JP7815127B2 - インターロイキン－１受容体関連キナーゼの二機能性分解剤およびその治療的使用 - Google Patents

インターロイキン－１受容体関連キナーゼの二機能性分解剤およびその治療的使用

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JP7815127B2
JP7815127B2 JP2022549454A JP2022549454A JP7815127B2 JP 7815127 B2 JP7815127 B2 JP 7815127B2 JP 2022549454 A JP2022549454 A JP 2022549454A JP 2022549454 A JP2022549454 A JP 2022549454A JP 7815127 B2 JP7815127 B2 JP 7815127B2
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mmol
methyl
tert
equiv
butyl
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JP2023514323A (ja
JP2023514323A5 (https=
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ワイリー ソラン パーマー，
ジェフリー ウー，
シェイラ ジプフェル，
ケレム オズボヤ，
ダリア ワイス，
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ニューリックス セラピューティクス，インコーポレイテッド
ギリアード サイエンシーズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022549454A 2020-02-19 2021-02-19 インターロイキン－１受容体関連キナーゼの二機能性分解剤およびその治療的使用 Active JP7815127B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062978635P 2020-02-19 2020-02-19
US62/978,635 2020-02-19
PCT/US2021/018710 WO2021168197A1 (en) 2020-02-19 2021-02-19 Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof

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JP2026016996A Division JP2026074171A (ja) 2020-02-19 2026-02-04 インターロイキン－１受容体関連キナーゼの二機能性分解剤およびその治療的使用

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JP2023514323A JP2023514323A (ja) 2023-04-05
JP2023514323A5 JP2023514323A5 (https=) 2024-02-27
JP7815127B2 true JP7815127B2 (ja) 2026-02-17

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Country Link
US (1) US12528814B2 (https=)
EP (1) EP4107158A1 (https=)
JP (1) JP7815127B2 (https=)
KR (1) KR20220155295A (https=)
CN (1) CN115335381A (https=)
AU (1) AU2021224923A1 (https=)
CA (1) CA3165009A1 (https=)
TW (1) TW202140489A (https=)
WO (1) WO2021168197A1 (https=)

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WO2021119159A1 (en) 2019-12-10 2021-06-17 Kymera Therapeutics, Inc. Irak degraders and uses thereof
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
US11739101B2 (en) 2020-05-06 2023-08-29 Nurix Therapeutics, Inc. Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof
CN117813307A (zh) 2021-08-18 2024-04-02 新锐思生物制药股份有限公司 白介素-1受体相关激酶的双官能降解物及其治疗用途
AR127625A1 (es) 2021-11-10 2024-02-14 Nurix Therapeutics Inc Degradadores bifuncionales inhibidores de la quinasa del progenitor hematopoyético y usos terapeuticos de los mismos
EP4446324A4 (en) * 2021-12-08 2026-05-06 Gluetacs Therapeutics Shanghai Co Ltd Ligand compounds for e3 ubiquitin ligase, protein degraders developed on basis of ligand compounds, and uses thereof
WO2023186069A1 (zh) * 2022-03-31 2023-10-05 石药集团中奇制药技术（石家庄）有限公司 一类白介素-1受体相关激酶4的双功能嵌合体杂环化合物及其制备方法、药用组合物和用途
JP2025513850A (ja) 2022-04-12 2025-04-30 ジェンザイム・コーポレーション 遺伝子治療のためのｉｒａｋ４モジュレーターの使用
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CN120202200A (zh) * 2023-06-01 2025-06-24 标新生物医药科技(上海)有限公司 基于氧代异吲哚啉基取代的四氢嘧啶二酮的化合物及其应用
AU2024325813A1 (en) * 2023-08-15 2026-03-05 Guangzhou Imd Pharmaceutical Co., Ltd. Compound targeting irak protein inhibition or degradation and use thereof
WO2025126115A1 (en) 2023-12-13 2025-06-19 Beigene Switzerland Gmbh Degradation of irak4 by conjugation of irak4 inhibitors with e3 ligase ligands and methods of use
WO2025149070A1 (zh) * 2024-01-10 2025-07-17 甘李药业股份有限公司 一种新型靶向白细胞介素1受体关联激酶4(irak4)的蛋白降解嵌合体化合物的合成及其应用
CN118406019B (zh) * 2024-07-02 2024-09-20 苏州源起材料科技有限公司 一种噻唑化合物生物医药砌块的合成方法
WO2026050190A1 (en) * 2024-08-27 2026-03-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Smyd3 protacs for the treatment of hpv-negative squamous cell carcinoma
CN119119080A (zh) * 2024-09-06 2024-12-13 上海信诺维生物医药有限公司 一种irak4的蛋白降解剂
CN120757537B (zh) * 2025-09-09 2026-01-06 广东省科学院动物研究所 Protac降解剂及其应用

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Also Published As

Publication number Publication date
CA3165009A1 (en) 2021-08-26
TW202140489A (zh) 2021-11-01
CN115335381A (zh) 2022-11-11
US12528814B2 (en) 2026-01-20
JP2023514323A (ja) 2023-04-05
AU2021224923A1 (en) 2022-08-11
KR20220155295A (ko) 2022-11-22
WO2021168197A1 (en) 2021-08-26
US20230142629A1 (en) 2023-05-11
EP4107158A1 (en) 2022-12-28

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