-27
US11634450B2 (en) 2023-04-25
JP2021529174A (ja) 2021-10-28
EP3814365A1 (en) 2021-05-05
US20210130386A1 (en) 2021-05-06
EP3814365B1 (en) 2025-09-17
AU2019294723A1 (en) 2020-12-17
JP7821573B2 (ja) 2026-02-27

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