JP7801223B2 - Ｃｄ２０６モジュレーター、その使用、および調製方法 - Google Patents

Ｃｄ２０６モジュレーター、その使用、および調製方法

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Publication number
JP7801223B2
JP7801223B2 JP2022537672A JP2022537672A JP7801223B2 JP 7801223 B2 JP7801223 B2 JP 7801223B2 JP 2022537672 A JP2022537672 A JP 2022537672A JP 2022537672 A JP2022537672 A JP 2022537672A JP 7801223 B2 JP7801223 B2 JP 7801223B2
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Japan
Prior art keywords
alkyl
compound
cancer
bond
mmol
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JP2022537672A
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English (en)
Japanese (ja)
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JP2023507610A5 (https=
JP2023507610A (ja
Inventor
ラウル ロランド カルヴォ，
ボロルマー バルジニャム，
アンドレス エドゥアルド ドゥルシー，
ウド ルドルフ，
マーク ジェイムズ ヘンダーソン，
フアン ホセ マルガン，
シン フー，
ノエル テレンス サウソール，
ルシケシュ ヴィラス サブル，
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US Department of Health and Human Services
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US Department of Health and Human Services
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Publication of JP2023507610A publication Critical patent/JP2023507610A/ja
Publication of JP2023507610A5 publication Critical patent/JP2023507610A5/ja
Priority to JP2026000422A priority Critical patent/JP2026053706A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022537672A 2019-12-19 2020-12-16 Ｃｄ２０６モジュレーター、その使用、および調製方法 Active JP7801223B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026000422A JP2026053706A (ja) 2019-12-19 2026-01-05 Ｃｄ２０６モジュレーター、その使用、および調製方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962950488P 2019-12-19 2019-12-19
US62/950,488 2019-12-19
PCT/US2020/065238 WO2021126923A1 (en) 2019-12-19 2020-12-16 Cd206 modulators their use and methods for preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026000422A Division JP2026053706A (ja) 2019-12-19 2026-01-05 Ｃｄ２０６モジュレーター、その使用、および調製方法

Publications (3)

Publication Number Publication Date
JP2023507610A JP2023507610A (ja) 2023-02-24
JP2023507610A5 JP2023507610A5 (https=) 2023-12-06
JP7801223B2 true JP7801223B2 (ja) 2026-01-16

Family

ID=74184891

Family Applications (2)

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JP2022537672A Active JP7801223B2 (ja) 2019-12-19 2020-12-16 Ｃｄ２０６モジュレーター、その使用、および調製方法
JP2026000422A Pending JP2026053706A (ja) 2019-12-19 2026-01-05 Ｃｄ２０６モジュレーター、その使用、および調製方法

Family Applications After (1)

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JP2026000422A Pending JP2026053706A (ja) 2019-12-19 2026-01-05 Ｃｄ２０６モジュレーター、その使用、および調製方法

Country Status (7)

Country Link
US (1) US20230056497A1 (https=)
EP (1) EP4077297A1 (https=)
JP (2) JP7801223B2 (https=)
CN (1) CN115768757B (https=)
AU (1) AU2020404978A1 (https=)
CA (1) CA3165339A1 (https=)
WO (1) WO2021126923A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210151945A (ko) 2019-04-12 2021-12-14 립타이드 바이오사이언스, 인코포레이티드 대식세포 활성을 조정하기 위한 방법
WO2023192935A1 (en) * 2022-03-30 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for the treatment for inflammation and fibrosis in retinal neovascular diseases
WO2025247783A1 (en) 2024-05-29 2025-12-04 Syngenta Crop Protection Ag Pesticidally active dihydro-benzoxazinone compounds
WO2025248032A1 (en) 2024-05-31 2025-12-04 Syngenta Crop Protection Ag Pesticidally active indazole compounds
WO2025257072A1 (en) 2024-06-14 2025-12-18 Syngenta Crop Protection Ag Pesticidally active 2-oxobenzimidazole compounds

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004513882A (ja) 2000-07-31 2004-05-13 シグナル　ファーマシューティカルズ，　インコーポレイテッド Ｊｎｋ阻害剤としてのインダゾール誘導体
US20050009876A1 (en) 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
JP2005522447A (ja) 2002-02-15 2005-07-28 シエーリング アクチエンゲゼルシャフト インターロイキン１２及びＩＦＮγにより介在される免疫反応を中断するための微小グリア細胞インヒビター
JP2008509985A (ja) 2004-08-18 2008-04-03 ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー 炎症治療用の新規トリアゾロピリジン化合物
JP2008509987A (ja) 2004-08-18 2008-04-03 ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー トリアゾロピリジン化合物
JP2008520730A (ja) 2004-11-23 2008-06-19 セルジーン・コーポレーション 中枢神経系傷害の治療用ｊｎｋ阻害剤
WO2011014462A1 (en) 2009-07-27 2011-02-03 Gilead Palo Alto, Inc. Fused heterocyclic compounds as ion channel modulators
JP2014521711A (ja) 2011-08-12 2014-08-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾロ［３，４−ｃ］ピリジン化合物と使用方法
WO2016089977A1 (en) 2014-12-03 2016-06-09 Celgene Corporation Substituted indazole compounds, compositions thereof, and methods of treatment therewith
JP2018526452A (ja) 2015-09-03 2018-09-13 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ Ｄｙｒｋ１ａの小分子抑制剤およびその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2818471A1 (en) * 2013-06-27 2014-12-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5
US10016480B2 (en) 2014-10-14 2018-07-10 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Peptide-based methods for treating pancreatic cancer
US20220340983A1 (en) * 2019-09-13 2022-10-27 Massachustts Institute Of Technology Systems and assays for identifying pu.1 inhibitors

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004513882A (ja) 2000-07-31 2004-05-13 シグナル　ファーマシューティカルズ，　インコーポレイテッド Ｊｎｋ阻害剤としてのインダゾール誘導体
US20050009876A1 (en) 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
JP2005522447A (ja) 2002-02-15 2005-07-28 シエーリング アクチエンゲゼルシャフト インターロイキン１２及びＩＦＮγにより介在される免疫反応を中断するための微小グリア細胞インヒビター
JP2008509985A (ja) 2004-08-18 2008-04-03 ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー 炎症治療用の新規トリアゾロピリジン化合物
JP2008509987A (ja) 2004-08-18 2008-04-03 ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー トリアゾロピリジン化合物
JP2008520730A (ja) 2004-11-23 2008-06-19 セルジーン・コーポレーション 中枢神経系傷害の治療用ｊｎｋ阻害剤
WO2011014462A1 (en) 2009-07-27 2011-02-03 Gilead Palo Alto, Inc. Fused heterocyclic compounds as ion channel modulators
JP2014521711A (ja) 2011-08-12 2014-08-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピラゾロ［３，４−ｃ］ピリジン化合物と使用方法
WO2016089977A1 (en) 2014-12-03 2016-06-09 Celgene Corporation Substituted indazole compounds, compositions thereof, and methods of treatment therewith
JP2018526452A (ja) 2015-09-03 2018-09-13 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ Ｄｙｒｋ１ａの小分子抑制剤およびその使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters，2010年，20(14)，4045-4049
Bioorganic & Medicinal Chemistry Letters，2010年，20(2)，469-473
CHEMMEDCHEM，2018年，13(1)，25-29

Also Published As

Publication number Publication date
EP4077297A1 (en) 2022-10-26
US20230056497A1 (en) 2023-02-23
JP2026053706A (ja) 2026-03-25
JP2023507610A (ja) 2023-02-24
WO2021126923A1 (en) 2021-06-24
CA3165339A1 (en) 2021-06-24
CN115768757B (zh) 2025-07-11
AU2020404978A1 (en) 2022-08-11
CN115768757A (zh) 2023-03-07

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